Page last updated: 2024-09-27

Chondrosarcoma, Mesenchymal

A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed with islands of cartilaginous matrix. Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in the younger age group and are highly metastatic. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1456)

Synonyms(1)

Synonym
Chondrosarcoma, Mesenchymal

Research Excerpts

Overview

ExcerptReference
"Mesenchymal chondrosarcoma is a rare malignant cartilaginous tumor arising within the bone or soft tissue."( Aida, S; Aoki, T; Takagi, K; Tanaka, S; Watanabe, M, 1996)
"Extraskeletal mesenchymal chondrosarcoma is a relatively uncommon entity, an orbital location being extremely rare."( Choi, KH; Mafee, MF; Shinaver, CN, 1997)
"Mesenchymal chondrosarcomas are distinct from conventional and dedifferentiated chondrosarcomas and are quite rare, making up less than 2% of all chondrosarcomas."( Agnantis, N; Demou, S; Soucacos, PN; Theodorou, DJ; Theodorou, SJ; Xenakis, T, 2001)
"Mesenchymal chondrosarcoma is a rare and aggressive form of chondrosarcoma."( Choe, G; Kim, KJ; Kim, SE; Lee, E; Lee, HY; Lee, WW, 2014)
"Mesenchymal chondrosarcomas are a rare variant of primary chondrosarcomas and can pose a diagnostic dilemma, especially when the features on conventional imaging are equivocal for an aggressive lesion."( Goh, GH; Uppaluri, SA; Yin, LH, 2015)
"Mesenchymal chondrosarcomas are rare and highly aggressive sarcomas occurring in bone and soft tissue, with poor overall survival."( Bovée, JV; Briaire-de Bruijn, IH; Cleton-Jansen, AM; de Jong, D; de Jong, Y; Fletcher, JA; Gelderblom, H; Kruisselbrink, AB; Marino-Enriquez, A; Suijker, J; Szuhai, K; van Maldegem, AM, 2016)

Research

Studies (35)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's6 (17.14)12.5806
2000's12 (34.29)18.1394
2010's12 (34.29)28.8240
2020's5 (14.29)9.53
DrugIndicatedRelationship StrengthStudiesTrials
formaldehyde0low10
ifosfamide0low10
temozolomide0low10
epirubicin0low10
propiconazole0low60
fluorodeoxyglucose f180low50
imatinib mesylate0low10
docetaxel anhydrous0low10
carboplatin0low10
glycogen0low10
dactinomycin0low10
bromochloroacetic acid0low20
calcitriol0low10
phosphorus0low10
gadolinium dtpa0low10
abt-7370low10
olaparib0medium11
3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea0low10
transforming growth factor beta0low20
nitrophenols0low10
dacarbazine0low10

Protein Targets (268)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
PPM1D protein7007
cytochrome P450 family 3 subfamily A polypeptide 44004
EWS/FLI fusion protein5005
G2002
cytochrome P450 2D63003
Interferon beta9009
HLA class I histocompatibility antigen, B alpha chain 2002
Fibroblast growth factor receptor 10101
Fibroblast growth factor receptor 20101
Fibroblast growth factor receptor 40101
Fibroblast growth factor receptor 30101
Fibroblast growth factor receptor 40101
Inositol hexakisphosphate kinase 12002
Smoothened homolog0101
cytochrome P450 2C9, partial2002
Chain A, Apoptosis regulator Bcl-X0101
Bcl-2-like protein 110101
Beta-casein0101
Apoptosis regulator Bcl-20224
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Adenosine receptor A2a0101
BH3-interacting domain death agonist0202
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog0011
Apoptosis regulator BAX 0101
Bcl-2-like protein 10224
Induced myeloid leukemia cell differentiation protein Mcl-10202
Aspartyl/asparaginyl beta-hydroxylase0101
Bcl-2-related protein A10112
Bcl-2 homologous antagonist/killer0213
Bcl-2-like protein 20202
Bcl2-associated agonist of cell death 0101
Bcl-2-binding component 3, isoforms 1/20101
Bcl-2-like protein 100101
RAR-related orphan receptor gamma5005
AR protein8008
aldehyde dehydrogenase 1 family, member A14004
nuclear receptor subfamily 1, group I, member 36006
retinoic acid nuclear receptor alpha variant 16006
thyroid stimulating hormone receptor4004
nuclear factor erythroid 2-related factor 2 isoform 15005
Cellular tumor antigen p535005
Nuclear receptor ROR-gamma2002
Chain A, Vitamin D Nuclear Receptor0011
Chain A, Beta-lactamase3003
Chain A, Ferritin light chain3003
Vitamin D3 receptor0011
USP1 protein, partial3003
Microtubule-associated protein tau2002
thioredoxin glutathione reductase1001
euchromatic histone-lysine N-methyltransferase 23003
mitogen-activated protein kinase 11001
nuclear receptor ROR-gamma isoform 13003
geminin5005
peripheral myelin protein 222002
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Bile salt export pump0707
Vitamin D-binding protein0011
Cytochrome P450 1A20102
Cytochrome P450 3A40305
Androgen receptor0101
Cytochrome P450 2D60202
Vitamin D3 receptor0124
Cytochrome P450 2C9 0102
Vitamin D3 receptor0113
Retinoic acid receptor RXR-alpha0011
Cytochrome P450 2C190101
Kappa-type opioid receptor0011
Vitamin D3 receptor0011
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0011
Vitamin D3 receptor0112
Transporter0101
Canalicular multispecific organic anion transporter 10606
Vitamin D3 receptor A0022
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
acetylcholinesterase2002
phosphopantetheinyl transferase2002
estrogen receptor 2 (ER beta)4004
vitamin D3 receptor isoform VDRA3003
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
DNA polymerase kappa isoform 12002
histone acetyltransferase KAT2A isoform 12002
ATP-dependent phosphofructokinase1001
Chain A, 2-oxoglutarate Oxygenase2002
interleukin 82002
hypoxia-inducible factor 1 alpha subunit2002
thyroid stimulating hormone receptor1001
glucocorticoid receptor [Homo sapiens]6006
estrogen-related nuclear receptor alpha5005
estrogen nuclear receptor alpha8008
peroxisome proliferator activated receptor gamma5005
activating transcription factor 62002
survival motor neuron protein isoform d3003
lamin isoform A-delta102002
Matrix metalloproteinase-90101
Inositol monophosphatase 11001
Isocitrate lyase0101
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Cruzipain1001
15-lipoxygenase, partial1001
TDP1 protein5005
GLI family zinc finger 35005
caspase 7, apoptosis-related cysteine protease2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
progesterone receptor3003
retinoid X nuclear receptor alpha5005
farnesoid X nuclear receptor5005
pregnane X nuclear receptor6006
peroxisome proliferator-activated receptor delta3003
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
caspase-32002
RAD510101
aryl hydrocarbon receptor4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
v-jun sarcoma virus 17 oncogene homolog (avian)1001
Histone H2A.x1001
Caspase-71001
Bloom syndrome protein isoform 11001
thyroid hormone receptor beta isoform a2002
caspase-31001
thyroid hormone receptor beta isoform 26006
huntingtin isoform 21001
cytochrome P450 3A4 isoform 11001
caspase-1 isoform alpha precursor1001
Gamma-aminobutyric acid receptor subunit pi1001
Voltage-dependent calcium channel gamma-2 subunit3003
ATP-dependent translocase ABCB10001
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Glutamate receptor 23003
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 10101
Caspase-71001
Spike glycoprotein6006
Gamma-aminobutyric acid receptor subunit alpha-11001
Growth factor receptor-bound protein 20101
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Pantothenate synthetase0101
Discoidin domain-containing receptor 20101
Growth factor receptor-bound protein 2 0101
Reverse transcriptase/RNaseH 0101
GABA theta subunit1001
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
ATPase family AAA domain-containing protein 55005
Ataxin-25005
Gamma-aminobutyric acid receptor subunit epsilon1001
67.9K protein1001
nuclear receptor subfamily 1, group I, member 22002
Serum paraoxonase/arylesterase 10202
Kinesin-like protein KIF110101
Nucleotide-binding oligomerization domain-containing protein 20101
Genome polyprotein 0101
Fumarate hydratase1001
polyprotein1001
Tyrosine-protein kinase Fyn0101
UDP-glucuronosyltransferase 2B70001
GALC protein1001
chromobox protein homolog 12002
Luciferase1001
glp-1 receptor, partial2002
thioredoxin reductase2002
SMAD family member 22002
SMAD family member 32002
IDH11001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
serine/threonine-protein kinase mTOR isoform 11001
DNA polymerase iota isoform a (long)2002
DNA repair protein RAD52 homolog isoform a0001
Tyrosine-protein kinase ABL10213
Cytochrome P450 2C80001
Mast/stem cell growth factor receptor Kit0112
Breakpoint cluster region protein0011
Platelet-derived growth factor receptor alpha0112
Cytochrome P450 3A50001
ATAD5 protein, partial1001
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
Poly [ADP-ribose] polymerase tankyrase-10101
Cholinesterase0101
Poly [ADP-ribose] polymerase 10224
Protein mono-ADP-ribosyltransferase PARP60101
Protein mono-ADP-ribosyltransferase PARP150101
Protein mono-ADP-ribosyltransferase PARP100112
Protein mono-ADP-ribosyltransferase PARP80011
Protein mono-ADP-ribosyltransferase PARP160112
Protein mono-ADP-ribosyltransferase PARP120101
Poly [ADP-ribose] polymerase tankyrase-20101
Histamine H3 receptor0101
Poly [ADP-ribose] polymerase 20123
Protein mono-ADP-ribosyltransferase PARP40112
Protein mono-ADP-ribosyltransferase PARP30123
pregnane X receptor1001
nonstructural protein 11001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Histamine H2 receptor1001
Guanine nucleotide-binding protein G1001
TAR DNA-binding protein 431001
heat shock protein 90, putative0001
chaperonin-containing TCP-1 beta subunit homolog1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
Carbonic anhydrase 120202
5'-AMP-activated protein kinase subunit beta-20001
Bile salt export pump0101
Carbonic anhydrase 10303
Carbonic anhydrase 20303
Albumin0101
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90202
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
polyadenylate-binding protein 10101
muscleblind-like protein 1 isoform 11001
Tyrosine-protein kinase ABL20101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]