Chondrosarcoma, Mesenchymal

A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed with islands of cartilaginous matrix. Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in the younger age group and are highly metastatic. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1456)

Synonyms(1)

Synonym
Chondrosarcoma, Mesenchymal

Research Excerpts

Overview

Excerpt	Reference
"Mesenchymal chondrosarcoma is a rare malignant cartilaginous tumor arising within the bone or soft tissue."	( Aida, S; Aoki, T; Takagi, K; Tanaka, S; Watanabe, M, 1996)
"Extraskeletal mesenchymal chondrosarcoma is a relatively uncommon entity, an orbital location being extremely rare."	( Choi, KH; Mafee, MF; Shinaver, CN, 1997)
"Mesenchymal chondrosarcomas are distinct from conventional and dedifferentiated chondrosarcomas and are quite rare, making up less than 2% of all chondrosarcomas."	( Agnantis, N; Demou, S; Soucacos, PN; Theodorou, DJ; Theodorou, SJ; Xenakis, T, 2001)
"Mesenchymal chondrosarcoma is a rare and aggressive form of chondrosarcoma."	( Choe, G; Kim, KJ; Kim, SE; Lee, E; Lee, HY; Lee, WW, 2014)
"Mesenchymal chondrosarcomas are a rare variant of primary chondrosarcomas and can pose a diagnostic dilemma, especially when the features on conventional imaging are equivocal for an aggressive lesion."	( Goh, GH; Uppaluri, SA; Yin, LH, 2015)
"Mesenchymal chondrosarcomas are rare and highly aggressive sarcomas occurring in bone and soft tissue, with poor overall survival."	( Bovée, JV; Briaire-de Bruijn, IH; Cleton-Jansen, AM; de Jong, D; de Jong, Y; Fletcher, JA; Gelderblom, H; Kruisselbrink, AB; Marino-Enriquez, A; Suijker, J; Szuhai, K; van Maldegem, AM, 2016)

Research

Studies (35)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	6 (17.14)	12.5806
2000's	12 (34.29)	18.1394
2010's	12 (34.29)	28.8240
2020's	5 (14.29)	9.53

Drug	Relationship Strength	Studies	Trials
formaldehyde	low	1	0
ifosfamide	low	1	0
temozolomide	low	1	0
epirubicin	low	1	0
propiconazole	low	6	0
fluorodeoxyglucose f18	low	5	0
imatinib mesylate	low	1	0
docetaxel anhydrous	low	1	0
carboplatin	low	1	0
glycogen	low	1	0
dactinomycin	low	1	0
bromochloroacetic acid	low	2	0
calcitriol	low	1	0
phosphorus	low	1	0
gadolinium dtpa	low	1	0
abt-737	low	1	0
olaparib	medium	1	1
3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea	low	1	0
transforming growth factor beta	low	2	0
nitrophenols	low	1	0
dacarbazine	low	1	0

Protein Targets (268)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
PPM1D protein	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
EWS/FLI fusion protein	5	0	0	5
G	2	0	0	2
cytochrome P450 2D6	3	0	0	3
Interferon beta	9	0	0	9
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Fibroblast growth factor receptor 1	0	1	0	1
Fibroblast growth factor receptor 2	0	1	0	1
Fibroblast growth factor receptor 4	0	1	0	1
Fibroblast growth factor receptor 3	0	1	0	1
Fibroblast growth factor receptor 4	0	1	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
Smoothened homolog	0	1	0	1
cytochrome P450 2C9, partial	2	0	0	2
Chain A, Apoptosis regulator Bcl-X	0	1	0	1
Bcl-2-like protein 11	0	1	0	1
Beta-casein	0	1	0	1
Apoptosis regulator Bcl-2	0	2	2	4
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Adenosine receptor A2a	0	1	0	1
BH3-interacting domain death agonist	0	2	0	2
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog	0	0	1	1
Apoptosis regulator BAX	0	1	0	1
Bcl-2-like protein 1	0	2	2	4
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Aspartyl/asparaginyl beta-hydroxylase	0	1	0	1
Bcl-2-related protein A1	0	1	1	2
Bcl-2 homologous antagonist/killer	0	2	1	3
Bcl-2-like protein 2	0	2	0	2
Bcl2-associated agonist of cell death	0	1	0	1
Bcl-2-binding component 3, isoforms 1/2	0	1	0	1
Bcl-2-like protein 10	0	1	0	1
RAR-related orphan receptor gamma	5	0	0	5
AR protein	8	0	0	8
aldehyde dehydrogenase 1 family, member A1	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
thyroid stimulating hormone receptor	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	5	0	0	5
Cellular tumor antigen p53	5	0	0	5
Nuclear receptor ROR-gamma	2	0	0	2
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
Chain A, Ferritin light chain	3	0	0	3
Vitamin D3 receptor	0	0	1	1
USP1 protein, partial	3	0	0	3
Microtubule-associated protein tau	2	0	0	2
thioredoxin glutathione reductase	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	3	0	0	3
mitogen-activated protein kinase 1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	3	0	0	3
geminin	5	0	0	5
peripheral myelin protein 22	2	0	0	2
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	6
Bile salt export pump	0	7	0	7
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	1	0	2
Cytochrome P450 3A4	0	3	0	5
Androgen receptor	0	1	0	1
Cytochrome P450 2D6	0	2	0	2
Vitamin D3 receptor	0	1	2	4
Cytochrome P450 2C9	0	1	0	2
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Cytochrome P450 2C19	0	1	0	1
Kappa-type opioid receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	6	0	6
Vitamin D3 receptor A	0	0	2	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
acetylcholinesterase	2	0	0	2
phosphopantetheinyl transferase	2	0	0	2
estrogen receptor 2 (ER beta)	4	0	0	4
vitamin D3 receptor isoform VDRA	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
DNA polymerase kappa isoform 1	2	0	0	2
histone acetyltransferase KAT2A isoform 1	2	0	0	2
ATP-dependent phosphofructokinase	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
interleukin 8	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
thyroid stimulating hormone receptor	1	0	0	1
glucocorticoid receptor [Homo sapiens]	6	0	0	6
estrogen-related nuclear receptor alpha	5	0	0	5
estrogen nuclear receptor alpha	8	0	0	8
peroxisome proliferator activated receptor gamma	5	0	0	5
activating transcription factor 6	2	0	0	2
survival motor neuron protein isoform d	3	0	0	3
lamin isoform A-delta10	2	0	0	2
Matrix metalloproteinase-9	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Isocitrate lyase	0	1	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Cruzipain	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
TDP1 protein	5	0	0	5
GLI family zinc finger 3	5	0	0	5
caspase 7, apoptosis-related cysteine protease	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
progesterone receptor	3	0	0	3
retinoid X nuclear receptor alpha	5	0	0	5
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	6	0	0	6
peroxisome proliferator-activated receptor delta	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
caspase-3	2	0	0	2
RAD51	0	1	0	1
aryl hydrocarbon receptor	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
Histone H2A.x	1	0	0	1
Caspase-7	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
caspase-3	1	0	0	1
thyroid hormone receptor beta isoform 2	6	0	0	6
huntingtin isoform 2	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
ATP-dependent translocase ABCB1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Glutamate receptor 2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Caspase-7	1	0	0	1
Spike glycoprotein	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Pantothenate synthetase	0	1	0	1
Discoidin domain-containing receptor 2	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
GABA theta subunit	1	0	0	1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
ATPase family AAA domain-containing protein 5	5	0	0	5
Ataxin-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
67.9K protein	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Serum paraoxonase/arylesterase 1	0	2	0	2
Kinesin-like protein KIF11	0	1	0	1
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Genome polyprotein	0	1	0	1
Fumarate hydratase	1	0	0	1
polyprotein	1	0	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
GALC protein	1	0	0	1
chromobox protein homolog 1	2	0	0	2
Luciferase	1	0	0	1
glp-1 receptor, partial	2	0	0	2
thioredoxin reductase	2	0	0	2
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
IDH1	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Tyrosine-protein kinase ABL1	0	2	1	3
Cytochrome P450 2C8	0	0	0	1
Mast/stem cell growth factor receptor Kit	0	1	1	2
Breakpoint cluster region protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Cytochrome P450 3A5	0	0	0	1
ATAD5 protein, partial	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Poly [ADP-ribose] polymerase tankyrase-1	0	1	0	1
Cholinesterase	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	2	2	4
Protein mono-ADP-ribosyltransferase PARP6	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP10	0	1	1	2
Protein mono-ADP-ribosyltransferase PARP8	0	0	1	1
Protein mono-ADP-ribosyltransferase PARP16	0	1	1	2
Protein mono-ADP-ribosyltransferase PARP12	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Histamine H3 receptor	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	2	3
Protein mono-ADP-ribosyltransferase PARP4	0	1	1	2
Protein mono-ADP-ribosyltransferase PARP3	0	1	2	3
pregnane X receptor	1	0	0	1
nonstructural protein 1	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Histamine H2 receptor	1	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
heat shock protein 90, putative	0	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Polyphenol oxidase 2	0	1	0	2
Carbonic anhydrase 12	0	2	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Bile salt export pump	0	1	0	1
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase 9	0	2	0	2
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
polyadenylate-binding protein 1	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Tyrosine-protein kinase ABL2	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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