Page last updated: 2024-09-28
Chondromatosis, Synovial
Rare, benign, chronic, progressive metaplasia in which cartilage is formed in the synovial membranes of joints, tendon sheaths, or bursae. Some of the metaplastic foci can become detached producing loose bodies. When the loose bodies undergo secondary calcification, the condition is called synovial osteochondromatosis.
Synonyms(7)
| Synonym |
|---|
| Henderson-Jones Syndrome |
| Synovial Chondromatosis |
| Synovial Chondrometaplasia |
| Reichel's Syndrome |
| Chondromatosis, Synovial |
| Synovial Osteochondromatosis |
| Osteochondromatosis, Synovial |
Research Excerpts
Overview
| Excerpt | Reference |
|---|---|
| "Synovial chondromatosis is a condition affecting joints in which metaplastic cartilage nodules arise from the synovium, causing pain, joint dysfunction, and ultimately joint destruction." | ( Alman, BA; Hopyan, S; Nadesan, P; Wunder, J; Yu, C, 2005) |
| "Synovial chondromatosis is characterized by the formation of osteocartilaginous nodules (free bodies) under the surface of the synovial membrane in joints." | ( Amagasa, T; Kino, K; Nakanishi, S; Sakamoto, K; Sskamoto, K; Yamaguchi, A; Yoshitake, H, 2009) |
| "Synovial chondromatosis is an uncommon condition, characterized by multinodular cartilagineous proliferation of the joint synovium." | ( Kuvat, SV; Mersa, B; Ozçelik, IB; Pilancı, O, 2010) |
| "Synovial chondromatosis is a non-neoplastic disease characterized by metaplasia of the connective tissue leading to chondrogenesis in the synovial membrane." | ( Kato, H; Matsumura, Y; Nakanishi, K; Nomura, J; Tagawa, T; Yanase, S, 2012) |
| "Tenosynovial chondromatosis is a benign chondrogenic metaplasia of extra-articular synovial tissue." | ( Flores, RR; Jordanov, MI; Thomson, AB; Winters, NI, 2015) |
| "Extraarticular synovial osteochondromatosis is a very rare benign disease whose aetiology may be primary or secondary to pre-existing pathology or after trauma." | ( García Espinosa, J; Martínez Martínez, A; Moya Sánchez, E, 2021) |
Context
| Excerpt | Reference |
|---|---|
| "Tenosynovial chondromatosis has not been well recognized because of its rarity, but it is clinically important because of its high rate of recurrence." | ( Daa, T; Hisaoka, M; Kashima, K; Kashima, N; Tsuji, K; Ueo, T; Yokoyama, S, 2004) |
Actions
| Excerpt | Reference |
|---|---|
| "We present a case of synovial chondromatosis affecting the interphalangeal joint where the disease did not clearly manifest itself on pre-operative radiographs." | ( Jones, JW; Spiers, JD; Wijeratna, MD, 2014) |
Research
Studies (40)
| Timeframe | Studies, This Condition (%) | All Conditions % |
|---|---|---|
| pre-1990 | 1 (2.50) | 23.3326 |
| 1990's | 11 (27.50) | 12.5806 |
| 2000's | 10 (25.00) | 18.1394 |
| 2010's | 14 (35.00) | 28.8240 |
| 2020's | 4 (10.00) | 9.53 |
Drugs Studied (21)
| Drug | Indicated | Relationship Strength | Studies | Trials |
|---|---|---|---|---|
| uric acid | 0 | low | 1 | 0 |
| triparanol | 0 | low | 1 | 0 |
| 3,3'-diaminobenzidine | 0 | low | 1 | 0 |
| tolonium chloride | 0 | low | 1 | 0 |
| gadolinium | 0 | low | 3 | 0 |
| calcium pyrophosphate | 0 | low | 3 | 0 |
| trolamine salicylate | 0 | low | 10 | 0 |
| technetium tc 99m hydroxymethylene diphosphonate | 0 | low | 2 | 0 |
| cortisone | 0 | low | 1 | 0 |
| succimer | 0 | low | 1 | 0 |
| interleukin-8 | 0 | low | 1 | 0 |
| transforming growth factor beta | 0 | low | 3 | 0 |
| technetium tc 99m medronate | 0 | low | 3 | 0 |
| technetium tc 99m dimercaptosuccinic acid | 0 | low | 1 | 0 |