Page last updated: 2024-09-28

Chondromatosis, Synovial

Rare, benign, chronic, progressive metaplasia in which cartilage is formed in the synovial membranes of joints, tendon sheaths, or bursae. Some of the metaplastic foci can become detached producing loose bodies. When the loose bodies undergo secondary calcification, the condition is called synovial osteochondromatosis.

Synonyms(7)

Synonym
Henderson-Jones Syndrome
Synovial Chondromatosis
Synovial Chondrometaplasia
Reichel's Syndrome
Chondromatosis, Synovial
Synovial Osteochondromatosis
Osteochondromatosis, Synovial

Research Excerpts

Overview

ExcerptReference
"Synovial chondromatosis is a condition affecting joints in which metaplastic cartilage nodules arise from the synovium, causing pain, joint dysfunction, and ultimately joint destruction."( Alman, BA; Hopyan, S; Nadesan, P; Wunder, J; Yu, C, 2005)
"Synovial chondromatosis is characterized by the formation of osteocartilaginous nodules (free bodies) under the surface of the synovial membrane in joints."( Amagasa, T; Kino, K; Nakanishi, S; Sakamoto, K; Sskamoto, K; Yamaguchi, A; Yoshitake, H, 2009)
"Synovial chondromatosis is an uncommon condition, characterized by multinodular cartilagineous proliferation of the joint synovium."( Kuvat, SV; Mersa, B; Ozçelik, IB; Pilancı, O, 2010)
"Synovial chondromatosis is a non-neoplastic disease characterized by metaplasia of the connective tissue leading to chondrogenesis in the synovial membrane."( Kato, H; Matsumura, Y; Nakanishi, K; Nomura, J; Tagawa, T; Yanase, S, 2012)
"Tenosynovial chondromatosis is a benign chondrogenic metaplasia of extra-articular synovial tissue."( Flores, RR; Jordanov, MI; Thomson, AB; Winters, NI, 2015)
"Extraarticular synovial osteochondromatosis is a very rare benign disease whose aetiology may be primary or secondary to pre-existing pathology or after trauma."( García Espinosa, J; Martínez Martínez, A; Moya Sánchez, E, 2021)

Context

ExcerptReference
"Tenosynovial chondromatosis has not been well recognized because of its rarity, but it is clinically important because of its high rate of recurrence."( Daa, T; Hisaoka, M; Kashima, K; Kashima, N; Tsuji, K; Ueo, T; Yokoyama, S, 2004)

Actions

ExcerptReference
"We present a case of synovial chondromatosis affecting the interphalangeal joint where the disease did not clearly manifest itself on pre-operative radiographs."( Jones, JW; Spiers, JD; Wijeratna, MD, 2014)

Research

Studies (40)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (2.50)23.3326
1990's11 (27.50)12.5806
2000's10 (25.00)18.1394
2010's14 (35.00)28.8240
2020's4 (10.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
uric acid0low10
triparanol0low10
3,3'-diaminobenzidine0low10
tolonium chloride0low10
gadolinium0low30
calcium pyrophosphate0low30
trolamine salicylate0low100
technetium tc 99m hydroxymethylene diphosphonate0low20
cortisone0low10
succimer0low10
interleukin-80low10
transforming growth factor beta0low30
technetium tc 99m medronate0low30
technetium tc 99m dimercaptosuccinic acid0low10

Protein Targets (169)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Luciferase3003
RAR-related orphan receptor gamma5005
GLI family zinc finger 34004
AR protein5005
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor4004
glucocorticoid receptor [Homo sapiens]5005
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha4004
estrogen-related nuclear receptor alpha3003
farnesoid X nuclear receptor3003
pregnane X nuclear receptor4004
estrogen nuclear receptor alpha6006
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
aryl hydrocarbon receptor3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
thyroid stimulating hormone receptor3003
activating transcription factor 61001
v-jun sarcoma virus 17 oncogene homolog (avian)4004
Histone H2A.x3003
histone deacetylase 9 isoform 32002
heat shock protein beta-14004
nuclear factor erythroid 2-related factor 2 isoform 14004
Voltage-dependent calcium channel gamma-2 subunit3003
Cellular tumor antigen p534004
Glutamate receptor 23003
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
endonuclease IV2002
dopamine D1 receptor2002
thioredoxin reductase2002
pregnane X receptor1001
GLS protein1001
TDP1 protein4004
aldehyde dehydrogenase 1 family, member A11001
regulator of G-protein signaling 42002
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma3003
euchromatic histone-lysine N-methyltransferase 22002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
peripheral myelin protein 22 isoform 12002
atrial natriuretic peptide receptor 1 precursor1001
chromobox protein homolog 11001
flap endonuclease 11001
geminin3003
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 11001
M-phase phosphoprotein 81001
muscarinic acetylcholine receptor M12002
Gamma-aminobutyric acid receptor subunit pi1001
Bile salt export pump0303
Glucocorticoid receptor0202
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Glycine receptor subunit alpha-30202
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 431001
GABA theta subunit1001
Multidrug and toxin extrusion protein 10101
Gamma-aminobutyric acid receptor subunit epsilon1001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
ATAD5 protein, partial1001
NFKB1 protein, partial1001
thyroid stimulating hormone receptor1001
arylsulfatase A1001
vasopressin V1b receptor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
DNA polymerase iota isoform a (long)1001
histone acetyltransferase KAT2A isoform 11001
relaxin receptor 1 isoform 11001
lamin isoform A-delta101001
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Tumor necrosis factor0101
Cholinesterase0101
Acetylcholinesterase0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Adenosine receptor A2b0101
Spike glycoprotein3014
Disintegrin and metalloproteinase domain-containing protein 171001
Inositol monophosphatase 11001
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chitotriosidase-10213
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Endochitinase B10213
Canalicular multispecific organic anion transporter 10202
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0213
Chain A, Ferritin light chain1001
USP1 protein, partial2002
thyroid hormone receptor beta isoform 23003
nuclear receptor ROR-gamma isoform 12002
DNA polymerase kappa isoform 11001
peripheral myelin protein 222002
Nuclear receptor subfamily 1 group I member 20011
Cytochrome P450 3A40101
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 3A50101
UDP-glucuronosyltransferase 1A40001
Serine/threonine-protein kinase mTOR0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Solute carrier organic anion transporter family member 1B10101
acetylcholinesterase2002
Fumarate hydratase2002
estrogen receptor 2 (ER beta)2002
cytochrome P450 family 3 subfamily A polypeptide 42002
G2002
cytochrome P450 2D62002
polyprotein2002
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Microtubule-associated protein tau0202
Inositol hexakisphosphate kinase 12002
cytochrome P450 2C9, partial2002
phosphopantetheinyl transferase1001
SMAD family member 21001
SMAD family member 31001
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
Caspase-71001
Spike glycoprotein0011
vitamin D3 receptor isoform VDRA1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
caspase-31001
Transmembrane protease serine 20011
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
C-8 sterol isomerase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sigma non-opioid intracellular receptor 10101
Angiotensin-converting enzyme 2 0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 22 member 60001
Solute carrier family 22 member 80101
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]