Page last updated: 2024-09-28

Chiari-Frommel Syndrome

A POSTPARTUM condition consists of persistent lactation (GALACTORRHEA) and AMENORRHEA in patients not BREAST FEEDING.

Synonyms(3)

Synonym
Frommel Disease
Chiari-Frommel Syndrome
Frommel's Disease

Research

Studies (57)

TimeframeStudies, This Condition (%)All Conditions %
pre-199055 (96.49)23.3326
1990's1 (1.75)12.5806
2000's1 (1.75)18.1394
2010's0 (0.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
iodine0low10
dihydroxyphenylalanine0low40
melatonin0low10
chlorpromazine0low30
cyclofenil0low10
metoclopramide0low10
metyrapone0low10
estriol0low10
thyroxine0low40
lynestrenol0low10
prednisone0low10
androsterone0low20
etiocholanolone0low10
dehydroepiandrosterone0low30
ethinyl estradiol0low30
methyltestosterone0low10
levodopa0low10
norethindrone0low10
medroxyprogesterone acetate0low10
phenothiazine0low10
medroxyprogesterone0low10
bromine0low20
bromocriptine0low40
phenyl acetate0low10
cortisone0low10
oxytocin0low10
stilbenes0low20
enclomiphene0low170
17-ketosteroids0low60
ethisterone0low10
pregnanediol0low30
ergoline0low20
menotropins0low10

Protein Targets (528)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, retinol dehydratase0101
acetylcholinesterase5005
RAR-related orphan receptor gamma170017
TDP1 protein160016
GLI family zinc finger 3160016
AR protein190019
estrogen receptor 2 (ER beta)100010
progesterone receptor160016
retinoic acid nuclear receptor alpha variant 1170017
retinoid X nuclear receptor alpha130013
estrogen-related nuclear receptor alpha150015
pregnane X nuclear receptor170017
estrogen nuclear receptor alpha210021
v-jun sarcoma virus 17 oncogene homolog (avian)120012
histone acetyltransferase KAT2A isoform 12002
Gamma-aminobutyric acid receptor subunit pi7108
Voltage-dependent calcium channel gamma-2 subunit8008
Sex hormone-binding globulin001010
Corticosteroid-binding globulin0505
Glucose-6-phosphate 1-dehydrogenase0303
Androgen receptor016016
Gamma-aminobutyric acid receptor subunit beta-17108
Gamma-aminobutyric acid receptor subunit delta7108
Gamma-aminobutyric acid receptor subunit gamma-27108
Glutamate receptor 29009
Gamma-aminobutyric acid receptor subunit alpha-57108
Gamma-aminobutyric acid receptor subunit alpha-37108
Gamma-aminobutyric acid receptor subunit gamma-17108
Gamma-aminobutyric acid receptor subunit alpha-27108
Gamma-aminobutyric acid receptor subunit alpha-47108
Gamma-aminobutyric acid receptor subunit gamma-37108
Gamma-aminobutyric acid receptor subunit alpha-67108
Solute carrier organic anion transporter family member 1A10202
Gamma-aminobutyric acid receptor subunit alpha-17108
Gamma-aminobutyric acid receptor subunit beta-37108
Gamma-aminobutyric acid receptor subunit beta-27108
TAR DNA-binding protein 436006
G-protein coupled bile acid receptor 10033
GABA theta subunit7108
Gamma-aminobutyric acid receptor subunit epsilon7108
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Genome polyprotein 0112
dopamine D1 receptor3003
thioredoxin reductase8008
ATAD5 protein, partial4004
Fumarate hydratase3003
GLS protein3003
regulator of G-protein signaling 43003
cytochrome P450 family 3 subfamily A polypeptide 4130013
glucocorticoid receptor [Homo sapiens]160016
G9009
polyprotein3003
peroxisome proliferator activated receptor gamma130013
euchromatic histone-lysine N-methyltransferase 2100010
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a150015
D(1A) dopamine receptor3003
vitamin D3 receptor isoform VDRA3003
chromobox protein homolog 1100010
thyroid hormone receptor beta isoform 2140014
serine/threonine-protein kinase mTOR isoform 12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
5-hydroxytryptamine receptor 4010010
Interferon beta9009
HLA class I histocompatibility antigen, B alpha chain 9009
Cellular tumor antigen p539009
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10203
Beta-1 adrenergic receptor0202
Cytochrome P450 3A40303
5-hydroxytryptamine receptor 1A0202
Alpha-2A adrenergic receptor0808
D(2) dopamine receptor0618
Alpha-2B adrenergic receptor0606
Alpha-2C adrenergic receptor0606
D0404
D(3) dopamine receptor0404
5-hydroxytryptamine receptor 1A0505
Alpha-2B adrenergic receptor0404
ATP-dependent translocase ABCB10101
D(1A) dopamine receptor0405
Alpha-2C adrenergic receptor0404
Alpha-2A adrenergic receptor0404
Alpha-1D adrenergic receptor0404
D(1B) dopamine receptor0404
5-hydroxytryptamine receptor 2A0819
5-hydroxytryptamine receptor 2C010111
5-hydroxytryptamine receptor 1B0606
D(4) dopamine receptor0404
D(3) dopamine receptor0809
Alpha-synuclein3407
5-hydroxytryptamine receptor 2B0808
5-hydroxytryptamine receptor 60606
D(2) dopamine receptor0517
Inositol hexakisphosphate kinase 19009
ATPase family AAA domain-containing protein 53003
Ataxin-24004
cytochrome P450 2C9, partial9009
ATP-dependent phosphofructokinase4004
Chain A, TYROSYL-DNA PHOSPHODIESTERASE7007
Proteasome subunit beta type-110001
phosphopantetheinyl transferase4004
USP1 protein, partial4004
NFKB1 protein, partial1001
Microtubule-associated protein tau5005
Thrombopoietin1001
Smad33003
caspase 7, apoptosis-related cysteine protease4004
nuclear receptor subfamily 1, group I, member 3130013
NADPH oxidase 10202
farnesoid X nuclear receptor8008
cytochrome P450 2D66006
67.9K protein2002
peroxisome proliferator-activated receptor delta9009
vitamin D (1,25- dihydroxyvitamin D3) receptor130013
Snq2p0002
caspase-34004
IDH14004
Adenylate cyclase type 1 0202
thyroid stimulating hormone receptor7007
Histone H2A.x5005
Caspase-71001
Spike glycoprotein0112
Replicase polyprotein 1ab0112
cytochrome P450 2D6 isoform 13003
cellular tumor antigen p53 isoform a1001
potassium voltage-gated channel subfamily H member 2 isoform d2002
caspase-31001
histone deacetylase 9 isoform 33003
heat shock protein beta-16006
mitogen-activated protein kinase 12002
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A2002
nuclear factor erythroid 2-related factor 2 isoform 1150015
geminin120012
DNA polymerase kappa isoform 14004
peripheral myelin protein 223003
survival motor neuron protein isoform d3003
cytochrome P450 3A4 isoform 17007
M-phase phosphoprotein 84004
muscarinic acetylcholine receptor M15005
lethal factor (plasmid)2002
lamin isoform A-delta10100010
Proteasome subunit alpha type-70001
Solute carrier family 22 member 1 0202
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Transmembrane protease serine 20112
Glutamate receptor ionotropic, NMDA 2D0101
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Transient receptor potential cation channel subfamily V member 10101
Glutamate receptor ionotropic, NMDA 3B0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Bile salt export pump0101
Potassium channel subfamily K member 20101
Bile salt export pump010010
Epidermal growth factor receptor0404
Albumin0011
Albumin0022
Major prion protein0011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Receptor tyrosine-protein kinase erbB-20202
Major prion protein0011
Integrin beta-31001
Cytochrome P450 1A20314
Tyrosine-protein kinase Fyn0303
Procathepsin L0112
Aldo-keto reductase family 1 member B10808
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40404
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M50404
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Cys-loop ligand-gated ion channel0101
Calmodulin-10213
Replicase polyprotein 1ab0112
Cytochrome P450 2D60617
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10404
Cytochrome P450 2C9 0101
Polyunsaturated fatty acid lipoxygenase ALOX150505
Angiotensin-converting enzyme0202
5-hydroxytryptamine receptor 2A0202
Alpha-1B adrenergic receptor0909
Sphingomyelin phosphodiesterase0101
D(2) dopamine receptor0202
Muscarinic acetylcholine receptor M30404
Proteasome subunit beta type-10001
Substance-K receptor0404
D(4) dopamine receptor0203
D(1B) dopamine receptor0102
Adenylate cyclase type 30202
UDP-glucuronosyltransferase 1A40001
Alpha-1D adrenergic receptor0303
Sodium-dependent noradrenaline transporter 0808
Sodium-dependent dopamine transporter0202
Histamine H2 receptor0404
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20202
Adenylate cyclase type 40202
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
Proteasome subunit beta type-50001
Trypanothione reductase0202
5-hydroxytryptamine receptor 2B0202
Histamine H1 receptor0101
Sodium-dependent serotonin transporter010010
Melanocortin receptor 40202
5-hydroxytryptamine receptor 7 0101
Melanocortin receptor 50202
Pleiotropic ABC efflux transporter of multiple drugs0204
5-hydroxytryptamine receptor 70101
Histamine H1 receptor0202
Mu-type opioid receptor0404
Glutamate receptor ionotropic, NMDA 1 0102
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Adenylate cyclase type 80202
Proteasome subunit beta type-100001
Delta-type opioid receptor0202
Kappa-type opioid receptor0404
Melanocortin receptor 30202
Alpha-1A adrenergic receptor010010
Histamine H2 receptor2002
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 70202
Cytochrome P450 2J20101
Gastrin/cholecystokinin type B receptor0101
Spike glycoprotein5117
Proteasome subunit alpha type-60012
Calmodulin 0112
Aldehyde oxidase 10101
Glutamate receptor ionotropic, NMDA 2A 0102
Glutamate receptor ionotropic, NMDA 2B0102
Glutamate receptor ionotropic, NMDA 2C0102
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Sodium-dependent dopamine transporter 0808
Adenylate cyclase type 60202
Adenylate cyclase type 50202
Glutamate receptor ionotropic, NMDA 10101
Aldehyde oxidase0303
Potassium voltage-gated channel subfamily H member 20303
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, NMDA 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Glutamate receptor ionotropic, NMDA 2C0101
Sodium channel protein type 9 subunit alpha0101
Glutamate receptor ionotropic, NMDA 2D0102
Nuclear receptor subfamily 3 group C member 3 0202
Adenylyl cyclase 7 0202
Proteasome subunit alpha-type 80001
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0102
Canalicular multispecific organic anion transporter 10606
D0101
Sodium channel protein type 2 subunit alpha0101
Proteasome subunit beta type-70001
Sigma non-opioid intracellular receptor 10404
Angiotensin-converting enzyme 2 0112
Sodium channel protein type 3 subunit alpha0101
Glutamate receptor ionotropic, NMDA 3A0102
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0202
Sodium channel protein type 10 subunit alpha0101
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
endonuclease IV2002
pregnane X receptor5005
aldehyde dehydrogenase 1 family, member A17007
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
peripheral myelin protein 22 isoform 12002
atrial natriuretic peptide receptor 1 precursor2002
flap endonuclease 12002
Glucocorticoid receptor018220
Glycine receptor subunit alpha-1018018
Glycine receptor subunit beta018018
Glycine receptor subunit alpha-2018018
Glycine receptor subunit alpha-3018018
Potassium voltage-gated channel subfamily A member 10011
Multidrug and toxin extrusion protein 10202
Chain A, Ferritin light chain1001
Estrogen receptor010313
hypoxia-inducible factor 1 alpha subunit5005
SMAD family member 25005
SMAD family member 35005
aryl hydrocarbon receptor6006
Beta-glucuronidase0101
Beta-glucuronidase0101
Glucose-6-phosphate 1-dehydrogenase 0101
NPC1-like intracellular cholesterol transporter 10011
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, 2-oxoglutarate Oxygenase3003
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
15-lipoxygenase, partial3003
Bloom syndrome protein isoform 13003
polyunsaturated fatty acid lipoxygenase ALOX122002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
Caspase-71001
Chain A, Beta-lactamase4004
Chain A, JmjC domain-containing histone demethylation protein 3A3003
glp-1 receptor, partial1001
chaperonin-containing TCP-1 beta subunit homolog1001
bromodomain adjacent to zinc finger domain 2B2002
ubiquitin-conjugating enzyme E2 N0101
protein AF-9 isoform a0001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
nuclear receptor ROR-gamma isoform 13003
Adenosine receptor A30606
Beta-3 adrenergic receptor0202
Prostaglandin G/H synthase 10202
C-8 sterol isomerase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
UDP-glucuronosyltransferase 2B70001
Lanosterol 14-alpha demethylase0011
Olfactory receptor 51E20011
UDP-glucuronosyltransferase 1A100001
Luciferase5005
interleukin 84004
PPM1D protein1001
thyroid stimulating hormone receptor1001
activating transcription factor 65005
lysosomal alpha-glucosidase preproprotein2002
thyroid hormone receptor beta isoform a3003
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Vpr1001
Solute carrier family 22 member 20101
Cytochrome P450 2B10101
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Cytochrome P450 2B60101
UDP-glucuronosyltransferase 1A1 0203
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Adenosine receptor A2a0202
Sulfotransferase 1A10214
Nuclear receptor ROR-gamma5005
Nuclear receptor subfamily 1 group I member 3 0101
Multidrug and toxin extrusion protein 20101
Estrogen receptor beta0224
nuclear receptor subfamily 1, group I, member 22002
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Polyphenol oxidase 20102
Guanine nucleotide-binding protein G3003
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)0101
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)0101
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)0101
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)0101
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)0101
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)0101
ClpP2002
Testosterone 17-beta-dehydrogenase 30101
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
apical membrane antigen 1, AMA13003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
EWS/FLI fusion protein3003
arylsulfatase A1001
pyruvate kinase1001
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
importin subunit beta-1 isoform 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
snurportin-11001
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)3003
Carbonic anhydrase 120001
Carbonic anhydrase 10001
Carbonic anhydrase 20001
Plasma kallikrein0001
Tyrosine-protein kinase Lck0101
Carbonic anhydrase 30001
Tyrosinase0101
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Adenosine receptor A10001
Adenosine receptor A2a0001
Carbonic anhydrase 5A, mitochondrial0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Solute carrier family 15 member 10101
Carbonic anhydrase0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Carbonic anhydrase 0001
Monocarboxylate transporter 100001
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
phosphoglycerate kinase1001
GALC protein2002
PINK12002
Parkin2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
Cytochrome P450 2C190202
Chain A, Cruzipain1001
nonstructural protein 11001
nuclear factor erythroid 2-related factor 2 isoform 22002
transcriptional regulator ERG isoform 32002
neuropeptide S receptor isoform A1001
Progesterone receptor0437
Mineralocorticoid receptor 0101
Androgen receptor0224
Androgen receptor0011
Aldo-keto reductase family 1 member C30101
Aldo-keto reductase family 1 member C2 0101
Aldo-keto reductase family 1 member C10101
Cytochrome P450 1A10101
Cytochrome P450 1A2 0101
Myeloperoxidase0202
Cholinesterase0101
Cytochrome P450 2C11 0101
Aromatase0202
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Acetylcholinesterase0202
Metabotropic glutamate receptor 10101
Acetylcholinesterase 0101
Mu-type opioid receptor0101
Nociceptin receptor0101
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear factor erythroid 2-related factor 20001
Cytochrome P450 1B10101
Palmitoleoyl-protein carboxylesterase NOTUM0101
Carboxylic ester hydrolase 0101
glucocerebrosidase1001
5-hydroxytryptamine receptor 3E0011
5-hydroxytryptamine receptor 3B0011
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 3A0202
5-hydroxytryptamine receptor 3A0011
6-phosphogluconate dehydrogenase, decarboxylating0101
Lactoperoxidase0101
5-hydroxytryptamine receptor 4 0102
5-hydroxytryptamine receptor 3D0011
5-hydroxytryptamine receptor 3C0011
5-hydroxytryptamine receptor 3B0101
5-hydroxytryptamine receptor 3B0202
Steroid 17-alpha-hydroxylase/17,20 lyase0101
Cytochrome P450 2C80101
Cytochrome P450 11B1, mitochondrial 0101
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B2, mitochondrial0101
Estrogen receptor0011
Estrogen receptor beta0011
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Vasopressin V2 receptor0112
Oxytocin receptor0224
Vasopressin V1a receptor0101
Vasopressin V1a receptor0213
Vasopressin V1b receptor0112
Vasopressin V1b receptor0101
Oxytocin receptor0101
Oxytocin receptor0011
Vasopressin V2 receptor 0101
DNA polymerase beta1001
rac GTPase-activating protein 1 isoform a0101
muscleblind-like protein 1 isoform 11001
Polyunsaturated fatty acid 5-lipoxygenase0101
Amine oxidase [flavin-containing] A0101
Cannabinoid receptor 10202
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 2 0101
Prostaglandin G/H synthase 1 0101
thioredoxin glutathione reductase1001
Tyrosinase0101
NAD(P)H dehydrogenase [quinone] 10001
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
serine/threonine-protein kinase PLK11001
Solute carrier organic anion transporter family member 1A40001
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 31001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]