Page last updated: 2024-09-27

Cheiralgia Paresthetica

Disease involving the RADIAL NERVE. Clinical features include weakness of elbow extension, elbow flexion, supination of the forearm, wrist and finger extension, and thumb abduction. Sensation may be impaired over regions of the dorsal forearm. Common sites of compression or traumatic injury include the AXILLA and radial groove of the HUMERUS.

Synonyms(18)

Synonym
Posterior Interosseous Nerve Syndrome
Lesion, Superficial Radial Nerve
Radial Nerve Diseases
Radial Nerve Entrapment
Supinator Syndrome
Radial Neuropathy
Superficial Radial Nerve Lesion
Wartenberg Syndrome
Radial Palsy
Radial Nerve Palsy
Radial Tunnel Syndrome
Radial Mononeuropathy
Radial Nerve Compression
Crutch Paralysis
Saturday Night Palsy
Wrist-Drop
Cheiralgia Paresthetica
Crutch Palsy

Research Excerpts

Research

Studies (47)

TimeframeStudies, This Condition (%)All Conditions %
pre-19902 (4.26)23.3326
1990's1 (2.13)12.5806
2000's21 (44.68)18.1394
2010's18 (38.30)28.8240
2020's5 (10.64)9.53
DrugIndicatedRelationship StrengthStudiesTrials
nickel0low10
diazepam0low10
diphenhydramine0low10
lidocaine0low10
khellin0low10
lamotrigine0low10
meperidine0low10
propofol0low10
prednisolone0low20
dichloroacetic acid0medium11
3,3'-iminodipropionitrile0low10
dimenhydrinate0low10
titanium0medium21
trolamine salicylate0low10
propiconazole0low10
fluorodeoxyglucose f180low10
foxes0low10
cortisone0low10
amiridine0medium11
vitamin k semiquinone radical0low10
hydromorphone0low10
lead0low10

Protein Targets (300)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
bromodomain adjacent to zinc finger domain 2B1001
mitogen-activated protein kinase 14004
Acetylcholinesterase0101
Cholinesterase0101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
endonuclease IV1001
dopamine D1 receptor1001
thioredoxin reductase4004
pregnane X receptor2002
RAR-related orphan receptor gamma6006
GLS protein4004
TDP1 protein6006
GLI family zinc finger 37007
AR protein8008
aldehyde dehydrogenase 1 family, member A14004
progesterone receptor6006
regulator of G-protein signaling 42002
glucocorticoid receptor [Homo sapiens]6006
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha4004
pregnane X nuclear receptor6006
estrogen nuclear receptor alpha8008
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
euchromatic histone-lysine N-methyltransferase 26006
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)5005
peripheral myelin protein 22 isoform 12002
atrial natriuretic peptide receptor 1 precursor1001
chromobox protein homolog 14004
heat shock protein beta-13003
flap endonuclease 12002
nuclear factor erythroid 2-related factor 2 isoform 13003
geminin5005
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 14004
M-phase phosphoprotein 81001
muscarinic acetylcholine receptor M15005
Gamma-aminobutyric acid receptor subunit pi4329
Bile salt export pump0808
Glucocorticoid receptor04110
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0202
Gamma-aminobutyric acid receptor subunit beta-14329
Gamma-aminobutyric acid receptor subunit delta4329
Gamma-aminobutyric acid receptor subunit gamma-24329
Gamma-aminobutyric acid receptor subunit alpha-54329
Gamma-aminobutyric acid receptor subunit alpha-34329
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Gamma-aminobutyric acid receptor subunit gamma-14329
Gamma-aminobutyric acid receptor subunit alpha-24329
Glycine receptor subunit alpha-30404
Gamma-aminobutyric acid receptor subunit alpha-44329
Gamma-aminobutyric acid receptor subunit gamma-34329
Gamma-aminobutyric acid receptor subunit alpha-64329
Gamma-aminobutyric acid receptor subunit alpha-14329
Gamma-aminobutyric acid receptor subunit beta-34329
Gamma-aminobutyric acid receptor subunit beta-24329
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 432002
GABA theta subunit4329
Multidrug and toxin extrusion protein 10202
Gamma-aminobutyric acid receptor subunit epsilon4329
Gamma-aminobutyric acid 0101
glp-1 receptor, partial3003
estrogen receptor 2 (ER beta)2002
nuclear receptor subfamily 1, group I, member 34004
cytochrome P450 family 3 subfamily A polypeptide 44004
estrogen-related nuclear receptor alpha6006
G3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
thyroid hormone receptor beta isoform 26006
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Voltage-dependent calcium channel gamma-2 subunit4004
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 3003
Fatty acid-binding protein, liver0202
Alpha-1-acid glycoprotein 10001
Albumin0012
Albumin0011
Cellular tumor antigen p538008
ATP-dependent translocase ABCB10001
Gamma-aminobutyric acid receptor subunit alpha-10203
Gamma-aminobutyric acid receptor subunit beta-10203
Neuronal acetylcholine receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit alpha-20203
Gamma-aminobutyric acid receptor subunit alpha-30203
Neuronal acetylcholine receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-10336
Translocator protein0113
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit beta-10213
Gamma-aminobutyric acid receptor subunit gamma-20325
5-hydroxytryptamine receptor 1A0213
Glutamate receptor 24004
Gamma-aminobutyric acid receptor subunit alpha-40203
Gamma-aminobutyric acid receptor subunit gamma-20203
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit beta-30325
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50235
Gamma-aminobutyric acid receptor subunit alpha-30224
Gamma-aminobutyric acid receptor subunit alpha-20224
Gamma-aminobutyric acid receptor subunit beta-20224
Gamma-aminobutyric acid receptor subunit alpha-40213
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit epsilon0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Neuronal acetylcholine receptor subunit alpha-70101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Gamma-aminobutyric acid receptor subunit alpha-60213
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit pi0101
Sphingosine-1-phosphate lyase 10101
Inositol hexakisphosphate kinase 13003
ATPase family AAA domain-containing protein 53003
Ataxin-24004
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit theta0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit theta0202
cytochrome P450 2C9, partial3003
activating transcription factor 62002
thyroid hormone receptor beta isoform a2002
lethal factor (plasmid)1001
lamin isoform A-delta104004
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial0101
hypoxia-inducible factor 1 alpha subunit2002
thyroid stimulating hormone receptor1001
Histone H2A.x2002
potassium voltage-gated channel subfamily H member 2 isoform d3003
5-hydroxytryptamine receptor 40606
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40404
Muscarinic acetylcholine receptor M50404
Alpha-2A adrenergic receptor0202
Cytochrome P450 2D60202
Muscarinic acetylcholine receptor M10404
Alpha-2B adrenergic receptor0202
Muscarinic acetylcholine receptor M30404
Sodium-dependent noradrenaline transporter 0606
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0404
5-hydroxytryptamine receptor 2C0606
Histamine H1 receptor0404
5-hydroxytryptamine receptor 2B0606
Nuclear receptor ROR-gamma1001
Inositol monophosphatase 11001
Sodium-dependent dopamine transporter 0202
Canalicular multispecific organic anion transporter 10303
Sigma non-opioid intracellular receptor 10202
Luciferase1001
phosphopantetheinyl transferase2002
USP1 protein, partial4004
Thrombopoietin1001
thyroid stimulating hormone receptor2002
EWS/FLI fusion protein2002
cytochrome P450 2D63003
cytochrome P450 2D6 isoform 13003
vitamin D3 receptor isoform VDRA3003
huntingtin isoform 21001
Cytochrome P450 2C9 0303
Angiotensin-converting enzyme0202
Histamine H1 receptor0012
Histamine H2 receptor1002
Histamine N-methyltransferase0001
Cytochrome P450 2J20202
Potassium voltage-gated channel subfamily H member 20505
Sodium channel protein type 5 subunit alpha0303
Solute carrier family 22 member 10101
Nuclear receptor subfamily 3 group C member 3 0202
Calcium release-activated calcium channel protein 10101
Protein orai-20101
Protein orai-30101
Histamine H4 receptor0101
Histamine H3 receptor0001
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0203
Solute carrier family 22 member 30001
Mu-type opioid receptor0224
Delta-type opioid receptor0202
Kappa-type opioid receptor0213
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
GALC protein2002
aryl hydrocarbon receptor3003
cytochrome P450 2C19 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
peripheral myelin protein 222002
histone acetyltransferase KAT2A isoform 12002
Cytochrome P450 1A10202
Cytochrome P450 1A20202
Cytochrome P450 3A40202
Cytochrome P450 2C190101
Cytochrome P450 1B10101
Bloom syndrome protein isoform 12002
D(1A) dopamine receptor2002
nuclear factor erythroid 2-related factor 2 isoform 22002
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0202
Dihydrofolate reductase0202
Potassium voltage-gated channel subfamily E member 10101
Sodium channel protein type 4 subunit alpha0203
Potassium voltage-gated channel subfamily KQT member 10101
Sodium channel protein type 9 subunit alpha0202
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0202
Sigma non-opioid intracellular receptor 10101
Sodium channel protein type 10 subunit alpha0101
Chain A, Beta-lactamase3003
Microtubule-associated protein tau1001
IDH11001
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20101
Potassium voltage-gated channel subfamily A member 50101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Liver carboxylesterase 10001
Sodium-dependent dopamine transporter0101
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0101
Kappa-type opioid receptor0101
Mu-type opioid receptor0101
Mu-type opioid receptor0101
luciferase0001
nuclear receptor subfamily 1, group I, member 21001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Androgen receptor0101
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Estrogen receptor beta0202
Chain A, Ferritin light chain3003
SMAD family member 21001
SMAD family member 31001
nonstructural protein 11001
farnesoid X nuclear receptor2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20001
DNA polymerase iota isoform a (long)3003
nuclear receptor ROR-gamma isoform 11001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Guanine nucleotide-binding protein G1001
heat shock protein 90, putative0001
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
caspase 7, apoptosis-related cysteine protease1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
caspase-31001
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90001
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Prostaglandin G/H synthase 10101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A80001
thioredoxin glutathione reductase1001
Rap guanine nucleotide exchange factor 31001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]