Page last updated: 2024-09-28

Charcot-Marie-Tooth Disease, Demyelinating, Type 4f

A group of slowly progressive inherited disorders affecting motor and sensory peripheral nerves. Subtypes include HMSNs I-VII. HMSN I and II both refer to CHARCOT-MARIE-TOOTH DISEASE. HMSN III refers to hypertrophic neuropathy of infancy. HMSN IV refers to REFSUM DISEASE. HMSN V refers to a condition marked by a hereditary motor and sensory neuropathy associated with spastic paraplegia (see SPASTIC PARAPLEGIA, HEREDITARY). HMSN VI refers to HMSN associated with an inherited optic atrophy (OPTIC ATROPHIES, HEREDITARY), and HMSN VII refers to HMSN associated with retinitis pigmentosa. (From Adams et al., Principles of Neurology, 6th ed, p1343)

Synonyms(20)

Synonym
HMSN
CMT4f
Hereditary Motor and Sensory Neuropathy
Hereditary Sensory and Motor Neuropathy
Charcot-Marie-Tooth Disease, Type 3
Charcot-Marie-Tooth Disease, Demyelinating, Type 4f
HMSN Type III
Hereditary, Type VII, Motor and Sensory Neuropathy
Hereditary, Type III, Motor and Sensory Neuropathy
Dejerine-Sottas Disease
HMSN Type VII
Herditary Sensory and Motor Neuropathy
Dejerine-Sottas Neuropathy
Hypertrophic Neuropathy of Dejerine-Sottas
HMSN3
Dejerine-Sottas Syndrome
Hereditary Motor and Sensory Neuropathies
Neuropathies, Hereditary Motor and Sensory
Hereditary Motor and Sensory Neuropathy Type III
Hereditary Motor and Sensory Neuropathy 3

Research Excerpts

Overview

ExcerptReference
"HMSNR is one of the most frequent types of IPN in this country and appears to be twice more frequent than HMSNL."( Haberlová, J; Laštůvková, J; Mazanec, R; Šafka Brožková, D; Seeman, P, 2016)

Actions

ExcerptReference
"HMSNR affects only patients with Roma origin, similar to the better known HMSN type Lom clarified earlier."( Haberlová, J; Laštůvková, J; Mazanec, R; Šafka Brožková, D; Seeman, P, 2016)

Research

Studies (119)

TimeframeStudies, This Condition (%)All Conditions %
pre-199011 (9.24)23.3326
1990's37 (31.09)12.5806
2000's34 (28.57)18.1394
2010's26 (21.85)28.8240
2020's11 (9.24)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
salicylic acid0low10
creatine0medium11
cytosine0low10
glycine0low20
pipecolic acid0low10
thymine0low10
phenytoin0low10
acetaminophen0low10
baclofen0low10
flumazenil0low130
gabapentin0low10
nortriptyline0low10
probucol0low10
prednisolone0low10
prednisone0low30
serine0low30
cyanides0low10
levodopa0medium21
tyrosine0low10
leucine0low40
methionine0low20
phenylalanine0low40
histidine0low20
threonine0low20
tryptophan0low10
isoleucine0low10
arginine0low50
fluoxymesterone0low10
rotenone0low10
thiophenes0low10
fluocortolone0low10
acetylcysteine0low10
vancomycin0low10
d-alpha tocopherol0low10
fluorescein0low10
silver0low20
gold0low10
phytanic acid0low20
clemastine0low10
tocopheryl nicotinate0low10
transferrin0low10
glutamic acid0low10
tramadol0low10
colforsin0low10
fomesafen0medium31
duloxetine hydrochloride0low10
carbidopa, levodopa drug combination0medium11
tris(2-carboxyethyl)phosphine0low10
pramipexole0low10
proline0low20
arachidonic acid0low10
phorbol-12,13-didecanoate0low10
enkephalin, leucine0low10
curcumin0medium31
myelin basic protein0low30
astaxanthine0low10
3-methylquercetin0low10
coenzyme q100low20
phenylephrine hydrochloride0medium11
ubiquinone 70low20
sulfur0low10
cysteine0low20
indocyanine green0low10
neuropeptide y0low10
vendex0low10
ubiquinone0low20
glycolipids0low10
hydroxocobalamin0low10
sybr green i0low10
vitamin b 120low10
folic acid0low10
carbidopa0medium11
concanavalin a0low10

Protein Targets (755)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE100010
flap endonuclease 1100010
DNA polymerase kappa isoform 18008
Carbonic anhydrase 120308
Pancreatic triacylglycerol lipase0202
Carbonic anhydrase 105012
Carbonic anhydrase 205012
Cytochrome P450 1A10113
Cytochrome P450 1A20102
Carbonic anhydrase 40409
Carbonic anhydrase 70308
Xanthine dehydrogenase/oxidase0101
Oligo-1,6-glucosidase IMA10101
Mitogen-activated protein kinase 100101
Aldo-keto reductase family 1 member B10101
Mitogen-activated protein kinase 140101
Cytochrome P450 1B10101
Inositol polyphosphate multikinase0101
Enoyl-acyl-carrier protein reductase 0101
3-oxoacyl-acyl-carrier protein reductase 0101
Aurora kinase B0101
Inositol hexakisphosphate kinase 20101
RAR-related orphan receptor gamma9009
ATAD5 protein, partial7007
GLS protein8008
Microtubule-associated protein tau100010
Smad34004
aldehyde dehydrogenase 1 family, member A1100010
thyroid stimulating hormone receptor110011
nuclear receptor subfamily 1, group I, member 39009
progesterone receptor110011
EWS/FLI fusion protein6007
retinoic acid nuclear receptor alpha variant 1140014
retinoid X nuclear receptor alpha100010
estrogen-related nuclear receptor alpha160016
estrogen nuclear receptor alpha220022
peroxisome proliferator activated receptor gamma100010
aryl hydrocarbon receptor7007
chromobox protein homolog 19009
thyroid hormone receptor beta isoform 28008
peripheral myelin protein 22130013
cytochrome P450 3A4 isoform 18008
Gamma-aminobutyric acid receptor subunit pi85013
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 409010
Solute carrier family 22 member 60303
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0303
Voltage-dependent calcium channel gamma-2 subunit5005
Bile salt export pump013013
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Myoglobin0101
Prostaglandin G/H synthase 10202
Carbonic anhydrase 30207
Cytochrome P450 3A40102
Cytochrome P450 2D60303
Cytochrome P450 2C9 0404
Polyunsaturated fatty acid lipoxygenase ALOX150202
Gamma-aminobutyric acid receptor subunit beta-185013
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta85013
Gamma-aminobutyric acid receptor subunit gamma-285215
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 25218
Gamma-aminobutyric acid receptor subunit alpha-585013
Gamma-aminobutyric acid receptor subunit alpha-385013
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0001
Prostaglandin G/H synthase 10202
Carbonic anhydrase 60207
Gamma-aminobutyric acid receptor subunit gamma-185013
Gamma-aminobutyric acid receptor subunit alpha-285013
Gamma-aminobutyric acid receptor subunit alpha-485013
Gamma-aminobutyric acid receptor subunit gamma-385013
Gamma-aminobutyric acid receptor subunit alpha-685013
Carbonic anhydrase 5A, mitochondrial0207
Prostaglandin G/H synthase 20316
Nuclear receptor ROR-gamma4004
Cytochrome P450 2J20303
Gamma-aminobutyric acid receptor subunit alpha-185215
Gamma-aminobutyric acid receptor subunit beta-385013
Gamma-aminobutyric acid receptor subunit beta-285215
Carbonic anhydrase 90207
GABA theta subunit85013
Canalicular multispecific organic anion transporter 10909
Carbonic anhydrase 150308
Carbonic anhydrase 130206
Gamma-aminobutyric acid receptor subunit epsilon85013
Carbonic anhydrase 140207
Carbonic anhydrase 5B, mitochondrial0207
toxin B0001
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, 2-oxoglutarate Oxygenase100010
Chain A, ATP-DEPENDENT DNA HELICASE Q15005
acetylcholinesterase5005
dopamine D1 receptor3003
15-lipoxygenase, partial4004
pregnane X receptor5005
phosphopantetheinyl transferase110011
USP1 protein, partial8008
NFKB1 protein, partial3003
Thrombopoietin3003
AR protein190019
regulator of G-protein signaling 48008
glucocorticoid receptor [Homo sapiens]160016
farnesoid X nuclear receptor6006
vitamin D (1,25- dihydroxyvitamin D3) receptor130013
arylsulfatase A7007
euchromatic histone-lysine N-methyltransferase 2170017
Bloom syndrome protein isoform 1120012
D(1A) dopamine receptor4004
thyroid hormone receptor beta isoform a7007
heat shock protein beta-16006
geminin130013
survival motor neuron protein isoform d5005
muscarinic acetylcholine receptor M19009
Histone deacetylase 30303
Histone deacetylase 40303
Guanine nucleotide-binding protein G2002
Histone deacetylase 10404
Histone deacetylase 70303
Histone deacetylase 20404
Polyamine deacetylase HDAC100303
Histone deacetylase 11 0303
Ataxin-27007
Histone deacetylase 80404
Histone deacetylase 60303
Histone deacetylase 90303
Histone deacetylase 50303
ATP-dependent phosphofructokinase7007
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN0011
Chain A, SERUM ALBUMIN0011
Chain A, SERUM ALBUMIN0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE7007
Chain A, Beta-lactamase2002
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
Chain A, Cruzipain3003
TDP1 protein160016
thioredoxin glutathione reductase5005
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
cellular tumor antigen p53 isoform a4004
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
vitamin D3 receptor isoform VDRA5005
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
nuclear receptor ROR-gamma isoform 16006
lethal(3)malignant brain tumor-like protein 1 isoform I1001
histone acetyltransferase KAT2A isoform 16006
DNA dC->dU-editing enzyme APOBEC-3G isoform 12002
caspase-1 isoform alpha precursor2002
lamin isoform A-delta10130013
Fatty-acid amide hydrolase 10101
Polyunsaturated fatty acid lipoxygenase ALOX15B4004
Prostaglandin G/H synthase 1 0001
Trypsin0101
Coagulation factor VII0101
60 kDa chaperonin0202
60 kDa heat shock protein, mitochondrial0303
Aromatase0101
Tissue factor0202
Fatty acid-binding protein, adipocyte0112
Nuclear receptor subfamily 4 group A member 20011
Histamine H2 receptor6108
10 kDa heat shock protein, mitochondrial0303
Calmodulin 0001
Disintegrin and metalloproteinase domain-containing protein 171001
Prostaglandin G/H synthase 20001
Solute carrier organic anion transporter family member 2A10001
Fatty acid-binding protein 50101
Fatty acid-binding protein 50011
Thiosulfate sulfurtransferase0303
Lanosterol 14-alpha demethylase0101
60 kDa chaperonin 0303
10 kDa chaperonin 0303
Solute carrier organic anion transporter family member 1B30202
Cytosolic phospholipase A2 gamma0101
Transient receptor potential cation channel subfamily V member 20101
Solute carrier organic anion transporter family member 1B10202
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
thioredoxin reductase120012
alpha-galactosidase2002
cytochrome P450 2C19 precursor5005
DNA polymerase iota isoform a (long)5005
lethal factor (plasmid)6006
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
GLI family zinc finger 3140014
67.9K protein2002
activating transcription factor 67007
Gamma-aminobutyric acid type B receptor subunit 20224
Gamma-aminobutyric acid type B receptor subunit 20303
Gamma-aminobutyric acid type B receptor subunit 10224
Gamma-aminobutyric acid type B receptor subunit 10202
cytochrome P450 2D6 isoform 13003
cytochrome P450 2C9 precursor3003
Solute carrier family 22 member 1 0202
5-hydroxytryptamine receptor 40404
Integrin beta-33014
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40404
Integrin alpha-IIb3014
Muscarinic acetylcholine receptor M50404
Alpha-2A adrenergic receptor0606
Muscarinic acetylcholine receptor M10404
Angiotensin-converting enzyme0202
D(2) dopamine receptor0426
Alpha-2B adrenergic receptor0505
Alpha-2C adrenergic receptor0505
Muscarinic acetylcholine receptor M30505
D(1A) dopamine receptor0516
Sodium-dependent noradrenaline transporter 0404
Histamine H2 receptor0527
Alpha-1D adrenergic receptor0404
5-hydroxytryptamine receptor 2A0415
5-hydroxytryptamine receptor 2C0404
Cytochrome P450 2C190303
Histamine H1 receptor0415
D(3) dopamine receptor0528
5-hydroxytryptamine receptor 2B0404
5-hydroxytryptamine receptor 60707
5-hydroxytryptamine receptor 70101
Sodium-dependent dopamine transporter 0404
Potassium voltage-gated channel subfamily H member 20303
Sigma intracellular receptor 20101
Nuclear receptor subfamily 3 group C member 3 0202
Sigma non-opioid intracellular receptor 10303
glp-1 receptor, partial6006
estrogen receptor 2 (ER beta)6006
cytochrome P450 family 3 subfamily A polypeptide 46006
pregnane X nuclear receptor100010
G4004
peroxisome proliferator-activated receptor delta5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
thyroid stimulating hormone receptor5005
nuclear receptor subfamily 1, group I, member 22002
nuclear receptor subfamily 0 group B member 10101
steroidogenic factor 10101
histone-lysine N-methyltransferase 2A isoform 2 precursor4004
nuclear factor erythroid 2-related factor 2 isoform 1110011
relaxin receptor 1 isoform 11001
relaxin receptor 2 isoform 11001
Nuclear receptor subfamily 1 group I member 20011
Rap guanine nucleotide exchange factor 32002
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 4004
Cellular tumor antigen p53100010
ATP-dependent translocase ABCB10101
5-hydroxytryptamine receptor 1A0202
Solute carrier family 2, facilitated glucose transporter member 10011
Adenylate cyclase type 20011
Adenylate cyclase type 80011
Adenylate cyclase type 10112
Inositol hexakisphosphate kinase 14004
ATPase family AAA domain-containing protein 54004
Relaxin receptor 10011
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 2C9, partial4004
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10708
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Chain A, Ferritin light chain5005
Luciferase4004
interleukin 81001
Nrf21001
hypoxia-inducible factor 1 alpha subunit5005
SMAD family member 23003
SMAD family member 33003
alkaline phosphatase, intestinal0101
apical membrane antigen 1, AMA12002
caspase 7, apoptosis-related cysteine protease2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
PINK11001
glucocerebrosidase2002
Parkin1001
bromodomain adjacent to zinc finger domain 2B3003
toll-like receptor 90101
caspase-32002
IDH14004
TPA: protein transporter TIM100101
thyrotropin-releasing hormone receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a8008
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x2002
lysosomal alpha-glucosidase preproprotein3003
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0101
hemoglobin subunit beta1001
polyunsaturated fatty acid lipoxygenase ALOX121001
perilipin-50101
intestinal alkaline phosphatase precursor0101
perilipin-10101
potassium voltage-gated channel subfamily H member 2 isoform d3003
transcriptional regulator ERG isoform 34004
huntingtin isoform 22002
importin subunit beta-1 isoform 14004
pyruvate kinase PKM isoform a1001
DNA polymerase beta3003
mitogen-activated protein kinase 11001
nuclear factor NF-kappa-B p105 subunit isoform 11001
snurportin-14004
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 13003
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
muscleblind-like protein 1 isoform 12002
alkaline phosphatase, germ cell type preproprotein0101
hypothetical protein SA14220101
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
neuropeptide S receptor isoform A3003
Prostaglandin E synthase0101
Acetylcholinesterase0202
Lysine-specific histone demethylase 1A0101
D-amino-acid oxidase0101
Phospholipase A20101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10202
Amyloid-beta precursor protein0102
Neuronal proto-oncogene tyrosine-protein kinase Src 0101
Cholinesterase0101
Heme oxygenase 1 0101
Glutathione S-transferase P0202
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Microtubule-associated protein tau0102
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0101
Tyrosinase0202
Aminopeptidase N0101
Aminopeptidase N0101
Alpha-1B adrenergic receptor0202
Sarcoplasmic/endoplasmic reticulum calcium ATPase 20202
Glycogen synthase kinase-3 beta0101
Amine oxidase [flavin-containing] A0202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Acetylcholinesterase0202
Heme oxygenase 20101
Alpha-1D adrenergic receptor0202
Amine oxidase [flavin-containing] B0202
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Proteasome subunit beta type-50101
17-beta-hydroxysteroid dehydrogenase type 20101
Alpha-synuclein3115
Alpha-1A adrenergic receptor0303
Glycogen synthase kinase-3 beta0101
Caspase-71001
Beta-secretase 10101
Cholinesterase0202
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Lactoylglutathione lyase0101
Histone acetyltransferase p3000101
TAR DNA-binding protein 433003
Serine/threonine-protein kinase PAK 10101
5-hydroxytryptamine receptor 40011
Sodium/bile acid cotransporter0011
Nuclear factor erythroid 2-related factor 20011
Thioredoxin reductase 1, cytoplasmic0101
Thioredoxin reductase 30101
Sortase A0101
CREB-binding protein0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 30202
Cysteine protease 0101
NACHT, LRR and PYD domains-containing protein 3 0101
Thioredoxin reductase 2, mitochondrial0101
CDGSH iron-sulfur domain-containing protein 10202
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Lymphocyte antigen 960011
Beta lactamase (plasmid)0101
Carbonic anhydrase0106
Deoxycytidine kinase0001
Alpha-tocopherol transfer protein0011
Fumarate hydratase2002
cytochrome P450 2D63003
polyprotein2002
Spike glycoprotein5005
Opioid receptor, delta 1b 0101
Opioid receptor homologue0101
Proenkephalin-B0011
Delta-type opioid receptor0214
Delta-type opioid receptor0101
Kappa-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Mu-type opioid receptor0325
Delta-type opioid receptor0314
Kappa-type opioid receptor0101
Kappa-type opioid receptor0213
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Mu-type opioid receptor0101
endonuclease IV2002
nuclear factor erythroid 2-related factor 2 isoform 24004
Gamma-aminobutyric acid receptor subunit pi0303
Gamma-aminobutyric acid receptor subunit delta0303
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Neuronal acetylcholine receptor subunit alpha-41102
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit alpha-30202
Neuronal acetylcholine receptor subunit beta-21102
Gamma-aminobutyric acid receptor subunit alpha-10325
Gamma-aminobutyric acid receptor subunit beta-10314
Gamma-aminobutyric acid receptor subunit gamma-20325
5-hydroxytryptamine receptor 1A0404
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit beta-30325
Gamma-aminobutyric acid receptor subunit alpha-50325
Gamma-aminobutyric acid receptor subunit alpha-30325
Gamma-aminobutyric acid receptor subunit alpha-20314
Gamma-aminobutyric acid receptor subunit beta-20314
Gamma-aminobutyric acid receptor subunit alpha-40314
Gamma-aminobutyric acid receptor subunit epsilon0303
Neuronal acetylcholine receptor subunit alpha-70101
Gamma-aminobutyric acid receptor subunit alpha-60314
Gamma-aminobutyric acid receptor subunit gamma-10303
Gamma-aminobutyric acid receptor subunit gamma-30303
Gamma-aminobutyric acid receptor subunit theta0303
Androgen receptor0415
Chain A, Dihydrofolate reductase0011
acid sphingomyelinase1001
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10202
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Voltage-dependent calcium channel subunit alpha-2/delta-10202
Gamma-aminobutyric acid 0112
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
Gamma-aminobutyric acid receptor subunit alpha-60112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit delta0112
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit gamma-30112
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10202
Sodium- and chloride-dependent GABA transporter 20303
Sodium- and chloride-dependent GABA transporter 30303
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-30112
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Sterol O-acyltransferase 10011
Gamma-aminobutyric acid receptor subunit alpha-50112
Gamma-aminobutyric acid receptor subunit pi0112
Gamma-aminobutyric acid receptor subunit alpha-40112
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0112
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10112
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor2002
Metabotropic glutamate receptor 80202
Metabotropic glutamate receptor 60113
Glutamate receptor ionotropic, NMDA 2D0101
Excitatory amino acid transporter 40101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, NMDA 1 05212
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Excitatory amino acid transporter 10203
Excitatory amino acid transporter 20203
Excitatory amino acid transporter 30203
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, NMDA 2A 04211
Glutamate receptor ionotropic, NMDA 2B04211
Glutamate receptor ionotropic, NMDA 2C04211
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 10113
Metabotropic glutamate receptor 20113
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50101
Carbonic anhydrase-like protein, putative0006
Glutamate receptor ionotropic, NMDA 2D04211
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B04211
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Glutamate receptor ionotropic, NMDA 3A04211
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 109010
Serine racemase0101
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
Chain A, HISTIDINE-BINDING PROTEIN0011
Plasma kallikrein0005
Histidine-binding periplasmic protein0011
Adenosine receptor A10004
5-hydroxytryptamine receptor 1D0102
Adenosine receptor A2a0004
Carbonic anhydrase0005
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 0005
Carbonic anhydrase0005
Carbonic anhydrase0005
Carbonic anhydrase 0005
Carbonic anhydrase 130002
Carbonic anhydrase 40001
Chain A, AMINOPEPTIDASE0202
Chain A, AMINOPEPTIDASE0202
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0303
Intestinal-type alkaline phosphatase0303
Phospholipase A-2-activating protein0303
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
pyruvate kinase1001
hexokinase-4 isoform 11001
atrial natriuretic peptide receptor 1 precursor3003
glucokinase regulatory protein1001
DNA polymerase eta isoform 11001
M-phase phosphoprotein 83003
Polyphenol oxidase 20104
Epidermal growth factor receptor0101
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Solute carrier family 15 member 10101
SLC16A10 protein0004
Monocarboxylate transporter 100004
phosphoglycerate kinase1001
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
Neuropeptide Y receptor type 10202
Neuropeptide Y receptor type 20202
NPC intracellular cholesterol transporter 1 precursor2002
atrial natriuretic peptide receptor 2 precursor2002
ras-related protein Rab-9A2002
serine/threonine-protein kinase mTOR isoform 12002
5-hydroxytryptamine receptor 2C0101
Cytochrome P450 2C80101
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D30101
5-hydroxytryptamine receptor 2A0101
5-hydroxytryptamine receptor 1B0202
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 60101
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0202
Sodium- and chloride-dependent betaine transporter0101
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
5-hydroxytryptamine receptor 3A0101
D(1A) dopamine receptor2002
Inositol monophosphatase 13003
Voltage-dependent N-type calcium channel subunit alpha-1B0101
5-hydroxytryptamine receptor 4 0101
Cytochrome P450 2D40101
5-hydroxytryptamine receptor 3B0101
Alkaline phosphatase, tissue-nonspecific isozyme 0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
E3 ubiquitin-protein ligase XIAP0101
Large neutral amino acids transporter small subunit 1 0101
GALC protein1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
peripheral myelin protein 22 isoform 13003
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Dihydrofolate reductase 0101
Sodium channel protein type 2 subunit alpha0101
Aldo-keto reductase family 1 member B10101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0102
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Fatty acid-binding protein, liver0202
Fatty acid-binding protein, liver0101
Peroxisomal sarcosine oxidase0001
Beta-2 adrenergic receptor0101
Beta-3 adrenergic receptor0101
D0101
D(3) dopamine receptor0112
D(4) dopamine receptor0112
D(1B) dopamine receptor0101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1E0101
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0101
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 5A0101
D(2) dopamine receptor0112
Solute carrier family 22 member 10001
D0101
Histamine H4 receptor0112
Solute carrier family 22 member 20001
luciferase0001
Estrogen receptor0202
Glucocorticoid receptor04211
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
Polyunsaturated fatty acid lipoxygenase ALOX150101
Vascular cell adhesion protein 10101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Neutral amino acid transporter A0202
Neutral amino acid transporter B(0)0202
Amino acid transporter0202
PPM1D protein1001
nonstructural protein 11001
NADH-ubiquinone oxidoreductase chain 10101
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial0101
Dihydroorotate dehydrogenase (fumarate)0101
Acyl carrier protein, mitochondrial0101
Dihydroorotate dehydrogenase 0101
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
5'-AMP-activated protein kinase subunit beta-20001
Albumin0112
Polymerase acidic protein0011
Stromelysin-10112
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
Pyruvate kinase PKM0011
Thymidine phosphorylase0101
Cruzipain0101
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Dihydrofolate reductase0202
Myeloperoxidase0101
Indoleamine 2,3-dioxygenase 10102
Substance-P receptor0101
Tryptophan 2,3-dioxygenase0102
Uracil nucleotide/cysteinyl leukotriene receptor0101
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Tubulin--tyrosine ligase0101
Taste receptor type 2 member 140001
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Sodium-dependent serotonin transporter0101
D-alanyl-D-alanine dipeptidase0101
Transporter0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]