Page last updated: 2024-09-27

Central Nervous System Schistosomiasis

SCHISTOSOMIASIS of the brain, spinal cord, or meninges caused by infections with trematodes of the genus SCHISTOSOMA (primarily SCHISTOSOMA JAPONICUM; SCHISTOSOMA MANSONI; and SCHISTOSOMA HAEMATOBIUM in humans). S. japonicum infections of the nervous system may cause an acute meningoencephalitis or a chronic encephalopathy. S. mansoni and S. haematobium nervous system infections are associated with acute transverse myelitis involving the lower portions of the spinal cord. (From Joynt, Clinical Neurology, 1998, Ch27, pp61-2)

Synonyms(6)

Synonym
Neuroschistosomiasis
Central Nervous System Schistosomiasis
Schistosomal Myelitis
Schistosomiasis, Central Nervous System
Schistosomal Myelopathy
Schistosomal Myeloradiculopathy

Research Excerpts

Overview

ExcerptReference
"Neuroschistosomiasis is a rare but serious complication of the schistosomiasis that can only be made after complete parasite identification and careful differential diagnosis."( Botterel, F; Brugières, P; Hosseini, H; Liance, M; Perignon, A; Poirier, P, 2009)
"Neuroschistosomiasis is one of the most severe clinical outcomes associated with schistosome infection."( Farrar, J; Gray, DJ; Hunstman, RJ; Li, YS; McManus, DP; Ross, AG, 2012)
"Recognition of neuroschistosomiasis is important so that early treatment with praziquantel and steroids can be started in an attempt to prevent severe disability."( Carod Artal, FJ, 2012)
"Neuroschistosomiasis is a severe disease caused by the presence of Schistosoma eggs and/or adult worms in the central nervous system."( Barros, VM; Braga Júnior, LL; Monteiro-Neto, V; Salgado, IA; Salgado, JV; Serra, SC; Silva, MJ, 2015)
"Neuroschistosomiasis is a severe complication of an infection with Schistosoma; this infection can lead to myelitis transversa."( Bosboom, RW; Cobussen, M; Hageman, ATM; Hassing, R; Machiels, JD; van Os, NJH, 2018)
"Neuroschistosomiasis is an uncommonly reported disease."( Kumar, A; Manamal, NA; Mani, J; Sanghvi, D; Singhal, T, 2018)
"Neuroschistosomiasis is a rare but severe manifestation of Schistosoma infection."( Anderson, R; Kumbla, S; Ryan, MM; Steer, A; Wen, SCH; Wray, A, 2019)
"Neuroschistosomiasis is a severe complication of schistosomiasis, triggered by the local immune reaction to egg deposition, with spinal cord involvement the most well recognised form."( Aggarwal, D; Chiodini, PL; de Wilton, A; Jäger, HR; Manji, H, 2021)

Context

ExcerptReference
"Neuroschistosomiasis has been increasingly reported not only in endemic areas but also in Western countries owing to immigration and international travel."( Carod Artal, FJ, 2012)

Treatment

ExcerptReference
"The best treatment for schistosomal myeloradiculopathy (SMR) remains undefined."( Antunes, CM; Lambertucci, JR; Maciel, PE; Ribas, JG; Silva, LC; Souza-Pereira, SR, 2004)

Research

Studies (45)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's23 (51.11)18.1394
2010's18 (40.00)28.8240
2020's4 (8.89)9.53
DrugIndicatedRelationship StrengthStudiesTrials
urea0low10
carbamazepine0low20
oxamniquine0low10
praziquantel0medium370
prednisolone0low20
prednisone0low80
methylprednisolone0low50
lucanthone hydrochloride0low60
gadolinium0low10
alovudine0low10
artemether0low10
gadolinium dtpa0low20
clove0low10

Protein Targets (160)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
TDP1 protein5005
cytochrome P450 family 3 subfamily A polypeptide 44004
retinoic acid nuclear receptor alpha variant 16006
Histone H2A.x2002
Thymidylate kinase0101
Reverse transcriptase/RNaseH 0102
AR protein7007
pregnane X nuclear receptor7007
estrogen nuclear receptor alpha7007
G2002
thyroid hormone receptor beta isoform 23003
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Bile salt export pump0505
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 2002
Inositol hexakisphosphate kinase 12002
Canalicular multispecific organic anion transporter 10505
cytochrome P450 2C9, partial2002
Chain A, Beta-lactamase2002
acetylcholinesterase2002
RAR-related orphan receptor gamma3003
USP1 protein, partial1001
thyroid stimulating hormone receptor1001
glucocorticoid receptor [Homo sapiens]4004
estrogen-related nuclear receptor alpha7007
IDH12002
euchromatic histone-lysine N-methyltransferase 21001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
thyroid hormone receptor beta isoform a1001
nuclear factor erythroid 2-related factor 2 isoform 24004
mitogen-activated protein kinase 13003
geminin3003
Vpr1001
lamin isoform A-delta104004
Bile salt export pump0202
Albumin0011
Major prion protein0011
Cellular tumor antigen p533003
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2C9 0202
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 2B60011
Sodium channel protein type 4 subunit alpha0102
Cytochrome P450 2J20202
Potassium voltage-gated channel subfamily H member 20101
Sodium channel protein type 9 subunit alpha0202
Frizzled-80011
P2X purinoceptor 40101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, Ferritin light chain1001
Chain A, Cruzipain1001
endonuclease IV1001
thioredoxin reductase2002
Microtubule-associated protein tau1001
nonstructural protein 12002
glucocerebrosidase1001
Bloom syndrome protein isoform 12002
peripheral myelin protein 22 isoform 11001
potassium voltage-gated channel subfamily H member 2 isoform d1001
DNA polymerase beta1001
DNA polymerase iota isoform a (long)2002
M-phase phosphoprotein 82002
neuropeptide S receptor isoform A2002
Spike glycoprotein1001
hypoxia-inducible factor 1 alpha subunit2002
PPM1D protein2002
GLI family zinc finger 34004
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
progesterone receptor3003
retinoid X nuclear receptor alpha3003
bromodomain adjacent to zinc finger domain 2B1001
nuclear receptor subfamily 1, group I, member 23003
muscleblind-like protein 1 isoform 13003
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor06213
Glycine receptor subunit alpha-10606
Androgen receptor0303
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Nuclear receptor subfamily 1 group I member 20011
ATP-dependent phosphofructokinase2002
GLS protein1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Guanine nucleotide-binding protein G1001
SMAD family member 21001
SMAD family member 31001
aldehyde dehydrogenase 1 family, member A13003
estrogen receptor 2 (ER beta)2002
regulator of G-protein signaling 41001
EWS/FLI fusion protein1001
cytochrome P450 2D61001
peroxisome proliferator activated receptor gamma1001
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
arylsulfatase A1001
aryl hydrocarbon receptor2002
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b0011
cellular tumor antigen p53 isoform a1001
survival motor neuron protein isoform d1001
cytochrome P450 3A4 isoform 11001
muscarinic acetylcholine receptor M11001
Gamma-aminobutyric acid receptor subunit pi1001
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
GABA theta subunit1001
Gamma-aminobutyric acid receptor subunit epsilon1001
luciferase0001
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Voltage-dependent calcium channel gamma-2 subunit1001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Glutamate receptor 21001
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Estrogen receptor beta0202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
pregnane X receptor1001
thioredoxin glutathione reductase1001
nuclear receptor subfamily 1, group I, member 32002
vitamin D3 receptor isoform VDRA1001
nuclear factor erythroid 2-related factor 2 isoform 12002
nuclear receptor ROR-gamma isoform 11001
Nuclear receptor ROR-gamma1001
caspase 7, apoptosis-related cysteine protease1001
peroxisome proliferator-activated receptor delta1001
caspase-31001
chromobox protein homolog 11001
lethal factor (plasmid)1001
Rap guanine nucleotide exchange factor 31001
Urease subunit alpha0101
Urease subunit beta0101
Olfactory receptor 51E20011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]