Page last updated: 2024-09-27

Central Cord Injury Syndrome

A syndrome associated with traumatic injury to the cervical or upper thoracic regions of the spinal cord characterized by weakness in the arms with relative sparing of the legs and variable sensory loss. This condition is associated with ischemia, hemorrhage, or necrosis involving the central portions of the spinal cord. Corticospinal fibers destined for the legs are spared due to their more external location in the spinal cord. This clinical pattern may emerge during recovery from spinal shock. Deficits may be transient or permanent.

Synonyms(3)

Synonym
Central Cord Syndrome
Central Cord Injury Syndrome
Central Spinal Cord Syndrome

Research

Studies (7)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's4 (57.14)18.1394
2010's2 (28.57)28.8240
2020's1 (14.29)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
amitriptyline0low10
carbamazepine0low10
gabapentin0low10
memantine0low10
phenyl acetate0low10

Protein Targets (253)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
thioredoxin reductase3003
USP1 protein, partial3003
NFKB1 protein, partial1001
GLS protein1001
cytochrome P450 family 3 subfamily A polypeptide 41001
cytochrome P450 2D61001
arylsulfatase A2002
cytochrome P450 2D6 isoform 11001
D(1A) dopamine receptor2002
chromobox protein homolog 11001
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase mTOR isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 11001
muscarinic acetylcholine receptor M12002
Solute carrier family 22 member 1 0202
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
Voltage-dependent L-type calcium channel subunit alpha-1F0101
5-hydroxytryptamine receptor 40202
Bile salt export pump0404
Albumin0022
High affinity nerve growth factor receptor0123
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
5-hydroxytryptamine receptor 2C0101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10202
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
5-hydroxytryptamine receptor 2A0101
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
5-hydroxytryptamine receptor 1A0202
Muscarinic acetylcholine receptor M30202
D(1A) dopamine receptor0202
D(1B) dopamine receptor0101
UDP-glucuronosyltransferase 1A40001
Sodium-dependent noradrenaline transporter 0202
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 60101
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0202
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
Histamine H1 receptor0202
D(3) dopamine receptor0202
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0203
UDP-glucuronosyltransferase 1A30001
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0101
Histamine H2 receptor1103
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
5-hydroxytryptamine receptor 70202
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Sodium-dependent dopamine transporter 0202
Potassium voltage-gated channel subfamily H member 20303
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0303
Sigma non-opioid intracellular receptor 10011
5-hydroxytryptamine receptor 4 0101
Nuclear receptor subfamily 3 group C member 3 0202
Canalicular multispecific organic anion transporter 10202
Sodium channel protein type 2 subunit alpha0101
Ataxin-21001
Sigma non-opioid intracellular receptor 10202
5-hydroxytryptamine receptor 3B0101
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0101
Sodium channel protein type 10 subunit alpha0101
Chain A, Beta-lactamase1001
acetylcholinesterase1001
RAR-related orphan receptor gamma1001
TDP1 protein1001
AR protein2002
thyroid stimulating hormone receptor3003
glucocorticoid receptor [Homo sapiens]2002
retinoic acid nuclear receptor alpha variant 12002
estrogen-related nuclear receptor alpha1001
pregnane X nuclear receptor1001
estrogen nuclear receptor alpha1001
IDH11001
euchromatic histone-lysine N-methyltransferase 23003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
thyroid hormone receptor beta isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 21001
mitogen-activated protein kinase 11001
geminin2002
Vpr1001
lamin isoform A-delta104004
Bile salt export pump0101
Major prion protein0011
Cellular tumor antigen p531001
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2C9 0101
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 2B60011
Cytochrome P450 2J20101
Frizzled-80011
P2X purinoceptor 40101
thioredoxin glutathione reductase1001
aldehyde dehydrogenase 1 family, member A11001
regulator of G-protein signaling 42002
EWS/FLI fusion protein1001
Bloom syndrome protein isoform 12002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
survival motor neuron protein isoform d1001
Voltage-dependent calcium channel subunit alpha-2/delta-10101
ATP-dependent phosphofructokinase1001
Chain A, Ferritin light chain1001
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
ATAD5 protein, partial1001
Hsf1 protein0011
bromodomain adjacent to zinc finger domain 2B1001
transcriptional regulator ERG isoform 31001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
peripheral myelin protein 222002
histone acetyltransferase KAT2A isoform 11001
neuropeptide S receptor isoform A1001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0101
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit delta0202
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-20213
Gamma-aminobutyric acid receptor subunit alpha-50202
Gamma-aminobutyric acid receptor subunit alpha-30202
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit alpha-20202
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit rho-20011
Gamma-aminobutyric acid receptor subunit alpha-60202
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-30202
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit beta-20213
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 431001
Histone deacetylase 10101
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
GABA theta subunit0202
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Gamma-aminobutyric acid receptor subunit epsilon0202
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
GLI family zinc finger 31001
thyroid hormone receptor beta isoform 21001
huntingtin isoform 21001
Solute carrier family 22 member 20001
Glutamate receptor ionotropic, NMDA 2D0101
Acetylcholinesterase0101
Glutamate receptor ionotropic, NMDA 3B0101
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit beta-40101
Acetylcholinesterase0101
Glutamate receptor ionotropic, NMDA 1 0202
Neuronal acetylcholine receptor subunit alpha-60101
Cholinesterase0101
Glutamate receptor ionotropic, NMDA 2A 0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0202
Glutamate receptor ionotropic, NMDA 3A0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]