Page last updated: 2024-09-27

Cardio-embolic Stroke

An ischemic stroke due to a blood clot, emboli or other types of blockage which forms somewhere other than the brain and subsequently travels near and restricts blood flow to the brain. Most often the origin of the clot is from the heart and is referred to as cardioembolic stroke.

Synonyms(3)

Synonym
Cardioembolic Stroke
Embolic Stroke
Cardio-embolic Stroke

Research Excerpts

Treatment

ExcerptReference
"To characterize microbleeds in embolic strokes of undetermined source (ESUS) and report interactions between microbleeds and the effects of random assignment to anticoagulant vs antiplatelet therapy."( Berkowitz, SD; Connolly, SJ; Field, TS; Hart, RG; Kasner, SE; Liu, YY; Lutsep, H; MartĂ­-FĂ bregas, J; Mikulik, R; Muir, KW; Mundl, H; Ntaios, G; O'Donnell, MJ; Olavarria, V; Santo, GC; Sharma, M; Shoamanesh, A; Smith, EE; Uchiyama, S; Veltkamp, R, 2021)
"Patients with cardioembolic stroke undergoing EVT from January 2013 to December 2020 were treated with EVT alone or EVT plus low-dose tirofiban."( Chen, J; Duan, J; Ji, X; Li, C; Li, S; Liu, G; Ma, Q; Ren, C; Song, H; Wang, R; Wu, C; Wu, L; Xu, J; Zhao, W, 2021)

Research

Studies (46)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's1 (2.17)28.8240
2020's45 (97.83)9.53
DrugIndicatedRelationship StrengthStudiesTrials
lactic acid0low10
nitrates0low10
nitrites0low10
uric acid0low10
amiodarone0low10
aspirin0medium1610
mephentermine0low10
oxybutynin0medium11
aldosterone0low10
adenosine diphosphate0low10
quinoxalines0low10
tirofiban0medium21
pinocembrin0low10
homocysteine0low20
dronedarone0low10
dabigatran0medium85
fibrin0low20
4-hydroxy-2-nonenal0low10
as 6052400low10
rivaroxaban0medium125
natriuretic peptide, brain0medium81
warfarin0low50
hirudin0low10

Protein Targets (389)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Microtubule-associated protein tau1001
vitamin D3 receptor isoform VDRA1001
Transient receptor potential cation channel subfamily A member 10011
Chain A, Heat Shock Protein 900011
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE0011
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE0011
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, Myosin Ie Heavy Chain0011
Chain A, Preprotein translocase secA0011
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Phosphoribosylformylglycinamidine synthase0101
Chain A, nucleoside diphosphate kinase A0011
Chain B, nucleoside diphosphate kinase A0011
Chain D, DNA polymerase III subunit gamma0011
Chain D, DNA polymerase III subunit gamma0011
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 30011
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 30011
Chain A, Kinesin-like protein KIF110101
regulator of G-protein signaling 42002
HPr kinase/phosphorylase0011
Mitogen-activated protein kinase kinase kinase 70011
ATP-dependent molecular chaperone HSP820001
Heat shock protein HSP 90-alpha0113
Heat shock protein HSP 90-beta0113
2-dehydropantoate 2-reductase0112
Heat shock 70 kDa protein 1A 0112
Endoplasmic reticulum chaperone BiP0011
Heat shock cognate 71 kDa protein0011
Pyruvate kinase PKM 0001
Pyruvate kinase PKLR 0001
Endoplasmin0001
Heat shock cognate 71 kDa protein0011
5'-nucleotidase0101
Mu-type opioid receptor0213
Delta-type opioid receptor0213
Kappa-type opioid receptor0213
Endoplasmin0112
P2Y purinoceptor 20011
Phosphatidylinositol 4-kinase alpha0202
P2X purinoceptor 10011
P2Y purinoceptor 10011
P2Y purinoceptor 10011
P2X purinoceptor 10011
P2X purinoceptor 40011
P2X purinoceptor 50011
P2X purinoceptor 60011
P2X purinoceptor 30011
Inositol monophosphatase 11001
Heat shock protein 75 kDa, mitochondrial0101
P2Y purinoceptor 60011
Phosphatidylinositol 4-kinase type 2-beta0202
P2Y purinoceptor 110011
Phosphatidylinositol 4-kinase type 2-alpha0202
P2Y purinoceptor 120011
Sensor protein kinase WalK0101
Phosphatidylinositol 4-kinase beta0202
P2X purinoceptor 20011
AR protein6006
glucocorticoid receptor [Homo sapiens]5005
thyroid hormone receptor beta isoform a3003
nuclear factor erythroid 2-related factor 2 isoform 21001
geminin3003
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0123
Androgen receptor0303
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10001
Guanine nucleotide-binding protein G2002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
acetylcholinesterase3003
phosphopantetheinyl transferase1001
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma4004
SMAD family member 22002
ATAD5 protein, partial2002
Fumarate hydratase3003
USP1 protein, partial2002
NFKB1 protein, partial1001
PPM1D protein3003
SMAD family member 32002
TDP1 protein3003
Thrombopoietin1001
caspase 7, apoptosis-related cysteine protease2002
aldehyde dehydrogenase 1 family, member A13003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
thyroid stimulating hormone receptor2002
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor3003
EWS/FLI fusion protein5005
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha2002
estrogen-related nuclear receptor alpha7007
farnesoid X nuclear receptor2002
pregnane X nuclear receptor3003
estrogen nuclear receptor alpha6006
G4004
cytochrome P450 2D66006
polyprotein3003
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma3003
caspase-32002
euchromatic histone-lysine N-methyltransferase 24004
thyroid stimulating hormone receptor3003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x2002
cytochrome P450 2D6 isoform 12002
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C9 precursor1001
D(1A) dopamine receptor2002
chromobox protein homolog 12002
potassium voltage-gated channel subfamily H member 2 isoform d1001
thyroid hormone receptor beta isoform 23003
heat shock protein beta-12002
huntingtin isoform 21001
mitogen-activated protein kinase 11001
flap endonuclease 12002
serine/threonine-protein kinase mTOR isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
nuclear receptor ROR-gamma isoform 11001
peripheral myelin protein 221001
survival motor neuron protein isoform d1001
cytochrome P450 3A4 isoform 11001
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)2002
lamin isoform A-delta102002
Gamma-aminobutyric acid receptor subunit pi1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Solute carrier organic anion transporter family member 1A40101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
5-hydroxytryptamine receptor 40202
Lysine-specific demethylase PHF20101
Bile salt export pump0505
Interferon beta5005
HLA class I histocompatibility antigen, B alpha chain 4004
Thyroid hormone receptor alpha0101
Receptor tyrosine-protein kinase erbB-20101
Cellular tumor antigen p533003
Integrin beta-32216
Tyrosine-protein kinase Fyn0101
ATP-dependent translocase ABCB10101
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20416
Muscarinic acetylcholine receptor M40404
ATP-dependent translocase ABCB10213
Integrin alpha-IIb2216
Beta-1 adrenergic receptor0202
Muscarinic acetylcholine receptor M50404
Alpha-2A adrenergic receptor0202
Adenosine receptor A30202
Cytochrome P450 2C80101
Thyroid hormone receptor alpha0101
Thyroid hormone receptor beta0101
Muscarinic acetylcholine receptor M10405
Beta-3 adrenergic receptor0202
D(2) dopamine receptor0202
Gamma-aminobutyric acid receptor subunit beta-11001
Alpha-1B adrenergic receptor0202
Lethal factor0101
Alpha-2B adrenergic receptor0202
Thyroid hormone receptor beta0101
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Muscarinic acetylcholine receptor M30404
ATP-dependent translocase ABCB10101
Substance-K receptor0202
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Sodium-dependent noradrenaline transporter 0404
Histamine H2 receptor0202
Endothelin-1 receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Lysine-specific demethylase 5A0101
Gamma-aminobutyric acid receptor subunit alpha-61001
B2 bradykinin receptor0202
Sodium-dependent serotonin transporter0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
D(3) dopamine receptor0404
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Squalene synthase0101
5-hydroxytryptamine receptor 2B0404
C-C chemokine receptor type 20202
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0202
Histamine H2 receptor1001
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 60202
Carnitine O-palmitoyltransferase 1, liver isoform0101
C-C chemokine receptor type 40202
Spike glycoprotein3003
Gamma-aminobutyric acid receptor subunit alpha-11102
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Sodium-dependent dopamine transporter 0404
Potassium voltage-gated channel subfamily H member 20202
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Squalene monooxygenase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0101
Lysine-specific demethylase 7A0101
GABA theta subunit1001
Carnitine O-palmitoyltransferase 1, muscle isoform0101
Inositol hexakisphosphate kinase 14004
Canalicular multispecific organic anion transporter 10404
Sodium channel protein type 2 subunit alpha0101
Ataxin-23003
Sigma non-opioid intracellular receptor 10415
Gamma-aminobutyric acid receptor subunit epsilon1001
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Histone lysine demethylase PHF80101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial4004
ATP-dependent phosphofructokinase1001
Chain A, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform0101
Chain A, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform0101
thioredoxin reductase3003
Parkin1001
arylsulfatase A1001
NPC intracellular cholesterol transporter 1 precursor1001
ras-related protein Rab-9A1001
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0101
Epidermal growth factor receptor0202
Casein kinase II subunit alpha'0101
Amine oxidase [flavin-containing] A0101
Amine oxidase [flavin-containing] B0101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
Dual specificity protein kinase CLK10101
Casein kinase II subunit beta0101
Casein kinase II subunit alpha0101
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Dual specificity tyrosine-phosphorylation-regulated kinase 20101
CDGSH iron-sulfur domain-containing protein 10101
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase2002
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 81001
GLS protein2002
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 45005
glucocerebrosidase1001
Rac1 protein0011
IDH11001
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Bloom syndrome protein isoform 11001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
DNA polymerase iota isoform a (long)1001
DNA polymerase kappa isoform 11001
Prostaglandin-H2 D-isomerase0101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Carbonic anhydrase 10404
Carbonic anhydrase 20404
Fatty acid-binding protein, liver0101
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10202
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin G/H synthase 20202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma1001
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Sigma non-opioid intracellular receptor 10011
Solute carrier family 22 member 20101
Prothrombin0303
Coagulation factor X0303
Plasminogen0101
Coagulation factor XII0202
Tissue-type plasminogen activator0101
Vitamin K-dependent protein C0101
Serine protease hepsin0101
Trypsin-10101
Trypsin-20101
Muscarinic acetylcholine receptor M10202
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Trypsin-30101
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
GLI family zinc finger 32002
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
aryl hydrocarbon receptor1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
activating transcription factor 61001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
Voltage-dependent calcium channel gamma-2 subunit2002
Replicase polyprotein 1ab0101
Glutamate receptor 22002
NACHT, LRR and PYD domains-containing protein 3 0101
ATPase family AAA domain-containing protein 51001
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Chain A, Ferritin light chain1001
Atrial natriuretic peptide receptor 10101
Carbonic anhydrase 40202
Carbonic anhydrase0202
Sodium/iodide cotransporter0101
Carbonic anhydrase 150202
Amyloid-beta precursor protein0101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M20101
Cytochrome P450 2C190101
Mu-type opioid receptor0101
MBT domain-containing protein 10101
Lethal(3)malignant brain tumor-like protein 40101
Muscarinic acetylcholine receptor0011
Lethal(3)malignant brain tumor-like protein 30101
Lethal(3)malignant brain tumor-like protein 10101
Cytochrome P450 1A10101
Cytochrome P450 1A20101
Serine/threonine-protein kinase pim-10101
4-hydroxyphenylpyruvate dioxygenase0101
Cytochrome P450 1B10101
Smad31001
67.9K protein1001
Chain A, Activated Factor Xa Heavy Chain0101
Suppressor of tumorigenicity 14 protein0101
Integrin subunit alpha 2b0101
Integrin beta-10101
Integrin alpha-V 0101
Integrin alpha-50101
Integrin beta-3 0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 22 member 60001
Solute carrier family 22 member 80101
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
Chain A, Beta-lactamase1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Albumin0011
Albumin0011
Cytochrome P450 2C9 0101
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]