Page last updated: 2024-09-27

Cardio-Cutaneous Syndrome

An autosomal dominant disorder with an acronym of its seven features (LENTIGO; ELECTROCARDIOGRAM abnormalities; ocular HYPERTELORISM; PULMONARY STENOSIS; abnormal genitalia; retardation of growth; and DEAFNESS or SENSORINEURAL HEARING LOSS). This syndrome is caused by mutations of PTPN11 gene encoding the non-receptor PROTEIN TYROSINE PHOSPHATASE, type 11, and is an allelic to NOONAN SYNDROME. Features of LEOPARD syndrome overlap with those of NEUROFIBROMATOSIS 1 which is caused by mutations in the NEUROFIBROMATOSIS 1 GENES.

Synonyms(9)

Synonym
Cardio-Cutaneous Syndrome
Noonan Syndrome with Multiple Lentigines
LEOPARD Syndrome, 1
Cardiomyopathic Lentiginosis
Leopard Syndrome 1
LEOPARD Syndrome
Multiple Lentigines Syndrome
Progressive Cardiomyopathic Lentiginosis
Lentiginosis Cardiomyopathic

Research Excerpts

Overview

ExcerptReference
"LEOPARD syndrome is a neuroectodermal disorder presumed to result from an abnormality in neural crest cells."( Russo, P; Tobias, JD; Torres, J, 2004)

Research

Studies (22)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's5 (22.73)18.1394
2010's14 (63.64)28.8240
2020's3 (13.64)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
amiodarone0low10
fentanyl0low10
propranolol0low10
sevoflurane0low10
tyrosine0low30
alpha-aminopyridine0low10
atracurium0low10
cisatracurium0low10
digoxin0low10
dasatinib0low10
sirolimus0low20
cysteine0low20
everolimus0low10
pd 1843520low10
losartan potassium0medium11
jaw0low10
atrial natriuretic factor0low10
endothelin-10low10
piperidines0low10
epidermal growth factor0low20
epoetin alfa0medium11
cyclosporine0low10
phenylhydrazonopyrazolone sulfonate 10low10
eye0low10

Protein Targets (909)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
AR protein7007
retinoic acid nuclear receptor alpha variant 15005
estrogen nuclear receptor alpha9009
thyroid stimulating hormone receptor4004
thyroid hormone receptor beta isoform 26006
Voltage-dependent calcium channel gamma-2 subunit4004
Heat shock protein HSP 90-alpha0011
Botulinum neurotoxin type A 0101
Neutrophil cytosol factor 10101
Glutamate receptor 24004
Nitric oxide synthase, endothelial0101
Nitric oxide synthase, brain0101
Nitric oxide synthase, brain 0101
Nitric oxide synthase, inducible0101
Kappa-type opioid receptor0213
Phosphatidylinositol 4-kinase alpha0101
Mu-type opioid receptor0213
Tyrosine-protein kinase 0011
Phosphatidylinositol 4-kinase type 2-beta0101
Phosphatidylinositol 4-kinase type 2-alpha0101
Phosphatidylinositol 4-kinase beta0123
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
acetylcholinesterase2002
phosphopantetheinyl transferase1001
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma5005
SMAD family member 22002
ATAD5 protein, partial3003
Fumarate hydratase3003
USP1 protein, partial3003
NFKB1 protein, partial1001
PPM1D protein3003
SMAD family member 32002
TDP1 protein8008
Thrombopoietin1001
caspase 7, apoptosis-related cysteine protease2002
aldehyde dehydrogenase 1 family, member A12002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
thyroid stimulating hormone receptor1001
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 34004
progesterone receptor4004
EWS/FLI fusion protein3003
glucocorticoid receptor [Homo sapiens]5005
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha5005
farnesoid X nuclear receptor4004
pregnane X nuclear receptor5005
G2002
cytochrome P450 2D61001
polyprotein3003
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma5005
caspase-32002
euchromatic histone-lysine N-methyltransferase 23003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x2002
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C9 precursor1001
D(1A) dopamine receptor2002
chromobox protein homolog 12002
thyroid hormone receptor beta isoform a2002
potassium voltage-gated channel subfamily H member 2 isoform d2002
heat shock protein beta-12002
huntingtin isoform 22002
mitogen-activated protein kinase 11001
flap endonuclease 11001
serine/threonine-protein kinase mTOR isoform 13003
nuclear factor erythroid 2-related factor 2 isoform 14004
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
nuclear receptor ROR-gamma isoform 14004
geminin6006
peripheral myelin protein 223003
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 11001
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)2002
lamin isoform A-delta102002
Gamma-aminobutyric acid receptor subunit pi1113
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Solute carrier organic anion transporter family member 1A40203
Voltage-dependent L-type calcium channel subunit alpha-1F0202
5-hydroxytryptamine receptor 40404
Lysine-specific demethylase PHF20101
Bile salt export pump0808
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 2002
Thyroid hormone receptor alpha0101
Receptor tyrosine-protein kinase erbB-20224
Cellular tumor antigen p535005
Integrin beta-32002
Tyrosine-protein kinase Fyn0347
ATP-dependent translocase ABCB10202
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20314
Muscarinic acetylcholine receptor M40202
ATP-dependent translocase ABCB10719
Integrin alpha-IIb2002
Beta-1 adrenergic receptor0415
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0326
Adenosine receptor A30314
Cytochrome P450 2C80202
Thyroid hormone receptor alpha0101
Thyroid hormone receptor beta0101
Muscarinic acetylcholine receptor M10314
Beta-3 adrenergic receptor0415
D(2) dopamine receptor0415
Androgen receptor0202
Gamma-aminobutyric acid receptor subunit beta-11113
Alpha-1B adrenergic receptor0314
Lethal factor0101
Alpha-2B adrenergic receptor0214
Thyroid hormone receptor beta0101
Gamma-aminobutyric acid receptor subunit delta1113
Gamma-aminobutyric acid receptor subunit gamma-21113
Gamma-aminobutyric acid receptor subunit alpha-51113
Gamma-aminobutyric acid receptor subunit alpha-31113
Muscarinic acetylcholine receptor M30314
ATP-dependent translocase ABCB10202
Substance-K receptor0202
D(1A) dopamine receptor0314
D(4) dopamine receptor0303
Gamma-aminobutyric acid receptor subunit gamma-11113
Gamma-aminobutyric acid receptor subunit alpha-21113
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Sodium-dependent noradrenaline transporter 0202
Histamine H2 receptor0202
Endothelin-1 receptor0415
5-hydroxytryptamine receptor 2A0415
5-hydroxytryptamine receptor 2C0415
Gamma-aminobutyric acid receptor subunit alpha-41113
Gamma-aminobutyric acid receptor subunit gamma-31113
Lysine-specific demethylase 5A0101
Gamma-aminobutyric acid receptor subunit alpha-61113
B2 bradykinin receptor0202
Sodium-dependent serotonin transporter0404
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Mu-type opioid receptor0527
D(3) dopamine receptor0303
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Squalene synthase0101
Delta-type opioid receptor0516
Kappa-type opioid receptor0516
5-hydroxytryptamine receptor 2B0415
C-C chemokine receptor type 20202
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0314
Histamine H2 receptor1001
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60415
Carnitine O-palmitoyltransferase 1, liver isoform0101
C-C chemokine receptor type 40202
Spike glycoprotein2013
Gamma-aminobutyric acid receptor subunit alpha-11113
Gamma-aminobutyric acid receptor subunit beta-31113
Gamma-aminobutyric acid receptor subunit beta-21113
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Sodium-dependent dopamine transporter 0202
Potassium voltage-gated channel subfamily H member 20505
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Sodium channel protein type 5 subunit alpha0404
Squalene monooxygenase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0101
Lysine-specific demethylase 7A0101
GABA theta subunit1113
Carnitine O-palmitoyltransferase 1, muscle isoform0101
Inositol hexakisphosphate kinase 12002
Canalicular multispecific organic anion transporter 10404
Sodium channel protein type 2 subunit alpha0101
Ataxin-26006
Sigma non-opioid intracellular receptor 10606
Gamma-aminobutyric acid receptor subunit epsilon1113
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Histone lysine demethylase PHF80101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial2002
ATP-dependent phosphofructokinase2002
NPYLR7B0011
Amine oxidase [flavin-containing] A 0011
Small conductance calcium-activated potassium channel protein 30112
Atrial natriuretic peptide receptor 10011
Atrial natriuretic peptide receptor 1 0011
Leukotriene C4 synthase0022
GALC protein1001
GLS protein1001
GLI family zinc finger 33003
Smad34004
cytochrome P450 family 3 subfamily A polypeptide 43003
67.9K protein3003
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
aryl hydrocarbon receptor1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
nuclear receptor subfamily 1, group I, member 21001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
tyrosine-protein kinase Yes1001
Bone morphogenetic protein receptor type-1B0044
Membrane-associated progesterone receptor component 10011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0123
Serine/threonine-protein kinase PLK40044
Serine/threonine-protein kinase 250022
ATP-dependent RNA helicase DDX3X0033
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0022
Pyridoxal kinase0033
Citron Rho-interacting kinase0044
Serine/threonine-protein kinase RIO30022
Dual specificity mitogen-activated protein kinase kinase 70022
Serine/threonine-protein kinase Chk10044
Inhibitor of nuclear factor kappa-B kinase subunit beta0124
Peripheral plasma membrane protein CASK0022
Aurora kinase A0145
Cyclin-G-associated kinase0044
Serine/threonine-protein kinase DCLK10022
Inhibitor of nuclear factor kappa-B kinase subunit alpha0123
Muscle, skeletal receptor tyrosine-protein kinase0022
Ephrin type-B receptor 60044
Peroxisomal acyl-coenzyme A oxidase 30033
Mitogen-activated protein kinase 130123
Transmembrane protease serine 20011
3-phosphoinositide-dependent protein kinase 10022
Mitogen-activated protein kinase kinase kinase 130022
Death-associated protein kinase 30022
Mitogen-activated protein kinase kinase kinase 70022
Receptor-interacting serine/threonine-protein kinase 20246
Mitotic checkpoint serine/threonine-protein kinase BUB10033
NUAK family SNF1-like kinase 10022
Dynamin-like 120 kDa protein, mitochondrial0033
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma0022
Tyrosine-protein kinase JAK20033
Eukaryotic translation initiation factor 5B0033
Rho-associated protein kinase 20044
Serine/threonine-protein kinase ULK10044
Serine/threonine-protein kinase/endoribonuclease IRE10044
Ribosomal protein S6 kinase alpha-50044
U5 small nuclear ribonucleoprotein 200 kDa helicase0033
Ribosomal protein S6 kinase alpha-40044
Serine/threonine-protein kinase 160044
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma0022
Serine/threonine-protein kinase PAK 30022
Cyclin-dependent kinase-like 50033
Serine/threonine-protein kinase 17B0022
Serine/threonine-protein kinase 100044
Serine/threonine-protein kinase D30044
Cyclin-dependent kinase 140022
Structural maintenance of chromosomes protein 20033
Mitogen-activated protein kinase kinase kinase 60044
Serine/threonine-protein kinase OSR10022
Mitogen-activated protein kinase kinase kinase kinase 40044
Serine/threonine-protein kinase LATS10044
Serine/threonine-protein kinase PAK 40044
Serine/threonine-protein kinase Chk20022
Tyrosine-protein kinase ABL10359
Tyrosine-protein kinase ABL10101
Proto-oncogene tyrosine-protein kinase Src0112
Epidermal growth factor receptor0145
Transthyretin0011
RAF proto-oncogene serine/threonine-protein kinase0224
High affinity nerve growth factor receptor0044
Guanine nucleotide-binding protein G(i) subunit alpha-20022
ADP/ATP translocase 20033
Cytochrome P450 1A20202
Neuronal proto-oncogene tyrosine-protein kinase Src 0001
Protein kinase C beta type0033
Insulin receptor0145
Tyrosine-protein kinase Lck0347
Proto-oncogene tyrosine-protein kinase LCK 0202
Cyclin-dependent kinase 10033
Glycogen phosphorylase, liver form0033
Tyrosine-protein kinase Fes/Fps0044
Macrophage colony-stimulating factor 1 receptor0224
Procathepsin L0011
Adenine phosphoribosyltransferase0033
Tyrosine-protein kinase Yes0145
Tyrosine-protein kinase Lyn0145
Proto-oncogene tyrosine-protein kinase receptor Ret0145
Insulin-like growth factor 1 receptor0145
Signal recognition particle receptor subunit alpha0033
Cytochrome c1, heme protein, mitochondrial0033
Hepatocyte growth factor receptor0044
Tyrosine-protein kinase HCK0246
Proto-oncogene tyrosine-protein kinase ROS0022
Platelet-derived growth factor receptor beta0246
Tyrosine-protein kinase Fgr0044
Quinolone resistance protein NorA0101
Wee1-like protein kinase 20022
Uncharacterized serine/threonine-protein kinase SBK30022
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0112
Serine/threonine-protein kinase A-Raf0033
Cytochrome P450 2D60202
Mast/stem cell growth factor receptor Kit0123
Glycogen phosphorylase, brain form0033
Breakpoint cluster region protein0247
Serine/threonine-protein kinase pim-10044
Fibroblast growth factor receptor 10145
Cytochrome P450 2A60101
Cytochrome P450 2C9 0303
Myosin light chain kinase, smooth muscle0011
Cyclin-dependent kinase 40044
ADP/ATP translocase 30033
Inosine-5'-monophosphate dehydrogenase 20033
Angiotensin-converting enzyme 0101
Proto-oncogene tyrosine-protein kinase Src0347
cAMP-dependent protein kinase type II-alpha regulatory subunit0033
Insulin receptor-related protein0022
Serine/threonine-protein kinase B-raf0044
Potassium voltage-gated channel subfamily E member 10202
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0044
Ribosyldihydronicotinamide dehydrogenase [quinone]0033
Platelet-derived growth factor receptor alpha0224
Tyrosine-protein kinase Blk0101
Tyrosine-protein kinase Fer0044
Protein kinase C alpha type0134
cAMP-dependent protein kinase catalytic subunit alpha0044
Vascular endothelial growth factor receptor 1 0022
General transcription and DNA repair factor IIH helicase subunit XPD0033
Interferon-induced, double-stranded RNA-activated protein kinase0022
Casein kinase II subunit alpha'0055
Ras-related protein Rab-6A0033
Serine/threonine-protein kinase MAK0022
Cytochrome P450 2B60101
Cyclin-dependent kinase 11B0022
Ephrin type-A receptor 10044
Fibroblast growth factor receptor 20022
Receptor tyrosine-protein kinase erbB-30022
Multifunctional protein ADE20033
Fibroblast growth factor receptor 40022
Fibroblast growth factor receptor 30022
cAMP-dependent protein kinase catalytic subunit gamma0022
cAMP-dependent protein kinase catalytic subunit beta0044
Ferrochelatase, mitochondrial0033
Ribosomal protein S6 kinase beta-10044
Tyrosine-protein kinase JAK10044
Protein kinase C eta type0022
Cyclin-dependent kinase 20145
Beta-adrenergic receptor kinase 10033
Probable ATP-dependent RNA helicase DDX60033
Activin receptor type-2A0022
Mitogen-activated protein kinase 3 0044
MAP/microtubule affinity-regulating kinase 30044
Deoxycytidine kinase0033
Mitogen-activated protein kinase 10044
Ephrin type-A receptor 20145
Ephrin type-A receptor 30022
Ephrin type-A receptor 80022
Ephrin type-B receptor 20145
Leukocyte tyrosine kinase receptor0022
Non-receptor tyrosine-protein kinase TYK20044
UMP-CMP kinase 0033
Phosphatidylethanolamine-binding protein 10033
Wee1-like protein kinase0044
Heme oxygenase 20033
Tyrosine-protein kinase receptor UFO0022
Mitogen-activated protein kinase 40022
S-adenosylmethionine synthase isoform type-20033
DnaJ homolog subfamily A member 10033
RAC-alpha serine/threonine-protein kinase0145
RAC-beta serine/threonine-protein kinase0145
G protein-coupled receptor kinase 40022
Cytochrome P450 2C190303
Dual specificity protein kinase TTK0044
DNA replication licensing factor MCM40033
Prostaglandin G/H synthase 20123
Tyrosine-protein kinase receptor Tie-10022
Vascular endothelial growth factor receptor 30022
Vascular endothelial growth factor receptor 20123
Dual specificity mitogen-activated protein kinase kinase 20246
Receptor-type tyrosine-protein kinase FLT30145
Bone morphogenetic protein receptor type-1A0044
Activin receptor type-1B0044
TGF-beta receptor type-10044
Serine/threonine-protein kinase receptor R30033
TGF-beta receptor type-20044
Electron transfer flavoprotein subunit beta0033
Tyrosine-protein kinase CSK0145
Glycine--tRNA ligase0033
Protein kinase C iota type0044
Exosome RNA helicase MTR40033
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0123
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0123
Serine/threonine-protein kinase mTOR0347
Megakaryocyte-associated tyrosine-protein kinase0022
Tyrosine-protein kinase Tec0145
Tyrosine-protein kinase TXK0123
Tyrosine-protein kinase ABL20044
Tyrosine-protein kinase FRK0044
G protein-coupled receptor kinase 60033
Tyrosine-protein kinase ZAP-700022
Tyrosine-protein kinase SYK0145
26S proteasome regulatory subunit 6B0033
Mitogen-activated protein kinase 80044
Mitogen-activated protein kinase 90044
Dual specificity mitogen-activated protein kinase kinase 40022
Dual specificity mitogen-activated protein kinase kinase 30044
Casein kinase I isoform alpha0145
Casein kinase I isoform delta0044
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0123
MAP kinase-activated protein kinase 20145
Cyclin-dependent kinase 80022
Elongation factor Tu, mitochondrial0033
Choline-phosphate cytidylyltransferase A0033
Cysteine--tRNA ligase, cytoplasmic0033
Casein kinase I isoform epsilon0044
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0033
Dual specificity protein kinase CLK10044
Dual specificity protein kinase CLK20044
Dual specificity protein kinase CLK30044
Glycogen synthase kinase-3 alpha0044
Glycogen synthase kinase-3 beta0044
Cyclin-dependent kinase 70044
Cyclin-dependent kinase 90044
Ras-related protein Rab-27A0033
Tyrosine-protein kinase Blk0123
Interleukin-1 receptor-associated kinase 10044
Potassium voltage-gated channel subfamily KQT member 10202
Ribosomal protein S6 kinase alpha-30145
Cytoplasmic tyrosine-protein kinase BMX0022
cAMP-dependent protein kinase catalytic subunit PRKX0022
Serine/threonine-protein kinase Nek20044
Serine/threonine-protein kinase Nek30044
Serine/threonine-protein kinase Nek40022
Tyrosine-protein kinase JAK30022
Dual specificity mitogen-activated protein kinase kinase 60044
Serine/threonine-protein kinase PLK10044
Death-associated protein kinase 10022
LIM domain kinase 10145
LIM domain kinase 20145
Mitogen-activated protein kinase 120123
Mitogen-activated protein kinase 100044
Tyrosine--tRNA ligase, cytoplasmic0033
5'-AMP-activated protein kinase subunit gamma-10034
5'-AMP-activated protein kinase catalytic subunit alpha-20023
Ephrin type-B receptor 30044
Ephrin type-A receptor 50044
Ephrin type-B receptor 40145
Ephrin type-B receptor 10022
Ephrin type-A receptor 40044
Adenylate kinase 2, mitochondrial0033
Adenosine kinase0033
Hormonally up-regulated neu tumor-associated kinase0022
Serine/threonine-protein kinase SIK10224
Receptor-interacting serine/threonine-protein kinase 40022
Ras-related protein Rab-100033
Cell division control protein 2 homolog0022
Actin-related protein 30033
Actin-related protein 20033
Calcium-dependent protein kinase 10022
GTP-binding nuclear protein Ran0033
Tubulin alpha-1A chain0011
Casein kinase II subunit alpha0134
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta0022
SRSF protein kinase 20022
Casein kinase I isoform gamma-20044
DNA-dependent protein kinase catalytic subunit0101
Mitogen-activated protein kinase kinase kinase 90022
Serine/threonine-protein kinase PknB0022
Cyclin-dependent kinase 30033
Cyclin-dependent kinase-like 10022
Cyclin-dependent kinase 60033
Cyclin-dependent-like kinase 5 0044
Cyclin-dependent kinase 160044
Cyclin-dependent kinase 170044
Myelin transcription factor 10101
ATP-dependent 6-phosphofructokinase, platelet type0033
Protein kinase C epsilon type0022
Dual specificity mitogen-activated protein kinase kinase 10246
Angiopoietin-1 receptor0022
Mitogen-activated protein kinase kinase kinase 100022
DNA topoisomerase 2-beta0033
Protein kinase C theta type0044
Activin receptor type-10044
Macrophage-stimulating protein receptor0044
Focal adhesion kinase 10145
Protein kinase C zeta type0123
Protein kinase C delta type0145
Tyrosine-protein kinase BTK0246
Tyrosine-protein kinase receptor TYRO30022
Cyclin-dependent kinase 180033
Activated CDC42 kinase 10145
Epithelial discoidin domain-containing receptor 10347
Tyrosine-protein kinase ITK/TSK0123
Myotonin-protein kinase0022
Mitogen-activated protein kinase kinase kinase kinase 20044
Mitogen-activated protein kinase kinase kinase 120022
Tyrosine-protein kinase Mer0033
Serine/threonine-protein kinase 40044
5'-AMP-activated protein kinase catalytic subunit alpha-10045
Serine/threonine-protein kinase PAK 10022
Dual specificity mitogen-activated protein kinase kinase 50044
Mitogen-activated protein kinase 70044
Serine/threonine-protein kinase PAK 20044
Serine/threonine-protein kinase 30044
Mitogen-activated protein kinase kinase kinase 10044
cGMP-dependent protein kinase 20022
Integrin-linked protein kinase0033
Rho-associated protein kinase 10044
Non-receptor tyrosine-protein kinase TNK10044
Serine/threonine-protein kinase PRP4 homolog0022
Receptor-interacting serine/threonine-protein kinase 10022
Calcium/calmodulin-dependent protein kinase type II subunit beta0022
Calcium/calmodulin-dependent protein kinase type II subunit gamma0044
Calcium/calmodulin-dependent protein kinase type II subunit delta0044
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0044
Activin receptor type-2B0044
Bone morphogenetic protein receptor type-20044
Protein-tyrosine kinase 60145
cGMP-dependent protein kinase 1 0044
Cyclin-dependent kinase 130044
Calcium/calmodulin-dependent protein kinase type 10022
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0044
Protein-tyrosine kinase 2-beta0044
Maternal embryonic leucine zipper kinase0044
Structural maintenance of chromosomes protein 1A0033
Chromodomain-helicase-DNA-binding protein 40033
Peroxisomal acyl-coenzyme A oxidase 10033
Serine/threonine-protein kinase D10022
Serine/threonine-protein kinase 380022
Receptor tyrosine-protein kinase erbB-40022
Ribosomal protein S6 kinase alpha-20022
Ephrin type-A receptor 70033
Delta(24)-sterol reductase0033
Ribosomal protein S6 kinase alpha-10145
Dual specificity testis-specific protein kinase 10044
Myosin light chain kinase, smooth muscle0044
Mitogen-activated protein kinase 110145
Serine/threonine-protein kinase STK110044
Rhodopsin kinase GRK10022
NT-3 growth factor receptor0022
Serine/threonine-protein kinase N10044
Serine/threonine-protein kinase N20044
Mitogen-activated protein kinase 140156
Calcium/calmodulin-dependent protein kinase type IV0044
Mitogen-activated protein kinase kinase kinase 110044
BDNF/NT-3 growth factors receptor0022
Mitogen-activated protein kinase 60022
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform0022
Discoidin domain-containing receptor 20246
AP2-associated protein kinase 10044
Myosin light chain kinase 30044
Uncharacterized aarF domain-containing protein kinase 50022
Serine/threonine-protein kinase SBK10022
Mitogen-activated protein kinase kinase kinase 190022
Putative heat shock protein HSP 90-beta 20033
Serine/threonine-protein kinase TNNI3K0022
Leucine-rich repeat serine/threonine-protein kinase 20022
Serine/threonine-protein kinase MRCK alpha0044
Serine/threonine-protein kinase MRCK gamma0044
Acyl-CoA dehydrogenase family member 100033
Serine/threonine-protein kinase Nek50022
Serine/threonine-protein kinase N30033
Breakpoint cluster region protein0101
Serine/threonine-protein kinase ULK30044
Dual serine/threonine and tyrosine protein kinase0022
Mitogen-activated protein kinase kinase kinase 150022
Uncharacterized protein FLJ452520033
Acyl-CoA dehydrogenase family member 110033
Serine/threonine-protein kinase/endoribonuclease IRE20033
Serine/threonine-protein kinase MARK20044
Serine/threonine-protein kinase TAO10044
STE20-related kinase adapter protein alpha0033
Myosin-140033
AarF domain-containing protein kinase 10033
Serine/threonine-protein kinase tousled-like 20022
Serine/threonine-protein kinase 32C0022
Serine/threonine-protein kinase pim-30022
ATP-dependent RNA helicase DDX420022
Serine/threonine-protein kinase VRK20022
Myosin light chain kinase family member 40022
Homeodomain-interacting protein kinase 10022
Calcium/calmodulin-dependent protein kinase type 1D0022
Mitogen-activated protein kinase kinase kinase kinase 30044
Cyclin-dependent kinase-like 30022
MAP kinase-activated protein kinase 50033
Serine/threonine-protein kinase BRSK20022
Serine/threonine-protein kinase NIM10022
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0022
Serine/threonine-protein kinase ULK20022
Misshapen-like kinase 10033
Serine/threonine-protein kinase DCLK20022
Calcium/calmodulin-dependent protein kinase kinase 10022
Casein kinase I isoform alpha-like0022
Homeodomain-interacting protein kinase 40022
Myosin-IIIa0022
Ankyrin repeat and protein kinase domain-containing protein 10022
Serine/threonine-protein kinase Nek110022
Atypical kinase COQ8A, mitochondrial0044
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0044
Mitogen-activated protein kinase 150044
Serine/threonine-protein kinase Nek90044
Serine/threonine-protein kinase BRSK10022
Serine/threonine-protein kinase 350022
Serine/threonine-protein kinase Nek70033
Rhodopsin kinase GRK70022
Serine/threonine-protein kinase 32A0022
Myosin-IIIb0022
ATP-dependent RNA helicase DDX10033
Dual specificity tyrosine-phosphorylation-regulated kinase 20022
Cyclin-dependent kinase-like 20022
Mitogen-activated protein kinase kinase kinase kinase 10044
Serine/threonine-protein kinase Sgk30022
Atypical kinase COQ8B, mitochondrial0022
Aurora kinase B0145
MAP/microtubule affinity-regulating kinase 40044
Calcium/calmodulin-dependent protein kinase type 1G0033
Serine/threonine-protein kinase Nek10044
Cyclin-dependent kinase 150022
ATPase family AAA domain-containing protein 54004
PAS domain-containing serine/threonine-protein kinase0033
Calcium/calmodulin-dependent protein kinase kinase 20044
EKC/KEOPS complex subunit TP53RK0033
Dual specificity testis-specific protein kinase 20033
SRSF protein kinase 10022
Protein cereblon0012
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0246
Mitogen-activated protein kinase kinase kinase 50044
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha0022
Mitogen-activated protein kinase kinase kinase 30044
Eukaryotic translation initiation factor 2-alpha kinase 10044
Serine/threonine-protein kinase RIO10022
MAP kinase-interacting serine/threonine-protein kinase 10022
Serine/threonine-protein kinase RIO20022
Cyclin-dependent kinase 190022
Transient receptor potential cation channel subfamily M member 60022
Testis-specific serine/threonine-protein kinase 10022
Angiotensin-converting enzyme 2 0011
Serine/threonine-protein kinase 330022
Nucleolar GTP-binding protein 10033
Serine/threonine-protein kinase D20044
Serine/threonine-protein kinase DCLK30022
NUAK family SNF1-like kinase 20033
RNA cytidine acetyltransferase0033
Serine/threonine-protein kinase SIK20145
Myosin light chain kinase 2, skeletal/cardiac muscle0022
STE20-like serine/threonine-protein kinase 0044
Serine/threonine-protein kinase TAO30044
Homeodomain-interacting protein kinase 20022
Tyrosine-protein kinase Srms0022
Homeodomain-interacting protein kinase 30022
Serine/threonine-protein kinase PLK30022
dCTP pyrophosphatase 10033
Dual specificity protein kinase CLK40044
MAP kinase-interacting serine/threonine-protein kinase 20022
Serine/threonine-protein kinase Nek60022
Casein kinase I isoform gamma-10044
Serine/threonine-protein kinase PAK 60022
SNF-related serine/threonine-protein kinase0022
Serine/threonine-protein kinase LATS20022
Serine/threonine-protein kinase 360022
Phenylalanine--tRNA ligase beta subunit0033
Isoleucine--tRNA ligase, mitochondrial0022
BMP-2-inducible protein kinase0044
Obg-like ATPase 10033
Midasin0033
Interleukin-1 receptor-associated kinase 40044
Serine/threonine-protein kinase 32B0022
Mitogen-activated protein kinase kinase kinase 200044
Cyclin-dependent kinase 120033
Serine/threonine-protein kinase PLK20022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130022
Serine/threonine-protein kinase MARK10022
Serine/threonine-protein kinase pim-20022
Serine/threonine-protein kinase PAK 50022
Serine/threonine-protein kinase 260044
eIF-2-alpha kinase GCN20022
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0033
Serine/threonine-protein kinase NLK0044
Serine/threonine-protein kinase 17A0022
STE20/SPS1-related proline-alanine-rich protein kinase0022
Ephrin type-A receptor 60022
5'-AMP-activated protein kinase subunit gamma-20034
Serine/threonine-protein kinase TBK10044
Septin-90033
Death-associated protein kinase 20022
Potassium voltage-gated channel subfamily D member 30202
Ribosomal protein S6 kinase alpha-60044
TRAF2 and NCK-interacting protein kinase0044
Serine/threonine-protein kinase tousled-like 10022
Serine/threonine-protein kinase TAO20044
Long-chain-fatty-acid--CoA ligase 50022
ALK tyrosine kinase receptor0022
Broad substrate specificity ATP-binding cassette transporter ABCG20202
SRSF protein kinase 30022
Serine/threonine-protein kinase ICK0033
Cyclin-dependent kinase 11A0022
Aurora kinase C0022
Calcium/calmodulin-dependent protein kinase type II subunit alpha0022
RAC-gamma serine/threonine-protein kinase0145
Serine/threonine-protein kinase 38-like0022
Microtubule-associated serine/threonine-protein kinase 10022
Serine/threonine-protein kinase SIK30145
Mitogen-activated protein kinase kinase kinase 20044
Thyroid hormone receptor-associated protein 30033
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0033
Mitogen-activated protein kinase kinase kinase kinase 50044
Receptor-interacting serine/threonine-protein kinase 30033
Serine/threonine-protein kinase MRCK beta0044
Interleukin-1 receptor-associated kinase 30044
Serine/threonine-protein kinase 240033
NF-kappa-B essential modulator0101
Casein kinase I isoform gamma-30044
Mitogen-activated protein kinase kinase kinase 40044
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, Beta-lactamase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Cruzipain1001
interleukin 81001
PAX80001
STAT3, partial0101
thioredoxin glutathione reductase1001
regulator of G-protein signaling 41001
alpha-galactosidase1001
IDH11001
activating transcription factor 62002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
NPC intracellular cholesterol transporter 1 precursor1001
tumor necrosis factor1001
nuclear factor erythroid 2-related factor 2 isoform 21001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
ras-related protein Rab-9A1001
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
Sodium/potassium-transporting ATPase subunit alpha-1 0202
Sodium/potassium-transporting ATPase subunit beta-10202
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
Sodium/potassium-transporting ATPase subunit beta-1 0101
Cytochrome P450 3A40303
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Sodium/potassium-transporting ATPase subunit alpha-20202
Sodium/potassium-transporting ATPase subunit alpha-10101
Nuclear receptor ROR-gamma1113
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1B30101
Solute carrier organic anion transporter family member 1B10202
vitamin D3 receptor isoform VDRA1001
Cell division cycle 7-related protein kinase0022
DNA topoisomerase 2-alpha0022
Myosin-100022
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0022
ATP-dependent RNA helicase DHX300022
Regulatory-associated protein of mTOR0202
Target of rapamycin complex subunit LST80202
Luciferase1001
Solute carrier family 22 member 1 0202
Nuclear receptor subfamily 1 group I member 20022
Amine oxidase [flavin-containing] A0101
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0202
Delta-type opioid receptor0202
Mu-type opioid receptor0213
Kappa-type opioid receptor0101
Histamine H1 receptor0101
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10202
Sigma non-opioid intracellular receptor 10101
Chymotrypsinogen A0101
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Intestinal-type alkaline phosphatase0101
Large neutral amino acids transporter small subunit 10202
Proton-coupled amino acid transporter 10102
Phospholipase A-2-activating protein0101
Type-1A angiotensin II receptor 0101
Type-1B angiotensin II receptor0202
Type-2 angiotensin II receptor0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
5-hydroxytryptamine receptor 1A0101
Type-1 angiotensin II receptor0101
Casein kinase II subunit beta0011
Casein kinase II subunit alpha 30011
thioredoxin reductase2002
Beta-1 adrenergic receptor 0113
arylsulfatase A1001
Bile salt export pump0202
Albumin0112
Beta-2 adrenergic receptor0213
5-hydroxytryptamine receptor 1A0101
Beta-2 adrenergic receptor0203
Beta-1 adrenergic receptor0214
Alpha-2C adrenergic receptor0124
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0214
Alpha-2B adrenergic receptor0011
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-2C adrenergic receptor0011
Alpha-2A adrenergic receptor0011
Alpha-1D adrenergic receptor0112
Alpha-1D adrenergic receptor0012
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0124
Alpha-1B adrenergic receptor0012
Vasopressin V1a receptor0112
5-hydroxytryptamine receptor 70101
Cytochrome P450 2J20101
Beta-2 adrenergic receptor0101
Sodium/bile acid cotransporter0101
Beta-2 adrenergic receptor0113
Nuclear receptor subfamily 2 group E member 10022
Chain A, 2-oxoglutarate Oxygenase1001
chaperonin-containing TCP-1 beta subunit homolog1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
histone acetyltransferase KAT2A isoform 11001
Estrogen receptor beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20103
Carbonic anhydrase 120102
5'-AMP-activated protein kinase subunit beta-20001
Carbonic anhydrase 10203
Carbonic anhydrase 20203
Polymerase acidic protein0011
Carbonic anhydrase 30102
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40102
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60102
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0102
Carbonic anhydrase 70102
Xanthine dehydrogenase/oxidase0101
Carbonic anhydrase 90102
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150102
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
Carbonic anhydrase 140102
Carbonic anhydrase 5B, mitochondrial0102
5'-AMP-activated protein kinase subunit beta-10001
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Eukaryotic translation initiation factor 4E0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Alpha-synuclein1001
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Peptidyl-prolyl cis-trans isomerase FKBP50101
Programmed cell death protein 40011
Serine/threonine-protein kinase mTOR 0101
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Plasma kallikrein0001
Adenosine receptor A10001
Adenosine receptor A2a0001
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
SLC16A10 protein0001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0001
Tubulin--tyrosine ligase0101
Glutamate receptor ionotropic, NMDA 3B0001
Monocarboxylate transporter 100001
Taste receptor type 2 member 140001
Glutamate receptor ionotropic, NMDA 3A0001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]