Page last updated: 2024-09-28

Cardiac Output, High

A state of elevated cardiac output due to conditions of either increased hemodynamic demand or reduced cardiac oxygen output. These conditions may include ANEMIA; ARTERIOVENOUS FISTULA; THYROTOXICOSIS; PREGNANCY; EXERCISE; FEVER; and HYPOXIA. In time, compensatory changes of the heart can lead to pathological form of high cardiac output and eventual HEART FAILURE.

Synonyms(2)

Synonym
Cardiac Output, High
High Cardiac Output

Research Excerpts

Treatment

ExcerptReference
"Early treatment of high cardiac output with atenolol decreases the risk for preeclampsia."( Brateng, DA; Carr, DB; Easterling, TR; Karumanchi, SA; Kawamura, C; Shofer, JB; Tran, LT, 2009)

Research

Studies (42)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's13 (30.95)12.5806
2000's20 (47.62)18.1394
2010's9 (21.43)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
lactic acid0low10
nitrates0low10
thiamine0low30
atenolol0medium21
furosemide0low10
isoflurane0low10
losartan0low10
propofol0low10
sevoflurane0low10
prednisolone0low10
aldosterone0low10
phenylephrine0low20
methylene blue0low20
methacholine chloride0medium11
arginine0medium21
platinum0medium11
calcium oxalate0low10
ng-nitroarginine methyl ester0low30
captopril0low20
simvastatin0low10
quinapril0low10
simendan0low10
fibrinogen0low10
omega-n-methylarginine0medium21
angiotensin ii0low20
lithium chloride0low30
digoxin0low10
alprostadil0low10
pituitrin0low20
atrial natriuretic factor0low20
endothelin-10medium11
natriuretic peptide, brain0low10
technetium tc 99m sulfur colloid0low10
adrenomedullin0low10
cyclic gmp0low10

Protein Targets (474)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
AR protein110011
glucocorticoid receptor [Homo sapiens]7007
thyroid hormone receptor beta isoform a3003
nuclear factor erythroid 2-related factor 2 isoform 26006
geminin7007
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0202
Mineralocorticoid receptor 0336
Androgen receptor0202
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10001
Guanine nucleotide-binding protein G2002
TDP1 protein7007
estrogen nuclear receptor alpha110011
peroxisome proliferator activated receptor gamma5005
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40709
Bile salt export pump010010
Cellular tumor antigen p537007
Thromboxane-A synthase 0101
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP1 subtype0101
Prostacyclin receptor0112
Nuclear receptor subfamily 4 group A member 20022
Solute carrier organic anion transporter family member 2A10102
Nuclear receptor subfamily 4 group A member 20011
Nuclear receptor subfamily 4 group A member 20011
Prostaglandin E2 receptor EP2 subtype0112
Canalicular multispecific organic anion transporter 10606
Solute carrier organic anion transporter family member 2A10001
Solute carrier organic anion transporter family member 2B10101
Solute carrier organic anion transporter family member 3A10001
glucocerebrosidase1001
DNA polymerase kappa isoform 11001
histone acetyltransferase KAT2A isoform 13003
Atrial natriuretic peptide receptor 30202
Type-1A angiotensin II receptor 0426
Type-1 angiotensin II receptor0011
Type-1B angiotensin II receptor0404
Type-1 angiotensin II receptor0439
Type-2 angiotensin II receptor0404
Type-2 angiotensin II receptor0303
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
thioredoxin reductase5005
phosphopantetheinyl transferase3003
NFKB1 protein, partial2002
GLS protein3003
thyroid stimulating hormone receptor4004
alpha-galactosidase2002
euchromatic histone-lysine N-methyltransferase 28008
cytochrome P450 2C19 precursor2002
chromobox protein homolog 12002
flap endonuclease 14004
DNA polymerase iota isoform a (long)5005
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)3003
Cytochrome P450 3A40102
Nitric oxide synthase, endothelial0204
Nitric oxide synthase, brain0304
Nitric oxide synthase, brain 0203
Nitric oxide synthase, inducible0203
Nitric oxide synthase, inducible0316
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase6006
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
regulator of G-protein signaling 43003
Beta-1 adrenergic receptor 0011
D(1A) dopamine receptor4004
lamin isoform A-delta104004
Gamma-aminobutyric acid receptor subunit pi3126
Fatty acid-binding protein, liver0202
Urease0101
Beta-2 adrenergic receptor0224
Beta-1 adrenergic receptor0224
Beta-3 adrenergic receptor0022
Gamma-aminobutyric acid receptor subunit beta-13126
Gamma-aminobutyric acid receptor subunit delta3126
Gamma-aminobutyric acid receptor subunit gamma-23126
5-hydroxytryptamine receptor 1A0213
Gamma-aminobutyric acid receptor subunit alpha-53126
Gamma-aminobutyric acid receptor subunit alpha-33126
Gamma-aminobutyric acid receptor subunit gamma-13126
Gamma-aminobutyric acid receptor subunit alpha-23126
Alpha-1D adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit alpha-43126
Gamma-aminobutyric acid receptor subunit gamma-33126
Gamma-aminobutyric acid receptor subunit alpha-63126
Alpha-1A adrenergic receptor0213
Alpha-1B adrenergic receptor0213
Gamma-aminobutyric acid receptor subunit alpha-13126
Gamma-aminobutyric acid receptor subunit beta-33126
Gamma-aminobutyric acid receptor subunit beta-23126
TAR DNA-binding protein 434004
Beta-2 adrenergic receptor0011
GABA theta subunit3126
Gamma-aminobutyric acid receptor subunit epsilon3126
Atrial natriuretic peptide receptor 10112
Atrial natriuretic peptide receptor 1 0011
GLI family zinc finger 38008
progesterone receptor5005
retinoic acid nuclear receptor alpha variant 19009
estrogen-related nuclear receptor alpha7007
Histone H2A.x4004
Voltage-dependent calcium channel gamma-2 subunit4004
Glutamate receptor 24004
Chain A, angiotensin converting enzyme0101
Chain A, angiotensin converting enzyme0101
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase3003
15-lipoxygenase, partial1001
Microtubule-associated protein tau3003
Thrombopoietin1001
thioredoxin glutathione reductase3003
cytochrome P450 family 3 subfamily A polypeptide 4110011
Metallo-beta-lactamase type 20112
peripheral myelin protein 22 isoform 11001
M-phase phosphoprotein 81001
transient receptor potential cation channel subfamily V member 11001
Prothrombin0101
Renin0101
Neprilysin0101
Neprilysin0202
Leukotriene A-4 hydrolase0213
EEF1AKMT4-ECE2 readthrough transcript protein0101
Angiotensin-converting enzyme 0415
Angiotensin-converting enzyme0304
Leukotriene A-4 hydrolase0101
Thymidine phosphorylase0011
Prostaglandin G/H synthase 10303
Prostaglandin G/H synthase 20404
Endothelin-converting enzyme 10101
Succinyl-diaminopimelate desuccinylase0202
Angiotensin-converting enzyme0202
Solute carrier family 15 member 10101
Beta-lactamase TEM0101
Mu-type opioid receptor0011
Beta-lactamase 0203
Beta-lactamase 0202
Angiotensin-converting enzyme 2 0202
Beta-lactamase class B VIM-2 0112
Phosphodiesterase 0101
Multidrug resistance-associated protein 50001
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0202
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0202
Chain A, Beta-lactamase2002
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Cruzipain2002
interleukin 81001
PAX80001
RAR-related orphan receptor gamma8008
SMAD family member 23003
ATAD5 protein, partial2002
PPM1D protein2002
SMAD family member 33003
STAT3, partial0101
Smad33003
estrogen receptor 2 (ER beta)5005
nuclear receptor subfamily 1, group I, member 33003
retinoid X nuclear receptor alpha4004
farnesoid X nuclear receptor5005
pregnane X nuclear receptor4004
67.9K protein1001
peroxisome proliferator-activated receptor delta3003
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
IDH13003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
thyroid stimulating hormone receptor4004
activating transcription factor 63003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
v-jun sarcoma virus 17 oncogene homolog (avian)7007
NPC intracellular cholesterol transporter 1 precursor1001
cellular tumor antigen p53 isoform a2002
tumor necrosis factor1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
thyroid hormone receptor beta isoform 25005
ras-related protein Rab-9A2002
nuclear factor erythroid 2-related factor 2 isoform 14004
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
nuclear receptor ROR-gamma isoform 11001
Solute carrier organic anion transporter family member 1A40102
Interferon beta6006
Sodium/potassium-transporting ATPase subunit alpha-1 0202
Sodium/potassium-transporting ATPase subunit beta-10202
Integrin beta-32002
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
ATP-dependent translocase ABCB10101
Sodium/potassium-transporting ATPase subunit beta-1 0101
ATP-dependent translocase ABCB10204
Integrin alpha-IIb2002
Replicase polyprotein 1ab0101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
ATP-dependent translocase ABCB10101
Sodium/potassium-transporting ATPase subunit alpha-20202
Sodium/potassium-transporting ATPase subunit alpha-10101
Nuclear receptor ROR-gamma1113
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4C10001
ATPase family AAA domain-containing protein 54004
Ataxin-24004
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1B30303
Solute carrier organic anion transporter family member 1B10404
Endothelin-1 receptor0101
aldehyde dehydrogenase 1 family, member A13003
EWS/FLI fusion protein4004
aryl hydrocarbon receptor3003
thyrotropin-releasing hormone receptor2002
Solute carrier family 22 member 60202
Carbonic anhydrase 120203
Bile salt export pump0202
Carbonic anhydrase 10607
Carbonic anhydrase 20607
Albumin0202
Carbonic anhydrase 30202
Glucose-6-phosphate 1-dehydrogenase0101
Cytochrome P450 2C9 0303
Carbonic anhydrase 40304
Carbonic anhydrase 60304
Serum paraoxonase/arylesterase 10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase 5A, mitochondrial0203
Carbonic anhydrase 70203
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Cytochrome P450 2J20202
6-phosphogluconate dehydrogenase, decarboxylating0101
Spike glycoprotein5005
Holo-[acyl-carrier-protein] synthase0101
Sodium/bile acid cotransporter0101
Carbonic anhydrase 90203
Multidrug and toxin extrusion protein 10202
Carbonic anhydrase 130203
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Carbonic anhydrase 140203
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Carbonic anhydrase 5B, mitochondrial0203
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit alpha-70101
acetylcholinesterase2002
cytochrome P450 2D64004
arylsulfatase A2002
potassium voltage-gated channel subfamily H member 2 isoform d1001
cytochrome P450 3A4 isoform 13003
inositol monophosphatase 11001
Cholecystokinin receptor type A1001
Gastrin/cholecystokinin type B receptor1001
Glycogen synthase kinase-3 beta0112
G4004
HLA class I histocompatibility antigen, B alpha chain 4004
Thromboxane A2 receptor 0102
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Adenosine receptor A2a0101
Type-1 angiotensin II receptor0112
Squalene synthase0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Inositol hexakisphosphate kinase 14004
Platelet glycoprotein VI0113
Type-1 angiotensin II receptor0112
cytochrome P450 2C9, partial4004
glp-1 receptor, partial3003
GALC protein1001
Bloom syndrome protein isoform 13003
galanin receptor type 30101
survival motor neuron protein isoform d3003
Chain E, Fibrin beta chain0101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, Ferritin light chain3003
Luciferase2002
T cell receptor, partial1001
luteinizing hormone receptor1001
integrase, partial0101
chaperonin-containing TCP-1 beta subunit homolog2002
lens epithelium-derived growth factor p750101
hypoxia-inducible factor 1 alpha subunit3003
Caspase 6, apoptosis-related cysteine peptidase0001
Fumarate hydratase1001
TSHR protein1001
Apoptotic peptidase activating factor 10101
caspase 7, apoptosis-related cysteine protease2002
hypothetical protein, conserved1001
isocitrate dehydrogenase 1, partial1001
polyprotein1001
luciferase1001
bromodomain adjacent to zinc finger domain 2B2002
caspase-32002
serine-protein kinase ATM isoform a1001
neutrophil cytosol factor 10101
caspase-9 isoform alpha precursor0101
histone deacetylase 9 isoform 31001
heat shock protein beta-13003
huntingtin isoform 21001
pyruvate kinase PKM isoform a1001
DNA polymerase beta1001
mitogen-activated protein kinase 11001
caspase-3 isoform a preproprotein0101
protein AF-9 isoform a0001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Vpr1001
muscleblind-like protein 1 isoform 11001
replicative DNA helicase0001
recombinase A0011
POsterior Segregation0011
DNA repair protein RAD52 homolog isoform a0001
neuropeptide S receptor isoform A1001
Glutathione reductase0101
Glutathione reductase, mitochondrial0102
Glycoprotein hormones alpha chain1001
Albumin0001
Amyloid-beta precursor protein0101
Dihydrolipoyl dehydrogenase, mitochondrial0102
Microtubule-associated protein tau0112
Alpha-1B adrenergic receptor0202
Amine oxidase [flavin-containing] A0101
Alpha-1D adrenergic receptor0202
Sodium-dependent noradrenaline transporter 0213
Cruzipain0101
Alpha-synuclein1001
Alpha-1A adrenergic receptor0202
Inositol monophosphatase 11001
Thioredoxin reductase 1, cytoplasmic0102
Dihydrolipoyl dehydrogenase 0102
Zinc finger protein mex-50011
phosphoglycerate kinase1001
Neutrophil elastase0202
Nitric oxide synthase, endothelial0303
Collagenase 30202
Carbonic anhydrase0101
Sodium/iodide cotransporter0101
Carbonic anhydrase 150202
vitamin D3 receptor isoform VDRA2002
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10001
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10102
Proteinase-activated receptor 10101
Nitric oxide synthase, brain0101
dopamine D1 receptor1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
Alpha-1B adrenergic receptor 0011
Alpha-2A adrenergic receptor0112
POU domain, class 2, transcription factor 10001
Alpha-2B adrenergic receptor0101
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0112
Alpha-2C adrenergic receptor0112
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-2B adrenergic receptor0001
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
luciferase0001
nuclear receptor subfamily 1, group I, member 22002
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Androgen receptor0202
Glutamine synthetase0011
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
USP1 protein, partial1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90001
5-hydroxytryptamine receptor 40202
Aldo-keto reductase family 1 member B10202
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Sodium- and chloride-dependent GABA transporter 10101
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit alpha-50011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30011
5-hydroxytryptamine receptor 2B0202
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20011
Sodium- and chloride-dependent betaine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-40011
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-60011
UDP-glucuronosyltransferase 1A80001
Liver carboxylesterase 10001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20102
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
PINK11001
Parkin1001
photoreceptor-specific nuclear receptor0101
serine/threonine-protein kinase PLK11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0202
Insulin receptor 0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Sigma non-opioid intracellular receptor 10101
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Solute carrier family 22 member 1 0102
Transketolase0011
Thiamine-binding periplasmic protein0011
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]