A sudden CARDIAC ARRHYTHMIA (e.g., VENTRICULAR FIBRILLATION) caused by a blunt, non-penetrating impact to the precordial region of chest wall. Commotio cordis often results in sudden death without prompt cardiopulmonary defibrillation.
| Synonym |
|---|
| Cardiac Concussion |
| Commotio Cordis |
| Excerpt | Reference |
|---|---|
| "Commotio cordis is potentialized by a lethal set of three including, a certain impact velocity, an exact location of the hit over the cardiac silhouette, and a precise timing 15 m/s prior to the peak of the T-wave." | ( Contargyris, C; Peytel, E, 2012) |
| Timeframe | Studies, This Condition (%) | All Conditions % |
|---|---|---|
| pre-1990 | 0 (0.00) | 23.3326 |
| 1990's | 0 (0.00) | 12.5806 |
| 2000's | 0 (0.00) | 18.1394 |
| 2010's | 2 (100.00) | 28.8240 |
| 2020's | 0 (0.00) | 9.53 |
| Drug | Indicated | Relationship Strength | Studies | Trials |
|---|---|---|---|---|
| blister | 0 | low | 1 | 0 |
| Protein | Potency Measurements | Inhibition Measurements | Activation Measurements | Drugs |
|---|---|---|---|---|
| TDP1 protein | 1 | 0 | 0 | 1 |
| Microtubule-associated protein tau | 1 | 0 | 0 | 1 |
| regulator of G-protein signaling 4 | 1 | 0 | 0 | 1 |
| Myosin-2 heavy chain, non muscle | 0 | 1 | 0 | 1 |
| Myosin-2 heavy chain | 0 | 1 | 0 | 1 |
| Myosin IC heavy chain | 0 | 1 | 0 | 1 |
| Cytochrome P450 2C19 | 0 | 1 | 0 | 1 |
| Myosin-9 | 0 | 1 | 0 | 1 |
| Myosin-10 | 0 | 1 | 0 | 1 |
| Unconventional myosin-X | 0 | 1 | 0 | 1 |
| Myosin-7 | 0 | 1 | 0 | 1 |
| Unconventional myosin-Ib | 0 | 1 | 0 | 1 |
| Myosin-4 | 0 | 1 | 0 | 1 |
| Myosin-14 | 0 | 1 | 0 | 1 |
| Nonmuscle myosin heavy chain | 0 | 1 | 0 | 1 |
| Unconventional myosin-Va | 0 | 1 | 0 | 1 |
| Myosin heavy chain, non-muscle | 0 | 1 | 0 | 1 |
| Unconventional myosin-XV | 0 | 1 | 0 | 1 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | ||||