Breast Cancer Lymphedema

Abnormal accumulation of lymph in the arm, shoulder and breast area associated with surgical treatment (e.g., MASTECTOMY) or radiation treatment of breast cancer.

Synonym
Breast Cancer Related Lymphedema
Breast Cancer Lymphedema
Postmastectomy Lymphedema
Post-mastectomy Lymphedema
Breast Cancer Treatment-Related Lymphedema
Breast Cancer-Related Arm Lymphedema

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	8 (28.57)	28.8240
2020's	20 (71.43)	9.53

Drug	Relationship Strength	Studies	Trials
letrozole	low	1	0
penicillin g	low	1	0
c.i. 42510	low	1	0
fluorescein-5-isothiocyanate	low	1	0
technetium	low	1	0
technetium 99m	low	1	0
iso-sulfan blue	low	1	0
docetaxel anhydrous	low	1	0
arbutin	medium	1	1
clindamycin	low	1	0
tamoxifen	low	2	0
diosmin	medium	1	1
indocyanine green	medium	14	2
warfarin	medium	1	1
technetium tc 99m sulfur colloid	low	1	0

Protein Targets (330)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
GLI family zinc finger 3	7	0	0	7
AR protein	7	0	0	7
Smad3	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
estrogen nuclear receptor alpha	7	0	0	7
IDH1	2	0	0	2
Polyphenol oxidase 2	0	1	0	2
Tyrosinase	0	1	0	1
Tyrosinase	0	1	0	1
Polyphenol oxidase 1	0	1	0	1
Taste receptor type 2 member 16	0	0	1	2
TDP1 protein	3	0	0	3
progesterone receptor	4	0	0	4
glucocorticoid receptor [Homo sapiens]	4	0	0	4
retinoid X nuclear receptor alpha	3	0	0	3
estrogen-related nuclear receptor alpha	7	0	0	7
peroxisome proliferator activated receptor gamma	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
thyroid hormone receptor beta isoform 2	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	4	0	0	4
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Cellular tumor antigen p53	5	0	0	5
Glutamate receptor 2	3	0	0	3
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
Protein-arginine deiminase type-4	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain A, Beta-lactamase	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Luciferase	2	0	0	2
acetylcholinesterase	2	0	0	2
ATAD5 protein, partial	1	0	0	1
USP1 protein, partial	3	0	0	3
PPM1D protein	4	0	0	4
aryl hydrocarbon receptor	1	0	0	1
Histone H2A.x	4	0	0	4
DNA polymerase beta	1	0	0	1
flap endonuclease 1	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
geminin	2	0	0	2
DNA polymerase kappa isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
Interferon beta	6	0	0	6
Aurora kinase B	0	1	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	4	0	0	4
farnesoid X nuclear receptor	2	0	0	2
pregnane X nuclear receptor	3	0	0	3
67.9K protein	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
caspase-3	2	0	0	2
thyroid stimulating hormone receptor	3	0	0	3
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	2	0	2
Bile salt export pump	0	5	0	5
Serum paraoxonase/arylesterase 1	0	1	0	1
Kinesin-like protein KIF11	0	1	0	1
Spike glycoprotein	1	0	1	2
Canalicular multispecific organic anion transporter 1	0	2	0	2
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
peroxisome proliferator-activated receptor delta	3	0	0	3
activating transcription factor 6	2	0	0	2
thyrotropin-releasing hormone receptor	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
heat shock protein beta-1	2	0	0	2
RAR-related orphan receptor gamma	3	0	0	3
Fumarate hydratase	2	0	0	2
G	2	0	0	2
cytochrome P450 2D6	1	0	0	1
polyprotein	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Inositol hexakisphosphate kinase 1	2	0	0	2
cytochrome P450 2C9, partial	2	0	0	2
thyroid stimulating hormone receptor	1	0	0	1
EWS/FLI fusion protein	2	0	0	2
cytochrome P450 2C19 precursor	1	0	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
core-binding factor subunit beta isoform 2	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Carbonic anhydrase 2	0	1	0	1
Estrogen receptor	0	3	1	5
Steryl-sulfatase	0	1	0	1
Aromatase	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
GABA theta subunit	2	0	0	2
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	2	2
Solute carrier family 22 member 6	0	1	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	2
Guanine nucleotide-binding protein G	1	0	0	1
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase VIM-1	0	0	0	1
Chain A, CES1 protein	0	1	0	1
Chain A, Ferritin light chain	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
Microtubule-associated protein tau	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
DNA polymerase III, partial	1	0	0	1
estrogen receptor 2 (ER beta)	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
glucocerebrosidase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
arylsulfatase A	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
Caspase-7	1	0	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
cytochrome P450 2D6 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
interferon gamma precursor	0	0	0	1
D(1A) dopamine receptor	1	0	0	1
chromobox protein homolog 1	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
caspase-3	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
lethal factor (plasmid)	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Transmembrane protease serine 2	0	0	1	1
5-hydroxytryptamine receptor 4	0	2	0	2
Serine/threonine-protein kinase D3	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Integrin beta-3	1	0	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor	0	0	1	2
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Progesterone receptor	0	1	0	1
Procathepsin L	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
ATP-dependent translocase ABCB1	0	2	1	3
Integrin alpha-IIb	1	0	0	1
Beta-1 adrenergic receptor	0	2	0	2
Cytochrome P450 3A4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Adenosine receptor A3	0	2	0	2
Replicase polyprotein 1ab	0	0	1	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Androgen receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Protein kinase C alpha type	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Cytochrome P450 2B6	0	1	0	1
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Protein kinase C eta type	0	1	0	1
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Adenosine receptor A2a	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Adenosine receptor A1	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Alpha-synuclein	1	0	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Histamine H2 receptor	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Estrogen receptor beta	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	2	0	2
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	1	0	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Albumin	0	0	1	1
Albumin	0	0	1	1
Cytochrome P450 2C9	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(6)

Research

Studies (28)

Protein Targets (330)

Breast Cancer Lymphedema

Synonyms(6)

Research

Studies (28)

Drugs Studied (19)

Protein Targets (330)