Branchial Cleft Cyst

A tumor derived from branchial epithelium or branchial rests. (Dorland, 27th ed)

Synonym
Branchial Cyst
Branchial Cleft Cyst
Branchial Cysts
Branchioma

Excerpt	Reference
"Even though branchial cleft cysts are currently accepted as a congenital anomaly, there is often a long delay until clinical presentation; branchial cleft cysts classically appear in the second to fourth decade of life."	( Anagnostopoulos, I; Doll, C; Heiland, M; Jöhrens, K; Raguse, JD, 2017)

Excerpt	Reference
"Six patients with Baker's cysts, 3 with branchial cleft cysts, and 2 with thyroglossal duct cysts were treated with percutaneous aspiration and absolute ethanol sclerotherapy using a 7-French pigtail catheter."	( Fukumoto, K; Kojima, T; Kontani, K; Murai, S; Tomonari, H; Tsujimoto, F, 1994)
"The data suggest that branchial cleft cyst (BCC) can be primarily treated with OK-432 sclerotherapy and only the remaining lesions with excision."	( Hyun Kim, K; Il Park, C; Roh, JL; Sung, MW, 2006)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	16 (32.65)	23.3326
1990's	10 (20.41)	12.5806
2000's	11 (22.45)	18.1394
2010's	10 (20.41)	28.8240
2020's	2 (4.08)	9.53

Drug	Relationship Strength	Studies	Trials
salicylic acid	low	1	0
iodine	low	2	0
phenol	low	1	0
fluorouracil	low	1	0
lidocaine	low	1	0
thalidomide	low	1	0
methylene blue	low	2	0
trichloroacetic acid	low	2	0
diatrizoate meglumine	low	1	0
gadolinium	low	1	0
barium sulfate	low	4	0
chlormerodrin	low	1	0
trolamine salicylate	low	1	0
propiconazole	low	1	0
fluorodeoxyglucose f18	low	1	0
carboplatin	low	1	0
inositol 3-phosphate	low	4	0
clindamycin	low	1	0
bromochloroacetic acid	low	4	0
picibanil	medium	8	1
mezlocillin	low	1	0
phenylephrine hydrochloride	low	1	0
barium	low	1	0
phosphorus	low	1	0
sodium tetradecyl sulfate	low	1	0
eye	low	1	0

Protein Targets (316)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	11	0	0	11
AR protein	11	0	0	11
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
thyroid stimulating hormone receptor	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
Cellular tumor antigen p53	6	0	0	6
Nuclear receptor ROR-gamma	1	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
acetylcholinesterase	5	0	0	5
phosphopantetheinyl transferase	3	0	0	3
estrogen receptor 2 (ER beta)	5	0	0	5
G	2	0	0	2
cytochrome P450 2D6	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	7	0	0	7
vitamin D3 receptor isoform VDRA	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
DNA polymerase kappa isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Inositol hexakisphosphate kinase 1	2	0	0	2
cytochrome P450 2C9, partial	2	0	0	2
ATP-dependent phosphofructokinase	3	0	0	3
Protein-arginine deiminase type-4	0	1	0	1
thioredoxin reductase	5	0	0	5
Hsf1 protein	0	0	1	1
chromobox protein homolog 1	6	0	0	6
geminin	7	0	0	7
survival motor neuron protein isoform d	4	0	0	4
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Luciferase	4	0	0	4
interleukin 8	1	0	0	1
endonuclease IV	1	0	0	1
glp-1 receptor, partial	5	0	0	5
Skn7p	0	0	0	1
pregnane X receptor	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
ATAD5 protein, partial	2	0	0	2
TDP1 protein	6	0	0	6
GLI family zinc finger 3	6	0	0	6
Microtubule-associated protein tau	3	0	0	3
Thrombopoietin	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
progesterone receptor	4	0	0	4
EWS/FLI fusion protein	2	0	0	2
nonstructural protein 1	2	0	0	2
glucocorticoid receptor [Homo sapiens]	5	0	0	5
retinoid X nuclear receptor alpha	10	0	0	10
estrogen-related nuclear receptor alpha	6	0	0	6
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	5	0	0	5
estrogen nuclear receptor alpha	11	0	0	11
67.9K protein	1	0	0	1
peroxisome proliferator-activated receptor delta	5	0	0	5
peroxisome proliferator activated receptor gamma	6	0	0	6
arylsulfatase A	2	0	0	2
IDH1	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Histone H2A.x	2	0	0	2
peripheral myelin protein 22 isoform 1	1	0	0	1
hemoglobin subunit beta	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
thyroid hormone receptor beta isoform 2	6	0	0	6
huntingtin isoform 2	2	0	0	2
flap endonuclease 1	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Vpr	3	0	0	3
peripheral myelin protein 22	2	0	0	2
muscleblind-like protein 1 isoform 1	2	0	0	2
lamin isoform A-delta10	3	0	0	3
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Solute carrier family 22 member 8	0	0	0	1
Bile salt export pump	0	4	0	4
Epidermal growth factor receptor	0	1	0	1
Amyloid-beta precursor protein	1	1	0	2
Thymidylate synthase	0	1	0	1
Aromatase	0	1	0	1
Glutamate receptor 2	4	0	0	4
Canalicular multispecific organic anion transporter 1	0	2	0	2
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
aryl hydrocarbon receptor	3	0	0	3
activating transcription factor 6	2	0	0	2
histone deacetylase 9 isoform 3	2	0	0	2
Chain A, Beta-lactamase	2	0	0	2
GLS protein	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
mitogen-activated protein kinase 1	2	0	0	2
cytochrome P450 3A4 isoform 1	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
GABA theta subunit	1	0	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Ferritin light chain	2	0	0	2
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
SMAD family member 2	2	0	0	2
Fumarate hydratase	1	0	0	1
PPM1D protein	1	0	0	1
SMAD family member 3	2	0	0	2
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
Smad3	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
hypothetical protein, conserved	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
polyprotein	1	0	0	1
luciferase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
caspase-3	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
serine-protein kinase ATM isoform a	1	0	0	1
Bloom syndrome protein isoform 1	3	0	0	3
neutrophil cytosol factor 1	0	1	0	1
thyroid hormone receptor beta isoform a	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
caspase-9 isoform alpha precursor	0	1	0	1
heat shock protein beta-1	2	0	0	2
pyruvate kinase PKM isoform a	1	0	0	1
DNA polymerase beta	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Albumin	0	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Sodium-dependent noradrenaline transporter	0	0	1	1
Cruzipain	0	1	0	1
Alpha-synuclein	1	0	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Spike glycoprotein	4	0	0	4
Guanine nucleotide-binding protein G	2	0	0	2
Inositol monophosphatase 1	1	0	0	1
TAR DNA-binding protein 43	2	0	0	2
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
Beta-lactamase OXA-7	0	0	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
alpha-galactosidase	1	0	0	1
Polyphenol oxidase 2	0	1	0	3
Carbonic anhydrase 12	0	2	0	2
Endolysin	0	0	1	1
Carbonic anhydrase 1	0	4	0	4
Carbonic anhydrase 2	0	4	0	4
Carbonic anhydrase 3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Cannabinoid receptor 1	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 6	0	3	0	3
Adenosine receptor A1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Carbonic anhydrase 7	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 9	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase 13	0	2	0	2
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
GALC protein	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Cytochrome P450 3A4	0	1	0	1
Histamine H2 receptor	1	0	0	1
heat shock protein 90, putative	0	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Bile salt export pump	0	1	0	1
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Cereblon isoform 4	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
cellular tumor antigen p53 isoform a	1	0	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Treatment

Research

Studies (49)

Protein Targets (316)

Branchial Cleft Cyst

Synonyms(4)

Research Excerpts

Overview

Treatment

Research

Studies (49)

Drugs Studied (32)

Protein Targets (316)