Page last updated: 2024-09-27

Borderline Lepromatous

A form of LEPROSY classified by the World Health Organization for the purpose of treatment, based on clinical manifestations and skin smear results. Patients with multibacillary leprosy have six or more lesions with or without positive skin smear results for the causative agent MYCOBACTERIUM LEPRAE. Multibacillary leprosy encompasses borderline lepromatous, midborderline, and lepromatous leprosy.

Synonyms(4)

Synonym
Borderline Lepromatous
Midborderline Lepromatous
Leprosy, Multibacillary
Multibacillary Leprosy

Research

Studies (63)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's1 (1.59)18.1394
2010's49 (77.78)28.8240
2020's13 (20.63)9.53
DrugIndicatedRelationship StrengthStudiesTrials
clofazimine0medium165
dapsone0medium174
isoniazid0low10
ofloxacin0medium41
thalidomide0low120
prednisolone0medium51
prednisone0low30
itraconazole0low10
methotrexate0medium11
apremilast0low40
glycolipids0low70
interleukin-80low10
minocycline0low30
lymecycline0low10
transforming growth factor beta0low30
technetium tc 99m medronate0low10
rifampin0medium195

Protein Targets (362)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Cytochrome P450 1A20404
Cytochrome P450 3A40404
Cytochrome P450 2D60202
Cytochrome P450 2C9 0505
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Cytochrome P450 2C190303
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Carboxylic ester hydrolase 0101
GLI family zinc finger 38008
cytochrome P450 family 3 subfamily A polypeptide 48008
estrogen-related nuclear receptor alpha7007
estrogen nuclear receptor alpha130013
thyroid hormone receptor beta isoform 28008
importin subunit beta-1 isoform 14004
mitogen-activated protein kinase 13003
snurportin-14004
GTP-binding nuclear protein Ran isoform 13003
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
geminin7007
streptokinase A precursor0033
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40809
Bile salt export pump011011
ATP-dependent translocase ABCB10202
Potassium voltage-gated channel subfamily H member 20202
Canalicular multispecific organic anion transporter 10808
Solute carrier organic anion transporter family member 1B30305
Solute carrier organic anion transporter family member 1B10304
Chain A, JmjC domain-containing histone demethylation protein 3A1001
phosphopantetheinyl transferase3003
USP1 protein, partial3003
TDP1 protein9009
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
glucocorticoid receptor [Homo sapiens]6006
G4004
cytochrome P450 2D63003
67.9K protein4004
euchromatic histone-lysine N-methyltransferase 26006
cytochrome P450 2D6 isoform 13003
vitamin D3 receptor isoform VDRA3003
chromobox protein homolog 12002
potassium voltage-gated channel subfamily H member 2 isoform d2002
transcriptional regulator ERG isoform 32002
mitogen-activated protein kinase kinase kinase kinase 2 isoform 10011
eyes absent homolog 2 isoform a1001
peripheral myelin protein 223003
lamin isoform A-delta103003
mitogen-activated protein kinase kinase kinase 3 isoform 10011
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 4004
Estrogen receptor0011
Spike glycoprotein0011
5-hydroxytryptamine receptor 1A0011
Cruzipain0101
Spike glycoprotein3003
C-terminal-binding protein 11001
Estrogen receptor beta0011
Inositol hexakisphosphate kinase 14004
Broad substrate specificity ATP-binding cassette transporter ABCG20203
cytochrome P450 2C9, partial4004
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase 0101
interleukin 82002
AR protein8008
Smad31001
thyroid stimulating hormone receptor2002
retinoid X nuclear receptor alpha6006
bromodomain adjacent to zinc finger domain 2B2002
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma4004
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
cytochrome P450 2C9 precursor1001
cytochrome P450 3A4 isoform 13003
muscleblind-like protein 1 isoform 12002
Gamma-aminobutyric acid receptor subunit pi3104
Bile salt export pump0606
Myeloperoxidase0202
Gamma-aminobutyric acid receptor subunit beta-13104
Dihydrofolate reductase0303
Gamma-aminobutyric acid receptor subunit delta3104
Gamma-aminobutyric acid receptor subunit gamma-23104
Gamma-aminobutyric acid receptor subunit alpha-53104
Gamma-aminobutyric acid receptor subunit alpha-33104
Gamma-aminobutyric acid receptor subunit gamma-13104
Gamma-aminobutyric acid receptor subunit alpha-23104
Gamma-aminobutyric acid receptor subunit alpha-43104
Gamma-aminobutyric acid receptor subunit gamma-33104
Gamma-aminobutyric acid receptor subunit alpha-63104
Histamine H2 receptor2002
5-hydroxytryptamine receptor 60101
Nuclear receptor ROR-gamma2002
Gamma-aminobutyric acid receptor subunit alpha-13104
Gamma-aminobutyric acid receptor subunit beta-33104
Gamma-aminobutyric acid receptor subunit beta-23104
GABA theta subunit3104
Gamma-aminobutyric acid receptor subunit epsilon3104
Chain A, 2-oxoglutarate Oxygenase5005
Luciferase1001
RAR-related orphan receptor gamma5005
GLS protein2002
nuclear receptor subfamily 1, group I, member 35005
EWS/FLI fusion protein7007
retinoic acid nuclear receptor alpha variant 15005
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
aryl hydrocarbon receptor3003
nuclear factor erythroid 2-related factor 2 isoform 15005
nuclear receptor ROR-gamma isoform 12002
histone acetyltransferase KAT2A isoform 15005
N-glycosylase/DNA lyase0101
Polyphenol oxidase 20203
Formamidopyrimidine-DNA glycosylase0101
DNA gyrase subunit A0203
DNA gyrase subunit B0203
Cytochrome P450 2C80101
Cytochrome P450 2A60101
Macrophage migration inhibitory factor0101
Endonuclease III-like protein 10101
DNA gyrase subunit B0304
DNA gyrase subunit A0304
Enoyl-[acyl-carrier-protein] reductase [NADH]0203
Pantothenate synthetase0101
Isocitrate lyase0101
Putative FAD-containing monooxygenase MymA0101
Dihydrofolate reductase0202
Endonuclease 8-like 10101
hypoxia-inducible factor 1 alpha subunit2002
Fumarate hydratase1001
GALC protein2002
estrogen receptor 2 (ER beta)3003
farnesoid X nuclear receptor3003
pregnane X nuclear receptor5005
polyprotein1001
activating transcription factor 61001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
heat shock protein beta-11001
Voltage-dependent calcium channel gamma-2 subunit3003
Cellular tumor antigen p536006
Glutamate receptor 23003
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
glp-1 receptor, partial1001
aldehyde dehydrogenase 1 family, member A18008
cytochrome P450 2C19 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
survival motor neuron protein isoform d3003
Cytochrome P450 1A10202
Cytochrome P450 1B10101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, Ferritin light chain2002
acid sphingomyelinase1001
dopamine D1 receptor1001
thioredoxin reductase3003
ClpP1001
15-lipoxygenase, partial2002
ATAD5 protein, partial1001
Microtubule-associated protein tau2002
progesterone receptor4004
Thymidylate synthase 0101
alpha-galactosidase1001
IDH11001
Thymidylate synthase 0101
Histone H2A.x1001
Bloom syndrome protein isoform 12002
cellular tumor antigen p53 isoform a1001
polyunsaturated fatty acid lipoxygenase ALOX121001
nuclear factor erythroid 2-related factor 2 isoform 24004
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
flap endonuclease 12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)1001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA polymerase kappa isoform 11001
M-phase phosphoprotein 81001
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20213
Thymidylate synthase0202
Integrin beta-31001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10022
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30001
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 431001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60102
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200202
Dihydrofolate reductase 0101
Solute carrier family 22 member 80102
Solute carrier family 22 member 60202
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40303
ATP-dependent phosphofructokinase1001
Albumin0145
Stromelysin-10112
Matrilysin0101
Multidrug transporter MdfA0101
Matrix metalloproteinase-90101
Cytochrome P450 2J20202
Protein mono-ADP-ribosyltransferase PARP150101
arylsulfatase A2002
STE240001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
CAAX prenyl protease0001
Trypsin0001
luciferase0001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)2002
nuclear receptor subfamily 1, group I, member 21001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor04211
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Histamine H1 receptor0011
Prostaglandin G/H synthase 20202
Nociceptin receptor0011
Estrogen receptor beta0202
pregnane X receptor1001
thioredoxin glutathione reductase1001
Chain A, Cruzipain1001
DNA-directed RNA polymerase subunit beta0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Solute carrier organic anion transporter family member 1A40101
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 2B1 0202
NH(3)-dependent NAD(+) synthetase0101
60 kDa heat shock protein, mitochondrial0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Cytochrome P450 2B60011
Arylacetamide deacetylase0102
Caspase-10101
Alpha-synuclein0101
Solute carrier organic anion transporter family member 1A10101
Solute carrier organic anion transporter family member 1A20101
10 kDa heat shock protein, mitochondrial0101
Glutathione S-transferase omega-10101
DNA-directed RNA polymerase subunit beta0101
Thiosulfate sulfurtransferase0101
Lanosterol 14-alpha demethylase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Carbonic anhydrase 10202
Polymerase acidic protein0011
Carbonic anhydrase 30101
Tyrosine-protein phosphatase YopH0101
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
Cereblon isoform 40202
thyroid hormone receptor beta isoform a2002
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 20101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
Chain A, Beta-lactamase1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
PPM1D protein1001
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]