Page last updated: 2024-09-27

Body-Weight Trajectory

A general pattern of body weight gain or loss over many years. Weight change trajectory is influenced by several determinants in children and adults.

Synonyms(5)

Synonym
Weight Change Trajectory
Body-Weight Trajectory
Weight Loss Trajectory
Weight Trajectory
Weight Gain Trajectory

Research Excerpts

Research

Studies (18)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's4 (22.22)28.8240
2020's14 (77.78)9.53
DrugIndicatedRelationship StrengthStudiesTrials
dichlorodiphenyl dichloroethylene0low10
ddt0low10
gliclazide0medium11
indapamide0medium11
perphenazine0medium11
risperidone0medium11
thiazoles0medium11
dehydroepiandrosterone sulfate0low10
s,n,n'-tripropylthiocarbamate0low10
manganese0low20
mercury0low20
cadmium0low20
trolamine salicylate0low20
ziprasidone0medium11
capecitabine0medium11
fluorodeoxyglucose f180low10
perindopril0medium11
oxytocin0low10
oxycodone0low10
selenium0low20
pituitrin0low10
quetiapine fumarate0medium11
indapamide, perindopril drug combination0medium11
pyrethrins0low10
exudates0low10
olanzapine0medium11
leptin0low30

Protein Targets (304)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma8008
TDP1 protein7007
estrogen nuclear receptor alpha9009
Liver carboxylesterase 10001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Cruzipain1001
interleukin 81001
pregnane X receptor1001
hypoxia-inducible factor 1 alpha subunit3003
SMAD family member 21001
SMAD family member 31001
GLI family zinc finger 34004
AR protein5005
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
thyroid stimulating hormone receptor4004
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 35005
progesterone receptor4004
cytochrome P450 family 3 subfamily A polypeptide 44004
glucocorticoid receptor [Homo sapiens]3003
retinoic acid nuclear receptor alpha variant 16006
retinoid X nuclear receptor alpha5005
estrogen-related nuclear receptor alpha7007
farnesoid X nuclear receptor4004
pregnane X nuclear receptor5005
G2002
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma2002
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
euchromatic histone-lysine N-methyltransferase 24004
aryl hydrocarbon receptor4004
thyroid stimulating hormone receptor4004
activating transcription factor 64004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Histone H2A.x2002
Caspase-72002
cellular tumor antigen p53 isoform a2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
thyroid hormone receptor beta isoform a2002
potassium voltage-gated channel subfamily H member 2 isoform d5005
caspase-32002
thyroid hormone receptor beta isoform 26006
heat shock protein beta-13003
mitogen-activated protein kinase 14004
nuclear factor NF-kappa-B p105 subunit isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 14004
geminin5005
peripheral myelin protein 222002
lethal factor (plasmid)3003
lamin isoform A-delta103003
Voltage-dependent calcium channel gamma-2 subunit2002
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Cellular tumor antigen p534004
Androgen receptor0202
Glutamate receptor 22002
Nuclear receptor ROR-gamma2002
Inositol hexakisphosphate kinase 12002
cytochrome P450 2C9, partial2002
Multidrug resistance-associated protein 40607
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Steryl-sulfatase0001
Multidrug resistance-associated protein 1 0001
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
G-protein coupled bile acid receptor 10011
ATP-binding cassette sub-family C member 110001
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1B20001
Solute carrier organic anion transporter family member 1B10001
Chain A, Beta-lactamase3003
Chain A, JmjC domain-containing histone demethylation protein 3A4004
Chain A, Ferritin light chain1001
bromodomain adjacent to zinc finger domain 2B4004
serine-protein kinase ATM isoform a1001
chromobox protein homolog 12002
lethal(3)malignant brain tumor-like protein 1 isoform I1001
cytochrome P450 3A4 isoform 12002
Gamma-aminobutyric acid receptor subunit pi2002
Gamma-aminobutyric acid receptor subunit beta-12002
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
GABA theta subunit2002
Gamma-aminobutyric acid receptor subunit epsilon2002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
phosphopantetheinyl transferase2002
Fumarate hydratase2002
GLS protein3003
aldehyde dehydrogenase 1 family, member A12002
EWS/FLI fusion protein4004
polyprotein2002
ATP-binding cassette sub-family C member 30505
Bile salt export pump0101
Bile salt export pump0505
Aldo-keto reductase family 1 member C30101
Aldo-keto reductase family 1 member C2 0101
Inositol monophosphatase 12002
Aldo-keto reductase family 1 member C10101
Canalicular multispecific organic anion transporter 10505
endonuclease IV2002
GALC protein1001
Smad33003
67.9K protein2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
lysosomal alpha-glucosidase preproprotein2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase iota isoform a (long)1001
DNA polymerase kappa isoform 11001
survival motor neuron protein isoform d3003
Carbonic anhydrase 120113
Carbonic anhydrase 10113
Carbonic anhydrase 20113
Carbonic anhydrase 30112
Polyunsaturated fatty acid lipoxygenase ALOX150202
Carbonic anhydrase 40113
Carbonic anhydrase 60113
Carbonic anhydrase 5A, mitochondrial0113
Carbonic anhydrase 70113
Carbonic anhydrase 90113
Carbonic anhydrase 130011
Carbonic anhydrase 130102
Carbonic anhydrase 140113
Carbonic anhydrase 5B, mitochondrial0113
5-hydroxytryptamine receptor 3E0202
vitamin D3 receptor isoform VDRA2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
FAD-linked sulfhydryl oxidase ALR0001
5-hydroxytryptamine receptor 40404
5-hydroxytryptamine receptor 3B0202
Muscarinic acetylcholine receptor M20303
Muscarinic acetylcholine receptor M40404
ATP-dependent translocase ABCB10002
Cytochrome P450 3A40303
5-hydroxytryptamine receptor 1A0336
5-hydroxytryptamine receptor 2C0404
Muscarinic acetylcholine receptor M50404
Alpha-2A adrenergic receptor0505
Muscarinic acetylcholine receptor M10314
Glucose-6-phosphate 1-dehydrogenase0101
Angiotensin-converting enzyme0505
D(2) dopamine receptor0708
5-hydroxytryptamine receptor 2A0505
Alpha-1B adrenergic receptor0303
Alpha-2B adrenergic receptor0505
Alpha-2C adrenergic receptor0505
D0303
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 1A0303
Alpha-2B adrenergic receptor0303
Muscarinic acetylcholine receptor M30505
D(1A) dopamine receptor0505
D(4) dopamine receptor0404
Alpha-2C adrenergic receptor0303
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0303
Alpha-1D adrenergic receptor0303
Sodium-dependent noradrenaline transporter 0101
Adenosine receptor A10101
Alpha-1D adrenergic receptor0606
5-hydroxytryptamine receptor 2A0607
5-hydroxytryptamine receptor 2C0505
D(4) dopamine receptor0101
5-hydroxytryptamine receptor 2B0404
Histamine H1 receptor0202
Sodium-dependent serotonin transporter0404
5-hydroxytryptamine receptor 70404
Alpha-1A adrenergic receptor0505
Histamine H1 receptor0517
Alpha-1B adrenergic receptor0404
D(3) dopamine receptor0505
5-hydroxytryptamine receptor 2B0505
Alpha-1A adrenergic receptor0303
5-hydroxytryptamine receptor 3A0202
5-hydroxytryptamine receptor 60404
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0303
Spike glycoprotein3003
D(2) dopamine receptor0505
Disintegrin and metalloproteinase domain-containing protein 172002
Potassium voltage-gated channel subfamily H member 20909
Sigma non-opioid intracellular receptor 10101
Transporter0303
Nuclear receptor subfamily 3 group C member 3 0505
5-hydroxytryptamine receptor 3D0202
5-hydroxytryptamine receptor 3C0202
Transporter0202
Solute carrier family 22 member 1 0101
Acetylcholinesterase0101
Delta-type opioid receptor0101
Kappa-type opioid receptor0011
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Mu-type opioid receptor0112
Delta-type opioid receptor0011
Kappa-type opioid receptor0101
Kappa-type opioid receptor0011
Mu-type opioid receptor0011
Sigma non-opioid intracellular receptor 10101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Vasopressin V2 receptor0112
Oxytocin receptor0224
Vasopressin V1a receptor0101
Vasopressin V1a receptor0213
Vasopressin V1b receptor0112
Vasopressin V1b receptor0101
Oxytocin receptor0101
Oxytocin receptor0011
Vasopressin V2 receptor 0101
IDH12002
Angiotensin-converting enzyme 0101
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
acetylcholinesterase3003
glp-1 receptor, partial1001
NFKB1 protein, partial1001
Microtubule-associated protein tau2002
Thrombopoietin1001
apical membrane antigen 1, AMA11001
caspase 7, apoptosis-related cysteine protease1001
NADPH oxidase 10101
regulator of G-protein signaling 41001
cytochrome P450 2D63003
glucocerebrosidase1001
Snq2p0001
caspase-31001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
cytochrome P450 2D6 isoform 12002
NPC intracellular cholesterol transporter 1 precursor1001
peripheral myelin protein 22 isoform 12002
cytochrome P450 2C19 precursor2002
D(1A) dopamine receptor1001
transcriptional regulator ERG isoform 32002
ubiquitin-conjugating enzyme E2 N0101
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A1001
protein AF-9 isoform a0001
serine/threonine-protein kinase mTOR isoform 11001
bcl-2-related protein A10101
nuclear receptor ROR-gamma isoform 12002
Vpr1001
M-phase phosphoprotein 81001
transient receptor potential cation channel subfamily V member 11001
muscarinic acetylcholine receptor M12002
DNA repair protein RAD52 homolog isoform a0001
neuropeptide S receptor isoform A1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Aldehyde oxidase 10101
Retinal dehydrogenase 10101
Integrin beta-31001
Integrin alpha-IIb1001
Cytochrome P450 2C9 0101
Pleiotropic ABC efflux transporter of multiple drugs0102
Histamine H2 receptor1001
D(1A) dopamine receptor1001
Cytochrome P450 2J20101
Aldehyde oxidase0101
Aldehyde oxidase 10101
Rap guanine nucleotide exchange factor 41001
Ataxin-22002
Aldehyde oxidase 1 0101
thioredoxin reductase1001
Solute carrier family 22 member 20101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Albumin0011
Cytochrome P450 2D60101
Beta-1 adrenergic receptor0101
Glycine receptor subunit alpha-10011
Sodium-dependent dopamine transporter0202
Histamine H2 receptor0202
5-hydroxytryptamine receptor 1B0202
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 2A0101
D(2) dopamine receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
5-hydroxytryptamine receptor 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
5-hydroxytryptamine receptor 1A0101
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
Histamine H3 receptor0101
thioredoxin glutathione reductase1001
arylsulfatase A1001
Aspartate aminotransferase, cytoplasmic0101
ATPase family AAA domain-containing protein 51001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]