Page last updated: 2024-09-28

Blepharophimosis

The abnormal narrowness of the palpebral fissure in the horizontal direction caused by the lateral displacement of the medial canthi of the eyelids. (Dorland, 27th ed)

Synonyms(1)

Synonym
Blepharophimosis

Research

Studies (38)

TimeframeStudies, This Condition (%)All Conditions %
pre-19902 (5.26)23.3326
1990's8 (21.05)12.5806
2000's18 (47.37)18.1394
2010's9 (23.68)28.8240
2020's1 (2.63)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
cytosine0low20
thymine0low10
2-propanol0low20
serine0low10
tyrosine0low10
histidine0low10
titanium0low10
propiconazole0low60
nsc-1727550low10
5'-o-(9-phenylxanthen-9-yl)-2'-deoxynebularine0low10
inositol 3-phosphate0low20
enclomiphene0low10
tamoxifen0low10
phenylephrine hydrochloride0low70
cysteine0low10
menotropins0low10
guanine0low10
eye0low30

Protein Targets (339)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma5005
GLI family zinc finger 35005
AR protein4004
aldehyde dehydrogenase 1 family, member A12002
retinoic acid nuclear receptor alpha variant 13003
retinoid X nuclear receptor alpha4004
estrogen nuclear receptor alpha6006
peroxisome proliferator-activated receptor delta3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
activating transcription factor 62002
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Histone H2A.x2002
thyroid hormone receptor beta isoform a2002
heat shock protein beta-12002
nuclear factor erythroid 2-related factor 2 isoform 14004
lamin isoform A-delta102002
Voltage-dependent calcium channel gamma-2 subunit3003
Glutamate receptor 23003
IDH14004
geminin5005
Deoxycytidine kinase0001
Chain A, Beta-lactamase3003
Chain A, JmjC domain-containing histone demethylation protein 3A2002
glp-1 receptor, partial3003
chaperonin-containing TCP-1 beta subunit homolog2002
phosphopantetheinyl transferase4004
TDP1 protein4004
Smad31001
bromodomain adjacent to zinc finger domain 2B2002
ubiquitin-conjugating enzyme E2 N0202
protein AF-9 isoform a0001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
nuclear receptor ROR-gamma isoform 13003
5-hydroxytryptamine receptor 40404
Epidermal growth factor receptor0202
Estrogen receptor0416
Receptor tyrosine-protein kinase erbB-20202
Tyrosine-protein kinase Fyn0202
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40404
Muscarinic acetylcholine receptor M50404
Alpha-2A adrenergic receptor0404
Adenosine receptor A30404
Cytochrome P450 2D60101
Muscarinic acetylcholine receptor M10404
Beta-3 adrenergic receptor0404
Alpha-1B adrenergic receptor0404
Alpha-2B adrenergic receptor0404
Alpha-2C adrenergic receptor0202
Muscarinic acetylcholine receptor M30404
Substance-K receptor0404
Prostaglandin G/H synthase 10303
Sodium-dependent noradrenaline transporter 0404
5-hydroxytryptamine receptor 2A0404
5-hydroxytryptamine receptor 2C0404
Sodium-dependent serotonin transporter0404
C-8 sterol isomerase0202
D(3) dopamine receptor0404
Alpha-synuclein2002
5-hydroxytryptamine receptor 2B0404
Alpha-1A adrenergic receptor0404
5-hydroxytryptamine receptor 60404
Sodium-dependent dopamine transporter 0404
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0314
Sigma non-opioid intracellular receptor 10404
Purine nucleoside phosphorylase0202
Hypoxanthine-guanine phosphoribosyltransferase0001
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Shiga toxin subunit A0101
Guanine deaminase0001
Chain A, HISTIDINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
ATAD5 protein, partial1001
euchromatic histone-lysine N-methyltransferase 23003
flap endonuclease 11001
cytochrome P450 3A4 isoform 12002
histone acetyltransferase KAT2A isoform 12002
Gamma-aminobutyric acid receptor subunit pi2002
Carbonic anhydrase 120103
Carbonic anhydrase 10205
Carbonic anhydrase 20205
Plasma kallikrein0002
Carbonic anhydrase 30103
Histidine-binding periplasmic protein0011
Gamma-aminobutyric acid receptor subunit beta-12002
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Carbonic anhydrase 40103
Carbonic anhydrase 60103
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Adenosine receptor A10002
5-hydroxytryptamine receptor 1D0001
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Adenosine receptor A2a0002
Carbonic anhydrase 5A, mitochondrial0103
Glutamate receptor ionotropic, NMDA 1 0002
Carbonic anhydrase0002
Carbonic anhydrase 70103
Carbonic anhydrase0002
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Glutamate receptor ionotropic, NMDA 2A 0002
Glutamate receptor ionotropic, NMDA 2B0002
Glutamate receptor ionotropic, NMDA 2C0002
Large neutral amino acids transporter small subunit 10202
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90103
Carbonic anhydrase 0002
Carbonic anhydrase-like protein, putative0002
Carbonic anhydrase0002
Carbonic anhydrase0002
Glutamate receptor ionotropic, NMDA 2D0002
Carbonic anhydrase 0002
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0002
GABA theta subunit2002
Carbonic anhydrase 40001
Carbonic anhydrase 150103
Carbonic anhydrase 130102
Gamma-aminobutyric acid receptor subunit epsilon2002
Glutamate receptor ionotropic, NMDA 3A0002
Carbonic anhydrase 140103
Carbonic anhydrase 5B, mitochondrial0103
Chain A, 2-oxoglutarate Oxygenase3003
thioredoxin reductase2002
GALC protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
glucocorticoid receptor [Homo sapiens]3003
estrogen-related nuclear receptor alpha4004
peroxisome proliferator activated receptor gamma3003
thyroid stimulating hormone receptor2002
beta-2 adrenergic receptor1001
Bloom syndrome protein isoform 11001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
chromobox protein homolog 13003
Vpr1001
peripheral myelin protein 221001
5-hydroxytryptamine receptor 2A0011
Cellular tumor antigen p533003
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Spike glycoprotein1012
Chain A, Ferritin light chain2002
pregnane X receptor1001
SMAD family member 22002
SMAD family member 32002
estrogen receptor 2 (ER beta)2002
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor2002
nonstructural protein 11001
farnesoid X nuclear receptor2002
pregnane X nuclear receptor2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
aryl hydrocarbon receptor1001
vitamin D3 receptor isoform VDRA2002
thyroid hormone receptor beta isoform 22002
heat shock protein HSP 90-alpha isoform 20001
DNA polymerase iota isoform a (long)1001
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Cytochrome P450 3A40202
Histamine H2 receptor2002
Guanine nucleotide-binding protein G1001
TAR DNA-binding protein 431001
ATPase family AAA domain-containing protein 52002
Ataxin-22002
heat shock protein 90, putative0001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
survival motor neuron protein isoform d1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20103
5'-AMP-activated protein kinase subunit beta-20001
Bile salt export pump0101
Bile salt export pump0202
Albumin0101
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Cystathionine gamma-lyase0101
Prostaglandin G/H synthase 20101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
DNA polymerase kappa isoform 11001
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)2002
Acetylcholinesterase0101
Pyruvate kinase PKM0011
Neutral amino acid transporter A0101
Cholinesterase0101
Neutral amino acid transporter B(0)0101
Proton-coupled amino acid transporter 10101
Amino acid transporter0101
Chain A, CES1 protein0101
acetylcholinesterase1001
Fumarate hydratase1001
USP1 protein, partial1001
PPM1D protein1001
Microtubule-associated protein tau1001
apical membrane antigen 1, AMA11001
DNA polymerase III, partial1001
caspase 7, apoptosis-related cysteine protease1001
regulator of G-protein signaling 41001
polyprotein1001
67.9K protein1001
glucocerebrosidase1001
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
arylsulfatase A1001
caspase-31001
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
Caspase-71001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
cytochrome P450 2D6 isoform 11001
NPC intracellular cholesterol transporter 1 precursor1001
cellular tumor antigen p53 isoform a1001
interferon gamma precursor0001
D(1A) dopamine receptor1001
transcriptional regulator ERG isoform 31001
caspase-31001
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
M-phase phosphoprotein 81001
streptokinase A precursor0011
Transmembrane protease serine 20011
ATP-binding cassette sub-family C member 30101
Multidrug resistance-associated protein 40101
Serine/threonine-protein kinase D30101
Interferon beta1001
Lysosomal acid glucosylceramidase0011
Integrin beta-31001
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0101
Estrogen receptor0012
Tyrosine-protein kinase Lck0101
Progesterone receptor0101
Procathepsin L0011
ATP-dependent translocase ABCB10213
Integrin alpha-IIb1001
Beta-1 adrenergic receptor0202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
Androgen receptor0202
Protein kinase C alpha type0101
5-hydroxytryptamine receptor 1A0202
Cytochrome P450 2B60101
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Thromboxane-A synthase 0101
Protein kinase C eta type0101
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0202
B2 bradykinin receptor0202
Adenosine receptor A10202
Melanocortin receptor 40202
Melanocortin receptor 50202
Mu-type opioid receptor0202
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Protein kinase C iota type0101
Melanocortin receptor 30202
D(1A) dopamine receptor1001
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Potassium voltage-gated channel subfamily H member 20202
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
Serine/threonine-protein kinase D10101
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Estrogen receptor beta0213
Canalicular multispecific organic anion transporter 10101
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
Thymidine phosphorylase0101
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
SLC16A10 protein0001
Tubulin--tyrosine ligase0101
Monocarboxylate transporter 100001
Taste receptor type 2 member 140001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]