Page last updated: 2024-09-27

Bilateral Periventricular Nodular Heterotopia

A disorder resulting from a defect in the pattern of neuronal migration in which ectopic collections of neurons lie along the lateral ventricles of the brain or just beneath, contiguously or in isolated patches.

Synonyms(9)

Synonym
Nodular Heterotopia, Bilateral Periventricular
Heterotopia, Familial Nodular
Periventricular Nodular Heterotopia 1
Heterotopia, Periventricular, X-Linked Dominant
Familial Nodular Heterotopia
Bilateral Periventricular Nodular Heterotopia
Periventricular Nodular Heterotopia
Periventricular Heterotopia
Periventricular Heterotopia, X-Linked

Research Excerpts

Research

Studies (20)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's1 (5.00)18.1394
2010's15 (75.00)28.8240
2020's4 (20.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
carbamazepine0low10
carmustine0low10
valproic acid0low20
lamotrigine0low20
risperidone0low10
trazodone0low10
thyroxine0low10
lysine0low10
bromodeoxyuridine0low10
tyrosine0low10
tryptophan0low10
5,6-dihydroxytryptamine0low10
oxcarbazepine0low10
fluorodeoxyglucose f180low30
biocytin0low10
propylthiouracil0low10
alpha-methyltryptophan, (l)-isomer0low10
methimazole0low10
methylazoxymethanol acetate0low20
methylazoxymethanol0low20
olanzapine0low10
5,7-dihydroxytryptamine creatinine0low10

Protein Targets (416)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Catechol O-methyltransferase0101
Sodium-dependent serotonin transporter0101
interleukin 82002
pregnane X receptor2002
RAR-related orphan receptor gamma3003
ATAD5 protein, partial3003
TDP1 protein9009
Microtubule-associated protein tau3003
AR protein4004
aldehyde dehydrogenase 1 family, member A15005
nuclear receptor subfamily 1, group I, member 36006
progesterone receptor2002
glucocorticoid receptor [Homo sapiens]4004
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha3003
estrogen-related nuclear receptor alpha8008
pregnane X nuclear receptor5005
estrogen nuclear receptor alpha8008
bromodomain adjacent to zinc finger domain 2B3003
arylsulfatase A4004
IDH12002
euchromatic histone-lysine N-methyltransferase 2110011
nuclear receptor subfamily 1, group I, member 21001
cellular tumor antigen p53 isoform a1001
Nuclear hormone receptor family member daf-120011
chromobox protein homolog 12002
nuclear factor erythroid 2-related factor 2 isoform 23003
thyroid hormone receptor beta isoform 24004
serine/threonine-protein kinase mTOR isoform 11001
oxysterols receptor LXR-beta isoform 10011
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
geminin7007
peripheral myelin protein 224004
survival motor neuron protein isoform d3003
muscarinic acetylcholine receptor M15005
Voltage-dependent calcium channel gamma-2 subunit2002
Thymidine kinase, cytosolic0101
Glutamate receptor 22002
Thymidine phosphorylase0001
Thymidylate kinase0101
Nuclear receptor ROR-gamma2002
Spike glycoprotein4004
Thymidine kinase0001
Thymidylate kinase0101
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Chain A, Beta-lactamase1001
acetylcholinesterase2002
USP1 protein, partial4004
thyroid stimulating hormone receptor6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
thyroid hormone receptor beta isoform a5005
mitogen-activated protein kinase 14004
Vpr1001
lamin isoform A-delta108008
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40808
Bile salt export pump0404
Bile salt export pump010010
Albumin0033
Major prion protein0011
Cellular tumor antigen p535005
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0202
Cytochrome P450 2C9 0101
UDP-glucuronosyltransferase 2B70103
Cytochrome P450 2B60011
Sodium channel protein type 4 subunit alpha0204
Cytochrome P450 2J20101
Potassium voltage-gated channel subfamily H member 20606
Sodium channel protein type 9 subunit alpha0303
Frizzled-80011
Canalicular multispecific organic anion transporter 10707
P2X purinoceptor 40202
endonuclease IV1001
GLI family zinc finger 35005
cytochrome P450 family 3 subfamily A polypeptide 42002
EWS/FLI fusion protein5005
cytochrome P450 2D63003
peroxisome proliferator activated receptor gamma5005
Bloom syndrome protein isoform 15005
peripheral myelin protein 22 isoform 14004
huntingtin isoform 21001
nuclear factor erythroid 2-related factor 2 isoform 16006
nuclear receptor ROR-gamma isoform 12002
Glutathione reductase, mitochondrial0303
Alpha-synuclein1001
Glutathione reductase0101
ATP-dependent phosphofructokinase3003
Chain A, Ferritin light chain1001
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
thioredoxin reductase6006
Hsf1 protein0011
regulator of G-protein signaling 41001
D(1A) dopamine receptor3003
transcriptional regulator ERG isoform 32002
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
histone acetyltransferase KAT2A isoform 12002
neuropeptide S receptor isoform A1001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit pi1203
Gamma-aminobutyric acid receptor subunit delta0101
Histone deacetylase 30303
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-11203
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit delta1203
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-21214
Gamma-aminobutyric acid receptor subunit alpha-51203
Gamma-aminobutyric acid receptor subunit alpha-31203
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Gamma-aminobutyric acid receptor subunit gamma-11203
Gamma-aminobutyric acid receptor subunit alpha-21203
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit alpha-41203
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit gamma-31203
Gamma-aminobutyric acid receptor subunit rho-20011
Gamma-aminobutyric acid receptor subunit alpha-61203
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40303
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit alpha-11214
Gamma-aminobutyric acid receptor subunit beta-31203
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit beta-21214
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 431001
Histone deacetylase 10303
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70303
GABA theta subunit1203
Histone deacetylase 20303
Polyamine deacetylase HDAC100303
Histone deacetylase 11 0303
Gamma-aminobutyric acid receptor subunit gamma-30101
Histone deacetylase 80303
Gamma-aminobutyric acid receptor subunit alpha-40011
Gamma-aminobutyric acid receptor subunit epsilon1203
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60303
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90303
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50303
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
GALC protein2002
cytochrome P450 2D6 isoform 13003
potassium voltage-gated channel subfamily H member 2 isoform d4004
Dihydrofolate reductase0202
Potassium voltage-gated channel subfamily E member 10101
Potassium voltage-gated channel subfamily KQT member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Sigma non-opioid intracellular receptor 10101
Sodium channel protein type 10 subunit alpha0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Cationic amino acid transporter 30101
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Luciferase2002
phosphopantetheinyl transferase4004
hypoxia-inducible factor 1 alpha subunit1001
estrogen receptor 2 (ER beta)1001
farnesoid X nuclear receptor2002
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x1001
heat shock protein beta-11001
Polyphenol oxidase 20204
Dopamine beta-hydroxylase 0202
Lactoperoxidase0101
Lanosterol 14-alpha demethylase0101
5-hydroxytryptamine receptor 3E0101
GLS protein2002
peroxisome proliferator-activated receptor delta3003
aryl hydrocarbon receptor3003
lysosomal alpha-glucosidase preproprotein1001
vitamin D3 receptor isoform VDRA2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
FAD-linked sulfhydryl oxidase ALR0001
5-hydroxytryptamine receptor 40606
5-hydroxytryptamine receptor 3B0101
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40303
ATP-dependent translocase ABCB10002
Cytochrome P450 3A40202
5-hydroxytryptamine receptor 1A0347
5-hydroxytryptamine receptor 2C0404
Muscarinic acetylcholine receptor M50303
Alpha-2A adrenergic receptor0606
Muscarinic acetylcholine receptor M10213
Glucose-6-phosphate 1-dehydrogenase0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Angiotensin-converting enzyme0303
D(2) dopamine receptor0505
5-hydroxytryptamine receptor 2A0505
Alpha-1B adrenergic receptor0303
Alpha-2B adrenergic receptor0606
Alpha-2C adrenergic receptor0606
D0202
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 1A0505
Alpha-2B adrenergic receptor0202
Muscarinic acetylcholine receptor M30404
D(1A) dopamine receptor0404
D(4) dopamine receptor0303
Alpha-2C adrenergic receptor0202
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0202
Alpha-1D adrenergic receptor0303
Sodium-dependent noradrenaline transporter 0101
Adenosine receptor A10102
Alpha-1D adrenergic receptor0606
5-hydroxytryptamine receptor 2A0606
5-hydroxytryptamine receptor 2C0606
D(4) dopamine receptor0101
5-hydroxytryptamine receptor 2B0404
Histamine H1 receptor0202
Sodium-dependent serotonin transporter0505
5-hydroxytryptamine receptor 70202
Alpha-1A adrenergic receptor0303
Histamine H1 receptor0617
Alpha-1B adrenergic receptor0202
D(3) dopamine receptor0606
5-hydroxytryptamine receptor 2B0606
Alpha-1A adrenergic receptor0303
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 60303
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0202
D(2) dopamine receptor0404
Disintegrin and metalloproteinase domain-containing protein 171001
Inositol monophosphatase 11001
Sigma non-opioid intracellular receptor 10202
Transporter0202
Nuclear receptor subfamily 3 group C member 3 0303
5-hydroxytryptamine receptor 3D0101
5-hydroxytryptamine receptor 3C0101
Transporter0202
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, 2-oxoglutarate Oxygenase3003
nonstructural protein 11001
polyadenylate-binding protein 10101
bcl-2-related protein A10101
DNA polymerase kappa isoform 12002
cytochrome P450 3A4 isoform 11001
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
cytochrome P450 2C19 precursor2002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
NADH-cytochrome b5 reductase 3 0101
Myeloperoxidase0202
Thyroid peroxidase0101
Taste receptor type 2 member 380012
Smad31001
thyroid stimulating hormone receptor2002
Solute carrier family 22 member 20101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Cytochrome P450 2D60101
Beta-1 adrenergic receptor0101
Glycine receptor subunit alpha-10011
Sodium-dependent dopamine transporter0101
Histamine H2 receptor0202
5-hydroxytryptamine receptor 1B0404
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 2A0101
D(2) dopamine receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
5-hydroxytryptamine receptor 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
5-hydroxytryptamine receptor 1A0101
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
Histamine H3 receptor0101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
apical membrane antigen 1, AMA11001
G1001
serine/threonine-protein kinase PLK11001
DNA polymerase eta isoform 11001
Solute carrier organic anion transporter family member 1A40001
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 31001
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Inositol hexakisphosphate kinase 11001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10001
cytochrome P450 2C9, partial1001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
Sigma non-opioid intracellular receptor 10202
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
thioredoxin glutathione reductase1001
flap endonuclease 11001
DNA polymerase iota isoform a (long)1001
M-phase phosphoprotein 81001
Carbonic anhydrase 120002
Dihydrofolate reductase0202
Carbonic anhydrase 10002
Carbonic anhydrase 20002
Plasma kallikrein0002
Alkaline phosphatase, tissue-nonspecific isozyme0101
Carbonic anhydrase 30002
Stromelysin-10101
Intestinal-type alkaline phosphatase0101
Indoleamine 2,3-dioxygenase 10102
Carbonic anhydrase 40002
Carbonic anhydrase 60002
Substance-P receptor0101
Carbonic anhydrase 5A, mitochondrial0002
Glutamate receptor ionotropic, NMDA 1 0002
Carbonic anhydrase0002
Carbonic anhydrase 70002
Tryptophan 2,3-dioxygenase0102
Carbonic anhydrase0002
Glutamate receptor ionotropic, NMDA 2A 0002
Glutamate receptor ionotropic, NMDA 2B0002
Glutamate receptor ionotropic, NMDA 2C0002
Large neutral amino acids transporter small subunit 10202
SLC16A10 protein0002
Uracil nucleotide/cysteinyl leukotriene receptor0101
Carbonic anhydrase 90002
Carbonic anhydrase 0002
Carbonic anhydrase-like protein, putative0002
Tryprostatin B synthase0001
Carbonic anhydrase0002
Carbonic anhydrase0002
Glutamate receptor ionotropic, NMDA 2D0002
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Carbonic anhydrase 0002
Glutamate receptor ionotropic, NMDA 3B0002
Monocarboxylate transporter 100002
Carbonic anhydrase 150002
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3A0002
Carbonic anhydrase 140002
Phospholipase A-2-activating protein0101
Carbonic anhydrase 5B, mitochondrial0002
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Adenosine receptor A2a0001
Tubulin--tyrosine ligase0101
Taste receptor type 2 member 140001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Cocaine esterase0101
UDP-glucuronosyltransferase 1A90001
Aldo-keto reductase family 1 member B10101
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 1-60001
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]