Page last updated: 2024-09-27

Benign Paroxysmal Positional Vertigo

Idiopathic recurrent VERTIGO associated with POSITIONAL NYSTAGMUS. It is associated with a vestibular loss without other neurological or auditory signs. Unlike in LABYRINTHITIS and VESTIBULAR NEURONITIS, inflammation in the ear is not observed.

Synonyms(7)

Synonym
Benign Recurrent Vertigo
Benign Paroxysmal Positional Vertigo
Vestibulopathy, Familial
Vertigo, Benign Paroxysmal Positional
Vertigo, Benign Recurrent
Familial Benign Recurrent Vertigo
Familial Vestibulopathy

Research Excerpts

Overview

ExcerptReference
"Benign paroxysmal positional vertigo is a common inner-ear pathology, characterised by episodic vertigo lasting for a few seconds that is associated with sudden change in the head position."( Johnson, I; Kelkar, A, 2018)
"Benign paroxysmal positional vertigo is a frequent diagnosed disorder, most of the patients are successfully treated with reposition maneuvers."( Carnevale, C; Morales-Olavarría, C; Sarría-Echegaray, P; Til-Pérez, G, 2021)

Treatment

ExcerptReference
"BACKGROUND Benign paroxysmal positional vertigo (BPPV) is one of the most common and most successfully treated vestibular disorders."( Dai, J; Hu, W; Li, WA; Yuan, J, 2017)
"Although acute attacks of benign paroxysmal positional vertigo (BPPV) may be treated with canalith repositioning maneuvers, there have been no well-designed prospective trials to prevent this highly prevalent and recurrent disorder."( Jeong, SH; Kim, JS, 2019)

Research

Studies (73)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's42 (57.53)28.8240
2020's31 (42.47)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
uric acid0low40
aspirin0low10
betahistine0medium157
carbamazepine0low10
clonazepam0low10
cyproheptadine0low10
meclizine0low10
oxidopamine0low10
prednisone0low20
penicillin g0low10
methylprednisolone0medium21
limestone0medium21
dimenhydrinate0medium31
trimetazidine0medium11
tricalcium phosphate0medium11
oxcarbazepine0low10
fomesafen0low10
3-(3,5-dichlorophenyl)-1-methyl-2,5-pyrrolidinedione0low10
cinnarizine0medium11
D-fructopyranose0low10
dinoprostone0low10
cholecalciferol0low20
topiramate0low20
phosphorus0medium21
indocyanine green0low10
scopolamine hydrobromide0low10
pituitrin0low10
phytoestrogens0low10
eye0low30

Protein Targets (502)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
Chain A, 2-oxoglutarate Oxygenase4004
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 82002
thioredoxin reductase5005
GLS protein2002
AR protein100010
aldehyde dehydrogenase 1 family, member A19009
thyroid stimulating hormone receptor5005
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 42002
EWS/FLI fusion protein4004
glucocorticoid receptor [Homo sapiens]8008
retinoic acid nuclear receptor alpha variant 17007
estrogen-related nuclear receptor alpha110011
estrogen nuclear receptor alpha120012
cytochrome P450 2D63003
glucocerebrosidase2002
peroxisome proliferator-activated receptor delta3003
Rac1 protein0011
IDH13003
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
euchromatic histone-lysine N-methyltransferase 27007
Bloom syndrome protein isoform 14004
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
DNA polymerase iota isoform a (long)1001
DNA polymerase kappa isoform 14004
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)2002
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40709
Solute carrier family 22 member 60303
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump013013
Epidermal growth factor receptor0101
Carbonic anhydrase 108010
Carbonic anhydrase 208111
Fatty acid-binding protein, liver0101
Integrin beta-30101
Myeloperoxidase0101
Prostaglandin G/H synthase 10202
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb0101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10303
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin G/H synthase 20303
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma4004
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-13205
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200303
Solute carrier family 22 member 60303
Canalicular multispecific organic anion transporter 10707
Sigma non-opioid intracellular receptor 10415
Sigma non-opioid intracellular receptor 10011
Histamine H3 receptor0101
Chain A, Beta-lactamase2002
acetylcholinesterase3003
RAR-related orphan receptor gamma4004
USP1 protein, partial5005
TDP1 protein7007
pregnane X nuclear receptor7007
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
thyroid hormone receptor beta isoform a3003
nuclear factor erythroid 2-related factor 2 isoform 24004
mitogen-activated protein kinase 13003
geminin8008
Vpr1001
lamin isoform A-delta102002
Bile salt export pump0303
Albumin0011
Major prion protein0011
Cellular tumor antigen p537007
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2C9 0202
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 2B60011
Sodium channel protein type 4 subunit alpha0102
Cytochrome P450 2J20202
Potassium voltage-gated channel subfamily H member 20303
Sodium channel protein type 9 subunit alpha0202
Frizzled-80011
P2X purinoceptor 40202
Chain A, Ferritin light chain3003
Chain A, Cruzipain3003
Luciferase2002
15-lipoxygenase, partial1001
Microtubule-associated protein tau3003
retinoid X nuclear receptor alpha8008
farnesoid X nuclear receptor4004
peroxisome proliferator activated receptor gamma2002
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
vitamin D3 receptor isoform VDRA5005
nuclear factor erythroid 2-related factor 2 isoform 16006
nuclear receptor ROR-gamma isoform 12002
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 13003
Gamma-aminobutyric acid receptor subunit pi3104
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Vitamin D3 receptor0114
Gamma-aminobutyric acid receptor subunit beta-13104
Gamma-aminobutyric acid receptor subunit delta3104
Gamma-aminobutyric acid receptor subunit gamma-23104
Gamma-aminobutyric acid receptor subunit alpha-53104
Gamma-aminobutyric acid receptor subunit alpha-33104
Glycine receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit gamma-13104
Gamma-aminobutyric acid receptor subunit alpha-23104
Gamma-aminobutyric acid receptor subunit alpha-43104
Gamma-aminobutyric acid receptor subunit gamma-33104
Gamma-aminobutyric acid receptor subunit alpha-63104
Vitamin D3 receptor0011
10 kDa heat shock protein, mitochondrial0101
Gamma-aminobutyric acid receptor subunit beta-33104
Gamma-aminobutyric acid receptor subunit beta-23104
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
GABA theta subunit3104
Gamma-aminobutyric acid receptor subunit epsilon3104
endonuclease IV1001
chaperonin-containing TCP-1 beta subunit homolog2002
hypoxia-inducible factor 1 alpha subunit5005
GLI family zinc finger 38008
Estrogen receptor 10101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
PINK11001
estrogen receptor 2 (ER beta)3003
progesterone receptor6006
G2002
Parkin1001
bromodomain adjacent to zinc finger domain 2B2002
thyroid stimulating hormone receptor3003
v-jun sarcoma virus 17 oncogene homolog (avian)4004
Histone H2A.x3003
lysosomal alpha-glucosidase preproprotein2002
chromobox protein homolog 12002
potassium voltage-gated channel subfamily H member 2 isoform d4004
thyroid hormone receptor beta isoform 26006
estrogen receptor beta isoform 10101
heat shock protein beta-12002
importin subunit beta-1 isoform 11001
flap endonuclease 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
M-phase phosphoprotein 81001
neuropeptide S receptor isoform A1001
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 2002
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M40808
Muscarinic acetylcholine receptor M50707
Alpha-2A adrenergic receptor0808
Neuronal acetylcholine receptor subunit alpha-41102
Muscarinic acetylcholine receptor M10808
Neuronal acetylcholine receptor subunit beta-21102
D(2) dopamine receptor0618
Alpha-2B adrenergic receptor0606
Alpha-2C adrenergic receptor0404
5-hydroxytryptamine receptor 1A0404
Muscarinic acetylcholine receptor M30707
Sodium-dependent noradrenaline transporter 0606
Alpha-1D adrenergic receptor0606
Cruzipain0101
5-hydroxytryptamine receptor 2A0606
5-hydroxytryptamine receptor 1B0404
Sodium-dependent serotonin transporter0303
Histamine H1 receptor0617
Mu-type opioid receptor0202
D(3) dopamine receptor0619
5-hydroxytryptamine receptor 2B0606
Spike glycoprotein3003
Inositol monophosphatase 12002
Sodium-dependent dopamine transporter 0404
Inositol hexakisphosphate kinase 12002
cytochrome P450 2C9, partial2002
ATP-dependent phosphofructokinase3003
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit beta-30202
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50202
Gamma-aminobutyric acid receptor subunit alpha-30202
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit epsilon0202
Gamma-aminobutyric acid receptor subunit alpha-60202
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit theta0202
phosphopantetheinyl transferase3003
ATAD5 protein, partial3003
Fumarate hydratase2002
PPM1D protein2002
nuclear receptor subfamily 1, group I, member 34004
regulator of G-protein signaling 43003
polyprotein2002
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a1001
cytochrome P450 2C19 precursor1001
D(1A) dopamine receptor2002
huntingtin isoform 21001
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase mTOR isoform 11001
peripheral myelin protein 223003
histone acetyltransferase KAT2A isoform 13003
chaperonin GroEL1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Sodium-dependent noradrenaline transporter0101
5-hydroxytryptamine receptor 40404
Voltage-dependent calcium channel gamma-2 subunit2002
Muscarinic acetylcholine receptor M20505
Muscarinic acetylcholine receptor M10303
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40202
5-hydroxytryptamine receptor 2C0101
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M20314
Glycogen phosphorylase, brain form0101
Glycogen phosphorylase, muscle form0101
Angiotensin-converting enzyme0202
5-hydroxytryptamine receptor 2A0202
D0202
D(3) dopamine receptor0202
Glutamate receptor 23003
Endothelin receptor type B0101
D(1A) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Endothelin receptor type B0101
Histamine H2 receptor0202
D(1B) dopamine receptor0202
5-hydroxytryptamine receptor 2C0404
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70202
UDP-glucuronosyltransferase 1A30001
Histamine H2 receptor1001
5-hydroxytryptamine receptor 60202
D(2) dopamine receptor0101
D(2) dopamine receptor0505
Sodium-dependent serotonin transporter0101
Nuclear receptor subfamily 3 group C member 3 0202
Histone-lysine N-methyltransferase SETD70202
Ataxin-22002
Transporter0202
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
Cytochrome P450 2D60101
SMAD family member 21001
SMAD family member 31001
activating transcription factor 62002
prostaglandin E2 receptor EP2 subtype1001
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0001
Solute carrier organic anion transporter family member 1A50001
Cytochrome P450 3A40213
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Prostaglandin E2 receptor EP1 subtype0213
Prostaglandin E2 receptor EP1 subtype0101
Prostaglandin E2 receptor EP4 subtype0213
Prostaglandin F2-alpha receptor0011
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP3 subtype0213
Prostaglandin E2 receptor EP2 subtype0213
Prostacyclin receptor0213
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 60103
Solute carrier family 22 member 70002
Prostaglandin E2 receptor EP2 subtype0101
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 80304
Solute carrier family 22 member 70001
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 110001
Solute carrier organic anion transporter family member 1B20001
Solute carrier family 22 member 70001
Chain A, Dihydrofolate reductase0011
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
acid sphingomyelinase1001
glp-1 receptor, partial1001
alpha-galactosidase1001
DNA polymerase beta1001
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10202
Alpha-synuclein1001
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
nonstructural protein 12002
nuclear receptor subfamily 1, group I, member 21001
muscleblind-like protein 1 isoform 11001
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor0415
Glycine receptor subunit alpha-10404
Androgen receptor0202
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
ATPase family AAA domain-containing protein 51001
Nuclear receptor subfamily 1 group I member 20011
GALC protein1001
polyadenylate-binding protein 10101
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
bcl-2-related protein A10101
urokinase plasminogen activator surface receptor precursor1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Glyceraldehyde-3-phosphate dehydrogenase0101
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
Sodium-dependent dopamine transporter0101
DNA repair protein RAD52 homolog0101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
streptokinase A precursor0011
Beta-lactamase0001
Solute carrier family 22 member 80102
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase0001
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Kappa-type opioid receptor0001
Solute carrier family 15 member 10101
Beta-lactamase TEM0102
Guanine nucleotide-binding protein G1001
Beta-lactamase0001
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Efflux transporter 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Beta-lactamase 0001
Class D beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase 0001
Solute carrier family 22 member 80102
Beta-lactamase VIM-1 0001
pregnane X receptor1001
thioredoxin glutathione reductase2002
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20102
Carbonic anhydrase 120304
5'-AMP-activated protein kinase subunit beta-20001
Albumin0101
Polymerase acidic protein0011
Carbonic anhydrase 30303
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40203
Carbonic anhydrase 60304
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0315
Carbonic anhydrase 70304
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90305
Carbonic anhydrase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150303
Carbonic anhydrase 130203
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140203
Carbonic anhydrase 5B, mitochondrial0304
5'-AMP-activated protein kinase subunit beta-10001
Carbonic anhydrase 0002
Carbonic anhydrase 0202
Carbonic anhydrase 0202
Carbonic anhydrase 0202
arylsulfatase A1001
Carbonic anhydrase0202
aryl hydrocarbon receptor1001
Carbonic anhydrase0202
D(4) dopamine receptor0101
Delta-type opioid receptor0202
Delta-type opioid receptor0202
Mu-type opioid receptor0202
Carbonic anhydrase0202
Mu-type opioid receptor0202
Beta-carbonic anhydrase 10202
Carbonic anhydrase 20202
Carbonic anhydrase, alpha family 0202
Carbonic anhydrase 0202
Carbonic anhydrase0202
Carbonic anhydrase 0202
Delta carbonic anhydrase0202
Carbonic anhydrase 0202
Carbonic anhydrase 40303
D(2) dopamine receptor0101
Chain A, Carbonic anhydrase 10101
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110001
Polyunsaturated fatty acid 5-lipoxygenase0101
Cytochrome P450 2C80101
Arachidonate 5-lipoxygenase-activating protein0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 20101
Cytochrome P450 2C190101
Carbonic anhydrase0101
Carbonic anhydrase 0101
Glutamate receptor ionotropic, NMDA 2B0101
Neuronal acetylcholine receptor subunit alpha-70101
Carbonic anhydrase0101
Carbonic anhydrase 130101
Smad31001
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Carnitine O-palmitoyltransferase 1, liver isoform0101
TAR DNA-binding protein 431001
Carnitine O-palmitoyltransferase 1, muscle isoform0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]