Page last updated: 2024-09-28

Benign Brenner Tumor

Brenner tumor of borderline malignancy.

Synonyms(6)

Synonym
Proliferative Brenner Tumor
Ovarian Brenner Tumor
Brenner Tumor
Benign Brenner Tumor
Brenner Tumor of Ovary
Malignant Brenner Tumor

Research Excerpts

Overview

ExcerptReference
"Most Brenner tumors are benign, with only 1% being malignant."( Acar, A; Çapar, M; Çelik, Ç; Gezginç, K; Karatayli, R; Tavli, L; Yazici, F, 2012)

Treatment

ExcerptReference
"Thirteen patients with malignant Brenner tumor of the ovary who were treated at Selçuk University Gynecology Department over a 6-year period from January 2004 to December 2010 were retrospectively analysed from hospital electronic medical records."( Acar, A; Çapar, M; Çelik, Ç; Gezginç, K; Karatayli, R; Tavli, L; Yazici, F, 2012)
"Malignant Brenner tumors (MBTs) of the ovary are very rare, and their definition, biology, and treatment modality have not been established."( Han, JH; Kim, DY; Kim, JH; Kim, YM; Kim, YT; Lee, SW; Nam, JH; Park, JY, 2015)

Research

Studies (67)

TimeframeStudies, This Condition (%)All Conditions %
pre-199040 (59.70)23.3326
1990's7 (10.45)12.5806
2000's8 (11.94)18.1394
2010's10 (14.93)28.8240
2020's2 (2.99)9.53
DrugIndicatedRelationship StrengthStudiesTrials
3-methylcholanthrene0low10
hydroxyindoleacetic acid0low10
aspirin0low10
guaifenesin0low10
ifosfamide0low10
labetalol0low10
estrone0low20
androstenedione0low10
17-alpha-hydroxyprogesterone0low10
c.i. 425100low10
dehydroepiandrosterone sulfate0low20
levonorgestrel0low10
technetium0low10
transferrin0low10
paclitaxel0low40
methyldopa0low10
metaperiodate0low10
carboplatin0low40
glycogen0low40
dactinomycin0low10
melphalan0low10
bromochloroacetic acid0low80
tamoxifen0low20
nadp0low10
gadolinium dtpa0low10
acid phosphatase0low20
nad0low10
mesna0low10
cyclin d10low20
lewis x antigen0low10
technetium tc 99m medronate0low10

Protein Targets (428)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
acetylcholinesterase5005
pregnane X receptor3003
SMAD family member 26006
SMAD family member 36006
TDP1 protein120012
GLI family zinc finger 3110011
Microtubule-associated protein tau6006
AR protein130013
progesterone receptor9009
glucocorticoid receptor [Homo sapiens]9009
retinoic acid nuclear receptor alpha variant 1100010
retinoid X nuclear receptor alpha100010
estrogen-related nuclear receptor alpha110011
farnesoid X nuclear receptor8008
pregnane X nuclear receptor100010
estrogen nuclear receptor alpha130013
G5005
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
arylsulfatase A4004
euchromatic histone-lysine N-methyltransferase 2100010
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
activating transcription factor 65005
nuclear receptor subfamily 1, group I, member 23003
chromobox protein homolog 17007
nuclear factor erythroid 2-related factor 2 isoform 1100010
geminin9009
survival motor neuron protein isoform d4004
histone acetyltransferase KAT2A isoform 13003
lamin isoform A-delta107007
Voltage-dependent calcium channel gamma-2 subunit7007
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 5005
Glucocorticoid receptor0202
Sex hormone-binding globulin0033
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0303
Adenosine receptor A30606
Replicase polyprotein 1ab0112
Androgen receptor0707
Alpha-1B adrenergic receptor0606
Glutamate receptor 27007
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Mitogen-activated protein kinase 3 0101
Alpha-1A adrenergic receptor0606
Sodium-dependent dopamine transporter 0606
TAR DNA-binding protein 434004
Inositol hexakisphosphate kinase 15005
cytochrome P450 2C9, partial5005
ATP-dependent phosphofructokinase4004
Luciferase3003
phosphopantetheinyl transferase6006
RAR-related orphan receptor gamma100010
caspase 7, apoptosis-related cysteine protease4004
aldehyde dehydrogenase 1 family, member A18008
nuclear receptor subfamily 1, group I, member 38008
peroxisome proliferator-activated receptor delta9009
peroxisome proliferator activated receptor gamma8008
caspase-34004
aryl hydrocarbon receptor3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
thyroid hormone receptor beta isoform a2002
heat shock protein beta-12002
Cellular tumor antigen p538008
Cytochrome P450 1A20101
Tyrosine-protein kinase Lck0202
Tyrosine-protein kinase Fyn0404
Aldo-keto reductase family 1 member B10606
Acetylcholinesterase0101
Sodium-dependent noradrenaline transporter 0606
Aryl hydrocarbon receptor0011
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
interleukin 83003
Smad34004
estrogen receptor 2 (ER beta)7007
regulator of G-protein signaling 44004
cytochrome P450 family 3 subfamily A polypeptide 47007
nonstructural protein 12002
Histone H2A.x6006
Caspase-74004
Bloom syndrome protein isoform 15005
peripheral myelin protein 22 isoform 14004
potassium voltage-gated channel subfamily H member 2 isoform d2002
caspase-34004
thyroid hormone receptor beta isoform 28008
importin subunit beta-1 isoform 13003
mitogen-activated protein kinase 11001
nuclear factor NF-kappa-B p105 subunit isoform 11001
snurportin-13003
GTP-binding nuclear protein Ran isoform 11001
DNA polymerase iota isoform a (long)5005
nuclear receptor ROR-gamma isoform 14004
peripheral myelin protein 225005
muscleblind-like protein 1 isoform 12002
neuropeptide S receptor isoform A2002
Beta-glucuronidase0101
Cholinesterase0101
Aromatase0305
Gastrin/cholecystokinin type B receptor0001
Testosterone 17-beta-dehydrogenase 30101
Alpha-synuclein1203
Nuclear receptor ROR-gamma5005
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Phospholipase A2 isoform 30011
Chain A, 2-oxoglutarate Oxygenase3003
GTP-binding protein (rab7)0011
ras protein, partial0011
thioredoxin reductase5005
GLS protein4004
thyroid stimulating hormone receptor2002
hypothetical protein, conserved3003
EWS/FLI fusion protein4004
cytochrome P450 2D63003
glucocerebrosidase3003
Rac1 protein0011
IDH14004
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
DNA polymerase kappa isoform 13003
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)3003
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40809
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump011011
Epidermal growth factor receptor0404
Carbonic anhydrase 10303
Carbonic anhydrase 20303
Fatty acid-binding protein, liver0101
Integrin beta-31203
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb1102
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10303
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin G/H synthase 20202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-15106
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Canalicular multispecific organic anion transporter 10707
Sigma non-opioid intracellular receptor 10415
Sigma non-opioid intracellular receptor 10011
thyroid stimulating hormone receptor3003
ATPase family AAA domain-containing protein 55005
Ataxin-27007
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
vitamin D3 receptor isoform VDRA5005
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Ferritin light chain2002
Chain A, Cruzipain1001
15-lipoxygenase, partial4004
hypoxia-inducible factor 1 alpha subunit3003
USP1 protein, partial5005
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
RAD510101
v-jun sarcoma virus 17 oncogene homolog (avian)3003
huntingtin isoform 21001
cytochrome P450 3A4 isoform 15005
caspase-1 isoform alpha precursor1001
Gamma-aminobutyric acid receptor subunit pi5005
ATP-dependent translocase ABCB10317
Gamma-aminobutyric acid receptor subunit beta-15005
Gamma-aminobutyric acid receptor subunit delta5005
Gamma-aminobutyric acid receptor subunit gamma-25005
Gamma-aminobutyric acid receptor subunit alpha-55005
Gamma-aminobutyric acid receptor subunit alpha-35005
Gamma-aminobutyric acid receptor subunit gamma-15005
Gamma-aminobutyric acid receptor subunit alpha-25005
Gamma-aminobutyric acid receptor subunit alpha-45005
Gamma-aminobutyric acid receptor subunit gamma-35005
Gamma-aminobutyric acid receptor subunit alpha-65005
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 10101
Caspase-71001
Spike glycoprotein2013
Growth factor receptor-bound protein 20101
Gamma-aminobutyric acid receptor subunit beta-35005
Gamma-aminobutyric acid receptor subunit beta-25005
Pantothenate synthetase0101
Discoidin domain-containing receptor 20101
Growth factor receptor-bound protein 2 0101
Reverse transcriptase/RNaseH 0101
GABA theta subunit5005
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
Gamma-aminobutyric acid receptor subunit epsilon5005
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Steryl-sulfatase0102
Multidrug resistance-associated protein 1 0001
Solute carrier organic anion transporter family member 1A10102
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
G-protein coupled bile acid receptor 10011
ATP-binding cassette sub-family C member 110001
Solute carrier organic anion transporter family member 1B30203
Solute carrier family 22 member 110001
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1B20001
Solute carrier organic anion transporter family member 1B10203
endonuclease IV3003
ATAD5 protein, partial3003
NFKB1 protein, partial2002
GALC protein2002
hexokinase-4 isoform 11001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
glucokinase regulatory protein1001
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
Rap guanine nucleotide exchange factor 33003
Estrogen receptor0428
Polyunsaturated fatty acid lipoxygenase ALOX150202
17-beta-hydroxysteroid dehydrogenase type 10203
Sodium-dependent serotonin transporter0404
Mu-type opioid receptor0011
5-hydroxytryptamine receptor 2B0606
Mu-type opioid receptor0011
Inositol monophosphatase 11001
Cytochrome P450 1B10101
Estrogen receptor beta0326
Ghrelin O-acyltransferase0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
flap endonuclease 12002
Fumarate hydratase3003
polyprotein3003
alpha-galactosidase1001
cytochrome P450 2C9 precursor1001
M-phase phosphoprotein 83003
Histamine H2 receptor2002
Uracil nucleotide/cysteinyl leukotriene receptor0101
Chain A, Beta-lactamase5005
Serum paraoxonase/arylesterase 10202
Beta-1 adrenergic receptor 0011
Beta-2 adrenergic receptor0213
Beta-1 adrenergic receptor0415
Cytochrome P450 2D60101
Beta-3 adrenergic receptor0213
5-hydroxytryptamine receptor 1A0404
Alpha-2B adrenergic receptor0011
Alpha-2C adrenergic receptor0011
Alpha-2A adrenergic receptor0011
Alpha-1D adrenergic receptor0415
5-hydroxytryptamine receptor 1B0404
Alpha-1A adrenergic receptor0011
Alpha-1B adrenergic receptor0011
Beta-2 adrenergic receptor0011
Heparanase0011
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
nuclear factor erythroid 2-related factor 2 isoform 21001
transcriptional regulator ERG isoform 32002
DNA polymerase beta2002
Progesterone receptor0112
glp-1 receptor, partial1001
thioredoxin glutathione reductase2002
Large neutral amino acids transporter small subunit 1 0101
Carbonic anhydrase 40101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 90101
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Caspase 6, apoptosis-related cysteine peptidase0001
apical membrane antigen 1, AMA12002
bromodomain adjacent to zinc finger domain 2B2002
pyruvate kinase1001
lysosomal alpha-glucosidase preproprotein1001
estrogen receptor beta isoform 10101
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
serine/threonine-protein kinase mTOR isoform 12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
Bile salt export pump0101
Cystathionine gamma-lyase0101
Solute carrier family 15 member 10101
D(1A) dopamine receptor2002
phosphoglycerate kinase1001
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Genome polyprotein 0101
67.9K protein2002
NPC intracellular cholesterol transporter 1 precursor2002
Tyrosine-protein kinase ABL10101
Tubulin alpha-1A chain0012
Tubulin beta chain0011
Tubulin beta-4A chain0113
Receptor tyrosine-protein kinase erbB-20202
Integrin alpha-V 0101
Tubulin beta chain0113
60 kDa chaperonin0101
Tubulin alpha-3C chain0113
Botulinum neurotoxin type A 0101
Apoptosis regulator Bcl-20101
60 kDa heat shock protein, mitochondrial0101
Fibroblast growth factor receptor 10101
Proto-oncogene tyrosine-protein kinase Src0101
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
ATP-dependent translocase ABCB10101
Substance-K receptor0404
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40102
Cholecystokinin receptor type A0202
Melanocortin receptor 50404
UDP-glucuronosyltransferase 2B10 0101
Delta-type opioid receptor0404
10 kDa heat shock protein, mitochondrial0101
Tubulin alpha-1B chain0113
Tubulin alpha-4A chain0113
Tubulin beta-4B chain0113
Bcl-2-like protein 10101
Tyrosine-protein kinase Mer0101
Tubulin beta-3 chain0214
Tubulin beta-2A chain0113
Thiosulfate sulfurtransferase0101
Beta-tubulin 0101
Tubulin beta-8 chain0113
60 kDa chaperonin 0101
Tubulin beta-2B chain0013
Tubulin alpha-3E chain0113
Tubulin alpha-1A chain0113
10 kDa chaperonin 0101
Similar to alpha-tubulin isoform 1 0013
Similar to alpha-tubulin isoform 1 0002
Tubulin alpha-1C chain0113
Tubulin beta-6 chain0113
Tubulin beta-2B chain0113
Tubulin beta-1 chain0113
Nucleotide-binding oligomerization domain-containing protein 20101
Chain A, CES1 protein0101
PPM1D protein1001
DNA polymerase III, partial1001
thyrotropin-releasing hormone receptor1001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a1001
interferon gamma precursor0001
D(1A) dopamine receptor1001
ubiquitin-conjugating enzyme E2 N0101
ras-related protein Rab-9A1001
streptokinase A precursor0011
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20011
5-hydroxytryptamine receptor 40202
Serine/threonine-protein kinase D30101
Lysosomal acid glucosylceramidase0011
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0101
Estrogen receptor0012
Procathepsin L0011
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Cytochrome P450 3A40101
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Muscarinic acetylcholine receptor M10202
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
Protein kinase C alpha type0101
Alpha-2B adrenergic receptor0202
Muscarinic acetylcholine receptor M30202
Cytochrome P450 2B60101
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
Thromboxane-A synthase 0101
Protein kinase C eta type0101
Histamine H2 receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Adenosine receptor A2a0202
B2 bradykinin receptor0202
Adenosine receptor A10202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Mu-type opioid receptor0202
D(3) dopamine receptor0202
Kappa-type opioid receptor0202
Protein kinase C iota type0101
Melanocortin receptor 30202
5-hydroxytryptamine receptor 60202
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Potassium voltage-gated channel subfamily H member 20202
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]
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