Barth Syndrome

Rare congenital X-linked disorder of lipid metabolism. Barth syndrome is transmitted in an X-linked recessive pattern. The syndrome is characterized by muscular weakness, growth retardation, DILATED CARDIOMYOPATHY, variable NEUTROPENIA, 3-methylglutaconic aciduria (type II) and decreases in mitochondrial CARDIOLIPIN level. Other biochemical and morphological mitochondrial abnormalities also exist.

Synonym
Barth Syndrome

Excerpt	Reference
"Barth syndrome is a rare X-linked disease in which mild hypocholesterolemia is observed in some patients."	( Hatch, GM; Hauff, KD, 2010)
"Barth syndrome is the first recognized human disease in which the primary causative factor is a defective remodeling of the signature mitochondrial phospholipid cardiolipin."	( Griač, P; Poloncová, K, 2011)
"Barth Syndrome is a rare X-linked disorder characterized principally by dilated cardiomyopathy, skeletal myopathy and neutropenia and caused by defects in tafazzin, an enzyme responsible for modifying the acyl chain moieties of cardiolipin."	( Kelley, RI; McClellan, R; Sandlers, Y; Vernon, HJ, 2014)
"Barth syndrome is a rare X-linked genetic disease classically characterized by cardiomyopathy, skeletal myopathy, growth retardation, neutropenia, and 3-methylglutaconic aciduria."	( Hatch, GM; Zegallai, HM, 2021)
"Barth syndrome is a rare and potentially fatal X-linked disease characterized by cardiomyopathy, skeletal muscle weakness, growth delays, and cyclic neutropenia."	( Sabbah, HN, 2022)
"Barth Syndrome is an X-linked disorder of mitochondrial cardiolipin metabolism caused by pathogenic variants in TAFAZZIN with pleiotropic effects including cardiomyopathy, neutropenia, growth delay, and skeletal myopathy."	( Chin, MT; Heyman, A; Hornby, B; Jefferies, J; Pu, WT; Takemoto, C; Thompson, R; Vernon, HJ; Wang, S, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	26 (50.00)	28.8240
2020's	26 (50.00)	9.53

Drug	Relationship Strength	Studies
acetic acid	low	1
pyruvic acid	low	1
leucine	low	2
arginine	low	2
nicotinamide mononucleotide	low	1
cetylpyridinium chloride anhydrous	low	1
bezafibrate	low	2
chimyl alcohol	low	1
coenzyme a	low	1
valerates	low	1
2-ethylhydracrylic acid	low	1
oleic acid	low	1
3-methylglutaconic acid	low	4
tempo	low	1
digoxin	low	1
cystine	low	1
vitamin k semiquinone radical	low	1
n-oleoylethanolamine	low	1
sirolimus	low	2
nad	low	2
phosphatidylcholines	low	1
cardiovascular agents	low	2
natriuretic peptide, brain	low	1

Protein Targets (580)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
glp-1 receptor, partial	1	0	0	1
TDP1 protein	5	0	0	5
geminin	6	0	0	6
estrogen nuclear receptor alpha	6	0	0	6
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	0	2	2
Tyrosine-protein kinase Fyn	0	0	2	2
Fibrinogen C domain-containing protein 1	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	5	0	0	5
phosphopantetheinyl transferase	3	0	0	3
NFKB1 protein, partial	2	0	0	2
GLS protein	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
alpha-galactosidase	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	3	0	0	3
cytochrome P450 2C19 precursor	2	0	0	2
chromobox protein homolog 1	5	0	0	5
flap endonuclease 1	3	0	0	3
DNA polymerase iota isoform a (long)	3	0	0	3
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	3	0	0	3
Cytochrome P450 3A4	0	2	1	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	1	0	0	1
Luciferase	2	0	0	2
RAR-related orphan receptor gamma	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	1	0	0	1
farnesoid X nuclear receptor	4	0	0	4
pregnane X nuclear receptor	2	0	0	2
G	1	0	0	1
peroxisome proliferator-activated receptor delta	3	0	0	3
peroxisome proliferator activated receptor gamma	4	0	0	4
D(1A) dopamine receptor	2	0	0	2
survival motor neuron protein isoform d	2	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	0	1	1
Glutamate receptor ionotropic, NMDA 3B	0	0	1	1
Bile salt export pump	0	1	0	1
5-hydroxytryptamine receptor 4	0	0	1	1
Bile salt export pump	0	4	0	4
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Fatty acid-binding protein, liver	0	2	0	2
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Peroxisome proliferator-activated receptor delta	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Peroxisome proliferator-activated receptor delta	0	0	2	3
Glutamate receptor ionotropic, NMDA 1	0	0	1	1
Peroxisome proliferator-activated receptor alpha	1	0	3	4
Glutamate receptor ionotropic, NMDA 2A	0	0	1	1
Glutamate receptor ionotropic, NMDA 2B	0	0	1	1
Glutamate receptor ionotropic, NMDA 2C	0	0	1	1
Glutamate receptor ionotropic, NMDA 3A	0	0	1	1
Inositol hexakisphosphate kinase 1	1	0	0	1
cytochrome P450 2C9, partial	1	0	0	1
Chain A, Ferritin light chain	3	0	0	3
acetylcholinesterase	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
SMAD family member 2	2	0	0	2
USP1 protein, partial	5	0	0	5
SMAD family member 3	2	0	0	2
GLI family zinc finger 3	2	0	0	2
Microtubule-associated protein tau	3	0	0	3
AR protein	2	0	0	2
caspase 7, apoptosis-related cysteine protease	1	0	0	1
estrogen receptor 2 (ER beta)	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
progesterone receptor	3	0	0	3
glucocorticoid receptor [Homo sapiens]	2	0	0	2
retinoic acid nuclear receptor alpha variant 1	4	0	0	4
retinoid X nuclear receptor alpha	2	0	0	2
estrogen-related nuclear receptor alpha	3	0	0	3
67.9K protein	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
caspase-3	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
activating transcription factor 6	2	0	0	2
thyrotropin-releasing hormone receptor	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
vitamin D3 receptor isoform VDRA	2	0	0	2
thyroid hormone receptor beta isoform 2	3	0	0	3
heat shock protein beta-1	2	0	0	2
mitogen-activated protein kinase 1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	3	0	0	3
nuclear receptor ROR-gamma isoform 1	3	0	0	3
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Cellular tumor antigen p53	4	0	0	4
Glutamate receptor 2	2	0	0	2
Caspase-2	0	0	1	1
Inositol monophosphatase 1	1	0	0	1
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Choline O-acetyltransferase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Histone acetyltransferase KAT2B	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
N-alpha-acetyltransferase 50	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Cruzipain	2	0	0	2
interleukin 8	1	0	0	1
PAX8	0	0	0	1
ATAD5 protein, partial	3	0	0	3
PPM1D protein	1	0	0	1
STAT3, partial	0	1	0	1
thioredoxin glutathione reductase	2	0	0	2
Smad3	2	0	0	2
regulator of G-protein signaling 4	1	0	0	1
IDH1	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
tumor necrosis factor	1	0	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
lamin isoform A-delta10	2	0	0	2
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Integrin beta-3	1	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	3
Integrin alpha-IIb	1	0	0	1
Replicase polyprotein 1ab	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Nuclear receptor ROR-gamma	2	1	1	4
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	2
Phospholipase A-2-activating protein	0	1	0	1
endonuclease IV	1	0	0	1
nonstructural protein 1	1	0	0	1
arylsulfatase A	1	0	0	1
FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0	0	0	1
Bloom syndrome protein isoform 1	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
DNA polymerase beta	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase kappa isoform 1	2	0	0	2
cytochrome P450 3A4 isoform 1	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Renin	0	0	1	1
Cytochrome P450 2C8	0	0	1	1
Fatty acid-binding protein, liver	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Cannabinoid receptor 1	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Cannabinoid receptor 2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Histamine H2 receptor	1	0	0	1
Cannabinoid receptor 2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Corticotropin-releasing factor receptor 2	0	1	0	1
Acid ceramidase	0	2	0	2
Glucose-dependent insulinotropic receptor	0	0	1	1
Transient receptor potential cation channel subfamily V member 1	0	0	1	1
Glucose-dependent insulinotropic receptor	0	0	1	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
GABA theta subunit	1	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
Transient receptor potential cation channel subfamily V member 2	0	2	0	2
heat shock protein 90, putative	0	0	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Atrial natriuretic peptide receptor 1	0	1	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Glutamate dehydrogenase 1, mitochondrial	0	1	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
Metabotropic glutamate receptor 3	0	1	0	1
Chain A, Adipocyte Lipid-binding Protein	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
putative potassium channel subunit	0	0	1	1
serine-protein kinase ATM isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
peripheral myelin protein 22	2	0	0	2
histone acetyltransferase KAT2A isoform 1	2	0	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Trypsin	0	1	0	1
Fatty acid-binding protein, liver	0	0	1	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Coagulation factor VII	0	1	0	1
DNA topoisomerase 1	0	1	0	1
Aromatase	0	1	0	1
Tissue factor	0	1	0	1
Fatty acid-binding protein, adipocyte	0	2	0	2
Protein kinase C alpha type	0	0	1	2
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Fatty acid-binding protein 5	0	1	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Prolyl 4-hydroxylase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Tyrosine-protein kinase ABL1	0	0	1	1
Epidermal growth factor receptor	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
High affinity nerve growth factor receptor	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	0	1	1
Insulin receptor	0	0	1	1
Cyclin-dependent kinase 1	0	0	1	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Serine/threonine-protein kinase pim-1	0	0	1	1
Fibroblast growth factor receptor 1	0	0	1	1
DNA topoisomerase 2-alpha	0	0	1	1
Cytochrome P450 2C9	0	1	0	1
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Inosine-5'-monophosphate dehydrogenase 2	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	0	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Casein kinase II subunit alpha'	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Cyclin-dependent kinase 2	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
Cytochrome P450 2C19	0	1	0	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Alpha-synuclein	1	0	0	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	1	2
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Adenosine kinase	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	0	1	1
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	0	1	1
Tyrosine-protein kinase BTK	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Mitogen-activated protein kinase 14	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Misshapen-like kinase 1	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Aurora kinase B	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Serine/threonine-protein kinase ICK	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Carbonic anhydrase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (52)

Protein Targets (580)

Barth Syndrome

Synonyms(1)

Research Excerpts

Overview

Research

Studies (52)

Drugs Studied (35)

Protein Targets (580)