Page last updated: 2024-09-27

Autoimmune Pancreatitis

Chronic pancreatitis associated with autoimmune diseases.

Synonyms(7)

Synonym
Type 2 Autoimmune Pancreatitis
Type 1 AIP
Type 1 Autoimmune Pancreatitis
Type 2 AIP
Idiopathic Duct-centric Pancreatitis
Autoimmune Pancreatitis
IgG4-related Pancreatitis

Research Excerpts

Overview

ExcerptReference
"Autoimmune pancreatitis is uncommon, responds to steroids and is usually associated with diabetes mellitus."( Durruty A, P; Gómez G, P; López S, G; Pinto K, E; Vargas R, C, 2019)

Treatment

ExcerptReference
"Among 103 patients with treated type 1 AIP, 44 (42."( Asbach, P; Denecke, T; Hamm, B; Jin, ZY; Lai, YM; Tan, B; Wang, Q; Xue, HD; Zhang, W; Zheng, WY; Zhu, L, 2019)
"In treated type 1 AIP, although imaging pattern may differ, pancreaticobiliary lesions are usually manifestations of disease relapse."( Asbach, P; Denecke, T; Hamm, B; Jin, ZY; Lai, YM; Tan, B; Wang, Q; Xue, HD; Zhang, W; Zheng, WY; Zhu, L, 2019)
"Fecal samples were obtained from type 1 AIP patients before and after prednisolone (PSL) treatment and subjected to 16S ribosomal RNA sequencing to evaluate the composition of intestinal bacteria."( Hara, A; Kamata, K; Kudo, M; Minaga, K; Otsuka, Y; Park, AM; Sekai, I; Watanabe, T; Yoshikawa, T, 2020)

Research

Studies (30)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's5 (16.67)28.8240
2020's25 (83.33)9.53
DrugIndicatedRelationship StrengthStudiesTrials
1-anilino-8-naphthalenesulfonate0low10
azathioprine0low40
mesalamine0low10
prednisolone0low100
prednisone0low40
colchicine0low10
methylprednisolone0low20
fluorescein0low10
fluorodeoxyglucose f180low20
methotrexate0low10
tacrolimus0low10
gadolinium dtpa0low10
c-peptide0low20
cyclosporine0low10

Protein Targets (327)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain B, pheromone binding protein0011
Chain A, pheromone binding protein0011
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, RNA-directed RNA polymerase NS50101
acid sphingomyelinase2002
thioredoxin reductase4004
USP1 protein, partial5005
TDP1 protein7007
vitamin D3 receptor isoform VDRA4004
importin subunit beta-1 isoform 12002
flap endonuclease 13003
serine/threonine-protein kinase PLK11001
snurportin-12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
GTP-binding nuclear protein Ran isoform 11001
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)3003
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
geminin6006
DNA polymerase kappa isoform 15005
fibroblast growth factor 22 isoform 1 precursor0001
Mitogen-activated protein kinase 130101
Beta-lactamase0101
Transthyretin0011
Fatty acid-binding protein, intestinal0112
Fatty acid-binding protein, adipocyte0112
Cyclin-A20101
Cannabinoid receptor 10011
Cyclin-dependent kinase 20123
Choline O-acetyltransferase0101
Mitogen-activated protein kinase 120101
Guanine nucleotide-binding protein G1001
Fatty acid-binding protein 50011
Fatty acid-binding protein 50011
Mitogen-activated protein kinase 110101
Mitogen-activated protein kinase 140101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, Ferritin light chain5005
interleukin 82002
acetylcholinesterase3003
phosphopantetheinyl transferase3003
RAR-related orphan receptor gamma4004
SMAD family member 22002
ATAD5 protein, partial3003
Fumarate hydratase2002
SMAD family member 32002
GLI family zinc finger 35005
Microtubule-associated protein tau3003
AR protein8008
thioredoxin glutathione reductase2002
nuclear receptor subfamily 1, group I, member 34004
EWS/FLI fusion protein2002
glucocorticoid receptor [Homo sapiens]7007
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha7007
farnesoid X nuclear receptor4004
pregnane X nuclear receptor7007
estrogen nuclear receptor alpha9009
G2002
polyprotein2002
P531001
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma5005
arylsulfatase A1001
IDH14004
euchromatic histone-lysine N-methyltransferase 25005
aryl hydrocarbon receptor5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
thyroid stimulating hormone receptor2002
activating transcription factor 63003
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x3003
Bloom syndrome protein isoform 13003
peripheral myelin protein 22 isoform 11001
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a3003
thyroid hormone receptor beta isoform 26006
heat shock protein beta-12002
nuclear factor erythroid 2-related factor 2 isoform 16006
peripheral myelin protein 224004
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 82002
muscleblind-like protein 1 isoform 14004
muscarinic acetylcholine receptor M12002
lamin isoform A-delta103003
Gamma-aminobutyric acid receptor subunit pi3003
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40607
Bile salt export pump0202
Voltage-dependent calcium channel gamma-2 subunit4004
Bile salt export pump0707
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 2002
Cellular tumor antigen p537007
Gamma-aminobutyric acid receptor subunit beta-13003
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Glutamate receptor 24004
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Nuclear receptor ROR-gamma3003
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
GABA theta subunit3003
Inositol hexakisphosphate kinase 12002
Canalicular multispecific organic anion transporter 10606
ATPase family AAA domain-containing protein 56006
Ataxin-26006
Gamma-aminobutyric acid receptor subunit epsilon3003
Protein-arginine deiminase type-40303
cytochrome P450 2C9, partial2002
Chain A, Beta-lactamase1001
Luciferase2002
endonuclease IV1001
PAX80001
pregnane X receptor2002
hypoxia-inducible factor 1 alpha subunit4004
PPM1D protein2002
Thrombopoietin1001
Smad31001
thyroid stimulating hormone receptor1001
estrogen receptor 2 (ER beta)4004
cytochrome P450 family 3 subfamily A polypeptide 42002
67.9K protein2002
glucocerebrosidase1001
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
nuclear receptor subfamily 1, group I, member 23003
cytochrome P450 2D6 isoform 11001
nuclear receptor subfamily 0 group B member 10101
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor2002
chromobox protein homolog 12002
thyroid hormone receptor beta isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 25005
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A1001
steroidogenic factor 10101
caspase-1 isoform alpha precursor3003
lethal factor (plasmid)1001
neuropeptide S receptor isoform A1001
Solute carrier family 22 member 30101
Tubulin alpha-1A chain0213
Tubulin beta chain0213
Plasma kallikrein0001
Tubulin beta-4A chain0225
ATP-dependent translocase ABCB10101
Tubulin beta chain0225
ATP-dependent translocase ABCB10102
Cytochrome P450 3A40202
Tubulin alpha-3C chain0225
Serine/threonine-protein kinase pim-10101
ATP-dependent translocase ABCB10101
Histamine H2 receptor2002
Tubulin alpha-1B chain0225
Tubulin alpha-4A chain0225
Tubulin beta-4B chain0225
Vesicular acetylcholine transporter0101
Tubulin beta-3 chain0225
Tubulin beta-2A chain0225
Tubulin polymerization-promoting protein0011
Tubulin beta-8 chain0225
Tubulin beta-2B chain0202
Tubulin alpha-3E chain0225
Tubulin alpha-1A chain0225
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
CREB-binding protein1001
Tubulin alpha-1C chain0225
Tubulin beta-6 chain0225
Tubulin beta-2B chain0225
Tubulin beta-1 chain0225
ATP-dependent phosphofructokinase3003
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
progesterone receptor5005
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
histone acetyltransferase KAT2A isoform 13003
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase2002
15-lipoxygenase, partial2002
GLS protein1001
aldehyde dehydrogenase 1 family, member A13003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
microphthalmia-associated transcription factor isoform 90101
Solute carrier organic anion transporter family member 2B1 0001
Tumor necrosis factor0101
Neuraminidase0101
Prostaglandin G/H synthase 10101
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Platelet-activating factor receptor1001
Cystathionine gamma-lyase0101
Prostaglandin G/H synthase 20202
Caspase-72002
Spike glycoprotein3003
10 kDa heat shock protein, mitochondrial0101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Solute carrier organic anion transporter family member 1B30002
Cystine/glutamate transporter0101
Hydroxyacid oxidase 10101
Solute carrier organic anion transporter family member 1B10102
large T antigen0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
dopamine D1 receptor1001
ClpP1001
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
transcriptional regulator ERG isoform 31001
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20011
Thymidylate synthase0202
Integrin beta-31001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 431001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80001
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier family 22 member 110001
Broad substrate specificity ATP-binding cassette transporter ABCG20102
nonstructural protein 11001
bromodomain adjacent to zinc finger domain 2B1001
Nuclear receptor subfamily 1 group I member 20022
Glucocorticoid receptor06213
Glycine receptor subunit alpha-10606
Androgen receptor0303
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Nuclear receptor subfamily 1 group I member 20011
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Cytochrome P450 2C9 0101
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
nuclear receptor ROR-gamma isoform 12002
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 3A50101
UDP-glucuronosyltransferase 1A40001
Serine/threonine-protein kinase mTOR0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]