Page last updated: 2024-09-27

Autoimmune Lymphoproliferative Syndrome

Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY.

Synonyms(10)

Synonym
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant
Canale Smith Syndrome
Caspase 8 Deficiency
Canale-Smith Syndrome
Caspase-8 Deficiency
Autoimmune Lymphoproliferative Syndrome
Autoimmune Lymphoproliferative Syndrome, Type IIb
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant
Autoimmune Lymphoproliferative Syndrome Type 2B
Autoimmune Lymphoproliferative Syndrome Type 2B (ALPS2B)

Research Excerpts

Research

Studies (37)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's30 (81.08)28.8240
2020's7 (18.92)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetazolamide0low10
hydroxychloroquine0low10
prednisolone0low30
prednisone0low10
methylprednisolone0low10
pyrroles0low10
durapatite0low10
tricalcium phosphate0low10
danazol0low20
etoposide0low10
fluorodeoxyglucose f180medium11
bendamustine hydrochloride0low10
bh 30low10
pentostatin0low20
mycophenolic acid0low40
tamoxifen0low10
rasagiline0low10
sirolimus0low100
tofacitinib0low10
abt-7370low20
piperidines0low10
nitrophenols0low20
vitamin b 120low60

Protein Targets (935)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Apoptosis regulator Bcl-X0101
PPM1D protein4004
EWS/FLI fusion protein2002
Bcl-2-like protein 110101
Interferon beta6006
Beta-casein0101
Apoptosis regulator Bcl-20224
Alpha-1B adrenergic receptor0505
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Adenosine receptor A2a0202
BH3-interacting domain death agonist0202
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog0011
Apoptosis regulator BAX 0101
Bcl-2-like protein 10224
Induced myeloid leukemia cell differentiation protein Mcl-10202
Aspartyl/asparaginyl beta-hydroxylase0101
Bcl-2-related protein A10112
Bcl-2 homologous antagonist/killer0213
Bcl-2-like protein 20202
Bcl2-associated agonist of cell death 0101
Bcl-2-binding component 3, isoforms 1/20101
Bcl-2-like protein 100101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase2002
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
thioredoxin reductase1001
GALC protein1001
GLI family zinc finger 37007
nuclear receptor subfamily 1, group I, member 36006
cytochrome P450 family 3 subfamily A polypeptide 43003
glucocorticoid receptor [Homo sapiens]8008
retinoic acid nuclear receptor alpha variant 16006
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha9009
Carbonic anhydrase 0101
Carbonic anhydrase 0101
arylsulfatase A2002
Carbonic anhydrase0101
euchromatic histone-lysine N-methyltransferase 24004
Bloom syndrome protein isoform 11001
thyroid hormone receptor beta isoform a1001
nuclear factor erythroid 2-related factor 2 isoform 16006
geminin8008
peripheral myelin protein 224004
survival motor neuron protein isoform d2002
muscleblind-like protein 1 isoform 12002
Gamma-aminobutyric acid receptor subunit pi2103
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40707
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Carbonic anhydrase 120215
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Bile salt export pump0909
Glycogen phosphorylase, muscle form0101
Renin0202
Carbonic anhydrase 10217
Carbonic anhydrase 20216
Carbonic anhydrase 20202
Cytochrome P450 1A20202
Carbonic anhydrase 30215
Cathepsin B0101
Cytochrome P450 3A40505
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C0101
Polyunsaturated fatty acid 5-lipoxygenase0202
Cytochrome P450 2C80202
Cytochrome P450 2D60202
Cytochrome P450 2A60202
Cytochrome P450 2C9 0505
5-hydroxytryptamine receptor 2A0101
Androgen receptor0808
Gamma-aminobutyric acid receptor subunit beta-12103
Translocator protein0101
Gamma-aminobutyric acid receptor subunit delta2103
Gamma-aminobutyric acid receptor subunit gamma-22103
Gamma-aminobutyric acid receptor subunit alpha-52103
Gamma-aminobutyric acid receptor subunit alpha-32103
Cannabinoid receptor 10101
Arachidonate 5-lipoxygenase-activating protein0101
Cytochrome P450 2B60202
Carbonic anhydrase 40214
Carbonic anhydrase 60214
Gamma-aminobutyric acid receptor subunit gamma-12103
Gamma-aminobutyric acid receptor subunit alpha-22103
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10101
Serum paraoxonase/arylesterase 10202
Dipeptidyl peptidase 40001
Gamma-aminobutyric acid receptor subunit alpha-42103
Gamma-aminobutyric acid receptor subunit gamma-32103
Endochitinase0101
Gamma-aminobutyric acid receptor subunit alpha-62103
5-hydroxytryptamine receptor 2B0101
Sodium-dependent serotonin transporter0202
Delta-type opioid receptor0101
Cytochrome P450 2C190303
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Carbonic anhydrase 5A, mitochondrial0215
Carbonic anhydrase0101
Kappa-type opioid receptor0101
Carbonic anhydrase 70214
Carbonic anhydrase0101
D(1A) dopamine receptor1102
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase0101
D(2) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit alpha-12103
Gamma-aminobutyric acid receptor subunit beta-32103
Gamma-aminobutyric acid receptor subunit beta-22103
Cholinesterase0101
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Fatty-acid amide hydrolase 10101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Glutamate receptor ionotropic, NMDA 2B0203
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70101
Carbonic anhydrase 90215
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase 30101
Carbonic anhydrase0102
Carbonic anhydrase0102
Carbonic anhydrase 0101
Sigma intracellular receptor 20202
Delta carbonic anhydrase0101
Sigma non-opioid intracellular receptor 10101
Renin0101
Carbonic anhydrase 0101
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130214
GABA theta subunit2103
Canalicular multispecific organic anion transporter 10809
Carbonic anhydrase 40202
Carbonic anhydrase 150102
Acidic mammalian chitinase0101
Carbonic anhydrase 130203
Carbonic anhydrase 70101
Gamma-aminobutyric acid receptor subunit epsilon2103
Carbonic anhydrase 0101
Carbonic anhydrase 140215
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Carbonic anhydrase 5B, mitochondrial0215
phosphopantetheinyl transferase2002
USP1 protein, partial3003
huntingtin isoform 21001
glp-1 receptor, partial3003
pregnane X receptor2002
hypoxia-inducible factor 1 alpha subunit5005
RAR-related orphan receptor gamma5005
SMAD family member 24004
SMAD family member 34004
TDP1 protein7007
AR protein7007
estrogen receptor 2 (ER beta)4004
progesterone receptor7007
farnesoid X nuclear receptor3003
pregnane X nuclear receptor6006
estrogen nuclear receptor alpha7007
G2002
cytochrome P450 2D61001
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma4004
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
thyroid stimulating hormone receptor3003
v-jun sarcoma virus 17 oncogene homolog (avian)5005
nuclear receptor subfamily 1, group I, member 23003
Histone H2A.x4004
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
thyroid hormone receptor beta isoform 25005
heat shock protein beta-13003
Voltage-dependent calcium channel gamma-2 subunit5005
Rap guanine nucleotide exchange factor 31001
HLA class I histocompatibility antigen, B alpha chain 2002
Estrogen receptor0618
Glucocorticoid receptor08215
Sex hormone-binding globulin0011
Cellular tumor antigen p536006
Glycine receptor subunit alpha-10808
Aldo-keto reductase family 1 member B10404
Alpha-2A adrenergic receptor0505
Adenosine receptor A30404
Beta-3 adrenergic receptor0404
Alpha-2B adrenergic receptor0505
Alpha-2C adrenergic receptor0303
Glutamate receptor 25106
Muscarinic acetylcholine receptor M30505
Glycine receptor subunit beta0808
Substance-K receptor0404
D(1A) dopamine receptor0404
Glycine receptor subunit alpha-20808
Sodium-dependent noradrenaline transporter 0404
Glycine receptor subunit alpha-30808
5-hydroxytryptamine receptor 2A0404
Sodium-dependent serotonin transporter0404
Mu-type opioid receptor0404
D(3) dopamine receptor0404
Kappa-type opioid receptor0404
Alpha-1A adrenergic receptor0404
Cytochrome P450 2J20303
Spike glycoprotein2024
Sodium-dependent dopamine transporter 0404
Inositol hexakisphosphate kinase 12002
ATPase family AAA domain-containing protein 56006
Ataxin-26006
cytochrome P450 2C9, partial2002
caspase 7, apoptosis-related cysteine protease2002
67.9K protein4004
caspase-32002
LMP1 [Human herpesvirus 4]0001
activating transcription factor 63003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
chromobox protein homolog 12002
nuclear factor erythroid 2-related factor 2 isoform 25005
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
DNA polymerase iota isoform a (long)1001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Prothrombin0001
Regulatory protein E20011
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10517
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0139
Polyunsaturated fatty acid lipoxygenase ALOX150101
DNA topoisomerase 20001
ATP-dependent translocase ABCB10101
UDP-glucuronosyltransferase 1A1 0002
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta01310
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0101
Integrase 0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0001
Solute carrier organic anion transporter family member 1B30202
Glutamate receptor ionotropic, NMDA 3A0001
Genome polyprotein 0101
Spike glycoprotein0022
Replicase polyprotein 1ab0022
lamin isoform A-delta102002
Transmembrane protease serine 20022
Procathepsin L0022
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40303
Muscarinic acetylcholine receptor M50303
Replicase polyprotein 1a0022
Replicase polyprotein 1ab0022
Replicase polyprotein 1ab0123
Replicase polyprotein 1ab0123
Muscarinic acetylcholine receptor M10303
Alpha-1D adrenergic receptor0404
Potassium voltage-gated channel subfamily H member 20303
Sigma intracellular receptor 20101
Cyclic GMP-AMP synthase0101
Sigma non-opioid intracellular receptor 10303
Angiotensin-converting enzyme 2 0022
Toll-like receptor 90101
Toll-like receptor 70101
acetylcholinesterase3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
nonstructural protein 11001
bromodomain adjacent to zinc finger domain 2B2002
IDH12002
Nuclear receptor subfamily 1 group I member 20022
Nuclear receptor subfamily 1 group I member 20011
ATP-dependent phosphofructokinase1001
Chain A, Inosine-5'-Monophosphate Dehydrogenase 20101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase1001
aldehyde dehydrogenase 1 family, member A12002
aryl hydrocarbon receptor2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
cytochrome P450 3A4 isoform 12002
lethal factor (plasmid)2002
UDP-glucuronosyltransferase 1A90001
Inosine-5'-monophosphate dehydrogenase 20213
Glutamate receptor 10101
Glutamate receptor 30101
Glutamate receptor 40101
Inosine-5'-monophosphate dehydrogenase 1 0202
Peroxisome proliferator-activated receptor gamma0011
Alpha-synuclein3003
TAR DNA-binding protein 431001
Inosine-5'-monophosphate dehydrogenase0102
UDP-glucuronosyltransferase 1A70001
UDP-glucuronosyltransferase 1A100001
UDP-glucuronosyltransferase 1A80001
Adenosine deaminase0101
Adenosine deaminase 0101
Adenosine deaminase 0101
luciferase0001
Fatty acid-binding protein, liver0101
Progesterone receptor0304
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Prostaglandin G/H synthase 20112
Nociceptin receptor0011
Estrogen receptor beta0415
thioredoxin glutathione reductase1001
vitamin D3 receptor isoform VDRA2002
nuclear receptor ROR-gamma isoform 13003
Nuclear receptor ROR-gamma1001
Cholinesterase0101
Amine oxidase [flavin-containing] B0202
Amine oxidase [flavin-containing] A 0202
Amine oxidase [flavin-containing] A0202
Acetylcholinesterase0101
Amine oxidase [flavin-containing] B0202
5-hydroxytryptamine receptor 60303
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] B0101
Smad31001
Bone morphogenetic protein receptor type-1B0022
Cell division cycle 7-related protein kinase0011
Serine/threonine-protein kinase PLK40022
ATP-dependent RNA helicase DDX3X0022
Pyridoxal kinase0022
Citron Rho-interacting kinase0022
Serine/threonine-protein kinase Chk10123
Aurora kinase A0022
Cyclin-G-associated kinase0022
Ephrin type-B receptor 60022
Peroxisomal acyl-coenzyme A oxidase 30022
Receptor-interacting serine/threonine-protein kinase 20022
Mitotic checkpoint serine/threonine-protein kinase BUB10022
Dynamin-like 120 kDa protein, mitochondrial0022
Tyrosine-protein kinase JAK20338
Eukaryotic translation initiation factor 5B0011
Rho-associated protein kinase 20123
Serine/threonine-protein kinase ULK10022
Serine/threonine-protein kinase/endoribonuclease IRE10022
Ribosomal protein S6 kinase alpha-50123
U5 small nuclear ribonucleoprotein 200 kDa helicase0022
Ribosomal protein S6 kinase alpha-40022
Serine/threonine-protein kinase 160022
Cyclin-dependent kinase-like 50022
Serine/threonine-protein kinase 100022
Serine/threonine-protein kinase D30123
Structural maintenance of chromosomes protein 20011
Mitogen-activated protein kinase kinase kinase 60022
Mitogen-activated protein kinase kinase kinase kinase 40022
Serine/threonine-protein kinase LATS10022
Serine/threonine-protein kinase PAK 40022
Tyrosine-protein kinase ABL10022
Epidermal growth factor receptor0224
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
High affinity nerve growth factor receptor0022
ADP/ATP translocase 20022
Protein kinase C beta type0123
Insulin receptor0123
Tyrosine-protein kinase Lck0224
Tyrosine-protein kinase Fyn0123
Cyclin-dependent kinase 10022
Eukaryotic translation initiation factor 4E0011
Glycogen phosphorylase, liver form0022
Tyrosine-protein kinase Fes/Fps0022
Adenine phosphoribosyltransferase0011
Tyrosine-protein kinase Yes0022
Tyrosine-protein kinase Lyn0022
Proto-oncogene tyrosine-protein kinase receptor Ret0022
Insulin-like growth factor 1 receptor0022
Signal recognition particle receptor subunit alpha0022
Cytochrome c1, heme protein, mitochondrial0022
Hepatocyte growth factor receptor0022
Tyrosine-protein kinase HCK0022
Platelet-derived growth factor receptor beta0022
Tyrosine-protein kinase Fgr0022
Serine/threonine-protein kinase A-Raf0022
Glycogen phosphorylase, brain form0022
Breakpoint cluster region protein0022
Serine/threonine-protein kinase pim-10022
Fibroblast growth factor receptor 10022
Cyclin-dependent kinase 40022
ADP/ATP translocase 30022
Proto-oncogene tyrosine-protein kinase Src0022
cAMP-dependent protein kinase type II-alpha regulatory subunit0011
Serine/threonine-protein kinase B-raf0022
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0022
Ribosyldihydronicotinamide dehydrogenase [quinone]0022
Tyrosine-protein kinase Fer0022
Protein kinase C alpha type0224
cAMP-dependent protein kinase catalytic subunit alpha0022
General transcription and DNA repair factor IIH helicase subunit XPD0022
Casein kinase II subunit alpha'0022
Ras-related protein Rab-6A0022
Ephrin type-A receptor 10022
Multifunctional protein ADE20022
cAMP-dependent protein kinase catalytic subunit beta0022
Ferrochelatase, mitochondrial0022
Ribosomal protein S6 kinase beta-10123
Tyrosine-protein kinase JAK10338
Cyclin-dependent kinase 20123
Beta-adrenergic receptor kinase 10022
Probable ATP-dependent RNA helicase DDX60022
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Mitogen-activated protein kinase 3 0022
MAP/microtubule affinity-regulating kinase 30022
Deoxycytidine kinase0022
Mitogen-activated protein kinase 10022
Ephrin type-A receptor 20022
Ephrin type-B receptor 20022
Non-receptor tyrosine-protein kinase TYK20338
UMP-CMP kinase 0011
Phosphatidylethanolamine-binding protein 10011
Wee1-like protein kinase0022
Heme oxygenase 20022
S-adenosylmethionine synthase isoform type-20022
DnaJ homolog subfamily A member 10022
RAC-alpha serine/threonine-protein kinase0123
RAC-beta serine/threonine-protein kinase0022
Dual specificity protein kinase TTK0022
DNA replication licensing factor MCM40011
Myosin-100011
Dual specificity mitogen-activated protein kinase kinase 20022
Receptor-type tyrosine-protein kinase FLT30022
Bone morphogenetic protein receptor type-1A0022
Activin receptor type-1B0022
TGF-beta receptor type-10022
Serine/threonine-protein kinase receptor R30022
TGF-beta receptor type-20022
Electron transfer flavoprotein subunit beta0011
Tyrosine-protein kinase CSK0123
Glycine--tRNA ligase0022
Protein kinase C iota type0123
Exosome RNA helicase MTR40022
Serine/threonine-protein kinase mTOR0123
Tyrosine-protein kinase Tec0123
Tyrosine-protein kinase ABL20022
Tyrosine-protein kinase FRK0022
G protein-coupled receptor kinase 60011
Tyrosine-protein kinase SYK0022
26S proteasome regulatory subunit 6B0022
Mitogen-activated protein kinase 80123
Mitogen-activated protein kinase 90022
Dual specificity mitogen-activated protein kinase kinase 30022
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Casein kinase I isoform alpha0022
Casein kinase I isoform delta0022
MAP kinase-activated protein kinase 20123
Elongation factor Tu, mitochondrial0022
Choline-phosphate cytidylyltransferase A0011
Cysteine--tRNA ligase, cytoplasmic0022
Casein kinase I isoform epsilon0022
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0022
Dual specificity protein kinase CLK10022
Dual specificity protein kinase CLK20022
Dual specificity protein kinase CLK30022
Glycogen synthase kinase-3 alpha0022
Glycogen synthase kinase-3 beta0123
Cyclin-dependent kinase 70022
Cyclin-dependent kinase 90022
Ras-related protein Rab-27A0011
Interleukin-1 receptor-associated kinase 10022
Ribosomal protein S6 kinase alpha-30123
Serine/threonine-protein kinase Nek20022
Serine/threonine-protein kinase Nek30022
Dual specificity mitogen-activated protein kinase kinase 60022
Serine/threonine-protein kinase PLK10022
LIM domain kinase 10022
LIM domain kinase 20022
Mitogen-activated protein kinase 100022
Tyrosine--tRNA ligase, cytoplasmic0022
5'-AMP-activated protein kinase subunit gamma-10022
Ephrin type-B receptor 30022
Ephrin type-A receptor 50022
Ephrin type-B receptor 40022
Ephrin type-A receptor 40022
Adenylate kinase 2, mitochondrial0022
Adenosine kinase0022
Ras-related protein Rab-100022
Actin-related protein 30022
Actin-related protein 20011
GTP-binding nuclear protein Ran0022
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Casein kinase I isoform gamma-20022
Cyclin-dependent kinase 60022
Cyclin-dependent-like kinase 5 0123
Cyclin-dependent kinase 160022
Cyclin-dependent kinase 170022
ATP-dependent 6-phosphofructokinase, platelet type0022
Dual specificity mitogen-activated protein kinase kinase 10022
Protein kinase C theta type0123
Activin receptor type-10022
Macrophage-stimulating protein receptor0022
Focal adhesion kinase 10022
Protein kinase C zeta type0112
Protein kinase C delta type0123
Tyrosine-protein kinase BTK0123
Cyclin-dependent kinase 180022
Activated CDC42 kinase 10022
Epithelial discoidin domain-containing receptor 10022
Mitogen-activated protein kinase kinase kinase kinase 20022
Tyrosine-protein kinase Mer0022
Serine/threonine-protein kinase 40022
5'-AMP-activated protein kinase catalytic subunit alpha-10022
Dual specificity mitogen-activated protein kinase kinase 50022
Mitogen-activated protein kinase 70022
Serine/threonine-protein kinase PAK 20022
Serine/threonine-protein kinase 30022
Mitogen-activated protein kinase kinase kinase 10022
Integrin-linked protein kinase0022
Peptidyl-prolyl cis-trans isomerase FKBP50101
Rho-associated protein kinase 10022
Non-receptor tyrosine-protein kinase TNK10022
Calcium/calmodulin-dependent protein kinase type II subunit gamma0022
Calcium/calmodulin-dependent protein kinase type II subunit delta0022
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0022
Activin receptor type-2B0022
Bone morphogenetic protein receptor type-20022
Protein-tyrosine kinase 60022
cGMP-dependent protein kinase 1 0022
Cyclin-dependent kinase 130022
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0022
Protein-tyrosine kinase 2-beta0022
Maternal embryonic leucine zipper kinase0022
Structural maintenance of chromosomes protein 1A0011
Chromodomain-helicase-DNA-binding protein 40022
Peroxisomal acyl-coenzyme A oxidase 10011
Delta(24)-sterol reductase0011
Ribosomal protein S6 kinase alpha-10022
Dual specificity testis-specific protein kinase 10022
Myosin light chain kinase, smooth muscle0022
Mitogen-activated protein kinase 110123
Serine/threonine-protein kinase STK110022
Serine/threonine-protein kinase N10022
Serine/threonine-protein kinase N20022
Mitogen-activated protein kinase 140123
Calcium/calmodulin-dependent protein kinase type IV0022
Mitogen-activated protein kinase kinase kinase 110022
Discoidin domain-containing receptor 20022
AP2-associated protein kinase 10022
Myosin light chain kinase 30022
Uncharacterized aarF domain-containing protein kinase 50022
Programmed cell death protein 40011
Putative heat shock protein HSP 90-beta 20022
Serine/threonine-protein kinase MRCK alpha0022
Serine/threonine-protein kinase MRCK gamma0022
Acyl-CoA dehydrogenase family member 100022
Serine/threonine-protein kinase N30011
Serine/threonine-protein kinase ULK30022
Uncharacterized protein FLJ452520022
Acyl-CoA dehydrogenase family member 110011
Serine/threonine-protein kinase/endoribonuclease IRE20022
Serine/threonine-protein kinase MARK20022
ATP-dependent RNA helicase DHX300022
Serine/threonine-protein kinase TAO10022
STE20-related kinase adapter protein alpha0022
Myosin-140022
AarF domain-containing protein kinase 10022
Mitogen-activated protein kinase kinase kinase kinase 30022
MAP kinase-activated protein kinase 50123
Regulatory-associated protein of mTOR0101
Misshapen-like kinase 10022
Atypical kinase COQ8A, mitochondrial0022
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0022
Mitogen-activated protein kinase 150022
Serine/threonine-protein kinase Nek90022
ATP-dependent RNA helicase DDX10022
Mitogen-activated protein kinase kinase kinase kinase 10022
Aurora kinase B0022
MAP/microtubule affinity-regulating kinase 40022
Calcium/calmodulin-dependent protein kinase type 1G0022
Serine/threonine-protein kinase Nek10022
PAS domain-containing serine/threonine-protein kinase0022
Calcium/calmodulin-dependent protein kinase kinase 20022
EKC/KEOPS complex subunit TP53RK0022
Dual specificity testis-specific protein kinase 20022
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0022
Mitogen-activated protein kinase kinase kinase 50022
Mitogen-activated protein kinase kinase kinase 30022
Eukaryotic translation initiation factor 2-alpha kinase 10022
Target of rapamycin complex subunit LST80101
Nucleolar GTP-binding protein 10022
Serine/threonine-protein kinase D20022
RNA cytidine acetyltransferase0022
Serine/threonine-protein kinase SIK20022
STE20-like serine/threonine-protein kinase 0022
Serine/threonine-protein kinase TAO30022
dCTP pyrophosphatase 10022
Dual specificity protein kinase CLK40022
Casein kinase I isoform gamma-10022
Serine/threonine-protein kinase mTOR 0101
Phenylalanine--tRNA ligase beta subunit0022
Isoleucine--tRNA ligase, mitochondrial0011
BMP-2-inducible protein kinase0022
Obg-like ATPase 10011
Midasin0022
Interleukin-1 receptor-associated kinase 40022
Mitogen-activated protein kinase kinase kinase 200022
Cyclin-dependent kinase 120022
Serine/threonine-protein kinase 260022
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0022
Serine/threonine-protein kinase NLK0022
5'-AMP-activated protein kinase subunit gamma-20022
Serine/threonine-protein kinase TBK10123
Septin-90022
Ribosomal protein S6 kinase alpha-60022
TRAF2 and NCK-interacting protein kinase0022
Serine/threonine-protein kinase TAO20022
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Serine/threonine-protein kinase ICK0022
RAC-gamma serine/threonine-protein kinase0022
Serine/threonine-protein kinase SIK30022
Mitogen-activated protein kinase kinase kinase 20022
Thyroid hormone receptor-associated protein 30022
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0022
Mitogen-activated protein kinase kinase kinase kinase 50022
Receptor-interacting serine/threonine-protein kinase 30022
Serine/threonine-protein kinase MRCK beta0022
Interleukin-1 receptor-associated kinase 30022
Serine/threonine-protein kinase 240022
Solute carrier organic anion transporter family member 1B10101
Casein kinase I isoform gamma-30022
Mitogen-activated protein kinase kinase kinase 40022
Chain A, CES1 protein0101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, Ferritin light chain1001
Fumarate hydratase1001
Microtubule-associated protein tau1001
apical membrane antigen 1, AMA11001
DNA polymerase III, partial1001
regulator of G-protein signaling 41001
polyprotein1001
glucocerebrosidase1001
thyrotropin-releasing hormone receptor1001
Caspase-71001
cytochrome P450 2D6 isoform 11001
NPC intracellular cholesterol transporter 1 precursor1001
cellular tumor antigen p53 isoform a1001
interferon gamma precursor0001
D(1A) dopamine receptor1001
transcriptional regulator ERG isoform 31001
caspase-31001
ubiquitin-conjugating enzyme E2 N0101
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
M-phase phosphoprotein 81001
streptokinase A precursor0011
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
5-hydroxytryptamine receptor 40202
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20213
Integrin beta-31001
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Estrogen receptor0012
Integrin alpha-IIb1001
Beta-1 adrenergic receptor0202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
5-hydroxytryptamine receptor 1A0303
D(4) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Prostaglandin G/H synthase 10101
Thromboxane-A synthase 0101
Protein kinase C eta type0112
Histamine H2 receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0202
B2 bradykinin receptor0202
Adenosine receptor A10202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Delta-type opioid receptor0202
5-hydroxytryptamine receptor 2B0202
Melanocortin receptor 30202
Histamine H2 receptor1001
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Protein kinase C epsilon type0112
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10112
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Emopamil-binding protein-like0101
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
Chain A, Tyrosine-protein kinase0101
Chain A, Tyrosine-protein kinase0101
Chain A, Tyrosine-protein kinase JAK20101
Leukotriene C4 synthase0011
tyrosine-protein kinase Yes1001
Serine/threonine-protein kinase Sgk10101
Membrane-associated progesterone receptor component 10011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0011
Serine/threonine-protein kinase 250011
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0011
Serine/threonine-protein kinase RIO30011
Dual specificity mitogen-activated protein kinase kinase 70112
Inhibitor of nuclear factor kappa-B kinase subunit beta0011
Peripheral plasma membrane protein CASK0011
Serine/threonine-protein kinase DCLK10011
Inhibitor of nuclear factor kappa-B kinase subunit alpha0011
Muscle, skeletal receptor tyrosine-protein kinase0011
Mitogen-activated protein kinase 130112
3-phosphoinositide-dependent protein kinase 10011
Mitogen-activated protein kinase kinase kinase 130011
Death-associated protein kinase 30011
Mitogen-activated protein kinase kinase kinase 70011
NUAK family SNF1-like kinase 10011
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma0011
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma0011
Serine/threonine-protein kinase PAK 30011
Serine/threonine-protein kinase 17B0011
Cyclin-dependent kinase 140011
Serine/threonine-protein kinase OSR10011
Serine/threonine-protein kinase Chk20011
RAF proto-oncogene serine/threonine-protein kinase0011
Macrophage colony-stimulating factor 1 receptor0011
Proto-oncogene tyrosine-protein kinase ROS0011
Wee1-like protein kinase 20011
Uncharacterized serine/threonine-protein kinase SBK30011
Mast/stem cell growth factor receptor Kit0011
Myosin light chain kinase, smooth muscle0011
Insulin receptor-related protein0011
Platelet-derived growth factor receptor alpha0011
Vascular endothelial growth factor receptor 1 0011
Interferon-induced, double-stranded RNA-activated protein kinase0011
Serine/threonine-protein kinase MAK0011
Cyclin-dependent kinase 11B0011
Fibroblast growth factor receptor 20011
Receptor tyrosine-protein kinase erbB-30011
Fibroblast growth factor receptor 40011
Fibroblast growth factor receptor 30011
cAMP-dependent protein kinase catalytic subunit gamma0011
Activin receptor type-2A0011
Ephrin type-A receptor 30011
Ephrin type-A receptor 80011
Leukocyte tyrosine kinase receptor0011
Tyrosine-protein kinase receptor UFO0011
Mitogen-activated protein kinase 40011
G protein-coupled receptor kinase 40011
Tyrosine-protein kinase receptor Tie-10011
Vascular endothelial growth factor receptor 30011
Vascular endothelial growth factor receptor 20011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0112
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0011
Megakaryocyte-associated tyrosine-protein kinase0011
Tyrosine-protein kinase TXK0112
Tyrosine-protein kinase ZAP-700011
Dual specificity mitogen-activated protein kinase kinase 40011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0011
Cyclin-dependent kinase 80011
Tyrosine-protein kinase Blk0112
Cytoplasmic tyrosine-protein kinase BMX0112
cAMP-dependent protein kinase catalytic subunit PRKX0011
Serine/threonine-protein kinase Nek40011
Tyrosine-protein kinase JAK30328
Death-associated protein kinase 10011
Mitogen-activated protein kinase 120112
5'-AMP-activated protein kinase catalytic subunit alpha-20011
Ephrin type-B receptor 10011
Hormonally up-regulated neu tumor-associated kinase0011
Serine/threonine-protein kinase SIK10011
Receptor-interacting serine/threonine-protein kinase 40011
Cell division control protein 2 homolog0011
Calcium-dependent protein kinase 10011
Tubulin alpha-1A chain0011
Casein kinase II subunit alpha0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta0011
SRSF protein kinase 20011
Mitogen-activated protein kinase kinase kinase 90011
Serine/threonine-protein kinase PknB0011
Cyclin-dependent kinase 30011
Cyclin-dependent kinase-like 10011
Angiopoietin-1 receptor0011
Mitogen-activated protein kinase kinase kinase 100011
Tyrosine-protein kinase receptor TYRO30011
Tyrosine-protein kinase ITK/TSK0112
Myotonin-protein kinase0011
Mitogen-activated protein kinase kinase kinase 120011
Serine/threonine-protein kinase PAK 10011
cGMP-dependent protein kinase 20011
Serine/threonine-protein kinase PRP4 homolog0011
Serine/threonine-protein kinase ATR0011
Receptor-interacting serine/threonine-protein kinase 10011
Calcium/calmodulin-dependent protein kinase type II subunit beta0011
Calcium/calmodulin-dependent protein kinase type 10011
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial0101
Serine/threonine-protein kinase 380011
Receptor tyrosine-protein kinase erbB-40112
Ribosomal protein S6 kinase alpha-20011
Ephrin type-A receptor 70011
Rhodopsin kinase GRK10011
NT-3 growth factor receptor0011
BDNF/NT-3 growth factors receptor0011
Mitogen-activated protein kinase 60011
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform0011
Serine/threonine-protein kinase SBK10011
Mitogen-activated protein kinase kinase kinase 190011
Serine/threonine-protein kinase TNNI3K0011
Rab-like protein 30011
Leucine-rich repeat serine/threonine-protein kinase 20011
Tyrosine-protein kinase JAK30101
Tyrosine-protein kinase JAK20101
Tyrosine-protein kinase JAK30101
Serine/threonine-protein kinase Nek50011
Dual serine/threonine and tyrosine protein kinase0011
Mitogen-activated protein kinase kinase kinase 150011
Serine/threonine-protein kinase tousled-like 20011
Serine/threonine-protein kinase 32C0011
Serine/threonine-protein kinase pim-30011
Serine/threonine-protein kinase VRK20011
Myosin light chain kinase family member 40011
Homeodomain-interacting protein kinase 10011
Calcium/calmodulin-dependent protein kinase type 1D0011
Cyclin-dependent kinase-like 30011
Serine/threonine-protein kinase BRSK20011
Serine/threonine-protein kinase NIM10011
Serine/threonine-protein kinase ULK20011
Serine/threonine-protein kinase DCLK20011
Calcium/calmodulin-dependent protein kinase kinase 10011
Casein kinase I isoform alpha-like0011
Homeodomain-interacting protein kinase 40011
Myosin-IIIa0011
Ankyrin repeat and protein kinase domain-containing protein 10011
Serine/threonine-protein kinase Nek110011
Serine/threonine-protein kinase BRSK10011
Serine/threonine-protein kinase 350011
Serine/threonine-protein kinase Nek70011
Rhodopsin kinase GRK70011
Serine/threonine-protein kinase 32A0011
Myosin-IIIb0011
Dual specificity tyrosine-phosphorylation-regulated kinase 20011
Cyclin-dependent kinase-like 20011
Serine/threonine-protein kinase Sgk30011
Atypical kinase COQ8B, mitochondrial0011
Cyclin-dependent kinase 150011
SRSF protein kinase 10011
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha0011
Serine/threonine-protein kinase RIO10011
MAP kinase-interacting serine/threonine-protein kinase 10011
Serine/threonine-protein kinase RIO20011
Cyclin-dependent kinase 190011
Transient receptor potential cation channel subfamily M member 60011
Testis-specific serine/threonine-protein kinase 10011
Serine/threonine-protein kinase 330011
Serine/threonine-protein kinase DCLK30011
NUAK family SNF1-like kinase 20011
Myosin light chain kinase 2, skeletal/cardiac muscle0011
Homeodomain-interacting protein kinase 20011
Tyrosine-protein kinase Srms0011
Homeodomain-interacting protein kinase 30011
Serine/threonine-protein kinase PLK30011
MAP kinase-interacting serine/threonine-protein kinase 20011
Serine/threonine-protein kinase Nek60011
Serine/threonine-protein kinase PAK 60011
SNF-related serine/threonine-protein kinase0011
Serine/threonine-protein kinase LATS20011
Serine/threonine-protein kinase 360011
Serine/threonine-protein kinase 32B0011
Serine/threonine-protein kinase PLK20011
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130011
Serine/threonine-protein kinase MARK10011
Serine/threonine-protein kinase pim-20011
Serine/threonine-protein kinase PAK 50011
eIF-2-alpha kinase GCN20011
Phosphatidylinositol 4-kinase beta0011
Serine/threonine-protein kinase 17A0011
STE20/SPS1-related proline-alanine-rich protein kinase0011
Ephrin type-A receptor 60011
Death-associated protein kinase 20011
Serine/threonine-protein kinase tousled-like 10011
Long-chain-fatty-acid--CoA ligase 50011
ALK tyrosine kinase receptor0011
SRSF protein kinase 30011
Cyclin-dependent kinase 11A0011
Aurora kinase C0011
Calcium/calmodulin-dependent protein kinase type II subunit alpha0011
Serine/threonine-protein kinase 38-like0011
Microtubule-associated serine/threonine-protein kinase 10011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]