Page last updated: 2024-09-28

Aschoff Bodies

A small round or oval, mostly subcutaneous nodule made up chiefly of a mass of Aschoff bodies and seen in cases of rheumatic fever. It is differentiated from the RHEUMATOID NODULE which appears in rheumatoid arthritis, most frequently over bony prominences. (From Dorland, 27th ed)

Synonyms(2)

Synonym
Aschoff Bodies
Rheumatic Nodule

Research

Studies (49)

TimeframeStudies, This Condition (%)All Conditions %
pre-199029 (59.18)23.3326
1990's8 (16.33)12.5806
2000's5 (10.20)18.1394
2010's7 (14.29)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
formaldehyde0low10
uric acid0low40
aspirin0low30
azathioprine0low10
cetirizine0low10
chloroquine0low10
cimetidine0low10
hydroxychloroquine0low20
pamidronate0low10
prednisolone0low10
thyroxine0low10
prednisone0low80
colchicine0low40
methylprednisolone0low10
gold0low20
trolamine salicylate0low140
homocysteine0low10
methotrexate0low110
cortisone0low10
fibrin0low10
retinol0low10
acid phosphatase0low10
ubiquinone0low10
egg white0low10
tetracycline0low10
salicylates0low10
vitamin b 120low10
allopurinol0low10

Protein Targets (543)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
interleukin 86006
TDP1 protein110011
AR protein130013
thyroid stimulating hormone receptor6006
estrogen receptor 2 (ER beta)5005
progesterone receptor7007
glucocorticoid receptor [Homo sapiens]110011
estrogen-related nuclear receptor alpha130013
estrogen nuclear receptor alpha150015
IDH17007
euchromatic histone-lysine N-methyltransferase 2120012
Bloom syndrome protein isoform 15005
transcriptional regulator ERG isoform 33003
thyroid hormone receptor beta isoform 29009
ras-related protein Rab-9A2002
nuclear factor erythroid 2-related factor 2 isoform 1110011
geminin110011
survival motor neuron protein isoform d5005
lamin isoform A-delta10100010
ATP-binding cassette sub-family C member 3012012
Multidrug resistance-associated protein 4012013
Polyphenol oxidase 20101
Voltage-dependent calcium channel gamma-2 subunit5005
Bile salt export pump014014
Hypoxanthine-guanine phosphoribosyltransferase0001
Cellular tumor antigen p53100010
Glutamate receptor 25005
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase 0101
Adenosine receptor A2a0011
Xanthine dehydrogenase/oxidase0202
Nuclear receptor ROR-gamma0101
Xanthine dehydrogenase/oxidase0214
Purine nucleoside phosphorylase0011
TAR DNA-binding protein 435005
Canalicular multispecific organic anion transporter 1011011
Shiga toxin subunit A0101
Histamine H3 receptor0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, 2-oxoglutarate Oxygenase3003
GTP-binding protein (rab7)0011
ras protein, partial0011
thioredoxin reductase9009
GLS protein4004
aldehyde dehydrogenase 1 family, member A16006
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 44004
EWS/FLI fusion protein7007
retinoic acid nuclear receptor alpha variant 19009
cytochrome P450 2D62002
glucocerebrosidase2002
peroxisome proliferator-activated receptor delta7007
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
DNA polymerase iota isoform a (long)4004
DNA polymerase kappa isoform 15005
muscarinic acetylcholine receptor M16006
lethal factor (plasmid)2002
Prostaglandin-H2 D-isomerase0101
Solute carrier family 22 member 60505
Prostaglandin G/H synthase 1 0303
Prostaglandin G/H synthase 2 0303
Epidermal growth factor receptor0202
Carbonic anhydrase 10404
Carbonic anhydrase 20415
Fatty acid-binding protein, liver0303
Integrin beta-31102
Myeloperoxidase0101
Prostaglandin G/H synthase 10404
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb1102
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10404
Adenosine receptor A10202
Adenosine receptor A2a0202
Substance-P receptor0202
Prostaglandin G/H synthase 20505
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0202
Nuclear receptor ROR-gamma5005
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-16107
Prostaglandin G/H synthase 20303
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200303
Solute carrier family 22 member 60303
Sigma non-opioid intracellular receptor 10213
Sigma non-opioid intracellular receptor 10011
Chain A, Ferritin light chain3003
acetylcholinesterase4004
phosphopantetheinyl transferase5005
RAR-related orphan receptor gamma9009
SMAD family member 22002
ATAD5 protein, partial5005
Fumarate hydratase2002
SMAD family member 32002
GLI family zinc finger 37007
Microtubule-associated protein tau4004
thioredoxin glutathione reductase2002
nuclear receptor subfamily 1, group I, member 38008
retinoid X nuclear receptor alpha9009
farnesoid X nuclear receptor4004
pregnane X nuclear receptor9009
G6006
polyprotein2002
P531001
peroxisome proliferator activated receptor gamma9009
arylsulfatase A4004
aryl hydrocarbon receptor6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
thyroid stimulating hormone receptor3003
activating transcription factor 62002
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x4004
peripheral myelin protein 22 isoform 12002
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a3003
heat shock protein beta-13003
peripheral myelin protein 225005
cytochrome P450 3A4 isoform 16006
M-phase phosphoprotein 84004
muscleblind-like protein 1 isoform 16006
Gamma-aminobutyric acid receptor subunit pi6006
Bile salt export pump0303
Interferon beta9009
HLA class I histocompatibility antigen, B alpha chain 6006
Gamma-aminobutyric acid receptor subunit beta-16006
Gamma-aminobutyric acid receptor subunit delta6006
Gamma-aminobutyric acid receptor subunit gamma-26006
Gamma-aminobutyric acid receptor subunit alpha-56006
Gamma-aminobutyric acid receptor subunit alpha-36006
Gamma-aminobutyric acid receptor subunit gamma-16006
Gamma-aminobutyric acid receptor subunit alpha-26006
Gamma-aminobutyric acid receptor subunit alpha-46006
Gamma-aminobutyric acid receptor subunit gamma-36006
Gamma-aminobutyric acid receptor subunit alpha-66006
Gamma-aminobutyric acid receptor subunit beta-36006
Gamma-aminobutyric acid receptor subunit beta-26006
GABA theta subunit6006
Inositol hexakisphosphate kinase 16006
ATPase family AAA domain-containing protein 55005
Ataxin-26006
Gamma-aminobutyric acid receptor subunit epsilon6006
Protein-arginine deiminase type-40303
cytochrome P450 2C9, partial6006
atrial natriuretic peptide receptor 2 precursor2002
Histamine H1 receptor0101
Angiopoietin-1 receptor0011
Potassium voltage-gated channel subfamily H member 20404
Multidrug and toxin extrusion protein 10303
Histamine H4 receptor0202
ATP-dependent phosphofructokinase6006
PPM1D protein3003
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
Spike glycoprotein0123
Replicase polyprotein 1ab0134
glucose-6-phosphate 1-dehydrogenase isoform b0101
flap endonuclease 14004
Transmembrane protease serine 20123
Dihydrofolate reductase 0202
DNA ligase0101
Riboflavin-binding protein0011
Major prion protein0011
Amyloid-beta precursor protein0202
Histidine-rich protein PFHRP-II0102
Procathepsin L0123
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40202
Cytochrome P450 3A40404
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Replicase polyprotein 1a0123
Replicase polyprotein 1ab0123
Replicase polyprotein 1ab0224
Spike glycoprotein0101
Replicase polyprotein 1ab0224
Muscarinic acetylcholine receptor M10202
Ribosyldihydronicotinamide dehydrogenase [quinone]0101
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
DNA ligase 10101
Muscarinic acetylcholine receptor M30202
Serine/threonine-protein kinase mTOR0101
Nuclear receptor subfamily 4 group A member 20011
Beta-secretase 10101
Spike glycoprotein1124
Calcium-dependent protein kinase 10011
MO15-related protein kinase Pfmrk 0101
DNA ligase A0101
Sigma intracellular receptor 20202
Phosphoethanolamine N-methyltransferase0101
Angiotensin-converting enzyme 2 0123
Cysteine proteinase falcipain 2a 0101
Cysteine proteinase falcipain 2a 0101
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
alpha-galactosidase2002
cytochrome P450 2C19 precursor3003
Solute carrier family 22 member 10101
Solute carrier family 22 member 20203
Solute carrier family 22 member 1 0202
Solute carrier family 22 member 20101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
ATP-dependent translocase ABCB10202
ATP-dependent translocase ABCB10214
Cytochrome P450 2D60101
Cytochrome P450 2C9 0606
Potassium-transporting ATPase alpha chain 10101
ATP-dependent translocase ABCB10202
Histamine H2 receptor0202
Histamine H1 receptor0022
Histamine H2 receptor3216
Potassium-transporting ATPase subunit beta0101
Cytochrome P450 2J20505
Aldehyde oxidase0101
Solute carrier family 22 member 60406
Solute carrier family 22 member 10202
Multidrug and toxin extrusion protein 20101
Solute carrier family 22 member 80508
Solute carrier family 22 member 110204
Solute carrier family 22 member 20202
Solute carrier family 22 member 40101
Solute carrier family 22 member 80202
Chain A, Beta-lactamase1001
Luciferase5005
endonuclease IV2002
PAX80001
pregnane X receptor4004
hypoxia-inducible factor 1 alpha subunit3003
USP1 protein, partial6006
Thrombopoietin1001
Smad31001
67.9K protein3003
nuclear receptor subfamily 1, group I, member 23003
cytochrome P450 2D6 isoform 12002
nuclear receptor subfamily 0 group B member 10101
cytochrome P450 2C9 precursor3003
chromobox protein homolog 15005
thyroid hormone receptor beta isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 25005
steroidogenic factor 10101
caspase-1 isoform alpha precursor2002
neuropeptide S receptor isoform A1001
Solute carrier family 22 member 30101
Tubulin alpha-1A chain0213
Tubulin beta chain0213
Plasma kallikrein0001
Tubulin beta-4A chain0225
Tubulin beta chain0225
Tubulin alpha-3C chain0225
Serine/threonine-protein kinase pim-10101
Tubulin alpha-1B chain0225
Tubulin alpha-4A chain0225
Tubulin beta-4B chain0225
Vesicular acetylcholine transporter0101
Tubulin beta-3 chain0225
Tubulin beta-2A chain0225
Tubulin polymerization-promoting protein0011
Tubulin beta-8 chain0225
Tubulin beta-2B chain0202
Tubulin alpha-3E chain0225
Tubulin alpha-1A chain0225
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
CREB-binding protein1001
Tubulin alpha-1C chain0225
Tubulin beta-6 chain0225
Tubulin beta-2B chain0225
Tubulin beta-1 chain0225
dopamine D1 receptor2002
regulator of G-protein signaling 41001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
atrial natriuretic peptide receptor 1 precursor1001
Glucocorticoid receptor08215
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10808
Corticosteroid-binding globulin0202
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
Potassium voltage-gated channel subfamily A member 10011
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Genome polyprotein 0101
Alpha-1D adrenergic receptor0202
Cyclic GMP-AMP synthase0101
Toll-like receptor 90101
Toll-like receptor 70101
NFKB1 protein, partial2002
nonstructural protein 13003
importin subunit beta-1 isoform 12002
snurportin-12002
Acid-sensing ion channel 30101
Solute carrier organic anion transporter family member 1A40102
Dihydrofolate reductase0304
Albumin0112
Albumin0101
Albumin0011
Cholinesterase0101
Fatty acid-binding protein, intestinal0101
Polyunsaturated fatty acid 5-lipoxygenase0203
UDP-glucuronosyltransferase 2B70001
Acetylcholinesterase0101
Prostaglandin G/H synthase 10101
Caspase-10202
Prostaglandin G/H synthase 2 0203
UDP-glucuronosyltransferase 1A30001
Aldo-keto reductase family 1 member C30101
Caspase-30101
Solute carrier organic anion transporter family member 1A10101
Caspase-40101
Caspase-50101
Caspase-90101
Acid-sensing ion channel 10101
Mu-type opioid receptor0101
Fatty-acid amide hydrolase 10101
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 1 0203
Dehydrogenase/reductase SDR family member 90101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
ClpP1001
15-lipoxygenase, partial3003
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
vitamin D3 receptor isoform VDRA3003
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 12002
transactivating tegument protein VP16 [Human herpesvirus 1]0101
histone acetyltransferase KAT2A isoform 13003
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0303
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30002
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30203
Broad substrate specificity ATP-binding cassette transporter ABCG20102
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
bromodomain adjacent to zinc finger domain 2B2002
Nuclear receptor subfamily 1 group I member 20022
Androgen receptor0505
Nuclear receptor subfamily 1 group I member 20011
Geranylgeranyl pyrophosphate synthase0101
Farnesyl pyrophosphate synthase0202
Hypoxanthine-guanine phosphoribosyltransferase0101
Farnesyl pyrophosphate synthase 0101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Parkin1001
potassium voltage-gated channel subfamily H member 2 isoform d2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
Alpha-synuclein1203
Disintegrin and metalloproteinase domain-containing protein 173003
luciferase0001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Nociceptin receptor0011
Estrogen receptor beta0202
nuclear receptor ROR-gamma isoform 12002
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Chain A, Cruzipain1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
mitogen-activated protein kinase 11001
Retinol-binding protein 40011
Beta-lactoglobulin0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, 146aa long hypothetical transcriptional regulator0011
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain B, Anthranilate phosphoribosyltransferase0101
Chain C, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Anthranilate phosphoribosyltransferase0101
Chain A, Glutathione S-transferase0101
histone deacetylase 9 isoform 31001
Solute carrier organic anion transporter family member 2B1 0202
Tumor necrosis factor0011
Interstitial collagenase0101
Fibroblast growth factor 10011
Thromboxane-A synthase 0101
Mitogen-activated protein kinase 10101
Flavin reductase (NADPH)0011
Sodium/bile acid cotransporter0101
Cystine/glutamate transporter0101
Solute carrier organic anion transporter family member 1B10203
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
heat shock protein HSP 90-alpha isoform 20101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Tetracycline resistance protein, class B0001
72 kDa type IV collagenase0101
Stromelysin-10101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
Multidrug transporter MdfA0101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Alpha-1B adrenergic receptor0101
Neutrophil collagenase0101
Alpha-1D adrenergic receptor0101
Alpha-1A adrenergic receptor0101
Collagenase 30101
Cannabinoid receptor 10101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Integrase 0101
P2Y purinoceptor 120101
Solute carrier family 22 member 70001
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
apical membrane antigen 1, AMA11001
serine/threonine-protein kinase PLK11001
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 31001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]