Page last updated: 2024-09-27

Arousal Disorders, Sleep

Sleep disorders characterized by impaired arousal from the deeper stages of sleep (generally stage III or IV sleep).

Synonyms(3)

Synonym
Sleep Arousal Disorders
Confusional Arousals
Arousal Disorders, Sleep

Research

Studies (30)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's13 (43.33)18.1394
2010's17 (56.67)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
melatonin0low10
clonazepam0low40
valproic acid0low10
lamotrigine0low10
apnea0low20
oxybutynin0low10
zolpidem0medium31
methamphetamine0low10
substance p0low10
pergolide0medium11
efavirenz0low10
fluorodeoxyglucose f180low10
s200980low10
pramipexole0low10
morphine0low10
deamino arginine vasopressin0medium31
pituitrin0low40
rifampin0low10

Protein Targets (393)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
thioredoxin reductase3003
ATAD5 protein, partial2002
TDP1 protein4004
Microtubule-associated protein tau2002
estrogen-related nuclear receptor alpha5005
arylsulfatase A1001
euchromatic histone-lysine N-methyltransferase 26006
Bloom syndrome protein isoform 13003
D(1A) dopamine receptor4004
lamin isoform A-delta103003
neuropeptide S receptor isoform A2002
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit pi3306
Gamma-aminobutyric acid receptor subunit delta0202
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Neuronal acetylcholine receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-10314
Gamma-aminobutyric acid receptor subunit beta-13306
Gamma-aminobutyric acid receptor subunit beta-10303
Gamma-aminobutyric acid receptor subunit delta3306
Gamma-aminobutyric acid receptor subunit gamma-20314
Gamma-aminobutyric acid receptor subunit gamma-23306
Gamma-aminobutyric acid receptor subunit alpha-53306
Gamma-aminobutyric acid receptor subunit alpha-33306
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit gamma-13306
Gamma-aminobutyric acid receptor subunit alpha-23306
Gamma-aminobutyric acid receptor subunit alpha-43306
Gamma-aminobutyric acid receptor subunit beta-30303
Gamma-aminobutyric acid receptor subunit gamma-33306
Gamma-aminobutyric acid receptor subunit alpha-63306
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50314
Gamma-aminobutyric acid receptor subunit alpha-30314
Gamma-aminobutyric acid receptor subunit alpha-20314
Gamma-aminobutyric acid receptor subunit beta-20314
Gamma-aminobutyric acid receptor subunit alpha-40303
Gamma-aminobutyric acid receptor subunit alpha-13306
Gamma-aminobutyric acid receptor subunit beta-33306
Gamma-aminobutyric acid receptor subunit beta-23306
Gamma-aminobutyric acid receptor subunit epsilon0202
Gamma-aminobutyric acid receptor subunit alpha-60303
Gamma-aminobutyric acid receptor subunit gamma-10202
GABA theta subunit3306
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit epsilon3306
Gamma-aminobutyric acid receptor subunit theta0202
Vasopressin V2 receptor0112
Oxytocin receptor0011
Vasopressin V1a receptor0112
Vasopressin V1b receptor0112
Translocator protein0101
Vasopressin V2 receptor 0112
Chain A, POL POLYPROTEIN0101
Chain A, POL POLYPROTEIN0101
Chain B, POL POLYPROTEIN0101
Chain A, POL POLYPROTEIN0101
Chain B, POL POLYPROTEIN0101
Chain A, Pol Polyprotein0101
Chain B, Pol Polyprotein0101
Chain A, Ferritin light chain1001
hypoxia-inducible factor 1 alpha subunit1001
RAR-related orphan receptor gamma4004
SMAD family member 21001
PPM1D protein1001
SMAD family member 31001
GLI family zinc finger 33003
AR protein4004
caspase 7, apoptosis-related cysteine protease2002
estrogen receptor 2 (ER beta)2002
progesterone receptor1001
cytochrome P450 family 3 subfamily A polypeptide 44004
glucocorticoid receptor [Homo sapiens]4004
retinoic acid nuclear receptor alpha variant 14004
farnesoid X nuclear receptor2002
pregnane X nuclear receptor4004
estrogen nuclear receptor alpha4004
G3003
cytochrome P450 2D66006
peroxisome proliferator activated receptor gamma3003
caspase-32002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
thyroid stimulating hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
nuclear receptor subfamily 1, group I, member 21001
thyroid hormone receptor beta isoform 21001
heat shock protein beta-11001
mitogen-activated protein kinase 12002
nuclear factor erythroid 2-related factor 2 isoform 13003
nuclear receptor ROR-gamma isoform 11001
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Voltage-dependent calcium channel gamma-2 subunit1001
Bile salt export pump0909
Prothrombin 0101
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Gag-Pol polyprotein0202
Cellular tumor antigen p533003
Gag-Pol polyprotein0101
5-hydroxytryptamine receptor 1A0203
Glutamate receptor 21001
Cytochrome P450 2B60012
Acetylcholinesterase0001
Kappa-type opioid receptor0303
Cannabinoid receptor 10101
Microsomal triglyceride transfer protein large subunit0101
Spike glycoprotein2002
Disintegrin and metalloproteinase domain-containing protein 170101
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120 0101
Reverse transcriptase/RNaseH 0218
Protease 0001
Inositol hexakisphosphate kinase 13003
Canalicular multispecific organic anion transporter 10606
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Fructose-1,6-bisphosphatase 1 0001
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Reverse transcriptase 0112
Cholesterol 24-hydroxylase0011
cytochrome P450 2C9, partial3003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
GALC protein1001
EWS/FLI fusion protein3003
cytochrome P450 2D6 isoform 12002
peripheral myelin protein 22 isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 21001
potassium voltage-gated channel subfamily H member 2 isoform d3003
geminin2002
muscarinic acetylcholine receptor M12002
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Dihydrofolate reductase0202
Potassium voltage-gated channel subfamily E member 10101
Sodium channel protein type 4 subunit alpha0102
Potassium voltage-gated channel subfamily KQT member 10101
Potassium voltage-gated channel subfamily H member 20303
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Sigma non-opioid intracellular receptor 10101
Sodium channel protein type 10 subunit alpha0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase2002
interleukin 82002
ClpP1001
phosphopantetheinyl transferase2002
aldehyde dehydrogenase 1 family, member A12002
nuclear receptor subfamily 1, group I, member 35005
regulator of G-protein signaling 42002
aryl hydrocarbon receptor2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
chromobox protein homolog 12002
ras-related protein Rab-9A1001
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 81001
Cytochrome P450 1A10101
Cytochrome P450 1A2 0101
Myeloperoxidase0101
Cytochrome P450 1A20101
Cholinesterase0101
Cytochrome P450 2C11 0101
Cytochrome P450 2D60202
Aromatase0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Acetylcholinesterase0101
Metabotropic glutamate receptor 10101
Acetylcholinesterase 0101
Mu-type opioid receptor0418
Nociceptin receptor0101
Alpha-1A adrenergic receptor0101
Melatonin receptor type 1A0426
Melatonin receptor type 1C0011
Melatonin receptor type 1A0224
Melatonin receptor type 1B0426
Melatonin receptor type 1C0224
Melatonin receptor type 1B0224
Nuclear receptor ROR-gamma2002
Nuclear factor erythroid 2-related factor 20001
Cytochrome P450 1B10101
Palmitoleoyl-protein carboxylesterase NOTUM0101
Carboxylic ester hydrolase 0101
Histamine H3 receptor0101
ATP-dependent phosphofructokinase1001
Solute carrier family 22 member 30101
Amine oxidase [flavin-containing] B0101
Sodium-dependent noradrenaline transporter 0213
Sodium-dependent serotonin transporter0011
Amine oxidase [flavin-containing] B0101
Synaptic vesicular amine transporter0101
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Sigma non-opioid intracellular receptor 10606
Opioid receptor, delta 1b 0101
Solute carrier family 22 member 1 0101
Acetylcholinesterase0101
Opioid receptor homologue0101
ATP-dependent translocase ABCB10101
Acyl-CoA desaturase 10101
ATP-dependent translocase ABCB10101
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40101
Cytochrome P450 3A40112
Muscarinic acetylcholine receptor M50101
Alpha-2A adrenergic receptor0314
Muscarinic acetylcholine receptor M20202
Translocator protein0112
Histidine decarboxylase0011
ATP-dependent translocase ABCB10101
Proteinase-activated receptor 10112
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0102
Delta-type opioid receptor0214
Kappa-type opioid receptor0214
Kappa-type opioid receptor0214
Mu-type opioid receptor0214
UDP-glucuronosyltransferase 1A30001
Delta-type opioid receptor0315
Kappa-type opioid receptor0214
Mu-type opioid receptor0215
Nociceptin receptor0101
5-hydroxytryptamine receptor 70101
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Beta-2 adrenergic receptor0101
Mas-related G-protein coupled receptor member X20022
Mu-type opioid receptor0101
Fumarate hydratase1001
GLS protein2002
polyprotein1001
flap endonuclease 11001
Amyloid-beta precursor protein0101
Aldo-keto reductase family 1 member B10303
Muscarinic acetylcholine receptor M20315
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M10304
Muscarinic acetylcholine receptor M30303
Cytochrome P450 2C190101
D(3) dopamine receptor0528
5-hydroxytryptamine receptor 2B0404
Sodium-dependent dopamine transporter 0202
MBT domain-containing protein 10101
Lethal(3)malignant brain tumor-like protein 40101
Muscarinic acetylcholine receptor0011
Lethal(3)malignant brain tumor-like protein 30101
Lethal(3)malignant brain tumor-like protein 10101
dopamine D1 receptor1001
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
5-hydroxytryptamine receptor 40202
5-hydroxytryptamine receptor 1A0202
5-hydroxytryptamine receptor 2C0101
D(2) dopamine receptor0437
5-hydroxytryptamine receptor 2A0101
Alpha-2B adrenergic receptor0303
Alpha-2C adrenergic receptor0303
D0202
D(3) dopamine receptor0213
Alpha-2B adrenergic receptor0101
D(2) dopamine receptor0101
D(1A) dopamine receptor0314
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0202
D(1B) dopamine receptor0101
5-hydroxytryptamine receptor 2A0224
5-hydroxytryptamine receptor 2C0314
5-hydroxytryptamine receptor 1B0202
5-hydroxytryptamine receptor 1D0101
D(4) dopamine receptor0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 60101
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
5-hydroxytryptamine receptor 3A0101
Alpha-synuclein0202
5-hydroxytryptamine receptor 60303
D(2) dopamine receptor0336
5-hydroxytryptamine receptor 4 0101
D0202
5-hydroxytryptamine receptor 3B0101
acetylcholinesterase1001
peripheral myelin protein 222002
Beta-2 adrenergic receptor0101
Beta-3 adrenergic receptor0101
D(4) dopamine receptor0112
D(1B) dopamine receptor0101
Histamine H2 receptor0123
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1E0101
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0101
Histamine H1 receptor0011
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 5A0101
Solute carrier family 22 member 10001
Histamine H4 receptor0112
Solute carrier family 22 member 20001
Chain A, Cruzipain1001
15-lipoxygenase, partial1001
thyroid stimulating hormone receptor1001
retinoid X nuclear receptor alpha1001
DNA-directed RNA polymerase subunit beta0101
peroxisome proliferator-activated receptor delta1001
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Solute carrier organic anion transporter family member 1A40101
Bile salt export pump0303
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 2B1 0202
Albumin0022
NH(3)-dependent NAD(+) synthetase0101
60 kDa heat shock protein, mitochondrial0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Arylacetamide deacetylase0102
Caspase-10101
Solute carrier organic anion transporter family member 1A10101
Solute carrier organic anion transporter family member 1A20101
Histamine H2 receptor1001
10 kDa heat shock protein, mitochondrial0101
Glutathione S-transferase omega-10101
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0101
DNA-directed RNA polymerase subunit beta0101
Thiosulfate sulfurtransferase0101
Lanosterol 14-alpha demethylase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Solute carrier organic anion transporter family member 1B30203
Solute carrier organic anion transporter family member 1B10203
DNA polymerase kappa isoform 11001
Substance-P receptor0202
Neuromedin-K receptor0011
Substance-K receptor0112
Substance-K receptor0202
Substance-P receptor0213
Neuromedin-K receptor0112
Substance-P receptor0101
Substance-K receptor0101
Substance-K receptor0101
Growth hormone secretagogue receptor type 10011
Luciferase2002
pregnane X receptor1001
thyroid hormone receptor beta isoform a1001
Cocaine esterase0101
Histone deacetylase 30202
UDP-glucuronosyltransferase 1A90001
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 2B70102
UDP-glucuronosyltransferase 1-60001
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Sigma non-opioid intracellular receptor 10101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
Sodium-dependent dopamine transporter0011
Neuronal acetylcholine receptor subunit alpha-70101
Sphingosine-1-phosphate lyase 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]