Page last updated: 2024-09-27

Anticipation, Genetic

The apparent tendency of certain diseases to appear at earlier AGE OF ONSET and with increasing severity in successive generations. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

Synonyms(2)

Synonym
Genetic Anticipation
Anticipation, Genetic

Research Excerpts

Context

ExcerptReference
"Genetic anticipation has been described in familial PPH."( Błaszczyk, A; Stepień-Wałek, A; Torbicki, A; Wozakowska-Kapłon, B, 2009)

Research

Studies (19)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's13 (68.42)18.1394
2010's6 (31.58)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0low10
cytosine0low10
citalopram0low10
fluorouracil0low10
mexiletine0low10
glutamine0low20
levodopa0low10
methionine0low10
histidine0low10
valine0low10
methylprednisolone0low10
etoposide0low10
trichostatin a0low10
D-fructopyranose0low10
topiramate0low10
iloprost0low10
cardiovascular agents0low10
transforming growth factor beta0low20
guanine0low10

Protein Targets (419)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
RAR-related orphan receptor gamma4004
TDP1 protein3003
AR protein5005
nuclear receptor subfamily 1, group I, member 33003
cytochrome P450 family 3 subfamily A polypeptide 41001
glucocorticoid receptor [Homo sapiens]5005
estrogen-related nuclear receptor alpha5005
pregnane X nuclear receptor5005
estrogen nuclear receptor alpha7007
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
nuclear factor erythroid 2-related factor 2 isoform 24004
heat shock protein beta-12002
importin subunit beta-1 isoform 12002
snurportin-12002
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
lamin isoform A-delta102002
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump0808
Cyclin-dependent kinase 10101
Heat shock protein HSP 90-beta0101
Glutamate receptor 23003
Xanthine dehydrogenase/oxidase0101
TAR DNA-binding protein 431001
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 54004
Ataxin-25005
thioredoxin reductase4004
aldehyde dehydrogenase 1 family, member A13003
EWS/FLI fusion protein3003
euchromatic histone-lysine N-methyltransferase 26006
NPC intracellular cholesterol transporter 1 precursor1001
D(1A) dopamine receptor2002
survival motor neuron protein isoform d3003
Solute carrier family 22 member 1 0101
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40707
Sodium-dependent noradrenaline transporter0101
5-hydroxytryptamine receptor 40202
Aldo-keto reductase family 1 member B10202
Tryptophan 5-hydroxylase 10101
Angiotensin-converting enzyme0202
Aldo-keto reductase family 1 member B10101
5-hydroxytryptamine receptor 1A0101
Acetylcholinesterase0101
Aromatase0101
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0101
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2C0202
Sodium-dependent serotonin transporter0213
Sodium-dependent serotonin transporter0101
Histamine H1 receptor0202
5-hydroxytryptamine receptor 2B0404
5-hydroxytryptamine receptor 70101
Spike glycoprotein2002
Sodium-dependent dopamine transporter 0101
Potassium voltage-gated channel subfamily H member 20303
Sigma intracellular receptor 20101
Sodium-dependent serotonin transporter0101
Sodium-dependent dopamine transporter0101
Nuclear receptor subfamily 3 group C member 3 0202
Canalicular multispecific organic anion transporter 10809
Sigma non-opioid intracellular receptor 10202
Sigma non-opioid intracellular receptor 10101
Transporter0202
ATP-dependent phosphofructokinase6006
GLI family zinc finger 34004
IDH13003
geminin5005
Deoxycytidine kinase0001
glp-1 receptor, partial2002
hypoxia-inducible factor 1 alpha subunit3003
SMAD family member 21001
SMAD family member 31001
caspase 7, apoptosis-related cysteine protease1001
progesterone receptor3003
retinoic acid nuclear receptor alpha variant 12002
retinoid X nuclear receptor alpha4004
67.9K protein2002
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma2002
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
caspase-31001
LMP1 [Human herpesvirus 4]0001
thyroid stimulating hormone receptor1001
activating transcription factor 61001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Histone H2A.x2002
chromobox protein homolog 14004
thyroid hormone receptor beta isoform 22002
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
nuclear factor erythroid 2-related factor 2 isoform 12002
DNA polymerase iota isoform a (long)2002
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Prothrombin0001
Regulatory protein E20011
Cellular tumor antigen p532002
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10203
Cytochrome P450 3A40202
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0117
Cytochrome P450 2C9 0303
Polyunsaturated fatty acid lipoxygenase ALOX150202
DNA topoisomerase 20001
ATP-dependent translocase ABCB10101
UDP-glucuronosyltransferase 1A1 0001
Serum paraoxonase/arylesterase 10101
Glutamate receptor ionotropic, NMDA 1 0003
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0003
Glutamate receptor ionotropic, NMDA 2B0104
Glutamate receptor ionotropic, NMDA 2C0003
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0118
Glutamate receptor ionotropic, NMDA 2D0003
Tubulin beta-2B chain0101
Integrase 0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0003
Solute carrier organic anion transporter family member 1B30202
Glutamate receptor ionotropic, NMDA 3A0003
Chain A, Uracil Phosphoribosyltransferase0101
Luciferase2002
interleukin 81001
endonuclease IV1001
acetylcholinesterase2002
Skn7p0001
pregnane X receptor1001
ATAD5 protein, partial3003
Microtubule-associated protein tau2002
Thrombopoietin1001
thyroid stimulating hormone receptor1001
estrogen receptor 2 (ER beta)1001
nonstructural protein 12002
farnesoid X nuclear receptor1001
arylsulfatase A3003
peripheral myelin protein 22 isoform 12002
hemoglobin subunit beta1001
huntingtin isoform 21001
flap endonuclease 14004
serine/threonine-protein kinase mTOR isoform 11001
Vpr1001
peripheral myelin protein 222002
muscleblind-like protein 1 isoform 12002
Solute carrier family 22 member 80001
Epidermal growth factor receptor0202
Amyloid-beta precursor protein1001
Thymidylate synthase0101
Aromatase0101
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Chain A, Glutamine Binding Protein0011
15-lipoxygenase, partial2002
GLS protein2002
Bloom syndrome protein isoform 12002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Carbonic anhydrase 10207
Carbonic anhydrase 20218
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Carbonic anhydrase-like protein, putative0003
Amino acid transporter0101
Purine nucleoside phosphorylase0202
Hypoxanthine-guanine phosphoribosyltransferase0001
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Shiga toxin subunit A0101
Guanine deaminase0001
Chain A, HISTIDINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
cytochrome P450 3A4 isoform 11001
histone acetyltransferase KAT2A isoform 11001
Gamma-aminobutyric acid receptor subunit pi1001
Carbonic anhydrase 120104
Plasma kallikrein0103
Carbonic anhydrase 30103
Histidine-binding periplasmic protein0011
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Carbonic anhydrase 40104
Carbonic anhydrase 60104
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Adenosine receptor A10002
5-hydroxytryptamine receptor 1D0001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Adenosine receptor A2a0002
Carbonic anhydrase 5A, mitochondrial0115
Carbonic anhydrase0103
Carbonic anhydrase 70104
Carbonic anhydrase0103
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Large neutral amino acids transporter small subunit 10404
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90104
Carbonic anhydrase 0103
Carbonic anhydrase0103
Carbonic anhydrase0103
Carbonic anhydrase 0103
Carbonic anhydrase 130102
GABA theta subunit1001
Carbonic anhydrase 40203
Carbonic anhydrase 150103
Carbonic anhydrase 130104
Gamma-aminobutyric acid receptor subunit epsilon1001
Carbonic anhydrase 140104
Carbonic anhydrase 5B, mitochondrial0104
Prostaglandin E2 receptor EP1 subtype0011
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP2 subtype0011
Prostacyclin receptor0213
Prostacyclin receptor0112
Solute carrier organic anion transporter family member 2A10001
Prostaglandin D2 receptor0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
dopamine D1 receptor1001
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
phosphopantetheinyl transferase1001
apical membrane antigen 1, AMA11001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
pyruvate kinase1001
hexokinase-4 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
glucokinase regulatory protein1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 11001
DNA polymerase kappa isoform 11001
M-phase phosphoprotein 81001
muscarinic acetylcholine receptor M11001
Polyphenol oxidase 20001
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Tyrosinase0101
Solute carrier family 15 member 10101
SLC16A10 protein0001
Monocarboxylate transporter 100001
phosphoglycerate kinase1001
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
PPM1D protein2002
G1001
bromodomain adjacent to zinc finger domain 2B1001
nuclear receptor subfamily 1, group I, member 21001
Nuclear receptor subfamily 1 group I member 20011
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 1001
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Androgen receptor0202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Inositol hexakisphosphate kinase 11001
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 2C9, partial1001
cytochrome P450 2D61001
Potassium channel subfamily K member 30101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Potassium channel subfamily K member 20101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Cytochrome P450 2J20101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0202
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
Sphingosine kinase 20202
Sphingosine kinase 10101
Chain A, Carbonic anhydrase 10101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110001
Polyunsaturated fatty acid 5-lipoxygenase0101
Cytochrome P450 2C80101
Arachidonate 5-lipoxygenase-activating protein0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 20101
Delta-type opioid receptor0101
Cytochrome P450 2C190202
Delta-type opioid receptor0101
Mu-type opioid receptor0101
D(2) dopamine receptor0101
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Neuronal acetylcholine receptor subunit alpha-70101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
Chain A, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)0101
Chain B, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)0101
Chain A, Histone deacetylase 7a0101
Chain A, Histone deacetylase 7a0101
Chain A, Ferritin light chain1001
Histone deacetylase 80101
regulator of G-protein signaling 41001
Histone deacetylase 0101
Lysine-specific demethylase 4E0101
glucocerebrosidase1001
unnamed protein product0001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
vitamin D3 receptor isoform VDRA1001
Histone deacetylase 10202
Histone deacetylase 30204
5-hydroxytryptamine receptor 3A0101
Histone deacetylase 30101
Integrin beta-30101
Cytochrome P450 1A20101
Integrin alpha-IIb0101
Coagulation factor VII0101
Leukotriene A-4 hydrolase0101
Cytochrome P450 2D60101
Vitamin D3 receptor0101
Tissue factor0101
Adenosine receptor A10101
Delta-type opioid receptor0101
Histamine H2 receptor0101
Histone deacetylase 40216
Histone deacetylase 20101
Histone deacetylase 10226
Splicing factor 3B subunit 30101
Histone deacetylase 10101
Adenosine receptor A10101
Histone deacetylase 0101
Histone deacetylase 40101
Polyamine deacetylase HDAC100101
Histone deacetylase 30101
Histone deacetylase-like amidohydrolase0202
Histone deacetylase 70101
NAD-dependent protein deacetylase sirtuin-60112
Histone deacetylase 80101
Histone deacetylase 70204
Histone deacetylase 110101
Histone deacetylase 20215
HD2 type histone deacetylase HDA106 0202
Polyamine deacetylase HDAC100204
Histone deacetylase 11 0204
Histone deacetylase 90101
Histone deacetylase 70101
Histone deacetylase 6 0101
Histone deacetylase 40101
Histone deacetylase 80204
Histone deacetylase 60215
Histone deacetylase 90204
Histone deacetylase 50204
Histone deacetylase 0101
Nuclear receptor corepressor 20202
Histone deacetylase 60101
Histone deacetylase 50101
Histone deacetylase 0101
Chain A, Arginase 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]