Page last updated: 2024-09-27

Anterior Compartment Syndrome

Rapid swelling, increased tension, pain, and ischemic necrosis of the muscles of the anterior tibial compartment of the leg, often following excessive PHYSICAL EXERTION.

Synonyms(2)

Synonym
Anterior Compartment Syndrome
Anterior Tibial Syndrome

Research

Studies (138)

TimeframeStudies, This Condition (%)All Conditions %
pre-199065 (47.10)23.3326
1990's22 (15.94)12.5806
2000's31 (22.46)18.1394
2010's15 (10.87)28.8240
2020's5 (3.62)9.53
DrugIndicatedRelationship StrengthStudiesTrials
aminocaproic acid0low10
dalteparin0low20
aspirin0low10
azathioprine0low10
cefuroxime0low10
cilostazol0low10
clonazepam0low10
pentetic acid0low10
gentamicin0low20
isoflurane0low10
orphenadrine0low10
trihexyphenidyl0low10
thyroxine0low40
penicillin g0low10
mannitol0low10
dichloroacetic acid0low10
ergotamine0low10
triphenyltetrazolium0low10
silver0low10
technetium0low20
trolamine salicylate0low10
cephalexin0low10
cefazolin0low10
fomesafen0low10
simvastatin0low10
ergonovine0low10
thiopental0low10
phosphorus0low10
technetium tc 99m stannous pyrophosphate0low10
technetium tc 99m pyrophosphate0low10
beta-escin0low10
gadolinium dtpa0low10
phosphatidylcholines0low10
salicylates0low10
cyclosporine0low10
technetium tc 99m medronate0low20
phosphorus radioisotopes0low10

Protein Targets (421)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, PLASMINOGEN0011
Chain A, PLASMINOGEN0011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain4004
Chain A, Apolipoprotein0011
15-lipoxygenase, partial2002
ATAD5 protein, partial3003
aldehyde dehydrogenase 1 family, member A14004
regulator of G-protein signaling 43003
cytochrome P450 family 3 subfamily A polypeptide 46006
EWS/FLI fusion protein6006
nonstructural protein 12002
glucocorticoid receptor [Homo sapiens]120012
arylsulfatase A5005
euchromatic histone-lysine N-methyltransferase 28008
D(1A) dopamine receptor1001
chromobox protein homolog 12002
thyroid hormone receptor beta isoform a3003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
geminin7007
histone acetyltransferase KAT2A isoform 12002
lamin isoform A-delta10100010
Rap guanine nucleotide exchange factor 32002
Plasminogen0213
Proton-coupled amino acid transporter 10202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase2002
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 82002
thioredoxin reductase6006
GLS protein3003
AR protein100010
thyroid stimulating hormone receptor3003
hypothetical protein, conserved1001
retinoic acid nuclear receptor alpha variant 14004
estrogen-related nuclear receptor alpha9009
estrogen nuclear receptor alpha120012
cytochrome P450 2D63003
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta5005
Rac1 protein0011
IDH13003
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Bloom syndrome protein isoform 15005
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
DNA polymerase iota isoform a (long)2002
DNA polymerase kappa isoform 12002
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)2002
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40506
Solute carrier family 22 member 60505
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump0707
Epidermal growth factor receptor0101
Carbonic anhydrase 10303
Carbonic anhydrase 20303
Fatty acid-binding protein, liver0101
Integrin beta-30101
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb0101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10202
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin G/H synthase 20303
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma2002
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-13306
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Canalicular multispecific organic anion transporter 10505
Sigma non-opioid intracellular receptor 10213
Sigma non-opioid intracellular receptor 10011
acetylcholinesterase2002
phosphopantetheinyl transferase3003
RAR-related orphan receptor gamma9009
SMAD family member 24004
Fumarate hydratase1001
SMAD family member 34004
TDP1 protein7007
GLI family zinc finger 36006
Microtubule-associated protein tau2002
thioredoxin glutathione reductase2002
nuclear receptor subfamily 1, group I, member 34004
retinoid X nuclear receptor alpha6006
farnesoid X nuclear receptor2002
pregnane X nuclear receptor5005
G4004
polyprotein1001
P531001
peroxisome proliferator activated receptor gamma4004
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
thyroid stimulating hormone receptor2002
activating transcription factor 63003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x3003
peripheral myelin protein 22 isoform 14004
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a1001
thyroid hormone receptor beta isoform 25005
heat shock protein beta-13003
nuclear factor erythroid 2-related factor 2 isoform 1100010
peripheral myelin protein 223003
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 83003
muscleblind-like protein 1 isoform 12002
Gamma-aminobutyric acid receptor subunit pi3205
Bile salt export pump0101
Voltage-dependent calcium channel gamma-2 subunit3003
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 4004
Cellular tumor antigen p538008
Gamma-aminobutyric acid receptor subunit beta-13205
Gamma-aminobutyric acid receptor subunit delta3205
Gamma-aminobutyric acid receptor subunit gamma-23205
Glutamate receptor 23003
Gamma-aminobutyric acid receptor subunit alpha-53205
Gamma-aminobutyric acid receptor subunit alpha-33205
Gamma-aminobutyric acid receptor subunit gamma-13205
Gamma-aminobutyric acid receptor subunit alpha-23205
Gamma-aminobutyric acid receptor subunit alpha-43205
Gamma-aminobutyric acid receptor subunit gamma-33205
Gamma-aminobutyric acid receptor subunit alpha-63205
Gamma-aminobutyric acid receptor subunit beta-33205
Gamma-aminobutyric acid receptor subunit beta-23205
GABA theta subunit3205
Inositol hexakisphosphate kinase 14004
ATPase family AAA domain-containing protein 54004
Ataxin-25005
Gamma-aminobutyric acid receptor subunit epsilon3205
Protein-arginine deiminase type-40101
cytochrome P450 2C9, partial4004
Dihydroorotate dehydrogenase 0101
Protease 0101
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20011
Potassium channel subfamily K member 90101
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Luciferase3003
Smad34004
apical membrane antigen 1, AMA12002
vitamin D3 receptor isoform VDRA3003
Solute carrier family 15 member 10404
Solute carrier family 22 member 60101
Solute carrier family 22 member 80202
Solute carrier family 22 member 110101
Solute carrier family 22 member 80304
bromodomain adjacent to zinc finger domain 2B3003
mitogen-activated protein kinase 12002
Solute carrier family 15 member 10101
B2 metallo-beta-lactamase 0002
Solute carrier family 15 member 20202
Solute carrier family 15 member 20203
endonuclease IV2002
Thrombopoietin1001
cytochrome P450 2C9 precursor1001
nuclear factor erythroid 2-related factor 2 isoform 23003
nuclear receptor ROR-gamma isoform 11001
neuropeptide S receptor isoform A1001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Cytochrome P450 2C9 0202
Histamine H2 receptor2002
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Spike glycoprotein3003
Guanine nucleotide-binding protein G2002
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
ATP-dependent phosphofructokinase3003
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Gamma-aminobutyric acid receptor subunit alpha-10102
Gamma-aminobutyric acid receptor subunit beta-10102
Neuronal acetylcholine receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit alpha-20102
Gamma-aminobutyric acid receptor subunit alpha-30102
Neuronal acetylcholine receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit alpha-40102
Gamma-aminobutyric acid receptor subunit gamma-20102
Gamma-aminobutyric acid receptor subunit beta-30202
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50202
Gamma-aminobutyric acid receptor subunit alpha-30202
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit epsilon0202
Gamma-aminobutyric acid receptor subunit alpha-60202
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit theta0202
Carbonic anhydrase 40101
Carbonic anhydrase 150101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial0101
5-hydroxytryptamine receptor 40606
ATP-dependent translocase ABCB10202
ATP-dependent translocase ABCB10303
Alpha-2A adrenergic receptor0606
D(2) dopamine receptor0404
Alpha-2B adrenergic receptor0606
5-hydroxytryptamine receptor 1A0404
ATP-dependent translocase ABCB10202
D(1A) dopamine receptor0404
5-hydroxytryptamine receptor 2A0606
5-hydroxytryptamine receptor 2C0606
5-hydroxytryptamine receptor 1B0404
D(3) dopamine receptor0404
5-hydroxytryptamine receptor 2B0606
5-hydroxytryptamine receptor 60606
Adenylate cyclase 0101
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Beta-2 adrenergic receptor0202
Beta-1 adrenergic receptor0202
Cytochrome P450 3A40101
Alpha-2C adrenergic receptor0202
Sodium-dependent dopamine transporter0101
Thromboxane-A synthase 0101
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 5A0101
hypoxia-inducible factor 1 alpha subunit2002
progesterone receptor2002
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit alpha-70101
USP1 protein, partial4004
estrogen receptor 2 (ER beta)3003
potassium voltage-gated channel subfamily H member 2 isoform d2002
lethal(3)malignant brain tumor-like protein 1 isoform I1001
TAR DNA-binding protein 432002
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0101
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40404
Muscarinic acetylcholine receptor M50404
Cytochrome P450 2D60202
Muscarinic acetylcholine receptor M10404
Muscarinic acetylcholine receptor M30404
Sodium-dependent noradrenaline transporter 0202
Histamine H2 receptor0202
Sodium-dependent serotonin transporter0202
Histamine H1 receptor0202
5-hydroxytryptamine receptor 70101
Glutamate receptor ionotropic, NMDA 10101
Potassium voltage-gated channel subfamily H member 20101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Multidrug and toxin extrusion protein 20101
Glutamate receptor ionotropic, NMDA 3A0101
Multidrug and toxin extrusion protein 10101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
streptokinase A precursor0011
Beta-lactamase0001
Solute carrier family 22 member 80102
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase0001
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Kappa-type opioid receptor0001
Beta-lactamase TEM0102
Beta-lactamase0001
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Efflux transporter 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Beta-lactamase 0001
Class D beta-lactamase0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase 0001
Beta-lactamase VIM-1 0001
GALC protein1001
cytochrome P450 2C19 precursor1001
flap endonuclease 11001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, 146aa long hypothetical transcriptional regulator0011
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain B, Anthranilate phosphoribosyltransferase0101
Chain C, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Anthranilate phosphoribosyltransferase0101
Chain A, Beta-lactamase1001
PINK11001
Parkin1001
photoreceptor-specific nuclear receptor0101
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
nuclear receptor subfamily 1, group I, member 21001
serine/threonine-protein kinase PLK12002
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0202
Insulin receptor 0101
Nuclear receptor subfamily 4 group A member 20011
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Sigma non-opioid intracellular receptor 10101
Solute carrier organic anion transporter family member 1B10102
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Fatty-acid amide hydrolase 10101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
DNA polymerase eta isoform 11001
Solute carrier organic anion transporter family member 1A40001
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
glp-1 receptor, partial1001
NFKB1 protein, partial1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
procathepsin L isoform 1 preproprotein0101
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Cytochrome P450 2J20101
atrial natriuretic peptide receptor 2 precursor1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]