Page last updated: 2024-09-27
Antenatal Myasthenia Gravis
A disorder of neuromuscular transmission that occurs in a minority of newborns born to women with myasthenia gravis. Clinical features are usually present at birth or develop in the first 3 days of life and consist of hypotonia and impaired respiratory, suck, and swallowing abilities. This condition is associated with the passive transfer of acetylcholine receptor antibodies through the placenta. In the majority of infants the myasthenic weakness resolves (i.e., transient neonatal myasthenia gravis) although this disorder may rarely continue beyond the neonatal period (i.e., persistent neonatal myasthenia gravis). (From Menkes, Textbook of Child Neurology, 5th ed, p823; Neurology 1997 Jan;48(1):50-4)
Synonyms(11)
| Synonym |
|---|
| Neonatal Myasthenia Gravis, Persistent |
| Neonatal Myasthenia Gravis, Transient |
| Myasthenia Gravis, Neonatal |
| Antenatal Myasthenia Gravis |
| Myasthenia Gravis, Neonatal, Persistent |
| Transient Neonatal Myasthenia Gravis |
| Persistent Neonatal Myasthenia Gravis |
| Myasthenia Gravis, Persistent, Neonatal |
| Myasthenia Gravis, Transient, Neonatal |
| Myasthenia Gravis, Neonatal, Transient |
| Neonatal Myasthenia Gravis |
Research Excerpts
Overview
| Excerpt | Reference |
|---|---|
| "The risk of transient neonatal myasthenia gravis is relatively small but exists even when the parturient has stable MG without elevated levels of anti-acetylcholine receptor antibodies." | ( de Seze, J; Defebvre, L; Delalande, S; Delrieu, O; Destée, A; Fourrier, F; Leys, D; Ramirez, C; Stojkovic, T; Vermersch, P, 2006) |
Research
Studies (15)
| Timeframe | Studies, This Condition (%) | All Conditions % |
|---|---|---|
| pre-1990 | 1 (6.67) | 23.3326 |
| 1990's | 0 (0.00) | 12.5806 |
| 2000's | 6 (40.00) | 18.1394 |
| 2010's | 8 (53.33) | 28.8240 |
| 2020's | 0 (0.00) | 9.53 |
Drugs Studied (10)
| Drug | Indicated | Relationship Strength | Studies | Trials |
|---|---|---|---|---|
| edrophonium | 0 | low | 3 | 0 |
| neostigmine | 0 | low | 5 | 0 |
| spironolactone | 0 | low | 1 | 0 |
| prednisone | 0 | low | 4 | 0 |
| pyridostigmine bromide | 0 | low | 5 | 0 |
| ephedrine | 0 | low | 1 | 0 |
| quinidine | 0 | low | 1 | 0 |
| rocuronium | 0 | low | 1 | 0 |