Page last updated: 2024-09-27

Ankyloglossia

A severe congenital restriction of TONGUE movement, resulting from fusion or adherence of the tongue to the floor of the mouth. In partial ankyloglossia (tongue-tie) the LINGUAL FRENUM is abnormally short, or is attached too close to the tip of the tongue. OMIM: 106280

Synonyms(3)

Synonym
Tongue Tie
Partial Ankyloglossia
Ankyloglossia

Research Excerpts

Overview

ExcerptReference
"Tongue-tie, or ankyloglossia, is a common condition characterized by an abnormally short or tight lingual frenulum and is known to cause breastfeeding difficulties, leading to damage to the nipple, early discontinuation of breastfeeding, and delayed infant growth."( Carnino, JM; Lara, FR; Levi, JR; Mwaura, AM; Walia, AS, 2023)

Research

Studies (16)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's5 (31.25)28.8240
2020's11 (68.75)9.53
DrugIndicatedRelationship StrengthStudiesTrials
vanillin0medium11
apnea0low10
sevoflurane0low20
thymidine0low10
sucrose0medium11
telbivudine0low10
inositol 3-phosphate0low70
folic acid0low20

Protein Targets (101)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
thioredoxin reductase1001
ATAD5 protein, partial1001
TDP1 protein1001
Microtubule-associated protein tau1001
estrogen-related nuclear receptor alpha2002
arylsulfatase A1001
euchromatic histone-lysine N-methyltransferase 21001
Bloom syndrome protein isoform 11001
D(1A) dopamine receptor1001
lamin isoform A-delta101001
neuropeptide S receptor isoform A1001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Dihydrofolate reductase0011
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, Ferritin light chain1001
acid sphingomyelinase1001
glp-1 receptor, partial1001
USP1 protein, partial1001
GLI family zinc finger 32002
AR protein3003
aldehyde dehydrogenase 1 family, member A12002
thyroid stimulating hormone receptor1001
retinoid X nuclear receptor alpha2002
estrogen nuclear receptor alpha3003
glucocerebrosidase1001
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
alpha-galactosidase1001
activating transcription factor 61001
lysosomal alpha-glucosidase preproprotein1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 21001
DNA polymerase beta1001
Multidrug resistance-associated protein 40102
Bile salt export pump0202
Cellular tumor antigen p531001
Thymidylate synthase0202
Thymidylate synthase0102
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10101
Alpha-synuclein1001
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Spike glycoprotein1001
Chain A, MALTOPORIN0011
Chain B, MALTOPORIN0011
pregnane X nuclear receptor1001
peripheral myelin protein 222002
Carbonic anhydrase 20112
Carbonic anhydrase 90112
EWS/FLI fusion protein1001
ATP-binding cassette sub-family C member 30101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Potassium voltage-gated channel subfamily E member 10101
Potassium voltage-gated channel subfamily KQT member 10101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Capsid protein 0011
Potassium voltage-gated channel subfamily H member 20101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Canalicular multispecific organic anion transporter 10101
Thymidine kinase 0102
glucocorticoid receptor [Homo sapiens]1001
Thymidine kinase, cytosolic0204
Thymidine kinase0102
Thymidine phosphorylase0001
Polyunsaturated fatty acid 5-lipoxygenase0101
Glucose-6-phosphate 1-dehydrogenase0101
Thymidine phosphorylase0001
Thymidylate kinase0101
Thymidine kinase, cytosolic 0002
Thymidine kinase0001
Thymidylate kinase0101
Thymidine kinase 0102
Sterol O-acyltransferase 10101
Thymidine kinase0001
Thymidine kinase0001
RAR-related orphan receptor gamma1001
GLS protein1001
estrogen receptor 2 (ER beta)1001
farnesoid X nuclear receptor1001
aryl hydrocarbon receptor1001
thyroid stimulating hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
Histone H2A.x1001
nuclear factor erythroid 2-related factor 2 isoform 11001
Transcription intermediary factor 1-alpha0101
Polyphenol oxidase 20101
Pancreatic triacylglycerol lipase0101
Androgen receptor0101
Succinate-semialdehyde dehydrogenase, mitochondrial0101
DNA-dependent protein kinase catalytic subunit0101
4-aminobutyrate aminotransferase, mitochondrial0101
Secreted chorismate mutase0101
E3 ubiquitin-protein ligase TRIM330101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]