Page last updated: 2024-09-28

Angle Class III

Malocclusion in which the mandible is anterior to the maxilla as reflected by the first relationship of the first permanent molar (mesioclusion).

Synonyms(6)

Synonym
Underbite
Habsburg Jaw
Malocclusion, Angle Class III
Prognathism, Mandibular
Angle Class III
Hapsburg Jaw

Research Excerpts

Research

Studies (432)

TimeframeStudies, This Condition (%)All Conditions %
pre-199035 (8.10)23.3326
1990's42 (9.72)12.5806
2000's113 (26.16)18.1394
2010's213 (49.31)28.8240
2020's29 (6.71)9.53
DrugIndicatedRelationship StrengthStudiesTrials
cytosine0low10
lactic acid0medium61
glycine0low10
nickel0medium133
thymine0low10
dantrolene0low10
isoflurane0low10
2-propanol0low10
propofol0medium11
tranexamic acid0medium11
penicillin g0low10
serine0low20
leucine0low10
phenylalanine0low20
threonine0low10
isoprene0medium101
acetylcysteine0low10
durapatite0low40
isopropyl methylphosphonic acid0low10
palladium0low10
titanium0medium467
chromium0low10
barium sulfate0low20
tricalcium phosphate0medium11
calcium sulfate0low10
trolamine salicylate0low20
fluorides0low10
cefazolin0low10
propiconazole0medium481
remifentanil0medium11
cobalt0low10
proline0low20
clevidipine0low10
fibrin0low10
inositol 3-phosphate0medium1676
tungsten carbide0low10
nitinol0low10
cholecalciferol0low10
rutin0low10
phenylephrine hydrochloride0medium1225
deamino arginine vasopressin0low10
cysteine0low10
amoxicillin-potassium clavulanate combination0medium11
jaw0medium312
vendex0medium161
silicate cement0low10
tetracycline0low10
transforming growth factor beta0low40
feldspar0low10
exudates0low40
guanine0low10
eye0low50

Protein Targets (504)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit1001
RAR-related orphan receptor gamma130013
GLI family zinc finger 37007
AR protein110011
aldehyde dehydrogenase 1 family, member A14004
retinoic acid nuclear receptor alpha variant 1100010
retinoid X nuclear receptor alpha6006
estrogen nuclear receptor alpha120012
peroxisome proliferator-activated receptor delta4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
activating transcription factor 64004
v-jun sarcoma virus 17 oncogene homolog (avian)4004
Histone H2A.x4004
thyroid hormone receptor beta isoform a6006
heat shock protein beta-13003
nuclear factor erythroid 2-related factor 2 isoform 19009
lamin isoform A-delta107007
Voltage-dependent calcium channel gamma-2 subunit3003
Glutamate receptor 23003
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, 2-oxoglutarate Oxygenase4004
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
acetylcholinesterase3003
dopamine D1 receptor1001
15-lipoxygenase, partial2002
pregnane X receptor2002
phosphopantetheinyl transferase5005
USP1 protein, partial3003
NFKB1 protein, partial1001
Microtubule-associated protein tau3003
Thrombopoietin1001
regulator of G-protein signaling 42002
glucocorticoid receptor [Homo sapiens]9009
farnesoid X nuclear receptor6006
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
arylsulfatase A1001
euchromatic histone-lysine N-methyltransferase 25005
Bloom syndrome protein isoform 13003
D(1A) dopamine receptor2002
thyroid hormone receptor beta isoform 25005
flap endonuclease 11001
geminin6006
peripheral myelin protein 223003
survival motor neuron protein isoform d2002
muscarinic acetylcholine receptor M13003
Histone deacetylase 30101
Solute carrier family 22 member 60404
Histone deacetylase 40101
Guanine nucleotide-binding protein G3003
Histone deacetylase 10101
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Ataxin-23003
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
ATP-dependent phosphofructokinase3003
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Luciferase3003
thioredoxin reductase2002
Smad32002
apical membrane antigen 1, AMA11001
cytochrome P450 2D63003
vitamin D3 receptor isoform VDRA4004
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Multidrug resistance-associated protein 40203
Solute carrier family 15 member 10202
Solute carrier family 22 member 60101
Solute carrier family 22 member 80203
Solute carrier family 22 member 110102
Solute carrier family 22 member 80203
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, Ferritin light chain3003
Chain A, Cruzipain2002
interleukin 83003
pregnane X nuclear receptor5005
peroxisome proliferator activated receptor gamma5005
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
nuclear receptor ROR-gamma isoform 13003
DNA polymerase kappa isoform 14004
cytochrome P450 3A4 isoform 12002
Gamma-aminobutyric acid receptor subunit pi2114
Cellular tumor antigen p536006
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Vitamin D3 receptor0114
Gamma-aminobutyric acid receptor subunit beta-12114
Gamma-aminobutyric acid receptor subunit delta2114
Gamma-aminobutyric acid receptor subunit gamma-22114
Gamma-aminobutyric acid receptor subunit alpha-52114
Gamma-aminobutyric acid receptor subunit alpha-32114
Glycine receptor subunit alpha-10022
Gamma-aminobutyric acid receptor subunit gamma-12114
Gamma-aminobutyric acid receptor subunit alpha-22114
Gamma-aminobutyric acid receptor subunit alpha-42114
Gamma-aminobutyric acid receptor subunit gamma-32114
Gamma-aminobutyric acid receptor subunit alpha-62114
Vitamin D3 receptor0011
Nuclear receptor ROR-gamma2114
10 kDa heat shock protein, mitochondrial0101
Gamma-aminobutyric acid receptor subunit alpha-12114
Gamma-aminobutyric acid receptor subunit beta-32114
Gamma-aminobutyric acid receptor subunit beta-22114
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
GABA theta subunit2114
Gamma-aminobutyric acid receptor subunit epsilon2114
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor4004
cytochrome P450 family 3 subfamily A polypeptide 44004
G2002
Bile salt export pump0505
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 2002
Inositol hexakisphosphate kinase 12002
cytochrome P450 2C9, partial2002
IDH13003
Deoxycytidine kinase0001
Vasopressin V2 receptor0112
Oxytocin receptor0011
Vasopressin V1a receptor0112
Vasopressin V1b receptor0112
Translocator protein0101
Vasopressin V2 receptor 0112
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Beta-lactamase2002
PAX80001
SMAD family member 22002
ATAD5 protein, partial2002
PPM1D protein1001
SMAD family member 32002
TDP1 protein3003
STAT3, partial0101
thioredoxin glutathione reductase2002
estrogen receptor 2 (ER beta)4004
estrogen-related nuclear receptor alpha8008
67.9K protein1001
alpha-galactosidase1001
thyroid stimulating hormone receptor4004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
NPC intracellular cholesterol transporter 1 precursor1001
cellular tumor antigen p53 isoform a3003
tumor necrosis factor1001
nuclear factor erythroid 2-related factor 2 isoform 21001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
ras-related protein Rab-9A1001
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
lethal factor (plasmid)3003
Solute carrier organic anion transporter family member 1A40102
Sodium/potassium-transporting ATPase subunit alpha-1 0202
Sodium/potassium-transporting ATPase subunit beta-10202
Integrin beta-33003
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
ATP-dependent translocase ABCB10101
Sodium/potassium-transporting ATPase subunit beta-1 0101
ATP-dependent translocase ABCB10102
Integrin alpha-IIb3003
Cytochrome P450 3A40303
Replicase polyprotein 1ab0101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
ATP-dependent translocase ABCB10101
Sodium/potassium-transporting ATPase subunit alpha-20202
Sodium/potassium-transporting ATPase subunit alpha-10101
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4C10001
ATPase family AAA domain-containing protein 52002
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1B30101
Solute carrier organic anion transporter family member 1B10101
Carbonic anhydrase 10305
Carbonic anhydrase 20305
Carbonic anhydrase 40204
Carbonic anhydrase0102
Carbonic anhydrase 150102
EWS/FLI fusion protein3003
aryl hydrocarbon receptor3003
thyrotropin-releasing hormone receptor1001
ATP-binding cassette sub-family C member 30202
Carbonic anhydrase 120103
Bile salt export pump0101
Albumin0101
Carbonic anhydrase 30102
Glucose-6-phosphate 1-dehydrogenase0101
Cytochrome P450 2C9 0101
Carbonic anhydrase 60103
Serum paraoxonase/arylesterase 10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase 5A, mitochondrial0103
Carbonic anhydrase 70103
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Cytochrome P450 2J20101
6-phosphogluconate dehydrogenase, decarboxylating0101
Spike glycoprotein2002
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0101
Carbonic anhydrase 90103
Canalicular multispecific organic anion transporter 10202
Multidrug and toxin extrusion protein 10101
Carbonic anhydrase 130103
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Carbonic anhydrase 140103
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Carbonic anhydrase 5B, mitochondrial0103
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Glutamate receptor ionotropic, NMDA 1 0315
Sodium- and chloride-dependent glycine transporter 10101
Glutamate receptor ionotropic, NMDA 2A 0214
Glutamate receptor ionotropic, NMDA 2B0214
Glutamate receptor ionotropic, NMDA 2C0214
Large neutral amino acids transporter small subunit 10304
Glutamate receptor ionotropic, NMDA 2D0214
Proton-coupled amino acid transporter 10405
Glutamate receptor ionotropic, NMDA 3B0214
Serine racemase0101
Olfactory receptor 51E20011
Glutamate receptor ionotropic, NMDA 3A0214
Sodium- and chloride-dependent glycine transporter 20101
Purine nucleoside phosphorylase0202
Hypoxanthine-guanine phosphoribosyltransferase0001
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Shiga toxin subunit A0101
Guanine deaminase0001
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit alpha-70101
thyroid stimulating hormone receptor2002
Chymotrypsinogen A0202
Chain A, AMINOPEPTIDASE0202
Chain A, AMINOPEPTIDASE0202
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0202
Intestinal-type alkaline phosphatase0202
Phospholipase A-2-activating protein0202
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
streptokinase A precursor0011
Beta-lactamase0001
Solute carrier family 22 member 80102
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase0102
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Kappa-type opioid receptor0001
Beta-lactamase TEM0102
Beta-lactamase0001
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Efflux transporter 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Beta-lactamase 0001
Class D beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase 0001
Beta-lactamase VIM-1 0001
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Plasma kallikrein0001
Alkaline phosphatase, tissue-nonspecific isozyme 0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
Adenosine receptor A10001
Adenosine receptor A2a0001
Carbonic anhydrase0001
E3 ubiquitin-protein ligase XIAP0101
SLC16A10 protein0001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Large neutral amino acids transporter small subunit 1 0101
Carbonic anhydrase 0001
Carbonic anhydrase 130001
Monocarboxylate transporter 100001
glp-1 receptor, partial2002
GALC protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein2002
mu-type opioid receptor isoform MOR-10011
chromobox protein homolog 12002
Vpr1001
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Neutral amino acid transporter A0202
Neutral amino acid transporter B(0)0202
Amino acid transporter0202
nonstructural protein 11001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20102
DNA polymerase iota isoform a (long)2002
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Histamine H2 receptor1001
TAR DNA-binding protein 431001
heat shock protein 90, putative0001
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
GLS protein1001
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90001
5-hydroxytryptamine receptor 40202
Aldo-keto reductase family 1 member B10303
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Prostaglandin G/H synthase 10101
Sodium-dependent noradrenaline transporter 0202
Sodium- and chloride-dependent GABA transporter 10101
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit alpha-50011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30011
5-hydroxytryptamine receptor 2B0202
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20011
Sodium- and chloride-dependent betaine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-40011
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-60011
UDP-glucuronosyltransferase 1A80001
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10101
Genome polyprotein 0101
Neuraminidase 0202
glycogen synthase kinase-3 beta isoform 10011
DNA polymerase beta1001
mitogen-activated protein kinase 11001
muscleblind-like protein 1 isoform 11001
Polyphenol oxidase 20101
Lysine-specific histone demethylase 1A0101
L-lactate dehydrogenase A chain0101
Albumin0101
Neuraminidase0101
Alpha-2A adrenergic receptor0101
Sialidase0101
Cystic fibrosis transmembrane conductance regulator0011
Alpha-2C adrenergic receptor0101
Acetylcholinesterase0101
Dipeptidyl peptidase 40101
Substance-P receptor0101
Bifunctional epoxide hydrolase 20101
Xanthine dehydrogenase/oxidase0101
Prolyl endopeptidase0101
Mitogen-activated protein kinase 100101
Mitogen-activated protein kinase 140101
Dihydroorotate dehydrogenase 0101
Substance-K receptor0101
Neuromedin-U receptor 20011
Acetylcholinesterase0101
Pyruvate kinase PKM0011
Cholinesterase0101
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Tetracycline resistance protein, class B0001
Muscarinic acetylcholine receptor M20101
72 kDa type IV collagenase0101
Stromelysin-10101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
Multidrug transporter MdfA0101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Alpha-1B adrenergic receptor0101
Neutrophil collagenase0101
Alpha-1D adrenergic receptor0101
Alpha-synuclein0101
Alpha-1A adrenergic receptor0101
Collagenase 30101
Cannabinoid receptor 10101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Integrase 0101
P2Y purinoceptor 120101
Protein-arginine deiminase type-40101
Solute carrier family 22 member 70001
Thymidine phosphorylase0101
Chain A, PLASMINOGEN0011
Chain A, PLASMINOGEN0011
Plasminogen0213
Urokinase-type plasminogen activator0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]