Page last updated: 2024-09-27

Angioid Streaks

Small breaks in the elastin-filled tissue of the retina.

Synonyms(1)

Synonym
Angioid Streaks

Research Excerpts

Treatment

ExcerptReference
"Two of the patients were treated for angioid streaks of the macular region, the third patient was treated for disciform macular degeneration."( Cambie, E; De Laey, JJ; François, J; Hanssens, M; Victoria-Troncoso, V, 1975)

Research

Studies (73)

TimeframeStudies, This Condition (%)All Conditions %
pre-199038 (52.05)23.3326
1990's11 (15.07)12.5806
2000's9 (12.33)18.1394
2010's12 (16.44)28.8240
2020's3 (4.11)9.53
DrugIndicatedRelationship StrengthStudiesTrials
ciprofloxacin0low10
deferoxamine0low10
erythrosine0low130
2-propanol0low10
pyrimethamine0low10
sulfamethazine0low10
hydroxyproline0low30
fluocinolone acetonide0medium11
tryptophan0low10
arginine0low10
triamcinolone acetonide0low20
durapatite0low10
d-alpha tocopherol0low10
fluorescein0low20
argon0low30
elastin0low20
inositol 3-phosphate0low10
osteoprotegerin0low10
barium0low10
phosphorus0low20
indocyanine green0medium222
phosphatidylcholines0low10
almagate0low20
eye0low110

Protein Targets (363)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma4004
GLI family zinc finger 37007
AR protein8008
aldehyde dehydrogenase 1 family, member A14004
retinoic acid nuclear receptor alpha variant 19009
retinoid X nuclear receptor alpha6006
estrogen nuclear receptor alpha8008
peroxisome proliferator-activated receptor delta5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
activating transcription factor 64004
v-jun sarcoma virus 17 oncogene homolog (avian)4004
Histone H2A.x3003
thyroid hormone receptor beta isoform a3003
heat shock protein beta-14004
nuclear factor erythroid 2-related factor 2 isoform 15005
lamin isoform A-delta107007
Voltage-dependent calcium channel gamma-2 subunit3003
Glutamate receptor 23003
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase3003
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
thioredoxin reductase3003
GALC protein2002
nuclear receptor subfamily 1, group I, member 33003
cytochrome P450 family 3 subfamily A polypeptide 46006
glucocorticoid receptor [Homo sapiens]6006
estrogen-related nuclear receptor alpha8008
Carbonic anhydrase 0101
Carbonic anhydrase 0101
arylsulfatase A2002
Carbonic anhydrase0101
euchromatic histone-lysine N-methyltransferase 27007
Bloom syndrome protein isoform 14004
geminin4004
peripheral myelin protein 222002
survival motor neuron protein isoform d3003
muscleblind-like protein 1 isoform 11001
Gamma-aminobutyric acid receptor subunit pi2204
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40303
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Carbonic anhydrase 120216
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Bile salt export pump0505
Glycogen phosphorylase, muscle form0101
Renin0202
Carbonic anhydrase 10218
Carbonic anhydrase 20217
Carbonic anhydrase 20202
Cytochrome P450 1A20202
Carbonic anhydrase 30216
Cathepsin B0101
Cytochrome P450 3A40203
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Cytochrome P450 2C80101
Cytochrome P450 2D60202
Cytochrome P450 2A60101
Cytochrome P450 2C9 0303
5-hydroxytryptamine receptor 2A0101
Androgen receptor0101
Gamma-aminobutyric acid receptor subunit beta-12204
Translocator protein0101
Gamma-aminobutyric acid receptor subunit delta2204
Gamma-aminobutyric acid receptor subunit gamma-22204
Gamma-aminobutyric acid receptor subunit alpha-52204
Gamma-aminobutyric acid receptor subunit alpha-32204
Cannabinoid receptor 10101
Arachidonate 5-lipoxygenase-activating protein0101
Cytochrome P450 2B60101
Carbonic anhydrase 40215
Carbonic anhydrase 60215
Gamma-aminobutyric acid receptor subunit gamma-12204
Gamma-aminobutyric acid receptor subunit alpha-22204
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10101
Serum paraoxonase/arylesterase 10101
Dipeptidyl peptidase 40102
Gamma-aminobutyric acid receptor subunit alpha-42204
Gamma-aminobutyric acid receptor subunit gamma-32204
Endochitinase0101
Gamma-aminobutyric acid receptor subunit alpha-62204
Adenosine receptor A2a0101
5-hydroxytryptamine receptor 2B0101
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0101
Cytochrome P450 2C190202
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Carbonic anhydrase 5A, mitochondrial0216
Carbonic anhydrase0102
Kappa-type opioid receptor0101
Carbonic anhydrase 70215
Carbonic anhydrase0101
D(1A) dopamine receptor0101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase0102
D(2) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit alpha-12204
Gamma-aminobutyric acid receptor subunit beta-32204
Gamma-aminobutyric acid receptor subunit beta-22204
Cholinesterase0101
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Fatty-acid amide hydrolase 10101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Glutamate receptor ionotropic, NMDA 2B0102
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70101
Carbonic anhydrase 90216
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0102
Carbonic anhydrase 30101
Carbonic anhydrase0103
Carbonic anhydrase0103
Carbonic anhydrase 0101
Sigma intracellular receptor 20101
Delta carbonic anhydrase0101
Sigma non-opioid intracellular receptor 10101
Renin0101
Carbonic anhydrase 0102
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130214
GABA theta subunit2204
Canalicular multispecific organic anion transporter 10303
Carbonic anhydrase 40202
Carbonic anhydrase 150103
Acidic mammalian chitinase0101
Carbonic anhydrase 130204
Carbonic anhydrase 70101
Gamma-aminobutyric acid receptor subunit epsilon2204
Carbonic anhydrase 0101
Carbonic anhydrase 140216
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Carbonic anhydrase 5B, mitochondrial0216
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
phosphopantetheinyl transferase3003
NFKB1 protein, partial1001
GLS protein3003
thyroid stimulating hormone receptor2002
alpha-galactosidase1001
cytochrome P450 2C19 precursor1001
chromobox protein homolog 12002
flap endonuclease 12002
DNA polymerase iota isoform a (long)4004
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)1001
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase3003
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase3003
Chain A, Cruzipain1001
TDP1 protein5005
EWS/FLI fusion protein2002
cytochrome P450 2C9 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
DNA gyrase subunit B0101
DNA gyrase subunit A0101
DNA gyrase subunit B0102
DNA gyrase subunit A0103
DNA gyrase subunit B0103
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0102
DNA topoisomerase 4 subunit A0102
DNA topoisomerase 2-alpha0104
DNA gyrase subunit A0102
Multidrug resistance protein MdtK0011
Histamine H2 receptor1001
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0001
Potassium voltage-gated channel subfamily H member 20203
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0101
Integrase 0101
USP1 protein, partial1001
Microtubule-associated protein tau3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
Rap guanine nucleotide exchange factor 31001
Cellular tumor antigen p536006
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
apical membrane antigen 1, AMA11001
67.9K protein2002
IDH13003
nuclear factor erythroid 2-related factor 2 isoform 23003
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
Lysine-specific demethylase 4A0101
Guanine nucleotide-binding protein G1001
Hypoxia-inducible factor 1-alpha0011
Methylcytosine dioxygenase TET20101
Deoxyhypusine hydroxylase0101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Genome polyprotein 0112
Luciferase1001
acetylcholinesterase3003
chaperonin-containing TCP-1 beta subunit homolog1001
SMAD family member 25005
ATAD5 protein, partial2002
Fumarate hydratase3003
SMAD family member 35005
thioredoxin glutathione reductase3003
hypothetical protein, conserved1001
farnesoid X nuclear receptor3003
G1001
cytochrome P450 2D63003
polyprotein3003
bromodomain adjacent to zinc finger domain 2B2002
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
aryl hydrocarbon receptor4004
thyroid stimulating hormone receptor4004
thyrotropin-releasing hormone receptor2002
vitamin D3 receptor isoform VDRA1001
thyroid hormone receptor beta isoform 24004
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
eyes absent homolog 2 isoform a1001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
DNA polymerase kappa isoform 12002
histone acetyltransferase KAT2A isoform 12002
relaxin receptor 1 isoform 11001
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 1001
Flavin reductase (NADPH)0011
Inositol hexakisphosphate kinase 11001
cytochrome P450 2C9, partial1001
large T antigen0101
Smad32002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
progesterone receptor4004
pregnane X nuclear receptor5005
nuclear receptor subfamily 1, group I, member 22002
mitogen-activated protein kinase 11001
Glucocorticoid receptor0404
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Chain A, Ferritin light chain1001
estrogen receptor 2 (ER beta)2002
peroxisome proliferator activated receptor gamma3003
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Proton-coupled amino acid transporter 10101
Amino acid transporter0101
glp-1 receptor, partial1001
pregnane X receptor1001
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
dual specificity protein phosphatase 30101
low molecular weight phosphotyrosine protein phosphatase isoform c0101
tyrosine-protein phosphatase non-receptor type 22 isoform 10101
cytochrome P450 3A4 isoform 12002
streptokinase A precursor0011
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 10101
Solute carrier family 22 member 1 0101
Dihydrofolate reductase0404
Dihydrofolate reductase 0101
Integrin beta-31001
Estrogen receptor0011
Beta-hexosaminidase subunit alpha0102
Beta-hexosaminidase subunit beta0101
Integrin alpha-IIb1001
Dihydrofolate reductase0214
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Dihydrofolate reductase0202
Substance-K receptor0101
Dihydrofolate reductase0101
Low molecular weight phosphotyrosine protein phosphatase0101
Nuclear receptor ROR-gamma1001
Spike glycoprotein1001
Pteridine reductase 10101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Trace amine-associated receptor 50011
Estrogen receptor beta0011
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Multidrug and toxin extrusion protein 10101
Dihydrofolate reductase0101
interleukin 81001
nuclear receptor ROR-gamma isoform 11001
TAR DNA-binding protein 431001
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
peripheral myelin protein 22 isoform 11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
M-phase phosphoprotein 81001
Plasma kallikrein0001
Myeloperoxidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Stromelysin-10101
Intestinal-type alkaline phosphatase0101
Indoleamine 2,3-dioxygenase 10102
Substance-P receptor0101
Glutamate receptor ionotropic, NMDA 1 0001
Tryptophan 2,3-dioxygenase0102
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Uracil nucleotide/cysteinyl leukotriene receptor0101
Carbonic anhydrase-like protein, putative0001
Tryprostatin B synthase0001
Glutamate receptor ionotropic, NMDA 2D0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Glutamate receptor ionotropic, NMDA 3B0001
Monocarboxylate transporter 100001
Glutamate receptor ionotropic, NMDA 3A0001
Phospholipase A-2-activating protein0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]