Page last updated: 2024-09-27

Aneurysmal Bone Cysts

Fibrous blood-filled cyst in the bone. Although benign it can be destructive causing deformity and fractures.

Synonyms(2)

Synonym
Bone Cysts, Aneurysmal
Aneurysmal Bone Cysts

Research Excerpts

Overview

ExcerptReference
"Aneurysmal bone cysts are benign active or aggressive bone tumors that commonly arise in the long bones, especially the femur, tibia, and humerus and the posterior elements of the spine."( Arkader, A; Chan, G; Dormans, JP; Kleposki, R, 2010)
"Aneurysmal bone cysts are rare lesions that occur more commonly in the first and second decades of life."( Angelini, A; Mavrogenis, AF; Rimondi, E; Rossi, G; Ruggieri, P, 2010)
"Aneurysmal bone cysts are non-neoplastic, expansile, osteolytic tumor-like conditions."( Akgül, T; Ozger, H; Sağlam, Y; Yıldız, F, 2012)
"Aneurysmal bone cysts are benign tumours that usually present in childhood."( Brosjö, O; Tsagozis, P, 2014)
"Aneurysmal bone cysts are benign bone lesions affecting long bones and vertebrae; only 2%-6% have cranial involvement, and even fewer show sphenoid or intraorbital involvement."( Arocho-Quinones, EV; Lew, SM; Self, S; Suchi, M; Zwagerman, NT, 2018)
"Aneurysmal bone cysts are rare, locally aggressive bone tumors."( van de Sande, MAJ; van der Heijden, L; van Geloven, TPG, 2023)
"Aneurysmal bone cysts are rare, locally aggressive bone tumors."( van de Sande, MAJ; van der Heijden, L; van Geloven, TPG, 2023)
"Aneurysmal bone cysts are rare, locally aggressive bone tumors."( van de Sande, MAJ; van der Heijden, L; van Geloven, TPG, 2023)

Actions

ExcerptReference
"Aneurysmal bone cysts affect all age groups but are more common before skeletal maturity (first two decades of life)."( Arkader, A; Chan, G; Dormans, JP; Kleposki, R, 2010)

Treatment

ExcerptReference
"Eighteen patients with aneurysmal bone cysts were treated percutaneously with alcoholic zein."( Bérard, J; Dubois, J; Guibaud, L; Herbreteau, D; Merland, JJ; Pracros, JP; Stempfle, N, 1998)
"Ten patients with aneurysmal bone cysts were treated with CT-guided percutaneous injection of Ethibloc into the cyst cavity."( Bruce, CE; Carty, H; Dorgan, JC; Garg, NK; Walsh, HP, 2000)
"Percutaneous sclerotherapy of aneurysmal bone cysts with Ethibloc is safe and effective."( Chigot, V; Dubois, J; Garel, L; Grimard, G; Isler, M, 2003)
"We treated three patients with aneurysmal bone cysts and seven with giant cell tumours who presented with a large osteolytic lesion in peri-articular areas of the knee."( Blunn, GW; Briggs, TW; Cannon, SR; Schindler, OS, 2007)
"The optimal treatment of aneurysmal bone cysts remains an area of debate."( Cummings, JE; Heck, RK; Smith, RA, 2010)
"During that period, patients with aneurysmal bone cysts were treated with intralesional curettage, burring, and bone grafting if the lesions showed an adequate cortical wall or a wall with thinned out portions which could be reconstructed with bone grafting."( Marfori, ML; Rubio, DA; Serrano, MV; Wang, EH, 2014)
"Percutaneous doxycycline for treatment for aneurysmal bone cysts (ABCs) has been shown to decrease recurrence rates, however, this requires multiple procedures, includes the risks soft tissue necrosis, and does not provide structural support."( Daley, E; Koueiter, D; Kurdziel, MD; Moore, DD, 2018)

Research

Studies (110)

TimeframeStudies, This Condition (%)All Conditions %
pre-19902 (1.82)23.3326
1990's9 (8.18)12.5806
2000's36 (32.73)18.1394
2010's51 (46.36)28.8240
2020's12 (10.91)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
phenol0low20
acetaminophen0medium11
diatrizoic acid0medium131
gentamicin0low10
iodixanol0low10
tranexamic acid0low10
methylprednisolone acetate0low10
methylprednisolone0low80
durapatite0low50
enbucrilate0medium71
titanium0low30
argon0low10
gadolinium0low20
tricalcium phosphate0low40
calcium sulfate0low30
propiconazole0low100
chromic phosphate0low20
fluorodeoxyglucose f180low10
zoledronic acid0low10
cortisone0low10
polidocanol0medium131
osteoprotegerin0low30
phenylephrine hydrochloride0low20
jaw0low20
ethyl octylphosphonofluoridate0low10
sodium tetradecyl sulfate0low10
technetium tc 99m medronate0low20
phosphorus radioisotopes0low30

Protein Targets (275)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma7007
ATAD5 protein, partial2002
GLS protein2002
Microtubule-associated protein tau1001
Smad31001
aldehyde dehydrogenase 1 family, member A13003
thyroid stimulating hormone receptor1001
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor5005
EWS/FLI fusion protein3003
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha8008
estrogen-related nuclear receptor alpha7007
estrogen nuclear receptor alpha100010
peroxisome proliferator activated receptor gamma6006
aryl hydrocarbon receptor2002
chromobox protein homolog 14004
thyroid hormone receptor beta isoform 25005
peripheral myelin protein 223003
cytochrome P450 3A4 isoform 12002
Gamma-aminobutyric acid receptor subunit pi2002
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Solute carrier family 22 member 60202
Carbonic anhydrase 120404
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0202
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump0606
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10606
Carbonic anhydrase 20606
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20001
Prostaglandin G/H synthase 10101
Carbonic anhydrase 30303
Cytochrome P450 3A40202
Cytochrome P450 2D60101
Cytochrome P450 2C9 0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-12002
Sulfotransferase 1A1 0002
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 23003
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0001
Carbonic anhydrase 40303
Prostaglandin G/H synthase 10202
Carbonic anhydrase 60404
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Carbonic anhydrase 5A, mitochondrial0303
Prostaglandin G/H synthase 20102
Carbonic anhydrase 70303
Nuclear receptor ROR-gamma1001
Cytochrome P450 2J20101
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Carbonic anhydrase 90404
GABA theta subunit2002
Canalicular multispecific organic anion transporter 10404
Carbonic anhydrase 150303
Carbonic anhydrase 130303
Gamma-aminobutyric acid receptor subunit epsilon2002
Carbonic anhydrase 140404
Carbonic anhydrase 5B, mitochondrial0303
toxin B0001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
endonuclease IV1001
dopamine D1 receptor1001
thioredoxin reductase3003
pregnane X receptor2002
TDP1 protein5005
GLI family zinc finger 35005
AR protein8008
regulator of G-protein signaling 41001
glucocorticoid receptor [Homo sapiens]7007
pregnane X nuclear receptor4004
peroxisome proliferator-activated receptor delta4004
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
euchromatic histone-lysine N-methyltransferase 22002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
peripheral myelin protein 22 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
heat shock protein beta-13003
flap endonuclease 11001
nuclear factor erythroid 2-related factor 2 isoform 16006
geminin6006
survival motor neuron protein isoform d2002
M-phase phosphoprotein 81001
muscarinic acetylcholine receptor M11001
Glucocorticoid receptor0404
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0101
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 432002
Multidrug and toxin extrusion protein 10101
cytochrome P450 family 3 subfamily A polypeptide 42002
Cellular tumor antigen p535005
Chymotrypsinogen A0101
ATP-dependent phosphofructokinase2002
acetylcholinesterase2002
hypoxia-inducible factor 1 alpha subunit3003
PPM1D protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
nonstructural protein 12002
G2002
bromodomain adjacent to zinc finger domain 2B1001
IDH13003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
nuclear receptor subfamily 1, group I, member 23003
nuclear factor erythroid 2-related factor 2 isoform 22002
muscleblind-like protein 1 isoform 11001
Nuclear receptor subfamily 1 group I member 20011
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Androgen receptor0202
Inositol hexakisphosphate kinase 12002
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 2C9, partial2002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
USP1 protein, partial2002
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Glucose-6-phosphate 1-dehydrogenase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, Lysozyme0011
Chain A, Lysozyme0011
Chain A, Lysozyme0011
Chain A, Lysozyme0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
cytochrome P450 2D62002
alpha-galactosidase1001
Polyphenol oxidase 20103
Endolysin0011
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit gamma-20011
Cannabinoid receptor 10101
Adenosine receptor A10101
Adenosine receptor A2a0101
Gamma-aminobutyric acid receptor subunit beta-20011
Spike glycoprotein3003
Carbonic anhydrase 0101
Beta-carbonic anhydrase 10101
Carbonic anhydrase0202
Carbonic anhydrase 0101
Carbonic anhydrase 30202
Carbonic anhydrase0101
Carbonic anhydrase 130101
Chain A, 2-oxoglutarate Oxygenase2002
glp-1 receptor, partial2002
GALC protein1001
thyroid stimulating hormone receptor3003
beta-2 adrenergic receptor1001
Bloom syndrome protein isoform 11001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
lamin isoform A-delta103003
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
phosphopantetheinyl transferase2002
SMAD family member 22002
SMAD family member 32002
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)3003
farnesoid X nuclear receptor3003
caspase-31001
thyroid hormone receptor beta isoform a2002
potassium voltage-gated channel subfamily H member 2 isoform d1001
huntingtin isoform 21001
nuclear receptor ROR-gamma isoform 12002
Chain A, Beta-lactamase1001
Chain A, Ferritin light chain1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
vitamin D3 receptor isoform VDRA1001
heat shock protein HSP 90-alpha isoform 20001
DNA polymerase iota isoform a (long)1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Histamine H2 receptor1001
Guanine nucleotide-binding protein G1001
heat shock protein 90, putative0001
chaperonin-containing TCP-1 beta subunit homolog1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
histone acetyltransferase KAT2A isoform 11001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
5'-AMP-activated protein kinase subunit beta-20001
Albumin0101
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
Luciferase1001
Chain A, PLASMINOGEN0011
Chain A, PLASMINOGEN0011
Plasminogen0213
Urokinase-type plasminogen activator0101
Fumarate hydratase1001
polyprotein1001
Butyrophilin subfamily 3 member A10012
Geranylgeranyl pyrophosphate synthase0203
72 kDa type IV collagenase0101
Farnesyl pyrophosphate synthase0202
Matrix metalloproteinase-90101
Neutrophil collagenase0101
Farnesyl diphosphate synthase0101
Matrix metalloproteinase-140101
Farnesyl pyrophosphate synthase 0202
Geranylgeranyl pyrophosphate synthase0202
Farnesyl pyrophosphate synthase 0101
H0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]