Aneurysmal Bone Cysts

Fibrous blood-filled cyst in the bone. Although benign it can be destructive causing deformity and fractures.

Synonym
Bone Cysts, Aneurysmal
Aneurysmal Bone Cysts

Excerpt	Reference
"Aneurysmal bone cysts are benign active or aggressive bone tumors that commonly arise in the long bones, especially the femur, tibia, and humerus and the posterior elements of the spine."	( Arkader, A; Chan, G; Dormans, JP; Kleposki, R, 2010)
"Aneurysmal bone cysts are rare lesions that occur more commonly in the first and second decades of life."	( Angelini, A; Mavrogenis, AF; Rimondi, E; Rossi, G; Ruggieri, P, 2010)
"Aneurysmal bone cysts are non-neoplastic, expansile, osteolytic tumor-like conditions."	( Akgül, T; Ozger, H; Sağlam, Y; Yıldız, F, 2012)
"Aneurysmal bone cysts are benign tumours that usually present in childhood."	( Brosjö, O; Tsagozis, P, 2014)
"Aneurysmal bone cysts are benign bone lesions affecting long bones and vertebrae; only 2%-6% have cranial involvement, and even fewer show sphenoid or intraorbital involvement."	( Arocho-Quinones, EV; Lew, SM; Self, S; Suchi, M; Zwagerman, NT, 2018)
"Aneurysmal bone cysts are rare, locally aggressive bone tumors."	( van de Sande, MAJ; van der Heijden, L; van Geloven, TPG, 2023)
"Aneurysmal bone cysts are rare, locally aggressive bone tumors."	( van de Sande, MAJ; van der Heijden, L; van Geloven, TPG, 2023)
"Aneurysmal bone cysts are rare, locally aggressive bone tumors."	( van de Sande, MAJ; van der Heijden, L; van Geloven, TPG, 2023)

Excerpt	Reference
"Aneurysmal bone cysts affect all age groups but are more common before skeletal maturity (first two decades of life)."	( Arkader, A; Chan, G; Dormans, JP; Kleposki, R, 2010)

Excerpt	Reference
"Eighteen patients with aneurysmal bone cysts were treated percutaneously with alcoholic zein."	( Bérard, J; Dubois, J; Guibaud, L; Herbreteau, D; Merland, JJ; Pracros, JP; Stempfle, N, 1998)
"Ten patients with aneurysmal bone cysts were treated with CT-guided percutaneous injection of Ethibloc into the cyst cavity."	( Bruce, CE; Carty, H; Dorgan, JC; Garg, NK; Walsh, HP, 2000)
"Percutaneous sclerotherapy of aneurysmal bone cysts with Ethibloc is safe and effective."	( Chigot, V; Dubois, J; Garel, L; Grimard, G; Isler, M, 2003)
"We treated three patients with aneurysmal bone cysts and seven with giant cell tumours who presented with a large osteolytic lesion in peri-articular areas of the knee."	( Blunn, GW; Briggs, TW; Cannon, SR; Schindler, OS, 2007)
"The optimal treatment of aneurysmal bone cysts remains an area of debate."	( Cummings, JE; Heck, RK; Smith, RA, 2010)
"During that period, patients with aneurysmal bone cysts were treated with intralesional curettage, burring, and bone grafting if the lesions showed an adequate cortical wall or a wall with thinned out portions which could be reconstructed with bone grafting."	( Marfori, ML; Rubio, DA; Serrano, MV; Wang, EH, 2014)
"Percutaneous doxycycline for treatment for aneurysmal bone cysts (ABCs) has been shown to decrease recurrence rates, however, this requires multiple procedures, includes the risks soft tissue necrosis, and does not provide structural support."	( Daley, E; Koueiter, D; Kurdziel, MD; Moore, DD, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (1.82)	23.3326
1990's	9 (8.18)	12.5806
2000's	36 (32.73)	18.1394
2010's	51 (46.36)	28.8240
2020's	12 (10.91)	9.53

Drug	Relationship Strength	Studies	Trials
salicylic acid	low	1	0
phenol	low	2	0
acetaminophen	medium	1	1
diatrizoic acid	medium	13	1
gentamicin	low	1	0
iodixanol	low	1	0
tranexamic acid	low	1	0
methylprednisolone acetate	low	1	0
methylprednisolone	low	8	0
durapatite	low	5	0
enbucrilate	medium	7	1
titanium	low	3	0
argon	low	1	0
gadolinium	low	2	0
tricalcium phosphate	low	4	0
calcium sulfate	low	3	0
propiconazole	low	10	0
chromic phosphate	low	2	0
fluorodeoxyglucose f18	low	1	0
zoledronic acid	low	1	0
cortisone	low	1	0
polidocanol	medium	13	1
osteoprotegerin	low	3	0
phenylephrine hydrochloride	low	2	0
jaw	low	2	0
ethyl octylphosphonofluoridate	low	1	0
sodium tetradecyl sulfate	low	1	0
technetium tc 99m medronate	low	2	0
phosphorus radioisotopes	low	3	0

Protein Targets (275)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	7	0	0	7
ATAD5 protein, partial	2	0	0	2
GLS protein	2	0	0	2
Microtubule-associated protein tau	1	0	0	1
Smad3	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
thyroid stimulating hormone receptor	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
progesterone receptor	5	0	0	5
EWS/FLI fusion protein	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	5	0	0	5
retinoid X nuclear receptor alpha	8	0	0	8
estrogen-related nuclear receptor alpha	7	0	0	7
estrogen nuclear receptor alpha	10	0	0	10
peroxisome proliferator activated receptor gamma	6	0	0	6
aryl hydrocarbon receptor	2	0	0	2
chromobox protein homolog 1	4	0	0	4
thyroid hormone receptor beta isoform 2	5	0	0	5
peripheral myelin protein 22	3	0	0	3
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	4	0	4
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Bile salt export pump	0	6	0	6
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	6	0	6
Carbonic anhydrase 2	0	6	0	6
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 3	0	3	0	3
Cytochrome P450 3A4	0	2	0	2
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Sulfotransferase 1A1	0	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Carbonic anhydrase 4	0	3	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 6	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Carbonic anhydrase 5A, mitochondrial	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	2
Carbonic anhydrase 7	0	3	0	3
Nuclear receptor ROR-gamma	1	0	0	1
Cytochrome P450 2J2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Carbonic anhydrase 9	0	4	0	4
GABA theta subunit	2	0	0	2
Canalicular multispecific organic anion transporter 1	0	4	0	4
Carbonic anhydrase 15	0	3	0	3
Carbonic anhydrase 13	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Carbonic anhydrase 14	0	4	0	4
Carbonic anhydrase 5B, mitochondrial	0	3	0	3
toxin B	0	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
endonuclease IV	1	0	0	1
dopamine D1 receptor	1	0	0	1
thioredoxin reductase	3	0	0	3
pregnane X receptor	2	0	0	2
TDP1 protein	5	0	0	5
GLI family zinc finger 3	5	0	0	5
AR protein	8	0	0	8
regulator of G-protein signaling 4	1	0	0	1
glucocorticoid receptor [Homo sapiens]	7	0	0	7
pregnane X nuclear receptor	4	0	0	4
peroxisome proliferator-activated receptor delta	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
peripheral myelin protein 22 isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
heat shock protein beta-1	3	0	0	3
flap endonuclease 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
geminin	6	0	0	6
survival motor neuron protein isoform d	2	0	0	2
M-phase phosphoprotein 8	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
Glucocorticoid receptor	0	4	0	4
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	4	0	4
Corticosteroid-binding globulin	0	1	0	1
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	2	0	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
Cellular tumor antigen p53	5	0	0	5
Chymotrypsinogen A	0	1	0	1
ATP-dependent phosphofructokinase	2	0	0	2
acetylcholinesterase	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
PPM1D protein	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
nonstructural protein 1	2	0	0	2
G	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
IDH1	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
muscleblind-like protein 1 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Androgen receptor	0	2	0	2
Inositol hexakisphosphate kinase 1	2	0	0	2
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
cytochrome P450 2C9, partial	2	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
USP1 protein, partial	2	0	0	2
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
cytochrome P450 2D6	2	0	0	2
alpha-galactosidase	1	0	0	1
Polyphenol oxidase 2	0	1	0	3
Endolysin	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Cannabinoid receptor 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Spike glycoprotein	3	0	0	3
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
glp-1 receptor, partial	2	0	0	2
GALC protein	1	0	0	1
thyroid stimulating hormone receptor	3	0	0	3
beta-2 adrenergic receptor	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
lamin isoform A-delta10	3	0	0	3
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
phosphopantetheinyl transferase	2	0	0	2
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
caspase 7, apoptosis-related cysteine protease	1	0	0	1
estrogen receptor 2 (ER beta)	3	0	0	3
farnesoid X nuclear receptor	3	0	0	3
caspase-3	1	0	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
huntingtin isoform 2	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
Chain A, Beta-lactamase	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Histamine H2 receptor	1	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
heat shock protein 90, putative	0	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Luciferase	1	0	0	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Plasminogen	0	2	1	3
Urokinase-type plasminogen activator	0	1	0	1
Fumarate hydratase	1	0	0	1
polyprotein	1	0	0	1
Butyrophilin subfamily 3 member A1	0	0	1	2
Geranylgeranyl pyrophosphate synthase	0	2	0	3
72 kDa type IV collagenase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Matrix metalloproteinase-9	0	1	0	1
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

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Treatment

Research

Studies (110)

Protein Targets (275)

Aneurysmal Bone Cysts

Synonyms(2)

Research Excerpts

Overview

Actions

Treatment

Research

Studies (110)

Drugs Studied (41)

Protein Targets (275)