Aleutian Disease of Mink

A slow progressive disease of mink caused by the ALEUTIAN MINK DISEASE VIRUS. It is characterized by poor reproduction, weight loss, autoimmunity, hypergammaglobulinemia, increased susceptibility to bacterial infections, and death from renal failure. The disease occurs in all color types, but mink which are homozygous recessive for the Aleutian gene for light coat color are particularly susceptible.

Synonym
Aleutian Disease of Mink
Aleutian Mink Disease

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	35 (83.33)	23.3326
1990's	3 (7.14)	12.5806
2000's	1 (2.38)	18.1394
2010's	1 (2.38)	28.8240
2020's	2 (4.76)	9.53

Drug	Relationship Strength	Studies
hydrochloric acid	low	1
creatine	low	1
formaldehyde	low	1
glycine	low	1
iodine	low	4
melatonin	low	1
urea	low	1
mercaptoethanol	low	1
glutaral	low	1
hydroxyurea	low	1
thymidine	low	1
uridine	low	1
tyrosine	low	1
betamethasone	low	1
hydantoins	low	1
phenyl acetate	low	1
foxes	low	3
biotin	low	1
cortisone	low	1
fibrin	low	2
dactinomycin	low	1
ovalbumin	low	3
ammonium sulfate	low	1
cellulose	low	1
interleukin-8	low	1
tetracycline	low	1
agar	low	1
ascophyllum	low	1
inosine pranobex	low	1
eye	low	2
concanavalin a	low	3

Protein Targets (390)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
pregnane X receptor	2	0	0	2
GLI family zinc finger 3	5	0	0	5
AR protein	9	0	0	9
progesterone receptor	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
glucocorticoid receptor [Homo sapiens]	6	0	0	6
estrogen-related nuclear receptor alpha	4	0	0	4
farnesoid X nuclear receptor	2	0	0	2
pregnane X nuclear receptor	7	0	0	7
estrogen nuclear receptor alpha	10	0	0	10
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
IDH1	1	0	0	1
aryl hydrocarbon receptor	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
galanin receptor type 3	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Bile salt export pump	0	5	0	5
Glucocorticoid receptor	0	4	0	4
Glycine receptor subunit alpha-1	0	4	0	4
Glutamate receptor 2	3	0	0	3
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Canalicular multispecific organic anion transporter 1	0	4	0	4
ORF73	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
RAR-related orphan receptor gamma	8	0	0	8
apical membrane antigen 1, AMA1	1	0	0	1
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
endonuclease IV	1	0	0	1
dopamine D1 receptor	1	0	0	1
thioredoxin reductase	3	0	0	3
GLS protein	3	0	0	3
TDP1 protein	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	4	0	0	4
regulator of G-protein signaling 4	2	0	0	2
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
retinoid X nuclear receptor alpha	5	0	0	5
peroxisome proliferator-activated receptor delta	3	0	0	3
peroxisome proliferator activated receptor gamma	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
peripheral myelin protein 22 isoform 1	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
chromobox protein homolog 1	3	0	0	3
heat shock protein beta-1	1	0	0	1
flap endonuclease 1	1	0	0	1
geminin	4	0	0	4
survival motor neuron protein isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	5	0	0	5
M-phase phosphoprotein 8	2	0	0	2
muscarinic acetylcholine receptor M1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	5	0	0	5
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit delta	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-2	5	0	0	5
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	1	0	0	1
GABA theta subunit	5	0	0	5
Multidrug and toxin extrusion protein 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	5	0	0	5
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Ferritin light chain	2	0	0	2
Chain A, Cruzipain	1	0	0	1
interleukin 8	3	0	0	3
15-lipoxygenase, partial	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
USP1 protein, partial	3	0	0	3
Microtubule-associated protein tau	1	0	0	1
caspase 7, apoptosis-related cysteine protease	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
estrogen receptor 2 (ER beta)	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
caspase-3	3	0	0	3
RAD51	0	1	0	1
activating transcription factor 6	3	0	0	3
Histone H2A.x	4	0	0	4
Caspase-7	1	0	0	1
Bloom syndrome protein isoform 1	3	0	0	3
caspase-3	1	0	0	1
thyroid hormone receptor beta isoform 2	2	0	0	2
huntingtin isoform 2	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
peripheral myelin protein 22	3	0	0	3
caspase-1 isoform alpha precursor	1	0	0	1
Interferon beta	1	0	0	1
Cellular tumor antigen p53	3	0	0	3
ATP-dependent translocase ABCB1	0	0	0	1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Nuclear receptor ROR-gamma	3	0	0	3
Caspase-7	1	0	0	1
Spike glycoprotein	1	0	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Pantothenate synthetase	0	1	0	1
Discoidin domain-containing receptor 2	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	1	4
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	4
Glutamate receptor ionotropic, NMDA 2B	0	2	1	4
Glutamate receptor ionotropic, NMDA 2C	0	2	1	4
Large neutral amino acids transporter small subunit 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	2	1	4
Glutamate receptor ionotropic, NMDA 3B	0	2	1	4
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Glutamate receptor ionotropic, NMDA 3A	0	2	1	4
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
DNA polymerase beta	1	0	0	1
DNA polymerase iota isoform a (long)	3	0	0	3
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Protein cereblon	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 1	0	1	0	2
Carbonic anhydrase 2	0	2	0	4
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 6	0	1	0	2
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase 9	0	2	0	4
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
acetylcholinesterase	2	0	0	2
Fumarate hydratase	1	0	0	1
NFKB1 protein, partial	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
EWS/FLI fusion protein	3	0	0	3
polyprotein	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
lamin isoform A-delta10	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Stromelysin-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Urease subunit alpha	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Urease subunit beta	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Luciferase	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
ClpP	1	0	0	1
phosphopantetheinyl transferase	2	0	0	2
ATAD5 protein, partial	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cholinesterase	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Acetylcholinesterase	0	1	0	1
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Nociceptin receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Histamine H3 receptor	0	1	0	1
ATP-dependent phosphofructokinase	1	0	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
hemoglobin subunit beta	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Replicase polyprotein 1ab	0	1	0	1
Histamine H2 receptor	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-synuclein	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidylate synthase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
Carbonic anhydrase 12	0	0	0	1
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase	0	0	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Taste receptor type 2 member 14	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
lethal factor (plasmid)	1	0	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Chain A, Cytidine Deaminase	0	1	0	1
nonstructural protein 1	1	0	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Cytidine deaminase	0	1	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Equilibrative nucleoside transporter 1	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Solute carrier family 28 member 3	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Research

Studies (42)

Protein Targets (390)

Aleutian Disease of Mink

Synonyms(2)

Research Excerpts

Research

Studies (42)

Drugs Studied (38)

Protein Targets (390)