Page last updated: 2024-09-27

Adrenal Cortical Rest Tumor

Neoplasm derived from displaced cells (rest cells) of the primordial ADRENAL GLANDS, generally in patients with CONGENITAL ADRENAL HYPERPLASIA. Adrenal rest tumors have been identified in TESTES; LIVER; and other tissues. They are dependent on ADRENOCORTICOTROPIN for growth and adrenal steroid secretion.

Synonyms(2)

Synonym
Adrenal Cortical Rest Tumor
Adrenal Rest Tumor

Research Excerpts

Treatment

ExcerptReference
"Testicular adrenal rest tumors (TART) frequently occur in patients with congenital adrenal hyperplasia (CAH) and can be detected and treated in childhood as well as in adolescence."( Hüppe, P; Rübben, I, 2014)

Research

Studies (75)

TimeframeStudies, This Condition (%)All Conditions %
pre-199025 (33.33)23.3326
1990's4 (5.33)12.5806
2000's16 (21.33)18.1394
2010's23 (30.67)28.8240
2020's7 (9.33)9.53
DrugIndicatedRelationship StrengthStudiesTrials
creatine0low10
aminoglutethimide0low10
ketoconazole0low10
metyrapone0low30
mitotane0low40
corticosterone0low10
prednisolone0low10
aldosterone0low10
prednisone0low10
estrone0medium41
etiocholanolone0low10
dehydroepiandrosterone0low40
levodopa0low10
androstenedione0medium161
desoxycorticosterone0low10
17-alpha-hydroxyprogesterone0medium141
methylprednisolone0low10
pregnenolone0low20
dihydrotestosterone0low20
dehydroepiandrosterone sulfate0low30
sodium hydroxide0low10
metomidate0low10
fludrocortisone0medium31
adosterol0low10
17-alpha-hydroxypregnenolone0low10
11-hydroxyprogesterone0low10
21-deoxycortisol0low20
pregnanetriol0low20
pregnenolone sulfate0low10
11-hydroxyandrostenedione0low20
11-hydroxytestosterone0low20
17-hydroxypregnenolone sulfate0low10
16-hydroxyprogesterone0low10
deflazacort0low10
adrenosterone0low10
cortodoxone0low20
etomidate0low10
17-ketosteroids0low90
11-ketotestosterone0low20
menotropins0low10

Protein Targets (379)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Cruzipain1001
IDH16006
DNA polymerase iota isoform a (long)4004
geminin150015
Sex hormone-binding globulin011213
acetylcholinesterase3003
pregnane X receptor4004
SMAD family member 24004
SMAD family member 34004
TDP1 protein140014
GLI family zinc finger 3130013
Microtubule-associated protein tau3003
AR protein170017
progesterone receptor150015
glucocorticoid receptor [Homo sapiens]170017
retinoic acid nuclear receptor alpha variant 1110011
retinoid X nuclear receptor alpha120012
estrogen-related nuclear receptor alpha150015
farnesoid X nuclear receptor5005
pregnane X nuclear receptor140014
estrogen nuclear receptor alpha170017
G5005
vitamin D (1,25- dihydroxyvitamin D3) receptor120012
arylsulfatase A4004
euchromatic histone-lysine N-methyltransferase 26006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a130013
activating transcription factor 63003
nuclear receptor subfamily 1, group I, member 26006
chromobox protein homolog 1110011
nuclear factor erythroid 2-related factor 2 isoform 1100010
survival motor neuron protein isoform d6006
histone acetyltransferase KAT2A isoform 11001
lamin isoform A-delta107007
Voltage-dependent calcium channel gamma-2 subunit4004
Interferon beta9009
HLA class I histocompatibility antigen, B alpha chain 5005
Glucocorticoid receptor09217
Glycine receptor subunit alpha-10808
Corticosteroid-binding globulin012012
Adenosine receptor A30404
Replicase polyprotein 1ab0101
Androgen receptor012113
Alpha-1B adrenergic receptor0404
Glutamate receptor 24004
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
Mitogen-activated protein kinase 3 0101
Alpha-1A adrenergic receptor0404
Sodium-dependent dopamine transporter 0606
TAR DNA-binding protein 436006
Inositol hexakisphosphate kinase 15005
cytochrome P450 2C9, partial5005
ATP-dependent phosphofructokinase4004
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)6006
nuclear factor erythroid 2-related factor 2 isoform 29009
Chain A, Beta-lactamase3003
glp-1 receptor, partial3003
USP1 protein, partial2002
DNA polymerase beta1001
muscleblind-like protein 1 isoform 13003
Alpha-synuclein2204
thyroid hormone receptor beta isoform a3003
Mineralocorticoid receptor 0448
Mineralocorticoid receptor0202
Solute carrier organic anion transporter family member 1A10204
Guanine nucleotide-binding protein G3003
thioredoxin reductase6006
cytochrome P450 family 3 subfamily A polypeptide 49009
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a7007
peripheral myelin protein 22 isoform 14004
potassium voltage-gated channel subfamily H member 2 isoform d4004
transcriptional regulator ERG isoform 32002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
cytochrome P450 3A4 isoform 18008
Gamma-aminobutyric acid receptor subunit pi8008
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40607
Sterol O-acyltransferase 10101
Bile salt export pump010010
Cholesterol side-chain cleavage enzyme, mitochondrial 0101
Triosephosphate isomerase0101
Steroid 17-alpha-hydroxylase/17,20 lyase0404
Cholesterol side-chain cleavage enzyme, mitochondrial0101
Aromatase09016
Gamma-aminobutyric acid receptor subunit beta-18008
Ribosyldihydronicotinamide dehydrogenase [quinone]0101
Gamma-aminobutyric acid receptor subunit delta8008
Gamma-aminobutyric acid receptor subunit gamma-28008
Gamma-aminobutyric acid receptor subunit alpha-58008
Gamma-aminobutyric acid receptor subunit alpha-38008
Aromatase0112
Gamma-aminobutyric acid receptor subunit gamma-18008
Gamma-aminobutyric acid receptor subunit alpha-28008
Thromboxane-A synthase 0202
Gamma-aminobutyric acid receptor subunit alpha-48008
Gamma-aminobutyric acid receptor subunit gamma-38008
Cytochrome P450 11B2, mitochondrial0101
Gamma-aminobutyric acid receptor subunit alpha-68008
Delta-type opioid receptor0101
Gamma-aminobutyric acid receptor subunit alpha-18008
Gamma-aminobutyric acid receptor subunit beta-38008
Gamma-aminobutyric acid receptor subunit beta-28008
GABA theta subunit8008
Canalicular multispecific organic anion transporter 10505
Gamma-aminobutyric acid receptor subunit epsilon8008
Chain A, HADH2 protein7007
Chain B, HADH2 protein7007
interleukin 82002
RAR-related orphan receptor gamma9009
Smad32002
aldehyde dehydrogenase 1 family, member A13003
estrogen receptor 2 (ER beta)7007
regulator of G-protein signaling 41001
nonstructural protein 14004
peroxisome proliferator-activated receptor delta6006
peroxisome proliferator activated receptor gamma7007
Histone H2A.x3003
Caspase-72002
Bloom syndrome protein isoform 15005
caspase-32002
thyroid hormone receptor beta isoform 29009
importin subunit beta-1 isoform 12002
mitogen-activated protein kinase 14004
nuclear factor NF-kappa-B p105 subunit isoform 12002
snurportin-12002
GTP-binding nuclear protein Ran isoform 11001
nuclear receptor ROR-gamma isoform 13003
peripheral myelin protein 224004
neuropeptide S receptor isoform A1001
Beta-glucuronidase0202
Cholinesterase0101
Gastrin/cholecystokinin type B receptor0001
Testosterone 17-beta-dehydrogenase 30303
Nuclear receptor ROR-gamma5005
NFKB1 protein, partial2002
GALC protein5005
Thrombopoietin1001
thyroid stimulating hormone receptor3003
heat shock protein beta-13003
serine/threonine-protein kinase mTOR isoform 11001
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0303
Solute carrier family 22 member 30101
Solute carrier family 22 member 30202
C-8 sterol isomerase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Solute carrier family 22 member 10202
Sigma non-opioid intracellular receptor 10101
Solute carrier family 22 member 20303
endonuclease IV2002
phosphopantetheinyl transferase3003
ATAD5 protein, partial2002
nuclear receptor subfamily 1, group I, member 35005
bromodomain adjacent to zinc finger domain 2B3003
muscarinic acetylcholine receptor M13003
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10101
hypoxia-inducible factor 1 alpha subunit6006
aryl hydrocarbon receptor4004
v-jun sarcoma virus 17 oncogene homolog (avian)6006
ATPase family AAA domain-containing protein 53003
Ataxin-23003
cytochrome P450 2D61001
Beta-glucuronidase0101
Glucose-6-phosphate 1-dehydrogenase0303
G-protein coupled bile acid receptor 10044
Glucose-6-phosphate 1-dehydrogenase 0101
NPC1-like intracellular cholesterol transporter 10011
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Steryl-sulfatase0102
Multidrug resistance-associated protein 1 0001
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
ATP-binding cassette sub-family C member 110001
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1B20001
Solute carrier organic anion transporter family member 1B10001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Chain A, Sex Hormone-Binding Globulin0011
thyrotropin-releasing hormone receptor1001
vitamin D3 receptor isoform VDRA2002
Plasma kallikrein0102
Progesterone receptor0101
Progesterone receptor0315
Glucocorticoid receptor0213
Sex hormone-binding globulin0101
Androgen receptor0428
Androgen receptor0112
Angiotensin-converting enzyme0011
Cannabinoid receptor 20101
Muscarinic acetylcholine receptor0101
Neuropeptide FF receptor 20001
ALK tyrosine kinase receptor0101
hexokinase-4 isoform 12002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
glucokinase regulatory protein2002
Rap guanine nucleotide exchange factor 31001
Estrogen receptor0416
Polyunsaturated fatty acid lipoxygenase ALOX150303
17-beta-hydroxysteroid dehydrogenase type 10203
Sodium-dependent serotonin transporter0606
Mu-type opioid receptor0011
5-hydroxytryptamine receptor 2B0404
Mu-type opioid receptor0011
Inositol monophosphatase 11001
Cytochrome P450 1B10101
Estrogen receptor beta0315
Ghrelin O-acyltransferase0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)0101
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)0101
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)0101
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)0101
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)0101
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)0101
ClpP1001
EWS/FLI fusion protein3003
lethal factor (plasmid)2002
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit beta0101
Acetylcholine receptor subunit gamma0101
Acetylcholine receptor subunit delta0101
Acetylcholine receptor subunit delta0101
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit gamma0101
Acetylcholine receptor subunit beta0101
Gamma-aminobutyric acid receptor subunit alpha-10112
Cytochrome P450 11B1, mitochondrial0303
Gamma-aminobutyric acid receptor subunit gamma-20112
Cytochrome P450 11B2, mitochondrial0303
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20112
Transporter0101
Estrogen receptor beta0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0202
Cytochrome P450 26A10101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump0101
3',5'-cyclic-AMP phosphodiesterase 0101
Camphor 5-monooxygenase0001
Phospholipase A2, major isoenzyme0101
Chymotrypsinogen A0101
Beta-lactamase0101
ATP-dependent translocase ABCB10202
Epoxide hydrolase 10001
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20202
ATP-dependent translocase ABCB10202
Cytochrome P450 2C11 0101
Cytochrome P450 3A40304
Steroid 21-hydroxylase0101
Alpha-2A adrenergic receptor0404
Cytochrome P450 2C80202
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Cholesterol side-chain cleavage enzyme, mitochondrial 0101
5-hydroxytryptamine receptor 2A0101
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2A20101
Cytochrome P450 11B1, mitochondrial 0202
Translocator protein0101
Alpha-2B adrenergic receptor0202
Cytochrome P450 7A1 0101
Estrogen receptor0101
ATP-dependent translocase ABCB10202
Substance-K receptor0202
UDP-glucuronosyltransferase 1A1 0101
Sodium-dependent noradrenaline transporter 0404
Histamine H2 receptor0202
Gonadotropin-releasing hormone receptor0112
Type-1 angiotensin II receptor0101
Malate dehydrogenase, cytoplasmic0101
Delta-type opioid receptor0202
Cytochrome P450 4F20101
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0202
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0101
Potassium voltage-gated channel subfamily H member 20101
Sodium/bile acid cotransporter0101
Lanosterol 14-alpha demethylase0314
Cytochrome P450 7A10101
Lanosterol 14-alpha demethylase 0202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Luciferase1001
dopamine D1 receptor1001
15-lipoxygenase, partial1001
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
GLS protein1001
apical membrane antigen 1, AMA11001
pyruvate kinase1001
atrial natriuretic peptide receptor 1 precursor1001
flap endonuclease 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
DNA polymerase eta isoform 11001
DNA polymerase kappa isoform 11001
M-phase phosphoprotein 82002
Polyphenol oxidase 20001
Carbonic anhydrase 120001
Epidermal growth factor receptor0101
Carbonic anhydrase 10001
Carbonic anhydrase 20001
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Carbonic anhydrase 30001
Tyrosinase0101
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Adenosine receptor A10001
Adenosine receptor A2a0001
Carbonic anhydrase 5A, mitochondrial0001
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Solute carrier family 15 member 10101
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0001
Glutamate receptor ionotropic, NMDA 3B0001
Monocarboxylate transporter 100001
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
phosphoglycerate kinase1001
PPM1D protein2002
Nuclear receptor subfamily 1 group I member 20011
Nuclear receptor subfamily 1 group I member 20011
Cytochrome P450 1A20101
Cytochrome P450 2D60101
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 2C190101
Fumarate hydratase1001
thyroid stimulating hormone receptor1001
polyprotein1001
serine-protein kinase ATM isoform a1001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Cellular tumor antigen p534004
5-hydroxytryptamine receptor 60202
Peroxisome proliferator-activated receptor alpha1001
Rap guanine nucleotide exchange factor 41001
luciferase0001
Fatty acid-binding protein, liver0101
Glucocorticoid receptor0011
Cytochrome P450 2C9 0101
Glutamine synthetase0011
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Cytochrome P450 2J20101
thioredoxin glutathione reductase1001
Glutamate receptor ionotropic, NMDA 2D0112
Glutamate receptor ionotropic, NMDA 2A0011
Glutamate receptor ionotropic, NMDA 2B0011
Glutamate receptor ionotropic, NMDA 2C0112
Cholesterol 24-hydroxylase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]