Page last updated: 2024-09-27

Adenocarcinoma in Situ

A lesion with cytological characteristics associated with invasive adenocarcinoma but the tumor cells are confined to the GLANDULAR EPITHELIAL CELLS of origin. Adenocarcinoma in situ of the CERVIX and the LUNG are the most common.

Synonyms(3)

Synonym
Adenocarcinoma, Intraepithelial
Adenocarcinoma in Situ
Adenocarcinoma, Preinvasive

Research Excerpts

Treatment

ExcerptReference
"The patient's adenocarcinoma in situ was disseminated in both lungs, thus chemotherapeutic treatment with cisplatin and pemetrexed was given."( Fang, Y; Givens, NT; Wakefield, MR; Wang, Y; Willson, CM; Yang, W; Zhao, L; Zhu, Z, 2021)

Research

Studies (11)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's7 (63.64)28.8240
2020's4 (36.36)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
formaldehyde0low10
bupivacaine0medium11
fentanyl0medium11
propofol0medium11
sevoflurane0medium11
methionine0low10
octyl 2-cyanoacrylate0low10
tridemorph0low10
simvastatin0low10
methotrexate0low10
capsaicin0low10
ceruletide0low10
epidermal growth factor0low10
pemetrexed0low10
alcian blue0low10

Protein Targets (349)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20011
Potassium channel subfamily K member 90101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
15-lipoxygenase, partial2002
phosphopantetheinyl transferase2002
RAR-related orphan receptor gamma2002
GLS protein2002
TDP1 protein4004
GLI family zinc finger 33003
Microtubule-associated protein tau2002
AR protein4004
aldehyde dehydrogenase 1 family, member A13003
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor3003
retinoic acid nuclear receptor alpha variant 13003
estrogen-related nuclear receptor alpha4004
pregnane X nuclear receptor3003
estrogen nuclear receptor alpha7007
67.9K protein2002
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma4004
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
chromobox protein homolog 12002
thyroid hormone receptor beta isoform 24004
mitogen-activated protein kinase 11001
nuclear factor erythroid 2-related factor 2 isoform 13003
DNA polymerase iota isoform a (long)3003
nuclear receptor ROR-gamma isoform 11001
peripheral myelin protein 222002
survival motor neuron protein isoform d3003
cytochrome P450 3A4 isoform 12002
transient receptor potential cation channel subfamily V member 11001
lamin isoform A-delta103003
Gamma-aminobutyric acid receptor subunit pi2114
Transient receptor potential cation channel subfamily V member 10213
Lysine-specific histone demethylase 1A0101
Voltage-dependent calcium channel gamma-2 subunit2002
Bile salt export pump0404
NADH-ubiquinone oxidoreductase chain 10101
Cytochrome P450 1A20101
Polyunsaturated fatty acid 5-lipoxygenase0101
Gamma-aminobutyric acid receptor subunit beta-12114
Gamma-aminobutyric acid receptor subunit delta2114
Gamma-aminobutyric acid receptor subunit gamma-22114
Glutamate receptor 22002
Gamma-aminobutyric acid receptor subunit alpha-52114
Gamma-aminobutyric acid receptor subunit alpha-32114
Cannabinoid receptor 10101
Acetylcholinesterase0202
Prostaglandin G/H synthase 10303
Gamma-aminobutyric acid receptor subunit gamma-12114
Gamma-aminobutyric acid receptor subunit alpha-22114
Gamma-aminobutyric acid receptor subunit alpha-42114
Gamma-aminobutyric acid receptor subunit gamma-32114
Gamma-aminobutyric acid receptor subunit alpha-62114
Cannabinoid receptor 2 0101
Nuclear receptor ROR-gamma1001
Spike glycoprotein4004
D(2) dopamine receptor0011
Gamma-aminobutyric acid receptor subunit alpha-12114
Gamma-aminobutyric acid receptor subunit beta-32114
Gamma-aminobutyric acid receptor subunit beta-22114
Inositol monophosphatase 11001
Potassium voltage-gated channel subfamily A member 10101
Corticotropin-releasing factor receptor 20101
Transient receptor potential cation channel subfamily V member 10214
GABA theta subunit2114
Transient receptor potential cation channel subfamily V member 40011
Gamma-aminobutyric acid receptor subunit epsilon2114
Transient receptor potential cation channel subfamily V member 20011
ATP-dependent phosphofructokinase2002
Luciferase1001
cytochrome P450 family 3 subfamily A polypeptide 43003
euchromatic histone-lysine N-methyltransferase 23003
potassium voltage-gated channel subfamily H member 2 isoform d1001
Solute carrier family 22 member 1 0101
Nuclear receptor subfamily 1 group I member 20011
ATP-dependent translocase ABCB10202
D(2) dopamine receptor0101
Amine oxidase [flavin-containing] A0101
D(4) dopamine receptor0101
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0202
Delta-type opioid receptor0303
Mu-type opioid receptor0314
Kappa-type opioid receptor0202
Histamine H1 receptor0101
Mu-type opioid receptor0213
D(3) dopamine receptor0101
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Kappa-type opioid receptor0202
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Potassium voltage-gated channel subfamily H member 20101
Sigma non-opioid intracellular receptor 10303
Sigma non-opioid intracellular receptor 10202
Sigma non-opioid intracellular receptor 10101
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
Large neutral amino acids transporter small subunit 10101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, Ferritin light chain3003
acid sphingomyelinase1001
dopamine D1 receptor1001
thioredoxin reductase2002
ClpP1001
ATAD5 protein, partial1001
USP1 protein, partial2002
EWS/FLI fusion protein3003
retinoid X nuclear receptor alpha4004
farnesoid X nuclear receptor3003
Thymidylate synthase 0202
alpha-galactosidase1001
IDH12002
Thymidylate synthase 0202
Histone H2A.x3003
Bloom syndrome protein isoform 12002
cellular tumor antigen p53 isoform a1001
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
vitamin D3 receptor isoform VDRA2002
nuclear factor erythroid 2-related factor 2 isoform 22002
transcriptional regulator ERG isoform 31001
importin subunit beta-1 isoform 11001
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
flap endonuclease 11001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0202
geminin3003
DNA polymerase kappa isoform 11001
M-phase phosphoprotein 81001
muscleblind-like protein 1 isoform 11001
histone acetyltransferase KAT2A isoform 12002
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40203
Bile salt export pump0202
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0405
Dihydrofolate reductase0304
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0304
Thymidylate synthase0303
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20314
Cellular tumor antigen p533003
Thymidylate synthase0404
Integrin beta-31001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0303
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10022
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0325
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0202
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0202
Dihydrofolate reductase0303
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30303
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0404
Multidrug resistance-associated protein 1 0001
Reduced folate transporter0303
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0202
TAR DNA-binding protein 432002
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60102
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30202
Solute carrier family 22 member 200202
Dihydrofolate reductase 0101
Solute carrier family 22 member 80102
Solute carrier family 22 member 60202
Dihydrofolate reductase0101
Canalicular multispecific organic anion transporter 10202
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0304
Multidrug resistance associated protein0102
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20001
Chain A, Thymidylate Synthase0101
Chain A, Thymidylate Synthase0101
Chain A, Thymidylate Synthase0101
tyrosine-protein kinase Yes1001
Serine hydroxymethyltransferase, cytosolic0112
Thymidylate synthase 0101
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
caspase 7, apoptosis-related cysteine protease1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
thyroid stimulating hormone receptor1001
G2002
caspase-31001
activating transcription factor 62002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)2002
D(1A) dopamine receptor1001
heat shock protein beta-12002
muscarinic acetylcholine receptor M11001
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90001
5-hydroxytryptamine receptor 40202
Carbonic anhydrase 10303
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Aldo-keto reductase family 1 member B10202
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Sodium-dependent noradrenaline transporter 0202
Sodium- and chloride-dependent GABA transporter 10101
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit alpha-50011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30011
5-hydroxytryptamine receptor 2B0202
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20011
Sodium- and chloride-dependent betaine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-40011
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-60011
Inositol hexakisphosphate kinase 12002
UDP-glucuronosyltransferase 1A80001
cytochrome P450 2C9, partial2002
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Albumin0101
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20202
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
Chain A, Beta-lactamase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
hypoxia-inducible factor 1 alpha subunit1001
SMAD family member 21001
SMAD family member 31001
Smad31001
PINK11001
regulator of G-protein signaling 41001
glucocorticoid receptor [Homo sapiens]1001
cytochrome P450 2D61001
Parkin1001
bromodomain adjacent to zinc finger domain 2B1001
photoreceptor-specific nuclear receptor0101
nuclear receptor subfamily 1, group I, member 21001
serine/threonine-protein kinase PLK11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0202
Insulin receptor 0101
Nuclear receptor subfamily 4 group A member 20011
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Solute carrier organic anion transporter family member 1B10101
Delta0101
Cycloeucalenol cycloisomerase0101
Sterol-8,7-isomerase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]