Acute Hemorrhagic Encephalomyelitis

A fulminant and often fatal demyelinating disease of the brain which primarily affects young adults and children. Clinical features include the rapid onset of weakness, SEIZURES, and COMA. It may follow a viral illness or MYCOPLASMA PNEUMONIAE infections but in most instances there is no precipitating event. Pathologic examination reveals marked perivascular demyelination and necrosis of white matter with microhemorrhages. (Adams et al., Principles of Neurology, 6th ed, pp924-5)

Synonym
Leukoencephalitis, Acute Hemorrhagic
Leukoencephalitis Acuta Hemorrhagica
Encephalomyelitis, Necrotizing Hemorrhagic
Encephalomyelitis, Acute Necrotizing Hemorrhagic
Hurst Disease
Necrotizing Encephalomyelitis, Hemorrhagic
Encephalomyelitis, Hemorrhagic Necrotizing
Hurst Syndrome
Hurst's Disease
Encephalitis, Acute Necrotizing
Acute Hemorrhagic Encephalomyelitis
Leukoencephalitis, Subacute Hemorrhagic
Hemorrhagic Encephalomyelitis, Necrotizing
Necrotizing Hemorrhagic Encephalomyelitis
Hemorrhagic Necrotizing Encephalomyelitis
Acute Hemorrhagic Leukoencephalitis

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	8 (14.81)	23.3326
1990's	2 (3.70)	12.5806
2000's	19 (35.19)	18.1394
2010's	15 (27.78)	28.8240
2020's	10 (18.52)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
methylmalonic acid	low	1	0
glycine	low	1	0
glycerol	low	1	0
taurine	low	1	0
thiamine	low	1	0
phenytoin	low	1	0
acetaminophen	low	1	0
amantadine	low	1	0
gentamicin	low	1	0
midazolam	low	1	0
phenobarbital	low	1	0
prednisolone	medium	2	1
spironolactone	low	1	0
aldosterone	low	1	0
prednisone	low	2	0
chloramphenicol	low	1	0
aspartic acid	low	1	0
cephalothin	low	1	0
leucine	low	1	0
ampicillin	low	1	0
mannitol	low	1	0
valine	low	1	0
isoleucine	low	1	0
methylprednisolone	low	13	0
gadolinium	low	2	0
glutamic acid	low	1	0
zanamivir	low	1	0
oseltamivir	low	5	0
beta-hydroxyisovaleric acid	low	1	0
homocysteine	low	1	0
valerates	low	2	0
methotrexate	low	3	0
beta-methylcrotonylglycine	low	1	0
angiotensin ii	low	1	0
myelin basic protein	low	1	0
lead	low	1	0
thiamine pyrophosphate	low	1	0
ubiquinone	low	1	0
cyclosporine	medium	3	1
exudates	low	2	0
acyclovir	low	6	0
levoleucovorin	low	1	0

Protein Targets (700)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	6	0	0	6
ATAD5 protein, partial	3	0	0	3
GLS protein	6	0	0	6
Microtubule-associated protein tau	4	0	0	4
Smad3	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
thyroid stimulating hormone receptor	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
progesterone receptor	6	0	0	6
EWS/FLI fusion protein	7	0	0	7
retinoic acid nuclear receptor alpha variant 1	10	0	0	10
retinoid X nuclear receptor alpha	6	0	0	6
estrogen-related nuclear receptor alpha	11	0	0	11
estrogen nuclear receptor alpha	15	0	0	15
peroxisome proliferator activated receptor gamma	4	0	0	4
aryl hydrocarbon receptor	4	0	0	4
chromobox protein homolog 1	4	0	0	4
thyroid hormone receptor beta isoform 2	8	0	0	8
peripheral myelin protein 22	5	0	0	5
cytochrome P450 3A4 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	4	0	6
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	7
Solute carrier family 22 member 6	0	2	0	3
Carbonic anhydrase 12	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	3	0	3
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Bile salt export pump	0	8	0	8
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	3	0	5
Carbonic anhydrase 2	0	3	1	6
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 3A4	0	3	0	3
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C9	0	4	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	4	0	6
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	1	4	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	1	4	1	7
UDP-glucuronosyltransferase 1-6	0	1	0	2
Glutamate receptor 2	4	2	1	7
Gamma-aminobutyric acid receptor subunit alpha-5	1	4	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	1	4	0	6
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	2
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	1	4	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	1	4	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	1	4	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	1	4	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	1	4	0	6
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Carbonic anhydrase 7	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Cytochrome P450 2J2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	1	4	1	7
Gamma-aminobutyric acid receptor subunit beta-3	1	4	0	6
Gamma-aminobutyric acid receptor subunit beta-2	1	4	1	7
Carbonic anhydrase 9	0	1	0	1
GABA theta subunit	1	4	0	6
Canalicular multispecific organic anion transporter 1	0	5	0	5
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	4	0	6
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
toxin B	0	0	0	1
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Ferritin light chain	4	0	0	4
Thymidine kinase	0	1	0	1
thioredoxin reductase	7	0	0	7
phosphopantetheinyl transferase	5	0	0	5
TDP1 protein	8	0	0	8
arylsulfatase A	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
activating transcription factor 6	6	0	0	6
Histone H2A.x	4	0	0	4
Bloom syndrome protein isoform 1	6	0	0	6
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
lamin isoform A-delta10	9	0	0	9
Solute carrier family 22 member 1	0	2	0	6
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	1	0	3
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	3
Thymidine kinase	0	1	0	1
AR protein	16	0	0	16
glucocorticoid receptor [Homo sapiens]	8	0	0	8
thyroid hormone receptor beta isoform a	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
geminin	13	0	0	13
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	5	3	9
Androgen receptor	0	6	0	7
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
acetylcholinesterase	4	0	0	4
NFKB1 protein, partial	1	0	0	1
GLI family zinc finger 3	12	0	0	12
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	5	0	0	5
putative alpha-glucosidase	1	0	0	1
heat shock protein beta-1	3	0	0	3
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Solute carrier family 22 member 2	0	1	0	3
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Glutamate receptor ionotropic, NMDA 1	0	6	2	8
Spike glycoprotein	6	0	0	6
Glutamate receptor ionotropic, NMDA 2A	0	6	2	8
Glutamate receptor ionotropic, NMDA 2B	0	6	2	8
Glutamate receptor ionotropic, NMDA 2C	0	6	2	8
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	6	2	8
Solute carrier family 22 member 1	0	3	0	4
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	6	2	8
Multidrug and toxin extrusion protein 1	0	2	0	2
Solute carrier family 22 member 2	0	3	0	4
Glutamate receptor ionotropic, NMDA 3A	0	6	2	8
ATP-dependent phosphofructokinase	5	0	0	5
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
Chain A, Cruzipain	2	0	0	2
Beta-lactamase	0	0	0	2
acid sphingomyelinase	2	0	0	2
apical membrane antigen 1, AMA1	1	0	0	1
farnesoid X nuclear receptor	4	0	0	4
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
DNA polymerase beta	2	0	0	2
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	4	0	0	4
DNA polymerase kappa isoform 1	6	0	0	6
60 kDa heat shock protein, mitochondrial	0	1	0	1
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	3	0	3
Solute carrier family 15 member 1	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	2	0	2
Thiosulfate sulfurtransferase	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	2
Efflux transporter	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	2
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	1	0	1
Metallo-b-lactamase	0	0	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Histamine H3 receptor	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	2
Beta-lactamase VIM-1	0	0	0	2
glucocerebrosidase	2	0	0	2
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	2	1	3
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	2	0	2
Type-1 angiotensin II receptor	0	2	2	4
Type-2 angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	2	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
cytochrome P450 2C19 precursor	2	0	0	2
lethal factor (plasmid)	2	0	0	2
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	2
Carbonic anhydrase 4	0	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
endonuclease IV	2	0	0	2
WRN	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
DNA (cytosine-5)-methyltransferase 1 isoform b	0	1	0	1
importin subunit beta-1 isoform 1	3	0	0	3
flap endonuclease 1	3	0	0	3
serine/threonine-protein kinase PLK1	1	0	0	1
snurportin-1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-1	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Beta-lactamase TEM	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 7	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 7	0	1	0	1
phosphoglycerate kinase	1	0	0	1
interleukin 8	1	0	0	1
pregnane X nuclear receptor	7	0	0	7
G	3	0	0	3
cytochrome P450 2D6	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
streptokinase A precursor	0	0	1	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Cellular tumor antigen p53	8	0	0	8
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Inositol hexakisphosphate kinase 1	3	0	0	3
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	3	0	0	3
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
muscarinic acetylcholine receptor M1	2	0	0	2
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Gamma-aminobutyric acid	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
D(1A) dopamine receptor	1	0	0	1
transcriptional regulator ERG isoform 3	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
TAR DNA-binding protein 43	3	0	0	3
Histone deacetylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	5	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Histone deacetylase 6	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Histone deacetylase 5	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
glp-1 receptor, partial	2	0	0	2
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
Metabotropic glutamate receptor 8	0	2	0	2
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Integrin beta-3	2	0	1	3
Integrin alpha-IIb	2	0	1	3
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
peroxisome proliferator-activated receptor delta	4	0	0	4
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	4	0	4
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
estrogen receptor 2 (ER beta)	5	0	0	5
thyroid stimulating hormone receptor	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
cellular tumor antigen p53 isoform a	2	0	0	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
USP1 protein, partial	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	1	0	0	1
ClpP	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
67.9K protein	3	0	0	3
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
IDH1	4	0	0	4
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
survival motor neuron protein isoform d	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	4	0	0	4
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Serine racemase	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
PPM1D protein	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
nonstructural protein 1	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Glucocorticoid receptor	0	8	3	16
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	4
Translocator protein	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Neuraminidase	0	4	0	4
Neuraminidase	0	4	0	4
Neuraminidase	0	4	0	4
Neuraminidase	0	3	0	3
Neuraminidase	0	1	0	1
Neuraminidase	0	4	0	4
Sialidase	0	1	0	1
Acyl-CoA desaturase 1	0	2	0	2
Liver carboxylesterase 1	0	0	0	1
Neuraminidase	0	4	0	4
Neuraminidase	0	4	0	4
Neuraminidase	0	2	0	2
Neuraminidase	0	2	0	2
Sialidase-4	0	3	0	3
Sialidase-1	0	2	0	2
Sialidase-3	0	3	0	3
Sialidase-2	0	3	0	3
Sodium channel protein type 1 subunit alpha	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
peripheral myelin protein 22 isoform 1	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
nuclear receptor ROR-gamma isoform 1	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	2
Histamine H2 receptor	1	0	0	1
Inositol monophosphatase 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	4	1	5
Progesterone receptor	0	4	1	6
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Androgen receptor	0	4	1	5
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	1	1	2
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	3	1	4
pregnane X receptor	3	0	0	3
thioredoxin glutathione reductase	1	0	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
Vpr	1	0	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Luciferase	1	0	0	1
GALC protein	2	0	0	2
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Chain A, Neuraminidase	0	1	0	1
Chain A, Neuraminidase	0	1	0	1
Chain A, Neuraminidase	0	1	0	1
Chain A, Neuraminidase	0	1	0	1
Chain A, Neuraminidase	0	1	0	1
Chain A, Neuraminidase	0	1	0	1
Chain A, NEURAMINIDASE	0	1	0	1
Chain A, Neuraminidase	0	1	0	1
Neuraminidase	0	1	0	1
Sialidase-1	0	1	0	1
Neuraminidase	0	1	0	1
Neuraminidase	0	1	0	1
Neuraminidase	0	1	1	2
Neuraminidase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Sialidase A	0	1	0	1
Neuraminidase	0	1	0	1
Neuraminidase	0	1	0	1
Neuraminidase	0	1	0	1
Neuraminidase	0	1	0	1
Neuraminidase	0	1	0	1
Integrase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Acute Hemorrhagic Encephalomyelitis

Synonyms(16)

Research Excerpts

Research

Studies (54)

Protein Targets (700)

Acute Hemorrhagic Encephalomyelitis

Synonyms(16)

Research Excerpts

Research

Studies (54)

Drugs Studied (50)

Protein Targets (700)