Page last updated: 2024-09-27

Acute Encephalitis Syndrome

Acute onset of fever accompanied by seizures, cerebral inflammation and a change in mental status (e.g., confusion, disorientation, and coma).

Synonyms(3)

Synonym
Encephalopathy, Febrile
Acute Febrile Encephalopathy
Acute Encephalitis Syndrome

Research Excerpts

Overview

ExcerptReference
"Acute febrile encephalopathy is a common syndrome in the tropics with high mortality encountered by emergency physicians."( Carey, RA; Iyyadurai, R; Job, M; Mathuram, AJ; Rajan, SJ; Turaka, VP, 2021)

Treatment

ExcerptReference
"Incidence of acute encephalitis syndrome among acute failure illness patients who received presumptive doxycycline or azithromycin treatment and those who did not receive this treatment."( Deoshatwar, A; Gupta, N; Mittal, M; Murhekar, M; Pandey, AK; Shete, V; Thangaraj, JWV; Velusamy, S; Zaman, K, 2020)
"Progression to acute encephalitis syndrome was seen in 6 of the 621 patients who received presumptive treatment, and 5 of the 104 who did not receive the treatment."( Deoshatwar, A; Gupta, N; Mittal, M; Murhekar, M; Pandey, AK; Shete, V; Thangaraj, JWV; Velusamy, S; Zaman, K, 2020)

Research

Studies (48)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's25 (52.08)28.8240
2020's23 (47.92)9.53
DrugIndicatedRelationship StrengthStudiesTrials
bupropion0low10
glycine0low20
thiamine0low20
amitriptyline0low10
antipyrine0low10
clonazepam0low10
cyclobenzaprine0low10
ddt0low10
flumazenil0low10
malathion0low10
edaravone0low10
thyroxine0low10
triiodothyronine0low10
venlafaxine hydrochloride0low10
artesunic acid0low10
methylenecyclopropylglycine0low20
biotin0low10
clindamycin0low10
zithromax0low20
hypoglycin a0low10

Protein Targets (418)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
thioredoxin reductase5005
USP1 protein, partial6006
NFKB1 protein, partial1001
GLS protein2002
cytochrome P450 family 3 subfamily A polypeptide 49009
cytochrome P450 2D64004
arylsulfatase A2002
cytochrome P450 2D6 isoform 13003
D(1A) dopamine receptor3003
chromobox protein homolog 14004
atrial natriuretic peptide receptor 2 precursor2002
serine/threonine-protein kinase mTOR isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 18008
muscarinic acetylcholine receptor M13003
Solute carrier family 22 member 1 0203
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Voltage-dependent L-type calcium channel subunit alpha-1F0101
5-hydroxytryptamine receptor 40202
Bile salt export pump0707
Albumin0011
High affinity nerve growth factor receptor0123
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
5-hydroxytryptamine receptor 2C0101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10202
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
5-hydroxytryptamine receptor 2A0101
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
5-hydroxytryptamine receptor 1A0303
Muscarinic acetylcholine receptor M30202
D(1A) dopamine receptor0202
D(1B) dopamine receptor0101
UDP-glucuronosyltransferase 1A40102
Sodium-dependent noradrenaline transporter 0505
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 60101
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0505
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
Histamine H1 receptor0202
D(3) dopamine receptor0202
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
UDP-glucuronosyltransferase 1A30001
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0101
Histamine H2 receptor2104
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 60202
5-hydroxytryptamine receptor 70101
Voltage-dependent N-type calcium channel subunit alpha-1B0202
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Sodium-dependent dopamine transporter 0505
Potassium voltage-gated channel subfamily H member 20202
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Sigma non-opioid intracellular receptor 10022
5-hydroxytryptamine receptor 4 0101
Nuclear receptor subfamily 3 group C member 3 0202
Canalicular multispecific organic anion transporter 10404
Sodium channel protein type 2 subunit alpha0101
Ataxin-22002
Sigma non-opioid intracellular receptor 10202
5-hydroxytryptamine receptor 3B0101
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0101
Sodium channel protein type 10 subunit alpha0101
ATAD5 protein, partial2002
GLI family zinc finger 36006
nuclear receptor subfamily 1, group I, member 36006
glucocorticoid receptor [Homo sapiens]4004
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha6006
estrogen nuclear receptor alpha8008
67.9K protein1001
peroxisome proliferator-activated receptor delta5005
thyroid hormone receptor beta isoform a5005
nuclear factor erythroid 2-related factor 2 isoform 23003
geminin8008
Cytochrome P450 2C9 0101
Cytochrome P450 2J20101
Nicotinate phosphoribosyltransferase0101
Chain A, Avidin0011
Chain A, Protein (streptavidin)0011
Chain B, Protein (streptavidin)0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin Complex With Biotin0011
Chain D, Circularly Permuted Core-streptavidin E51/a460011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Avidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, JmjC domain-containing histone demethylation protein 3A1001
RAR-related orphan receptor gamma5005
apical membrane antigen 1, AMA13003
nonstructural protein 10101
green fluorescent protein, partial0101
vitamin D3 receptor isoform VDRA3003
insulin-degrading enzyme isoform 10011
Streptavidin0011
Receptor-type tyrosine-protein phosphatase beta0001
histone acetyltransferase KAT2A isoform 12002
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit gamma0101
Integrin alpha-50101
Acetylcholine receptor subunit beta0101
UDP-glucuronosyltransferase 2B70102
Neuronal acetylcholine receptor subunit beta-20102
UDP-glucuronosyltransferase 1-60102
Cytochrome P450 2B60002
UDP-glucuronosyltransferase 1A1 0203
Sodium-dependent dopamine transporter0101
Neuronal acetylcholine receptor subunit beta-40102
Neuronal acetylcholine receptor subunit alpha-30101
Cytochrome P450 2C190101
UDP-glucuronosyltransferase 2B10 0101
Neuronal acetylcholine receptor subunit alpha-70101
Neuronal acetylcholine receptor subunit alpha-40102
Acetylcholine receptor subunit delta0101
ATP-dependent phosphofructokinase2002
Protein-arginine deiminase type-40202
Gamma-aminobutyric acid receptor subunit pi0404
Gamma-aminobutyric acid receptor subunit pi3317
Gamma-aminobutyric acid receptor subunit delta0404
Gamma-aminobutyric acid receptor subunit alpha-10303
Gamma-aminobutyric acid receptor subunit beta-10303
Neuronal acetylcholine receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit alpha-20303
Gamma-aminobutyric acid receptor subunit alpha-30303
Neuronal acetylcholine receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-10415
Gamma-aminobutyric acid receptor subunit beta-13317
Gamma-aminobutyric acid receptor subunit beta-10404
Gamma-aminobutyric acid receptor subunit delta3317
Gamma-aminobutyric acid receptor subunit gamma-20415
Gamma-aminobutyric acid receptor subunit gamma-23317
Gamma-aminobutyric acid receptor subunit alpha-53317
Gamma-aminobutyric acid receptor subunit alpha-33317
Gamma-aminobutyric acid receptor subunit alpha-40303
Gamma-aminobutyric acid receptor subunit gamma-20303
Gamma-aminobutyric acid receptor subunit gamma-13317
Gamma-aminobutyric acid receptor subunit alpha-23317
Gamma-aminobutyric acid receptor subunit alpha-43317
Gamma-aminobutyric acid receptor subunit beta-30415
Gamma-aminobutyric acid receptor subunit gamma-33317
Gamma-aminobutyric acid receptor subunit alpha-63317
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50415
Gamma-aminobutyric acid receptor subunit alpha-30415
Gamma-aminobutyric acid receptor subunit alpha-20404
Gamma-aminobutyric acid receptor subunit beta-20404
Gamma-aminobutyric acid receptor subunit alpha-40404
Gamma-aminobutyric acid receptor subunit alpha-13317
Gamma-aminobutyric acid receptor subunit beta-33317
Gamma-aminobutyric acid receptor subunit beta-23317
Gamma-aminobutyric acid receptor subunit epsilon0404
Gamma-aminobutyric acid receptor subunit alpha-60404
Gamma-aminobutyric acid receptor subunit gamma-10404
GABA theta subunit3317
Gamma-aminobutyric acid receptor subunit gamma-30404
Gamma-aminobutyric acid receptor subunit epsilon3317
Gamma-aminobutyric acid receptor subunit theta0404
15-lipoxygenase, partial2002
Fumarate hydratase1001
PPM1D protein2002
Thrombopoietin1001
thyroid stimulating hormone receptor5005
EWS/FLI fusion protein3003
polyprotein1001
euchromatic histone-lysine N-methyltransferase 25005
cellular tumor antigen p53 isoform a2002
atrial natriuretic peptide receptor 1 precursor1001
peripheral myelin protein 223003
Interferon beta7007
Inositol monophosphatase 11001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Cruzipain1001
interleukin 83003
pregnane X receptor1001
hypoxia-inducible factor 1 alpha subunit3003
SMAD family member 22002
SMAD family member 32002
TDP1 protein6006
AR protein5005
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
estrogen receptor 2 (ER beta)2002
progesterone receptor4004
estrogen-related nuclear receptor alpha6006
farnesoid X nuclear receptor3003
pregnane X nuclear receptor6006
G5005
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
aryl hydrocarbon receptor5005
thyroid stimulating hormone receptor2002
activating transcription factor 62002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x3003
Caspase-71001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
potassium voltage-gated channel subfamily H member 2 isoform d1001
caspase-31001
thyroid hormone receptor beta isoform 25005
heat shock protein beta-12002
mitogen-activated protein kinase 11001
nuclear factor NF-kappa-B p105 subunit isoform 12002
lethal factor (plasmid)2002
lamin isoform A-delta104004
Voltage-dependent calcium channel gamma-2 subunit1001
HLA class I histocompatibility antigen, B alpha chain 5005
Cellular tumor antigen p534004
Androgen receptor0101
Glutamate receptor 21001
Nuclear receptor ROR-gamma3003
Inositol hexakisphosphate kinase 15005
cytochrome P450 2C9, partial5005
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, 2-oxoglutarate Oxygenase1001
acetylcholinesterase2002
Microtubule-associated protein tau1001
caspase 7, apoptosis-related cysteine protease1001
aldehyde dehydrogenase 1 family, member A13003
glucocerebrosidase2002
caspase-31001
IDH12002
lysosomal alpha-glucosidase preproprotein1001
flap endonuclease 12002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
DNA polymerase iota isoform a (long)1001
nuclear receptor ROR-gamma isoform 12002
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 13003
replicative DNA helicase0001
recombinase A0011
UDP-glucuronosyltransferase 1A90002
UDP-glucuronosyltransferase 2B170001
Amyloid-beta precursor protein0101
UDP-glucuronosyltransferase 1A70001
endonuclease IV1001
phosphopantetheinyl transferase2002
regulator of G-protein signaling 41001
Bloom syndrome protein isoform 11001
cytochrome P450 2C19 precursor1001
muscleblind-like protein 1 isoform 12002
Bile salt export pump0101
Neuronal acetylcholine receptor subunit alpha-70101
TAR DNA-binding protein 432002
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Glutamate receptor ionotropic, NMDA 1 0213
Sodium- and chloride-dependent glycine transporter 10101
Glutamate receptor ionotropic, NMDA 2A 0213
Glutamate receptor ionotropic, NMDA 2B0213
Glutamate receptor ionotropic, NMDA 2C0213
Large neutral amino acids transporter small subunit 10101
Glutamate receptor ionotropic, NMDA 2D0213
Proton-coupled amino acid transporter 10101
Glutamate receptor ionotropic, NMDA 3B0213
Serine racemase0101
Olfactory receptor 51E20011
Glutamate receptor ionotropic, NMDA 3A0213
Sodium- and chloride-dependent glycine transporter 20101
Luciferase1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
Spike glycoprotein1001
Carboxylic ester hydrolase 0101
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 60101
Transketolase0011
Thiamine-binding periplasmic protein0011
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
serine/threonine-protein kinase PLK11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase kappa isoform 11001
Solute carrier organic anion transporter family member 1A40103
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50002
Rap guanine nucleotide exchange factor 31001
Transthyretin0103
Thyroid hormone receptor alpha0235
Thyroid hormone receptor beta0235
Proliferating cell nuclear antigen0202
Retinoic acid receptor RXR-alpha0022
Peroxisome proliferator-activated receptor gamma0044
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 1A30002
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10002
glp-1 receptor, partial2002
neuropeptide S receptor isoform A1001
Prothrombin0011
Androgen receptor0101
Thyroid hormone receptor beta0101
Adenosine receptor A10202
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4A10001
Solute carrier organic anion transporter family member 1C10101
Solute carrier organic anion transporter family member 1B30001
nuclear receptor subfamily 1, group I, member 21001
streptokinase A precursor0011
twin arginine protein translocation system - TatA protein0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Cytochrome P450 3A40101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]