Page last updated: 2024-09-27

Activated Protein C Resistance

A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.

Synonyms(2)

Synonym
APC Resistance
Activated Protein C Resistance

Research Excerpts

Overview

ExcerptReference
"APC resistance is not associated with IBD but, when present, increases the risk of thromboembolism."( Kapiotis, S; Katzenschlager, R; Miehsler, W; Novacek, G; Speiser, W; Vogelsang, H, 1999)
"aPC resistance is common in patients being evaluated for possible hypercoagulability."( Houston, DS; Zarychanski, R, 2004)

Context

ExcerptReference
"TAM-induced APC resistance has not been reported yet."( Fimmers, R; Kuhn, WC; Müller, J; Oldenburg, J; Pötzsch, B; Rudlowski, C; Rühl, H; Schröder, L; Sukhitashvili, S; Welz, J, 2014)

Treatment

ExcerptReference
"Serum levels of modified activated protein C resistance, antithrombin III, fibrinogen, factor VIIIa, factor VIII, factor IX, activated partial thromboplastin time, prothrombin time, thrombin time, and lipoprotein (a) were measured before and 6 months after the treatment and analyzed for changes in extrinsic and intrinsic coagulation parameters."( Ayhan, A; Baykal, C; Demirol, A; Kirazli, S, 2001)

Research

Studies (218)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's21 (9.63)12.5806
2000's127 (58.26)18.1394
2010's63 (28.90)28.8240
2020's7 (3.21)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0low20
beta-alanine0low20
glycine0medium21
dalteparin0medium91
acetazolamide0low10
aspirin0medium141
azathioprine0low10
etilefrine0low10
flumazenil0medium31
hydroxyurea0low10
metformin0medium11
metoprolol0low10
oxybutynin0low10
phenindione0low20
thalidomide0medium52
hydroxyproline0low10
thyroxine0low10
norethindrone acetate0medium22
prednisone0low30
glutamine0low40
ethinyl estradiol0medium129
norethindrone0medium44
medroxyprogesterone acetate0medium22
threonine0low10
arginine0medium81
methylprednisolone0medium21
pyrroles0low10
thiophenes0low20
dydrogesterone0medium11
pyrazines0low10
chlormadinone acetate0low10
cyproterone acetate0low40
nandrolone0medium22
homocystine0low10
levonorgestrel0medium129
d-alpha tocopherol0medium11
fluorescein-5-isothiocyanate0low10
ethinyl estradiol-norgestrel combination0medium32
estetrol0medium11
etoposide0medium21
promegestone0medium11
desogestrel0medium105
raloxifene hydrochloride0medium33
atorvastatin0low10
dienogest0medium22
drospirenone0medium31
trimegestone0medium11
fluindione0low20
fibrinogen0medium213
homocysteine0medium202
mci 90380medium31
vitamin b 60low10
perindopril0low10
st 14350medium11
melagatran0medium11
dabigatran0low60
lenalidomide0low10
bortezomib0low10
fibrin0low70
tibolone0medium22
tamoxifen0medium42
dermatan sulfate0low10
gestodene0medium42
bilirubin0low10
vitamin k semiquinone radical0low20
deamino arginine vasopressin0low30
ximelagatran0medium11
rivaroxaban0low100
apixaban0low20
bivalirudin0low10
ristocetin0low10
menotropins0medium21
ro13-99040low10
heparitin sulfate0low10
acenocoumarol0low10
warfarin0medium231
phenprocoumon0low30
calca protein, human0low10
globotriaosylceramide0low10
hirudin0low10
carboxypeptidase b0low10
vitamin b 120low30
thromboplastin0low140
chondroitin sulfates0low10
exudates0low10
guanine0low30
folic acid0low30

Protein Targets (820)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE130013
Luciferase4004
RAR-related orphan receptor gamma270027
retinoid X nuclear receptor alpha240024
G200020
peroxisome proliferator activated receptor gamma180018
euchromatic histone-lysine N-methyltransferase 2230023
thyroid stimulating hormone receptor130013
chromobox protein homolog 19009
parathyroid hormone/parathyroid hormone-related peptide receptor precursor5005
geminin260026
muscleblind-like protein 1 isoform 17007
Interferon beta260026
HLA class I histocompatibility antigen, B alpha chain 200020
Guanine nucleotide-binding protein G2002
Inositol hexakisphosphate kinase 1200020
cytochrome P450 2C9, partial200020
Chain A, TYROSYL-DNA PHOSPHODIESTERASE100010
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase9009
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
thioredoxin reductase140014
GALC protein1001
GLI family zinc finger 3250025
nuclear receptor subfamily 1, group I, member 3220022
cytochrome P450 family 3 subfamily A polypeptide 4230023
glucocorticoid receptor [Homo sapiens]300030
retinoic acid nuclear receptor alpha variant 1290029
estrogen-related nuclear receptor alpha330033
Carbonic anhydrase 0101
Carbonic anhydrase 0101
arylsulfatase A6006
Carbonic anhydrase0101
Bloom syndrome protein isoform 1100010
thyroid hormone receptor beta isoform a110011
nuclear factor erythroid 2-related factor 2 isoform 1240024
peripheral myelin protein 22110011
survival motor neuron protein isoform d6006
Gamma-aminobutyric acid receptor subunit pi93113
ATP-binding cassette sub-family C member 3023023
Multidrug resistance-associated protein 4023025
Carbonic anhydrase0101
Solute carrier family 22 member 60202
Carbonic anhydrase 120316
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Bile salt export pump030030
Glycogen phosphorylase, muscle form0101
Renin0202
Carbonic anhydrase 105111
Carbonic anhydrase 206213
Carbonic anhydrase 20202
Cytochrome P450 1A20101
Carbonic anhydrase 30316
Cathepsin B0101
Cytochrome P450 3A40607
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C0203
Polyunsaturated fatty acid 5-lipoxygenase0202
Cytochrome P450 2C80101
Cytochrome P450 2D60303
Cytochrome P450 2A60101
Cytochrome P450 2C9 0505
5-hydroxytryptamine receptor 2A0202
Androgen receptor023023
Gamma-aminobutyric acid receptor subunit beta-193113
Translocator protein0101
Gamma-aminobutyric acid receptor subunit delta93113
Gamma-aminobutyric acid receptor subunit gamma-293113
Gamma-aminobutyric acid receptor subunit alpha-593113
Gamma-aminobutyric acid receptor subunit alpha-393113
Cannabinoid receptor 10101
Arachidonate 5-lipoxygenase-activating protein0101
Cytochrome P450 2B60303
Carbonic anhydrase 40416
Carbonic anhydrase 60315
Gamma-aminobutyric acid receptor subunit gamma-193113
Gamma-aminobutyric acid receptor subunit alpha-293113
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10404
Serum paraoxonase/arylesterase 10202
Dipeptidyl peptidase 40102
Gamma-aminobutyric acid receptor subunit alpha-493113
Gamma-aminobutyric acid receptor subunit gamma-393113
Endochitinase0101
Gamma-aminobutyric acid receptor subunit alpha-693113
Adenosine receptor A2a0303
5-hydroxytryptamine receptor 2B0101
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0101
Cytochrome P450 2C190505
Delta-type opioid receptor0202
Mu-type opioid receptor0303
Carbonic anhydrase 5A, mitochondrial0417
Carbonic anhydrase0101
Kappa-type opioid receptor0101
Carbonic anhydrase 70315
Carbonic anhydrase0101
D(1A) dopamine receptor2103
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase0101
D(2) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit alpha-194114
Gamma-aminobutyric acid receptor subunit beta-393113
Gamma-aminobutyric acid receptor subunit beta-293113
Cholinesterase0101
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Fatty-acid amide hydrolase 10101
Beta-carbonic anhydrase 10202
Carbonic anhydrase 20101
Glutamate receptor ionotropic, NMDA 2B0416
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70202
Carbonic anhydrase 90418
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase 30101
Carbonic anhydrase0102
Carbonic anhydrase0102
Carbonic anhydrase 0101
Sigma intracellular receptor 20101
Delta carbonic anhydrase0101
Sigma non-opioid intracellular receptor 10101
Renin0101
Carbonic anhydrase 0101
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130315
GABA theta subunit93113
Canalicular multispecific organic anion transporter 1024025
Carbonic anhydrase 40202
Carbonic anhydrase 150203
Acidic mammalian chitinase0101
Carbonic anhydrase 130203
Carbonic anhydrase 70101
Gamma-aminobutyric acid receptor subunit epsilon93113
Carbonic anhydrase 0101
Carbonic anhydrase 140316
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Carbonic anhydrase 5B, mitochondrial0316
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
TDP1 protein280028
AR protein360036
pregnane X nuclear receptor270027
estrogen nuclear receptor alpha380038
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a200020
nuclear factor erythroid 2-related factor 2 isoform 2150015
heat shock protein beta-1110011
importin subunit beta-1 isoform 14004
snurportin-14004
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 12002
lamin isoform A-delta10150015
Voltage-dependent calcium channel gamma-2 subunit170017
Cyclin-dependent kinase 10101
Heat shock protein HSP 90-beta0101
Glutamate receptor 2170017
Xanthine dehydrogenase/oxidase0101
TAR DNA-binding protein 434004
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 5150015
Ataxin-2160016
Chain A, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)0101
EWS/FLI fusion protein160016
Coagulation factor X0101
Prothrombin010213
Coagulation factor X0909
Trypsin-10505
Trypsin-20505
Trypsin-30505
Spike glycoprotein130114
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
phosphopantetheinyl transferase100010
NFKB1 protein, partial2002
GLS protein5005
thyroid stimulating hormone receptor7007
alpha-galactosidase3003
cytochrome P450 2C19 precursor2002
flap endonuclease 15005
DNA polymerase iota isoform a (long)110011
muscarinic acetylcholine receptor M14004
lethal factor (plasmid)6006
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase7007
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein8008
Chain B, HADH2 protein8008
Chain A, 2-oxoglutarate Oxygenase7007
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 84004
aldehyde dehydrogenase 1 family, member A1150015
hypothetical protein, conserved1001
cytochrome P450 2D6120012
glucocerebrosidase5005
peroxisome proliferator-activated receptor delta170017
Rac1 protein0011
IDH1100010
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
DNA polymerase kappa isoform 15005
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0202
Fatty acid-binding protein, liver0202
Integrin beta-36107
Myeloperoxidase0101
Prostaglandin G/H synthase 10202
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb6107
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10404
Substance-P receptor0101
Prostaglandin G/H synthase 20404
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma6006
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20202
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Sigma non-opioid intracellular receptor 10415
Sigma non-opioid intracellular receptor 10011
Chain A, Cruzipain5005
SMAD family member 2130013
SMAD family member 3130013
caspase 7, apoptosis-related cysteine protease7007
estrogen receptor 2 (ER beta)150015
vitamin D (1,25- dihydroxyvitamin D3) receptor200020
caspase-37007
Caspase-75005
vitamin D3 receptor isoform VDRA110011
caspase-35005
thyroid hormone receptor beta isoform 2260026
Solute carrier organic anion transporter family member 2B1 0001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0202
Cellular tumor antigen p53260026
ATP-dependent translocase ABCB108113
Insulin receptor 0101
Dipeptidyl peptidase 40101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Histone deacetylase 10303
Histone deacetylase 20202
Solute carrier organic anion transporter family member 1B30407
Histone deacetylase 60303
Broad substrate specificity ATP-binding cassette transporter ABCG20103
Solute carrier organic anion transporter family member 1B10306
Chain A, Ferritin light chain110011
acetylcholinesterase9009
ATAD5 protein, partial7007
Fumarate hydratase8008
Microtubule-associated protein tau100010
thioredoxin glutathione reductase6006
farnesoid X nuclear receptor140014
polyprotein8008
P531001
aryl hydrocarbon receptor7007
activating transcription factor 6130013
v-jun sarcoma virus 17 oncogene homolog (avian)130013
Histone H2A.x140014
peripheral myelin protein 22 isoform 14004
hemoglobin subunit beta2002
cellular tumor antigen p53 isoform a7007
cytochrome P450 3A4 isoform 19009
M-phase phosphoprotein 84004
Bile salt export pump0303
Protein-arginine deiminase type-40202
regulator of G-protein signaling 43003
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent betaine transporter0101
Glutamate receptor ionotropic, NMDA 1 0315
Sodium- and chloride-dependent GABA transporter 30101
Glutamate receptor ionotropic, NMDA 2A 0315
Glutamate receptor ionotropic, NMDA 2C0315
Glutamate receptor ionotropic, NMDA 2D0315
Proton-coupled amino acid transporter 10303
Glutamate receptor ionotropic, NMDA 3B0315
Sodium- and chloride-dependent GABA transporter 20101
Glutamate receptor ionotropic, NMDA 3A0315
Chain A, Putative fructose-1,6-bisphosphate aldolase6006
USP1 protein, partial130013
caspase-1 isoform alpha precursor2002
Caspase-72002
Inositol monophosphatase 13003
Chain H, Proteasome component PUP10101
Chain I, Proteasome component PUP30101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Proteasome subunit beta type-110101
PPM1D protein8008
progesterone receptor240024
nuclear receptor subfamily 1, group I, member 2100010
26S proteasome non-ATPase regulatory subunit 110101
26S proteasome non-ATPase regulatory subunit 120101
26S proteasome non-ATPase regulatory subunit 140101
Proteasome subunit alpha type-70101
Histone deacetylase 30101
26S proteasome non-ATPase regulatory subunit 30101
Chymotrypsinogen A0101
Cathepsin B0101
Neutrophil elastase0101
Cathepsin G0202
Lysosomal protective protein0101
Chymotrypsinogen B0101
26S proteasome regulatory subunit 6A0101
Nuclear factor NF-kappa-B p105 subunit0101
Proteasome subunit beta type-10102
Chymase0101
Proteasome subunit alpha type-10101
Proteasome subunit alpha type-20101
Proteasome subunit alpha type-30101
Proteasome subunit alpha type-40101
Proteasome subunit beta type-80101
Proteasome subunit beta type-80101
Proteasome subunit beta type-90101
Proteasome subunit alpha type-50101
Proteasome subunit beta type-40101
Proteasome subunit beta type-60101
Proteasome subunit beta type-50203
26S proteasome regulatory subunit 70101
Lon protease homolog, mitochondrial0101
Proteasome subunit beta type-100101
26S proteasome regulatory subunit 6B0101
26S proteasome non-ATPase regulatory subunit 80101
Proteasome subunit beta type-30101
Proteasome subunit beta type-20102
26S proteasome non-ATPase regulatory subunit 70101
26S proteasome non-ATPase regulatory subunit 40101
26S proteasome complex subunit SEM10101
Proteasome subunit alpha type-60101
26S proteasome regulatory subunit 40101
26S proteasome regulatory subunit 80101
26S proteasome regulatory subunit 10B0101
Nuclear factor NF-kappa-B p100 subunit 0101
Transcription factor p650101
26S proteasome non-ATPase regulatory subunit 20101
26S proteasome non-ATPase regulatory subunit 60101
Proteasomal ubiquitin receptor ADRM10101
ATP-dependent Clp protease proteolytic subunit0112
NACHT, LRR and PYD domains-containing protein 3 0101
Proteasome subunit alpha-type 80101
Proteasome subunit beta type-70101
26S proteasome non-ATPase regulatory subunit 10101
Histone deacetylase 80202
26S proteasome non-ATPase regulatory subunit 130101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
bromodomain adjacent to zinc finger domain 2B5005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a130013
transcriptional regulator ERG isoform 36006
mitogen-activated protein kinase 13003
neuropeptide S receptor isoform A3003
Glucocorticoid receptor018326
Glycine receptor subunit alpha-1018018
Glycine receptor subunit beta018018
Glycine receptor subunit alpha-2018018
Glycine receptor subunit alpha-3018018
pregnane X receptor5005
Smad32002
67.9K protein7007
D(1A) dopamine receptor3003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 15005
nuclear receptor ROR-gamma isoform 17007
Progesterone receptor09515
Androgen receptor0628
Adenosine receptor A2b0101
Mu-type opioid receptor0606
ORF730011
endonuclease IV3003
glp-1 receptor, partial4004
LMP1 [Human herpesvirus 4]0003
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0303
serine/threonine-protein kinase mTOR isoform 12002
transactivating tegument protein VP16 [Human herpesvirus 1]0303
nuclear receptor coactivator 3 isoform a0303
Thymidine kinase 2, mitochondrial0101
Thymidine kinase, cytosolic0101
Thymidine kinase0101
Thymidylate synthase0304
Thymidine kinase0101
Deoxycytidine kinase0001
Probable deoxycytidylate deaminase0001
Cytidine deaminase0102
E3 ubiquitin-protein ligase Mdm20101
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Thymidine kinase0101
Deoxynucleoside kinase0101
Rap guanine nucleotide exchange factor 34004
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
Solute carrier family 22 member 20303
Plasminogen0404
Coagulation factor XII0202
Tissue-type plasminogen activator0303
Vitamin K-dependent protein C0202
Serine protease hepsin0101
Muscarinic acetylcholine receptor M10202
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Multidrug and toxin extrusion protein 20202
Multidrug and toxin extrusion protein 10303
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
hypoxia-inducible factor 1 alpha subunit9009
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
huntingtin isoform 22002
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
histone acetyltransferase KAT2A isoform 15005
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
Transthyretin0203
NADH-ubiquinone oxidoreductase chain 40001
72 kDa type IV collagenase0101
DNA topoisomerase 2-alpha0118
Carbonyl reductase [NADPH] 10001
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
Platelet-activating factor receptor1001
Multidrug resistance-associated protein 1 0204
Histamine H2 receptor3003
Reverse transcriptase/RNaseH 0101
Vasopressin V2 receptor0112
Oxytocin receptor0011
Vasopressin V1a receptor0112
Vasopressin V1b receptor0112
Translocator protein0101
Vasopressin V2 receptor 0112
potassium voltage-gated channel subfamily H member 2 isoform d2002
Sex hormone-binding globulin0055
urokinase-type plasminogen activator precursor5005
plasminogen precursor5005
urokinase plasminogen activator surface receptor precursor5005
lysosomal alpha-glucosidase preproprotein2002
Vpr1001
Cytochrome P450 2B10101
Estrogen receptor012316
Aldo-keto reductase family 1 member B10606
Neuronal acetylcholine receptor subunit alpha-41102
Adenosine receptor A30404
Neuronal acetylcholine receptor subunit beta-21102
Polyunsaturated fatty acid lipoxygenase ALOX150202
Alpha-1B adrenergic receptor0404
UDP-glucuronosyltransferase 1A1 0204
Sodium-dependent noradrenaline transporter 0606
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Adenosine receptor A2a0404
Sodium-dependent serotonin transporter0808
Kappa-type opioid receptor0404
Alpha-1A adrenergic receptor0404
Sulfotransferase 1A10214
Sodium-dependent dopamine transporter 0606
Aldehyde oxidase0101
Nuclear receptor subfamily 1 group I member 3 0101
Estrogen receptor beta07310
galanin receptor type 30101
D(3) dopamine receptor isoform e1001
Regulatory protein E20011
ATP-dependent translocase ABCB10101
DNA topoisomerase 10102
DNA topoisomerase 20001
ATP-dependent translocase ABCB10101
Caspase-30101
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0118
Tubulin beta-2B chain0101
Integrase 0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
cytochrome P450 2D6 isoform 12002
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit alpha-30202
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit gamma-20213
5-hydroxytryptamine receptor 1A0415
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit beta-30213
Gamma-aminobutyric acid receptor subunit alpha-50213
Gamma-aminobutyric acid receptor subunit alpha-30213
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit epsilon0202
Gamma-aminobutyric acid receptor subunit alpha-60202
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit theta0202
thyrotropin-releasing hormone receptor2002
Chain A, Dihydrofolate reductase0011
acid sphingomyelinase2002
DNA polymerase beta3003
Thymidylate synthase0404
Dihydrofolate reductase0235
Aldo-keto reductase family 1 member B10101
Alpha-synuclein3003
Folylpolyglutamate synthase, mitochondrial0104
Solute carrier organic anion transporter family member 1A30103
Folylpolyglutamate synthase, mitochondrial0104
Multidrug resistance associated protein0103
Chain A, Glutamine Binding Protein0011
15-lipoxygenase, partial3003
Neutral amino acid transporter A0202
Asc-type amino acid transporter 10202
Neutral amino acid transporter B(0)0202
Carbonic anhydrase-like protein, putative0001
Amino acid transporter0202
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10101
Serine racemase0101
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
Purine nucleoside phosphorylase0202
Hypoxanthine-guanine phosphoribosyltransferase0002
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Shiga toxin subunit A0101
Guanine deaminase0001
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Stromelysin-10011
Urease subunit alpha0101
Ribonucleoside-diphosphate reductase large subunit0101
Urease subunit beta0101
Cereblon isoform 40303
Bromodomain-containing protein 40101
Tyrosine-protein kinase ABL10012
Breakpoint cluster region protein0001
DNA-binding protein Ikaros0014
DNA damage-binding protein 10213
Protein cereblon0429
Zinc finger protein Aiolos0011
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
Prothrombin 0101
Cationic trypsin0202
PINK11001
nonstructural protein 14004
Parkin1001
Mineralocorticoid receptor 0314
Androgen receptor0011
Histamine H2 receptor0404
5-hydroxytryptamine receptor 1B0303
Aldo-keto reductase family 1 member C30101
Aldo-keto reductase family 1 member C2 0101
Aldo-keto reductase family 1 member C10101
Chain H, Prothrombin0101
Chain H, Prothrombin0101
Urokinase-type plasminogen activator0101
Coagulation factor XI0101
Coagulation factor VII0101
Disintegrin and metalloproteinase domain-containing protein 170101
Chain A, JmjC domain-containing histone demethylation protein 3A3003
apical membrane antigen 1, AMA13003
UDP-glucose 6-dehydrogenase0101
Solute carrier family 22 member 80001
UDP-glucose 6-dehydrogenase0101
Purine nucleoside phosphorylase0011
UDP-glucuronosyltransferase 1A1 0101
Solute carrier family 22 member 1 0202
Dihydrofolate reductase0304
Solute carrier family 22 member 10001
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
dopamine D1 receptor1001
ClpP1001
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
DNA polymerase eta isoform 12002
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Kappa-type opioid receptor0101
Reduced folate transporter0202
6-phosphogluconate dehydrogenase, decarboxylating0101
Dihydrofolate reductase0101
Pteridine reductase 10101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80001
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Solute carrier family 22 member 110001
Nuclear receptor subfamily 1 group I member 20022
Nuclear receptor subfamily 1 group I member 20011
Beta-1 adrenergic receptor 0011
Beta-2 adrenergic receptor0213
Beta-1 adrenergic receptor0415
Beta-3 adrenergic receptor0213
Beta-1 adrenergic receptor0112
Beta-1 adrenergic receptor0101
Cytochrome P450 2J20202
Beta-2 adrenergic receptor0011
Corticosteroid-binding globulin0202
5-hydroxytryptamine receptor 70101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial0101
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial0101
Estrogen receptor0124
Estrogen receptor beta0124
Amyloid-beta precursor protein0101
Muscarinic acetylcholine receptor M20416
Muscarinic acetylcholine receptor M40404
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M50404
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10405
Muscarinic acetylcholine receptor M30404
D(3) dopamine receptor0404
5-hydroxytryptamine receptor 2B0404
MBT domain-containing protein 10101
Lethal(3)malignant brain tumor-like protein 40101
Muscarinic acetylcholine receptor0011
Lethal(3)malignant brain tumor-like protein 30101
Lethal(3)malignant brain tumor-like protein 10101
Angiotensin-converting enzyme 0101
Gag-Pol polyprotein0101
Gag-Pol polyprotein0101
Protease 0303
luciferase0001
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Prolyl 4-hydroxylase, beta polypeptide0001
nuclear factor NF-kappa-B p105 subunit isoform 11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
HLA class I histocompatibility antigen, A alpha chain 0011
Gastric inhibitory polypeptide receptor0101
Chain A, Activated Factor Xa Heavy Chain0101
Suppressor of tumorigenicity 14 protein0101
Chain A, CES1 protein0101
DNA polymerase III, partial1001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
NPC intracellular cholesterol transporter 1 precursor1001
interferon gamma precursor0001
ubiquitin-conjugating enzyme E2 N0101
ras-related protein Rab-9A1001
streptokinase A precursor0011
Transmembrane protease serine 20011
5-hydroxytryptamine receptor 40202
Serine/threonine-protein kinase D30101
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20101
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0101
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Procathepsin L0011
Alpha-2A adrenergic receptor0202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
Protein kinase C alpha type0101
Alpha-2B adrenergic receptor0202
Substance-K receptor0202
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Thromboxane-A synthase 0101
Protein kinase C eta type0101
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
B2 bradykinin receptor0202
Adenosine receptor A10202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Delta-type opioid receptor0202
Protein kinase C iota type0101
Melanocortin receptor 30202
5-hydroxytryptamine receptor 60202
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Potassium voltage-gated channel subfamily H member 20202
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
serine/threonine-protein kinase PLK11001
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Albumin0011
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]