Acquired Neuromyotonia

A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)

Synonym
Isaacs-Mertens Syndrome
Myokymia, Continuous
Isaacs Syndrome
Continuous Muscle Activity Syndrome
Gamstorp-Wohlfart Syndrome
Isaacs' Syndrome
Syndrome of Continuous Muscle Activity
Myokymia, Myotonia, Muscle Wasting, And Hyperhidrosis
Quantal Squander
Acquired Neuromyotonia
Pseudomyotonia Syndrome of Isaacs
Pseudomyotonia
Neuromyotonia

Excerpt	Reference
"Ocular neuromyotonia is a rare clinical entity, which is characterized by spontaneous spasm of ocular muscles resulting in paroxysmal diplopia and strabismus."	( Ilhan, S; Yürüten, B, 2003)
"Ocular neuromyotonia is a rare ocular motility disorder characterized by involuntary contractions of one or several ocular motor muscles."	( Gräf, M; Koop, G, 2006)
"The diagnosis of Isaacs' syndrome is based on the clinical features and classic electromyographic findings."	( Mitrabhakdi, E; Phanthumchinda, K; Sukajintanakarn, D, 2006)
"Neuromyotonia is a heterogeneous condition and can present in varied ways including diffuse nonspecific pain."	( Kumar, H; Mathew, V; Panagariya, A; Sharma, B, 2006)
"Ocular neuromyotonia is a rare disturbance of ocular motility, characterized by paroxysmal monocular involuntary spasms of one or more extraocular muscles supplied by the third, fourth or sixth cranial nerves."	( Hayashi, H; Isozaki, E; Kuroda, M; Matsubara, S; Yoshida, H, 2007)
"Neuromyotonia is a disorder of hyperexcitability of the peripheral nerve."	( Eikermann, M; Forde, R; Ginsburg, G; Martyn, JA, 2009)
"Ocular neuromyotonia is an episodic involuntary contraction of one or more of the extraocular muscles resulting from spontaneous neural discharges of the oculomotor nerve."	( Chang, MH; Kim, SB; Kyung, SE; Oh, SY, 2013)
"Ocular neuromyotonia is an unusual condition in which sustained, undesired contraction of one or more extraocular muscles occurs after normal muscle activation."	( Blitz, AM; Cruz, FM; Subramanian, PS, 2013)

Excerpt	Reference
"The characteristic symptoms of ocular neuromyotonia and the typical history of a previous intracranial tumor, treated neurosurgically with adjuvant radiotherapy, lead to the hypothesis that ephaptic transmission in the cranial nerve is the underlying pathophysiological mechanism in the development of ocular neuromyotonia."	( Gräf, M; Koop, G, 2006)
"She was diagnosed with ocular neuromyotonia and successfully treated with oral carbamazepine."	( Aroichane, M; de Saint Sardos, A; Ospina, LH; Vincent, A, 2008)
"If patients with neuromyotonia receive anesthesia, we recommend that smaller doses of a nondepolarizing muscle relaxant be administered, accompanied by monitoring of neuromuscular function, so as to provide optimal muscle relaxation while avoiding overdose and prolonged postoperative recovery."	( Eikermann, M; Forde, R; Ginsburg, G; Martyn, JA, 2009)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (1.30)	23.3326
1990's	3 (3.90)	12.5806
2000's	35 (45.45)	18.1394
2010's	25 (32.47)	28.8240
2020's	13 (16.88)	9.53

Drug	Relationship Strength	Studies
gamma-aminobutyric acid	low	5
carbamates	low	1
melatonin	low	1
4-aminopyridine	low	1
phenytoin	low	4
acetazolamide	low	1
azathioprine	low	2
carbamazepine	low	31
clonazepam	low	2
diazoxide	low	1
fluorouracil	low	1
gabapentin	low	3
mianserin	low	1
mirtazapine	low	1
prednisolone	low	1
thyroxine	low	1
prednisone	low	7
amifampridine	low	1
serine	low	1
leucine	low	3
histidine	low	3
threonine	low	2
arginine	low	2
methylprednisolone	low	4
pyridostigmine bromide	low	1
thiophenes	low	1
alpha-aminopyridine	low	1
ethylnitrosourea	low	1
deoxycytidine	low	1
dronabinol	low	1
tramadol	low	1
oxcarbazepine	low	2
flupirtine	low	1
duloxetine hydrochloride	low	1
capecitabine	low	1
venlafaxine hydrochloride	low	1
ezogabine	low	1
leupeptins	low	1
rocuronium	low	1
tacrolimus	low	1
mycophenolic acid	low	1
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	low	1
pregabalin	low	1
nad	low	1
eye	low	1
gq1b ganglioside	low	1

Protein Targets (683)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, Cruzipain	1	0	0	1
thioredoxin reductase	10	0	0	10
RAR-related orphan receptor gamma	11	0	0	11
USP1 protein, partial	7	0	0	7
Microtubule-associated protein tau	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	11	0	0	11
thyroid stimulating hormone receptor	8	0	0	8
estrogen receptor 2 (ER beta)	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
glucocorticoid receptor [Homo sapiens]	17	0	0	17
cytochrome P450 2D6	4	0	0	4
glucocerebrosidase	1	0	0	1
IDH1	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	20	0	0	20
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
cytochrome P450 2D6 isoform 1	5	0	0	5
chromobox protein homolog 1	7	0	0	7
transcriptional regulator ERG isoform 3	4	0	0	4
thyroid hormone receptor beta isoform 2	13	0	0	13
mitogen-activated protein kinase 1	3	0	0	3
geminin	19	0	0	19
peripheral myelin protein 22	10	0	0	10
survival motor neuron protein isoform d	8	0	0	8
lethal factor (plasmid)	5	0	0	5
lamin isoform A-delta10	13	0	0	13
Potassium channel subfamily K member 2	0	0	1	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Cellular tumor antigen p53	14	0	0	14
Potassium voltage-gated channel subfamily A member 3	0	0	1	1
Acetylcholinesterase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
ATP-dependent phosphofructokinase	8	0	0	8
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	5	0	0	5
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
GALC protein	2	0	0	2
GLI family zinc finger 3	13	0	0	13
nuclear receptor subfamily 1, group I, member 3	11	0	0	11
retinoic acid nuclear receptor alpha variant 1	14	0	0	14
retinoid X nuclear receptor alpha	7	0	0	7
estrogen-related nuclear receptor alpha	13	0	0	13
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	7	0	0	7
Carbonic anhydrase	0	1	0	1
Bloom syndrome protein isoform 1	7	0	0	7
thyroid hormone receptor beta isoform a	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
muscleblind-like protein 1 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	7	5	0	12
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	14
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	2	1	6
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	17	0	17
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	2	1	9
Carbonic anhydrase 2	0	2	1	8
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Carbonic anhydrase 3	0	2	1	6
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	2	0	3
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	4	0	4
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	4	0	4
5-hydroxytryptamine receptor 2A	0	4	0	4
Androgen receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	7	5	0	12
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	7	5	0	12
Gamma-aminobutyric acid receptor subunit gamma-2	7	5	1	13
Gamma-aminobutyric acid receptor subunit alpha-5	7	5	0	12
Gamma-aminobutyric acid receptor subunit alpha-3	7	5	0	12
Cannabinoid receptor 1	0	3	1	4
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	1	2
Carbonic anhydrase 4	0	2	1	5
Carbonic anhydrase 6	0	2	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	7	5	0	12
Gamma-aminobutyric acid receptor subunit alpha-2	7	5	0	12
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	1	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	7	5	0	12
Gamma-aminobutyric acid receptor subunit gamma-3	7	5	0	12
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	7	5	0	12
Adenosine receptor A2a	0	1	0	2
5-hydroxytryptamine receptor 2B	0	3	0	3
Sodium-dependent serotonin transporter	0	4	0	4
Delta-type opioid receptor	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	2	1	6
Carbonic anhydrase	0	1	0	2
Kappa-type opioid receptor	0	1	1	2
Carbonic anhydrase 7	0	2	1	5
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	2
D(2) dopamine receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	7	5	1	13
Gamma-aminobutyric acid receptor subunit beta-3	7	5	0	12
Gamma-aminobutyric acid receptor subunit beta-2	7	5	1	13
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	2
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	2	1	6
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	2
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	5
GABA theta subunit	7	5	0	12
Canalicular multispecific organic anion transporter 1	0	14	0	14
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 15	0	1	0	3
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	2	0	4
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	7	5	0	12
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	2	1	6
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	1	6
AR protein	16	0	0	16
estrogen nuclear receptor alpha	23	0	0	23
thyroid stimulating hormone receptor	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Heat shock protein HSP 90-alpha	0	0	1	1
Botulinum neurotoxin type A	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Glutamate receptor 2	5	1	1	9
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	4
Phosphatidylinositol 4-kinase alpha	0	1	0	1
Tyrosine-protein kinase	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	1	0	1
Phosphatidylinositol 4-kinase type 2-alpha	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	1	0	1
glp-1 receptor, partial	6	0	0	6
GLS protein	7	0	0	7
aryl hydrocarbon receptor	8	0	0	8
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
POU domain, class 2, transcription factor 1	0	0	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
phosphopantetheinyl transferase	6	0	0	6
NFKB1 protein, partial	2	0	0	2
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	3	0	0	3
flap endonuclease 1	5	0	0	5
DNA polymerase iota isoform a (long)	3	0	0	3
muscarinic acetylcholine receptor M1	6	0	0	6
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, inducible	0	0	0	1
Cationic amino acid transporter 3	0	1	0	1
Chain A, Ferritin light chain	4	0	0	4
interleukin 8	4	0	0	4
acetylcholinesterase	7	0	0	7
SMAD family member 2	2	0	0	2
ATAD5 protein, partial	7	0	0	7
Fumarate hydratase	4	0	0	4
SMAD family member 3	2	0	0	2
TDP1 protein	16	0	0	16
thioredoxin glutathione reductase	3	0	0	3
EWS/FLI fusion protein	11	0	0	11
farnesoid X nuclear receptor	4	0	0	4
pregnane X nuclear receptor	14	0	0	14
G	5	0	0	5
polyprotein	4	0	0	4
P53	1	0	0	1
peroxisome proliferator-activated receptor delta	6	0	0	6
peroxisome proliferator activated receptor gamma	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	14	0	0	14
activating transcription factor 6	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Histone H2A.x	3	0	0	3
peripheral myelin protein 22 isoform 1	4	0	0	4
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	1	0	0	1
heat shock protein beta-1	2	0	0	2
cytochrome P450 3A4 isoform 1	7	0	0	7
M-phase phosphoprotein 8	3	0	0	3
Bile salt export pump	0	2	0	2
Interferon beta	8	0	0	8
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Nuclear receptor ROR-gamma	3	0	0	3
Inositol hexakisphosphate kinase 1	5	0	0	5
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	9	0	0	9
Protein-arginine deiminase type-4	0	1	0	1
cytochrome P450 2C9, partial	5	0	0	5
Proteasome subunit beta type-11	0	1	0	1
PPM1D protein	2	0	0	2
vitamin D3 receptor isoform VDRA	5	0	0	5
Calpain-9	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Cathepsin B	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Aromatase	0	3	0	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Calpain-2 catalytic subunit	0	1	0	1
Proteasome subunit beta type-1	0	2	0	2
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
NF-kappa-B inhibitor alpha	0	0	1	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	2	0	2
Proteasome subunit beta type-10	0	1	0	1
Cathepsin K	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	2	0	2
Proteasome subunit alpha type-6	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Proteasome subunit beta type-7	0	1	0	1
Gamma-secretase subunit PEN-2	0	1	0	1
Liver carboxylesterase 1	0	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
Vpr	2	0	0	2
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	1	3
Sodium channel protein type 3 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	1	3
Sodium channel protein type 4 subunit alpha	0	2	0	4
Cytochrome P450 2J2	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	3	0	3
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-1	0	4	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	4	1	5
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	1	5
Gamma-aminobutyric acid receptor subunit epsilon	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	0	4
Gamma-aminobutyric acid receptor subunit theta	0	4	0	4
Thymidine kinase 2	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	1
AAA family ATPase	0	0	0	1
Reverse transcriptase/RNaseH	0	0	1	1
regulator of G-protein signaling 4	7	0	0	7
D(1A) dopamine receptor	3	0	0	3
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	5	0	0	5
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Coagulation factor VII	0	1	0	1
Tissue factor	0	1	0	1
Glutamate receptor 1	0	1	1	4
Glutamate receptor 3	0	1	1	4
Glutamate receptor 4	0	1	1	4
Nicotinamide phosphoribosyltransferase	0	0	1	1
ATP-binding cassette sub-family C member 8	0	1	1	2
ATP-sensitive inward rectifier potassium channel 11	0	1	1	2
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
Fatty-acid amide hydrolase 1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
Transient receptor potential cation channel subfamily A member 1	0	0	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Cannabinoid receptor 1	0	2	1	4
Glycine receptor subunit alpha-1	0	0	1	1
Cannabinoid receptor 2	0	2	1	4
D(3) dopamine receptor	0	3	1	4
Cannabinoid receptor 1	0	1	0	1
Cannabinoid receptor 2	0	1	1	2
N-arachidonyl glycine receptor	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Monoglyceride lipase	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Cannabinoid receptor 2	0	2	0	2
G-protein coupled receptor 55	0	1	1	2
Smad3	2	0	0	2
caspase 7, apoptosis-related cysteine protease	2	0	0	2
progesterone receptor	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
caspase-3	2	0	0	2
Alpha-synuclein	2	0	0	2
Spike glycoprotein	6	0	0	6
pregnane X receptor	3	0	0	3
Potassium voltage-gated channel subfamily KQT member 3	0	0	2	5
Potassium voltage-gated channel subfamily KQT member 2	0	0	2	5
UDP-glucuronosyltransferase 1A9	0	0	1	2
UDP-glucuronosyltransferase 2B11	0	0	1	1
UDP-glucuronosyltransferase 2B17	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 3	0	0	1	1
UDP-glucuronosyltransferase 2B4	0	0	1	1
UDP-glucuronosyltransferase 2A1	0	0	1	1
UDP-glucuronosyltransferase 2A2	0	0	1	1
UDP-glucuronosyltransferase 1-6	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	1	1	4
UDP-glucuronosyltransferase 1A4	0	0	1	3
UDP-glucuronosyltransferase 1A3	0	0	1	1
UDP-glucuronosyltransferase 1A5	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	0	1	1
UDP-glucuronosyltransferase 2B15	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 4	0	0	1	2
UDP-glucuronosyltransferase 2A3	0	0	1	1
UDP-glucuronosyltransferase 2B28	0	0	1	1
UDP-glucuronosyltransferase 1A7	0	0	1	2
UDP-glucuronosyltransferase 1A10	0	0	1	2
UDP-glucuronosyltransferase 1A8	0	0	1	2
Potassium voltage-gated channel subfamily KQT member 5	0	0	1	3
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Luciferase	1	0	0	1
endonuclease IV	3	0	0	3
Skn7p	0	0	0	1
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
Thrombopoietin	1	0	0	1
nonstructural protein 1	3	0	0	3
67.9K protein	2	0	0	2
huntingtin isoform 2	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	1	0	1
Amyloid-beta precursor protein	1	0	0	1
Thymidylate synthase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
15-lipoxygenase, partial	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
hexokinase-4 isoform 1	1	0	0	1
cytochrome P450 2C9 precursor	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
glucokinase regulatory protein	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
Histamine H2 receptor	3	1	0	5
Caspase-7	1	0	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
phosphoglycerate kinase	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
TAR DNA-binding protein 43	3	0	0	3
Histone deacetylase 1	0	1	0	1
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Histone deacetylase 6	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	1
Histidine-binding periplasmic protein	0	0	1	1
5-hydroxytryptamine receptor 1D	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
ClpP	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cholinesterase	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Acetylcholinesterase	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	5	1	6
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Histamine H3 receptor	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
5-hydroxytryptamine receptor 3E	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
5-hydroxytryptamine receptor 1A	0	3	2	5
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	4	0	4
Muscarinic acetylcholine receptor M1	0	2	0	2
D(2) dopamine receptor	0	3	0	3
Alpha-1B adrenergic receptor	0	4	1	5
Alpha-2B adrenergic receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	4	0	4
D	0	2	0	2
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	3	0	3
Alpha-2B adrenergic receptor	0	2	1	3
Muscarinic acetylcholine receptor M3	0	2	0	2
Endothelin receptor type B	0	1	0	1
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	1	3
Alpha-2A adrenergic receptor	0	2	1	3
Alpha-1D adrenergic receptor	0	4	1	5
Sodium-dependent noradrenaline transporter	0	5	0	5
5-hydroxytryptamine receptor 3A	0	2	0	2
Endothelin receptor type B	0	1	0	1
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Endothelin-1 receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	3	0	3
5-hydroxytryptamine receptor 2C	0	3	0	3
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 1D	0	2	0	2
5-hydroxytryptamine receptor 1F	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	3	0	3
5-hydroxytryptamine receptor 7	0	2	0	2
5-hydroxytryptamine receptor 7	0	3	0	3
Alpha-1A adrenergic receptor	0	2	0	2
Type-2 angiotensin II receptor	0	3	0	3
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Histamine H1 receptor	0	3	0	3
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 3A	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	3
Inositol monophosphatase 1	2	0	0	2
5-hydroxytryptamine receptor 4	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
G-protein coupled receptor	0	1	0	1
Transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
polyadenylate-binding protein 1	0	1	0	1
bcl-2-related protein A1	0	1	0	1
DNA polymerase kappa isoform 1	4	0	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	2
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
apical membrane antigen 1, AMA1	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier family 22 member 1	0	1	0	1
Mu-type opioid receptor	0	1	1	2
Delta-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(13)

Research Excerpts

Overview

Treatment

Research

Studies (77)

Protein Targets (683)

Acquired Neuromyotonia

Synonyms(13)

Research Excerpts

Overview

Treatment

Research

Studies (77)

Drugs Studied (58)

Protein Targets (683)