Page last updated: 2024-09-28

Acquired Global Dyslexia

A receptive visual aphasia characterized by the loss of a previously possessed ability to comprehend the meaning or significance of handwritten words, despite intact vision. This condition may be associated with posterior cerebral artery infarction (INFARCTION, POSTERIOR CEREBRAL ARTERY) and other BRAIN DISEASES.

Synonyms(6)

Synonym
Acquired Spelling Dyslexia
Alexia, Acquired
Acquired Global Dyslexia
Word Blindness, Acquired
Dyslexia, Acquired
Reading Disability, Acquired

Research

Studies (14)

TimeframeStudies, This Condition (%)All Conditions %
pre-19907 (50.00)23.3326
1990's4 (28.57)12.5806
2000's1 (7.14)18.1394
2010's2 (14.29)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
melatonin0low10
amobarbital0low10
clonazepam0low10
methylphenidate0low10
pyrimethamine0low10
sulfadiazine0low10
prednisone0low10
technetium0low10
naloxone0low10
technetium tc 99m exametazime0low10
acyclovir0low10
levoleucovorin0low10

Protein Targets (330)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain1001
Thymidine kinase 0101
thioredoxin reductase3003
phosphopantetheinyl transferase3003
GLS protein1001
TDP1 protein5005
Smad33003
thyroid stimulating hormone receptor3003
EWS/FLI fusion protein4004
arylsulfatase A1001
euchromatic histone-lysine N-methyltransferase 24004
activating transcription factor 61001
Histone H2A.x3003
Bloom syndrome protein isoform 12002
hemoglobin subunit beta1001
atrial natriuretic peptide receptor 1 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
lamin isoform A-delta104004
Solute carrier family 22 member 1 0102
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Solute carrier family 22 member 60001
Bile salt export pump0202
Bile salt export pump0707
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20001
Cytochrome P450 2C9 0303
Cytochrome P450 2J20202
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0011
Solute carrier family 22 member 60001
Thymidine kinase 0101
Solute carrier family 22 member 80001
Canalicular multispecific organic anion transporter 10505
Thymidine kinase0101
AR protein7007
farnesoid X nuclear receptor2002
estrogen nuclear receptor alpha8008
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit pi2103
Gamma-aminobutyric acid receptor subunit delta0202
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Neuronal acetylcholine receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-12103
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit delta2103
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit gamma-22103
Gamma-aminobutyric acid receptor subunit alpha-52103
Gamma-aminobutyric acid receptor subunit alpha-32103
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit gamma-12103
Gamma-aminobutyric acid receptor subunit alpha-22103
Gamma-aminobutyric acid receptor subunit alpha-42103
Gamma-aminobutyric acid receptor subunit beta-30202
Gamma-aminobutyric acid receptor subunit gamma-32103
Gamma-aminobutyric acid receptor subunit alpha-62103
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50202
Gamma-aminobutyric acid receptor subunit alpha-30202
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit alpha-12103
Gamma-aminobutyric acid receptor subunit beta-32103
Gamma-aminobutyric acid receptor subunit beta-22103
Gamma-aminobutyric acid receptor subunit epsilon0202
Gamma-aminobutyric acid receptor subunit alpha-60202
Gamma-aminobutyric acid receptor subunit gamma-10202
GABA theta subunit2103
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit epsilon2103
Gamma-aminobutyric acid receptor subunit theta0202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma5005
nuclear receptor subfamily 1, group I, member 35005
progesterone receptor4004
retinoic acid nuclear receptor alpha variant 15005
estrogen-related nuclear receptor alpha5005
v-jun sarcoma virus 17 oncogene homolog (avian)4004
nuclear factor erythroid 2-related factor 2 isoform 15005
Eyes absent homolog 20101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Voltage-dependent calcium channel gamma-2 subunit4004
Cellular tumor antigen p535005
Amyloid-beta precursor protein0101
Angiotensin-converting enzyme 0101
Glutamate receptor 24004
Histamine H2 receptor1001
Metallo-beta-lactamase VIM-130101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase VIM-1 0101
Luciferase1001
pregnane X receptor3003
GLI family zinc finger 34004
estrogen receptor 2 (ER beta)3003
retinoid X nuclear receptor alpha1001
pregnane X nuclear receptor5005
peroxisome proliferator activated receptor gamma2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
thyroid hormone receptor beta isoform 23003
nuclear receptor ROR-gamma isoform 12002
Chain A, 2-oxoglutarate Oxygenase1001
interleukin 81001
ClpP1001
ATAD5 protein, partial1001
caspase 7, apoptosis-related cysteine protease1001
aldehyde dehydrogenase 1 family, member A14004
regulator of G-protein signaling 41001
caspase-31001
aryl hydrocarbon receptor1001
cytochrome P450 2D6 isoform 13003
peripheral myelin protein 22 isoform 12002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
chromobox protein homolog 12002
ras-related protein Rab-9A1001
geminin3003
cytochrome P450 3A4 isoform 12002
M-phase phosphoprotein 81001
muscarinic acetylcholine receptor M12002
Cytochrome P450 1A10101
Cytochrome P450 1A2 0101
Myeloperoxidase0101
Cytochrome P450 1A20101
Cholinesterase0101
Cytochrome P450 2C11 0101
Cytochrome P450 2D60303
Aromatase0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Acetylcholinesterase0101
Metabotropic glutamate receptor 10101
Acetylcholinesterase 0101
Mu-type opioid receptor0325
Nociceptin receptor0101
Alpha-1A adrenergic receptor0202
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear receptor ROR-gamma3003
Nuclear factor erythroid 2-related factor 20001
Cytochrome P450 1B10101
Palmitoleoyl-protein carboxylesterase NOTUM0101
Carboxylic ester hydrolase 0101
Histamine H3 receptor0202
ATP-dependent phosphofructokinase1001
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0202
Sodium-dependent serotonin transporter0303
Sodium-dependent dopamine transporter 0202
cytochrome P450 2D63003
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M20101
Histidine decarboxylase0011
D(3) dopamine receptor0202
Adenosine receptor A10101
Delta-type opioid receptor0214
Delta-type opioid receptor0224
Kappa-type opioid receptor0102
Kappa-type opioid receptor0123
Mu-type opioid receptor0214
Delta-type opioid receptor0214
Kappa-type opioid receptor0213
Kappa-type opioid receptor0225
Mu-type opioid receptor0102
Mu-type opioid receptor0213
Sigma non-opioid intracellular receptor 10101
Beta-2 adrenergic receptor0101
Sigma non-opioid intracellular receptor 10101
UDP-glucuronosyltransferase 1A80001
Sigma non-opioid intracellular receptor 10101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Microtubule-associated protein tau1001
glucocorticoid receptor [Homo sapiens]3003
vitamin D3 receptor isoform VDRA2002
peripheral myelin protein 224004
Cystathionine gamma-lyase0101
Succinyl-diaminopimelate desuccinylase0101
thioredoxin glutathione reductase1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
nuclear factor erythroid 2-related factor 2 isoform 22002
Glucocorticoid receptor0213
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
glp-1 receptor, partial2002
SMAD family member 21001
Fumarate hydratase1001
GALC protein1001
SMAD family member 31001
cytochrome P450 family 3 subfamily A polypeptide 42002
polyprotein1001
67.9K protein1001
peroxisome proliferator-activated receptor delta1001
IDH11001
thyroid stimulating hormone receptor2002
cellular tumor antigen p53 isoform a1001
potassium voltage-gated channel subfamily H member 2 isoform d2002
dual specificity protein phosphatase 30101
low molecular weight phosphotyrosine protein phosphatase isoform c0101
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
tyrosine-protein phosphatase non-receptor type 22 isoform 10101
survival motor neuron protein isoform d2002
streptokinase A precursor0011
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 10101
Dihydrofolate reductase0202
Dihydrofolate reductase 0101
Interferon beta1001
Integrin beta-31001
Estrogen receptor0011
Beta-hexosaminidase subunit alpha0102
Beta-hexosaminidase subunit beta0101
Integrin alpha-IIb1001
Dihydrofolate reductase0214
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Dihydrofolate reductase0202
Substance-K receptor0101
Dihydrofolate reductase0101
Low molecular weight phosphotyrosine protein phosphatase0101
Dipeptidyl peptidase 40101
Spike glycoprotein2002
Pteridine reductase 10101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Trace amine-associated receptor 50011
Estrogen receptor beta0011
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Multidrug and toxin extrusion protein 10101
Dihydrofolate reductase0101
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
acetylcholinesterase1001
cytochrome P450 2C19 precursor1001
transcriptional regulator ERG isoform 32002
Solute carrier family 22 member 20101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
5-hydroxytryptamine receptor 40202
Albumin0011
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M40101
ATP-dependent translocase ABCB10001
Cytochrome P450 3A40101
5-hydroxytryptamine receptor 1A0123
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M50101
Alpha-2A adrenergic receptor0202
Muscarinic acetylcholine receptor M10101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
5-hydroxytryptamine receptor 2A0202
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0202
Beta-1 adrenergic receptor0101
Alpha-2C adrenergic receptor0202
D0101
5-hydroxytryptamine receptor 1A0202
Alpha-2B adrenergic receptor0101
Muscarinic acetylcholine receptor M30202
D(1A) dopamine receptor0202
D(4) dopamine receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Glycine receptor subunit alpha-10011
Alpha-1D adrenergic receptor0101
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
5-hydroxytryptamine receptor 2B0202
Histamine H1 receptor0101
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0202
5-hydroxytryptamine receptor 2A0101
Histamine H1 receptor0202
Alpha-1B adrenergic receptor0101
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 2B0202
5-hydroxytryptamine receptor 60101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
D(2) dopamine receptor0101
D(2) dopamine receptor0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
5-hydroxytryptamine receptor 2B0101
Potassium voltage-gated channel subfamily H member 20202
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Transporter0101
5-hydroxytryptamine receptor 1A0101
Nuclear receptor subfamily 3 group C member 3 0202
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
Transporter0101
Aurora kinase A0101
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 60101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]
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