Page last updated: 2024-09-28

Acquired Gerstmann Syndrome

A disorder of cognition characterized by the tetrad of finger agnosia, dysgraphia, DYSCALCULIA, and right-left disorientation. The syndrome may be developmental or acquired. Acquired Gerstmann syndrome is associated with lesions in the dominant (usually left) PARIETAL LOBE which involve the angular gyrus or subjacent white matter. (From Adams et al., Principles of Neurology, 6th ed, p457)

Synonyms(10)

Synonym
Developmental Gerstmann Syndrome
Gerstmann Syndrome 2
Gerstmann's Syndrome
Gerstmann Syndrome
Acquired Gerstmann's Syndrome
Syndrome de Gerstmann
Finger-Agnosia-Left-Right-Confusion-Acalculia-Agraphia
Gerstmann-Badal Syndrome
Developmental Gerstmann's Syndrome
Acquired Gerstmann Syndrome

Research Excerpts

Research

Studies (13)

TimeframeStudies, This Condition (%)All Conditions %
pre-19907 (53.85)23.3326
1990's3 (23.08)12.5806
2000's1 (7.69)18.1394
2010's2 (15.38)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
formic acid0low10
choline0low10
lactic acid0low10
azathioprine0low20
amphetamine0low10
mesalamine0low10
prednisolone0low10
aspartic acid0low10
n-acetylaspartic acid0low10
methotrexate0low10
acyclovir0low10
eye0low10

Protein Targets (464)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE6006
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase1001
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
thioredoxin reductase6006
GALC protein1001
GLI family zinc finger 34004
nuclear receptor subfamily 1, group I, member 33003
cytochrome P450 family 3 subfamily A polypeptide 44004
glucocorticoid receptor [Homo sapiens]5005
retinoic acid nuclear receptor alpha variant 16006
retinoid X nuclear receptor alpha5005
estrogen-related nuclear receptor alpha6006
Carbonic anhydrase 0101
Carbonic anhydrase 0101
arylsulfatase A4004
Carbonic anhydrase0101
euchromatic histone-lysine N-methyltransferase 29009
Bloom syndrome protein isoform 16006
thyroid hormone receptor beta isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 15005
geminin5005
peripheral myelin protein 223003
survival motor neuron protein isoform d4004
muscleblind-like protein 1 isoform 13003
Gamma-aminobutyric acid receptor subunit pi3104
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40607
Carbonic anhydrase0101
Solute carrier family 22 member 60203
Carbonic anhydrase 120215
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Bile salt export pump0808
Glycogen phosphorylase, muscle form0101
Renin0202
Carbonic anhydrase 104110
Carbonic anhydrase 204210
Carbonic anhydrase 20202
Cytochrome P450 1A20101
Carbonic anhydrase 30215
Cathepsin B0101
Cytochrome P450 3A40101
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C0315
Polyunsaturated fatty acid 5-lipoxygenase0101
Cytochrome P450 2C80101
Cytochrome P450 2D60101
Cytochrome P450 2A60202
Cytochrome P450 2C9 0303
5-hydroxytryptamine receptor 2A0314
Androgen receptor0202
Gamma-aminobutyric acid receptor subunit beta-13104
Translocator protein0101
Gamma-aminobutyric acid receptor subunit delta3104
Gamma-aminobutyric acid receptor subunit gamma-23104
Gamma-aminobutyric acid receptor subunit alpha-53104
Gamma-aminobutyric acid receptor subunit alpha-33104
Cannabinoid receptor 10101
Arachidonate 5-lipoxygenase-activating protein0101
Cytochrome P450 2B60101
Carbonic anhydrase 40214
Carbonic anhydrase 60214
Gamma-aminobutyric acid receptor subunit gamma-13104
Gamma-aminobutyric acid receptor subunit alpha-23104
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10202
Serum paraoxonase/arylesterase 10101
Dipeptidyl peptidase 40001
Gamma-aminobutyric acid receptor subunit alpha-43104
Gamma-aminobutyric acid receptor subunit gamma-33104
Endochitinase0101
Gamma-aminobutyric acid receptor subunit alpha-63104
Adenosine receptor A2a0202
5-hydroxytryptamine receptor 2B0213
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0101
Cytochrome P450 2C190101
Delta-type opioid receptor0202
Mu-type opioid receptor0202
Carbonic anhydrase 5A, mitochondrial0215
Carbonic anhydrase0101
Kappa-type opioid receptor0101
Carbonic anhydrase 70214
Carbonic anhydrase0101
D(1A) dopamine receptor0101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase0101
D(2) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit alpha-13205
Gamma-aminobutyric acid receptor subunit beta-33104
Gamma-aminobutyric acid receptor subunit beta-23104
Cholinesterase0101
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Fatty-acid amide hydrolase 10101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Glutamate receptor ionotropic, NMDA 2B0202
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70202
Carbonic anhydrase 90215
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase 30101
Carbonic anhydrase0102
Carbonic anhydrase0102
Carbonic anhydrase 0101
Sigma intracellular receptor 20101
Delta carbonic anhydrase0101
Sigma non-opioid intracellular receptor 10202
Renin0101
Carbonic anhydrase 0101
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130214
GABA theta subunit3104
Canalicular multispecific organic anion transporter 10606
Carbonic anhydrase 40203
Carbonic anhydrase 150102
Acidic mammalian chitinase0101
Carbonic anhydrase 130203
Carbonic anhydrase 70101
Gamma-aminobutyric acid receptor subunit epsilon3104
Carbonic anhydrase 0101
Carbonic anhydrase 140215
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Carbonic anhydrase 5B, mitochondrial0215
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Ferritin light chain4004
Thymidine kinase 0101
phosphopantetheinyl transferase5005
GLS protein4004
TDP1 protein5005
Smad31001
thyroid stimulating hormone receptor2002
EWS/FLI fusion protein4004
activating transcription factor 62002
Histone H2A.x4004
hemoglobin subunit beta2002
atrial natriuretic peptide receptor 1 precursor2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
lamin isoform A-delta104004
Solute carrier family 22 member 1 0002
Bile salt export pump0303
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20001
Cytochrome P450 2J20202
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0011
Solute carrier family 22 member 60002
Thymidine kinase 0101
Solute carrier family 22 member 80002
Thymidine kinase0101
Solute carrier family 22 member 30101
Phenylethanolamine N-methyltransferase0202
Substance-P receptor0101
5-hydroxytryptamine receptor 1A0112
Cytochrome P450 2A50101
Sodium-dependent dopamine transporter0101
5-hydroxytryptamine receptor 1B0112
5-hydroxytryptamine receptor 1D0112
5-hydroxytryptamine receptor 1F0112
5-hydroxytryptamine receptor 60011
5-hydroxytryptamine receptor 7 0011
5-hydroxytryptamine receptor 5A0011
5-hydroxytryptamine receptor 5B0011
5-hydroxytryptamine receptor 3A0011
5-hydroxytryptamine receptor 4 0011
Beta-2 adrenergic receptor0101
5-hydroxytryptamine receptor 3B0011
Sigma non-opioid intracellular receptor 10112
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
aldehyde dehydrogenase 1 family, member A15005
cytochrome P450 2C19 precursor2002
lethal factor (plasmid)2002
Metabotropic glutamate receptor 60011
Excitatory amino acid transporter 40101
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0001
Glutamate receptor ionotropic, NMDA 1 0101
Excitatory amino acid transporter 10101
Excitatory amino acid transporter 20101
Excitatory amino acid transporter 30101
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2C0101
Metabotropic glutamate receptor 10011
Metabotropic glutamate receptor 20011
Carbonic anhydrase-like protein, putative0001
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Glutamate receptor ionotropic, NMDA 3A0101
Chain A, Phospholipase A2 isoform 30011
Chain A, 2-oxoglutarate Oxygenase3003
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 82002
AR protein6006
hypothetical protein, conserved1001
estrogen nuclear receptor alpha7007
cytochrome P450 2D62002
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta4004
Rac1 protein0011
IDH13003
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
DNA polymerase iota isoform a (long)3003
DNA polymerase kappa isoform 14004
muscarinic acetylcholine receptor M14004
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0101
Fatty acid-binding protein, liver0202
Integrin beta-32103
Myeloperoxidase0101
Prostaglandin G/H synthase 10202
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb2103
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10202
Substance-P receptor0101
Prostaglandin G/H synthase 20404
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma2002
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200303
Solute carrier family 22 member 60303
Sigma non-opioid intracellular receptor 10011
acetylcholinesterase2002
RAR-related orphan receptor gamma5005
SMAD family member 21001
ATAD5 protein, partial2002
Fumarate hydratase1001
SMAD family member 31001
Microtubule-associated protein tau2002
thioredoxin glutathione reductase1001
farnesoid X nuclear receptor2002
pregnane X nuclear receptor4004
G1001
polyprotein1001
P531001
peroxisome proliferator activated receptor gamma3003
aryl hydrocarbon receptor3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
thyroid stimulating hormone receptor3003
v-jun sarcoma virus 17 oncogene homolog (avian)5005
peripheral myelin protein 22 isoform 12002
cellular tumor antigen p53 isoform a3003
thyroid hormone receptor beta isoform 22002
heat shock protein beta-12002
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 83003
Voltage-dependent calcium channel gamma-2 subunit3003
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 1001
Cellular tumor antigen p533003
Glutamate receptor 23003
Inositol hexakisphosphate kinase 11001
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Protein-arginine deiminase type-40303
cytochrome P450 2C9, partial1001
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10102
Solute carrier family 22 member 20001
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit alpha-40101
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Neuronal acetylcholine receptor subunit alpha-50101
Acetylcholinesterase0101
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0001
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Solute carrier family 22 member 10102
High affinity choline transporter 10101
Neuronal acetylcholine receptor subunit alpha-100101
Solute carrier family 22 member 20102
ATP-dependent phosphofructokinase2002
endonuclease IV1001
dopamine D1 receptor2002
pregnane X receptor1001
progesterone receptor3003
regulator of G-protein signaling 41001
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
chromobox protein homolog 12002
flap endonuclease 12002
Glucocorticoid receptor04110
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0202
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 432002
Multidrug and toxin extrusion protein 10101
estrogen receptor 2 (ER beta)2002
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Luciferase1001
15-lipoxygenase, partial2002
USP1 protein, partial2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
cytochrome P450 2C9 precursor1001
vitamin D3 receptor isoform VDRA2002
microphthalmia-associated transcription factor isoform 90101
histone acetyltransferase KAT2A isoform 12002
caspase-1 isoform alpha precursor2002
Solute carrier organic anion transporter family member 2B1 0001
Tumor necrosis factor0101
Neuraminidase0101
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Platelet-activating factor receptor1001
Cystathionine gamma-lyase0101
Histamine H2 receptor1001
Caspase-72002
Spike glycoprotein2002
10 kDa heat shock protein, mitochondrial0101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Solute carrier organic anion transporter family member 1B30002
Cystine/glutamate transporter0101
Hydroxyacid oxidase 10101
Solute carrier organic anion transporter family member 1B10001
large T antigen0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
ClpP1001
67.9K protein2002
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
nuclear factor erythroid 2-related factor 2 isoform 23003
transcriptional regulator ERG isoform 32002
importin subunit beta-1 isoform 11001
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier family 22 member 110001
Broad substrate specificity ATP-binding cassette transporter ABCG20001
Rap guanine nucleotide exchange factor 41001
luciferase0001
hypoxia-inducible factor 1 alpha subunit1001
nuclear receptor subfamily 1, group I, member 21001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]