Page last updated: 2024-09-27
ASC Atypical Squamous Cells
Morphological abnormalities of the cervical EPITHELIUM, usually revealed in PAP SMEAR, which do not meet the criteria for squamous CERVICAL INTRAEPITHELIAL NEOPLASIA or SQUAMOUS CELL CARCINOMAS of the CERVIX It may be a sign of infection with certain types of human papillomavirus (HPV).or sign of a benign (not cancer) growth, such as a cyst or polyp or, in menopausal women, of low hormone levels. More testing, such as HPV test, may be needed.
Synonyms(9)
| Synonym |
|---|
| ASC Atypical Squamous Cells |
| Atypical Squamous Cells of the Cervix |
| ASC-US |
| Atypical Cervical Squamous Cells |
| ASCUS |
| Atypical Squamous Cells of Undetermined Significance |
| Atypical Squamous Cells |
| ASC-H Atypical Squamous Cells, Cannot Rule Out High-Grade Squamous Intra-epithelial Lesion |
| Atypical Squamous Cells, Cannot Rule Out High-Grade Squamous Intra-Epithelial Lesion |
Research Excerpts
Treatment
| Excerpt | Reference |
|---|
| "A total of 356 women with ASCUS or L-SIL were enrolled and divided into two groups: 1) 176 patients, treated with topical β-glucan; and 2) 180 patients who were only followed-up." | ( Burratti, M; Carrone, A; Laccetta, G; Mancino, P, 2015) |
| "The second arm was made up of 124 ASCUS positive women who had undergone a vaginal administration of estriolo, the HPV test and colposcopy." | ( Bonanno, G; Bruno, MT; Coco, A; Di Pasqua, S, 2019) |
Research
Studies (13)
| Timeframe | Studies, This Condition (%) | All Conditions % |
|---|
| pre-1990 | 1 (7.69) | 23.3326 |
| 1990's | 0 (0.00) | 12.5806 |
| 2000's | 0 (0.00) | 18.1394 |
| 2010's | 10 (76.92) | 28.8240 |
| 2020's | 2 (15.38) | 9.53 |
Protein Targets (96)
| Protein | Potency Measurements | Inhibition Measurements | Activation Measurements | Drugs |
|---|
| estrogen nuclear receptor alpha | 5 | 0 | 0 | 5 |
| Free fatty acid receptor 3 | 0 | 0 | 1 | 1 |
| Free fatty acid receptor 2 | 0 | 1 | 1 | 2 |
| Tyrosine-protein kinase Lck | 0 | 0 | 1 | 1 |
| Tyrosine-protein kinase Fyn | 0 | 0 | 1 | 1 |
| Fibrinogen C domain-containing protein 1 | 0 | 1 | 0 | 1 |
| GLI family zinc finger 3 | 4 | 0 | 0 | 4 |
| AR protein | 3 | 0 | 0 | 3 |
| estrogen receptor 2 (ER beta) | 2 | 0 | 0 | 2 |
| progesterone receptor | 2 | 0 | 0 | 2 |
| glucocorticoid receptor [Homo sapiens] | 2 | 0 | 0 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | 2 | 0 | 0 | 2 |
| thyroid hormone receptor beta isoform 2 | 2 | 0 | 0 | 2 |
| geminin | 2 | 0 | 0 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | 3 | 0 | 0 | 3 |
| Bile salt export pump | 0 | 2 | 0 | 2 |
| Estrogen receptor | 0 | 2 | 0 | 2 |
| Glucocorticoid receptor | 0 | 2 | 0 | 2 |
| Sex hormone-binding globulin | 0 | 0 | 1 | 1 |
| Glycine receptor subunit alpha-1 | 0 | 2 | 0 | 2 |
| Corticosteroid-binding globulin | 0 | 1 | 0 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | 0 | 1 | 0 | 1 |
| Androgen receptor | 0 | 1 | 0 | 1 |
| UDP-glucuronosyltransferase 2B7 | 0 | 0 | 0 | 1 |
| Glutamate receptor 2 | 3 | 0 | 0 | 3 |
| Glycine receptor subunit beta | 0 | 2 | 0 | 2 |
| Glycine receptor subunit alpha-2 | 0 | 2 | 0 | 2 |
| Glycine receptor subunit alpha-3 | 0 | 2 | 0 | 2 |
| Sodium-dependent serotonin transporter | 0 | 2 | 0 | 2 |
| Alpha-synuclein | 1 | 1 | 0 | 2 |
| Solute carrier organic anion transporter family member 1A1 | 0 | 1 | 0 | 1 |
| Lanosterol 14-alpha demethylase | 0 | 0 | 1 | 1 |
| Olfactory receptor 51E2 | 0 | 0 | 1 | 1 |
| UDP-glucuronosyltransferase 1A10 | 0 | 0 | 0 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | 1 | 0 | 0 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | 1 | 0 | 0 | 1 |
| Chain A, Dihydrofolate reductase | 0 | 0 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | 1 | 0 | 0 | 1 |
| Chain A, HADH2 protein | 1 | 0 | 0 | 1 |
| Chain B, HADH2 protein | 1 | 0 | 0 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | 1 | 0 | 0 | 1 |
| Chain A, Ferritin light chain | 1 | 0 | 0 | 1 |
| acid sphingomyelinase | 1 | 0 | 0 | 1 |
| glp-1 receptor, partial | 1 | 0 | 0 | 1 |
| USP1 protein, partial | 1 | 0 | 0 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | 1 | 0 | 0 | 1 |
| thyroid stimulating hormone receptor | 1 | 0 | 0 | 1 |
| retinoid X nuclear receptor alpha | 1 | 0 | 0 | 1 |
| estrogen-related nuclear receptor alpha | 2 | 0 | 0 | 2 |
| glucocerebrosidase | 1 | 0 | 0 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | 1 | 0 | 0 | 1 |
| alpha-galactosidase | 1 | 0 | 0 | 1 |
| activating transcription factor 6 | 1 | 0 | 0 | 1 |
| lysosomal alpha-glucosidase preproprotein | 1 | 0 | 0 | 1 |
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | 1 | 0 | 0 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | 1 | 0 | 0 | 1 |
| DNA polymerase beta | 1 | 0 | 0 | 1 |
| Multidrug resistance-associated protein 4 | 0 | 0 | 0 | 1 |
| Cellular tumor antigen p53 | 2 | 0 | 0 | 2 |
| Thymidylate synthase | 0 | 2 | 0 | 2 |
| Thymidylate synthase | 0 | 1 | 0 | 1 |
| Dihydrofolate reductase | 0 | 0 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | 0 | 1 | 0 | 1 |
| Folylpolyglutamate synthase, mitochondrial | 0 | 0 | 0 | 1 |
| Solute carrier organic anion transporter family member 1A3 | 0 | 1 | 0 | 1 |
| Folylpolyglutamate synthase, mitochondrial | 0 | 0 | 0 | 1 |
| Multidrug resistance associated protein | 0 | 0 | 0 | 1 |
| Luciferase | 1 | 0 | 0 | 1 |
| acetylcholinesterase | 1 | 0 | 0 | 1 |
| RAR-related orphan receptor gamma | 2 | 0 | 0 | 2 |
| Fumarate hydratase | 1 | 0 | 0 | 1 |
| TDP1 protein | 1 | 0 | 0 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | 1 | 0 | 0 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | 1 | 0 | 0 | 1 |
| farnesoid X nuclear receptor | 1 | 0 | 0 | 1 |
| pregnane X nuclear receptor | 1 | 0 | 0 | 1 |
| G | 1 | 0 | 0 | 1 |
| cytochrome P450 2D6 | 1 | 0 | 0 | 1 |
| polyprotein | 1 | 0 | 0 | 1 |
| aryl hydrocarbon receptor | 1 | 0 | 0 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | 1 | 0 | 0 | 1 |
| thyroid stimulating hormone receptor | 1 | 0 | 0 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | 1 | 0 | 0 | 1 |
| Histone H2A.x | 1 | 0 | 0 | 1 |
| histone deacetylase 9 isoform 3 | 1 | 0 | 0 | 1 |
| heat shock protein beta-1 | 1 | 0 | 0 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | 1 | 0 | 0 | 1 |
| Interferon beta | 1 | 0 | 0 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | 1 | 0 | 0 | 1 |
| Microtubule-associated protein tau | 0 | 2 | 0 | 2 |
| Spike glycoprotein | 1 | 0 | 0 | 1 |
| Inositol hexakisphosphate kinase 1 | 1 | 0 | 0 | 1 |
| cytochrome P450 2C9, partial | 1 | 0 | 0 | 1 |
| Chain A, Uracil-DNA Glycosylase | 0 | 1 | 0 | 1 |
| TAR DNA-binding protein 43 | 1 | 0 | 0 | 1 |
| Protein cereblon | 0 | 2 | 0 | 2 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |