4p Deletion Syndrome

A syndrome that is considered as part of the spectrum of Wolf-Hirschhorn Syndrome variability. It maps to the short arm of chromosome 4, at 4p16.

Synonym
4p Deletion Syndrome
4p- Syndrome
Pitt Syndrome
Wolf-Hirchhorn Syndrome
Wolf Syndrome
Del(4p) Syndrome
Chromosome 4p Syndrome
Mental Retardation, Unusual Facies, And Intrauterine Growth Retardation
Partial Monosomy 4p
Chromosome 4p Monosomy
Chromosome 4p Deletion Syndrome
Wolf-Hirschhorn Syndrome
Pitt-Rogers-Danks Syndrome

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	3 (12.00)	18.1394
2010's	16 (64.00)	28.8240
2020's	6 (24.00)	9.53

Drug	Relationship Strength	Studies
bromide	low	2
hydrogen	low	1
melatonin	low	1
urea	low	1
phenytoin	low	1
carbamazepine	low	1
clobazam	low	1
valproic acid	low	1
hydroxyurea	low	1
lamotrigine	low	1
phenobarbital	low	2
piracetam	low	1
lysine	low	2
kainic acid	low	1
oxcarbazepine	low	1
potassium bromide	low	1
isomethyleugenol	low	5
cannabidiol	low	1
levetiracetam	low	3
topiramate	low	1
nad	low	1
acyclovir	low	1
eye	low	1

Protein Targets (386)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Ferritin light chain	2	0	0	2
Thymidine kinase	0	1	0	1
thioredoxin reductase	7	0	0	7
phosphopantetheinyl transferase	4	0	0	4
GLS protein	5	0	0	5
TDP1 protein	6	0	0	6
Smad3	1	0	0	1
thyroid stimulating hormone receptor	4	0	0	4
EWS/FLI fusion protein	5	0	0	5
arylsulfatase A	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	10	0	0	10
activating transcription factor 6	1	0	0	1
Histone H2A.x	3	0	0	3
Bloom syndrome protein isoform 1	8	0	0	8
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
lamin isoform A-delta10	7	0	0	7
Solute carrier family 22 member 1	0	0	0	1
ATP-binding cassette sub-family C member 3	0	9	0	9
Multidrug resistance-associated protein 4	0	9	0	9
Solute carrier family 22 member 6	0	0	0	1
Bile salt export pump	0	3	0	3
Bile salt export pump	0	12	0	12
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	4	0	4
Cytochrome P450 2J2	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	9	0	9
Thymidine kinase	0	1	0	1
Carbonic anhydrase 1	0	4	0	5
Carbonic anhydrase 2	0	5	1	8
Carbonic anhydrase 4	0	4	0	5
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 15	0	2	0	2
PPM1D protein	1	0	0	1
Acetylcholinesterase	0	1	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Interferon beta	2	0	0	2
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Cytochrome P450 2C11	0	2	0	2
Cytochrome P450 3A4	0	2	0	2
5-hydroxytryptamine receptor 1A	0	0	1	1
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2A6	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Cytochrome P450 2B6	0	1	1	2
Cytochrome P450 3A5	0	1	0	1
Cannabinoid receptor 1	0	1	0	2
D(1A) dopamine receptor	0	1	0	1
Cytochrome P450 3A7	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Caspase-1	0	0	1	1
Cytochrome P450 2C19	0	2	0	2
Cannabinoid receptor 2	0	1	1	3
Mu-type opioid receptor	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Delta-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Spike glycoprotein	3	0	0	3
Cholinesterase	0	1	0	1
N-acylethanolamine-hydrolyzing acid amidase	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
Heat sensitive channel TRPV3	0	1	1	2
Sigma intracellular receptor 2	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Transient receptor potential cation channel subfamily V member 1	0	1	1	2
Transient receptor potential cation channel subfamily M member 8	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	1	2
Transient receptor potential cation channel subfamily V member 2	0	1	1	2
G-protein coupled receptor 55	0	0	1	1
Diacylglycerol lipase-alpha	0	1	0	1
Histamine H3 receptor	0	2	0	2
Chain A, Beta-lactamase	2	0	0	2
acetylcholinesterase	3	0	0	3
RAR-related orphan receptor gamma	3	0	0	3
USP1 protein, partial	2	0	0	2
AR protein	6	0	0	6
glucocorticoid receptor [Homo sapiens]	2	0	0	2
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
estrogen-related nuclear receptor alpha	7	0	0	7
pregnane X nuclear receptor	7	0	0	7
estrogen nuclear receptor alpha	7	0	0	7
IDH1	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
thyroid hormone receptor beta isoform a	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
mitogen-activated protein kinase 1	2	0	0	2
geminin	8	0	0	8
Vpr	1	0	0	1
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Cellular tumor antigen p53	5	0	0	5
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	3
Sodium channel protein type 4 subunit alpha	0	3	0	6
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Sodium channel protein type 9 subunit alpha	0	4	0	4
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Fumarate hydratase	1	0	0	1
NFKB1 protein, partial	1	0	0	1
polyprotein	1	0	0	1
peripheral myelin protein 22 isoform 1	4	0	0	4
vitamin D3 receptor isoform VDRA	2	0	0	2
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
cytochrome P450 3A4 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	3	1	0	4
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Stromelysin-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Urease subunit alpha	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	3	1	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	3	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	3	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	3	1	0	4
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	3	1	0	4
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	3	1	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	3	1	0	4
Gamma-aminobutyric acid receptor subunit beta-3	3	1	0	4
Gamma-aminobutyric acid receptor subunit beta-2	3	1	0	4
Urease subunit beta	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Inositol monophosphatase 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Carbonic anhydrase 9	0	3	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
GABA theta subunit	3	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	3	1	0	4
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Chain A, Glutamate receptor 2	0	0	1	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain C, Glutamate receptor 2	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
endonuclease IV	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
chromobox protein homolog 1	5	0	0	5
thyroid hormone receptor beta isoform 2	2	0	0	2
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
DNA polymerase kappa isoform 1	2	0	0	2
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Metabotropic glutamate receptor 6	0	0	1	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Glutamate receptor ionotropic, NMDA 1	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 5	0	0	1	1
Glutamate receptor ionotropic, kainate 2	0	2	2	4
Glutamate receptor 1	0	1	1	2
Glutamate receptor 2	0	1	1	2
Glutamate receptor 3	0	0	1	1
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Glutamate receptor 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	3
Glutamate receptor ionotropic, NMDA 2B	0	3	1	4
Glutamate receptor ionotropic, NMDA 2C	0	2	1	3
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	2	1	3
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	1	3
Glutamate receptor ionotropic, NMDA 3A	0	2	1	3
ATP-dependent phosphofructokinase	3	0	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
GALC protein	2	0	0	2
cytochrome P450 2D6	1	0	0	1
cytochrome P450 2D6 isoform 1	2	0	0	2
D(1A) dopamine receptor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
muscarinic acetylcholine receptor M1	3	0	0	3
Dihydrofolate reductase	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
flap endonuclease 1	2	0	0	2
Synaptic vesicle glycoprotein 2A	0	2	0	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Cationic amino acid transporter 3	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
interleukin 8	1	0	0	1
ClpP	1	0	0	1
ATAD5 protein, partial	2	0	0	2
GLI family zinc finger 3	4	0	0	4
caspase 7, apoptosis-related cysteine protease	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
regulator of G-protein signaling 4	2	0	0	2
caspase-3	2	0	0	2
aryl hydrocarbon receptor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
M-phase phosphoprotein 8	2	0	0	2
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cholinesterase	0	1	0	1
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Acetylcholinesterase	0	1	0	1
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Nociceptin receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear receptor ROR-gamma	2	0	0	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Microtubule-associated protein tau	2	0	0	2
nonstructural protein 1	1	0	0	1
polyadenylate-binding protein 1	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
bcl-2-related protein A1	0	1	0	1
peripheral myelin protein 22	1	0	0	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Gamma-aminobutyric acid	0	1	0	1
G	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Dihydrofolate reductase	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Histamine H2 receptor	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
cytochrome P450 2C9, partial	1	0	0	1
Hsf1 protein	0	0	1	2
farnesoid X nuclear receptor	2	0	0	2
peroxisome proliferator activated receptor gamma	2	0	0	2
Guanine nucleotide-binding protein G	1	0	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
retinoid X nuclear receptor alpha	2	0	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 12	0	1	0	2
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	0	0	1
Carbonic anhydrase 3	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Carbonic anhydrase 6	0	1	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 13	0	1	0	2
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
peroxisome proliferator-activated receptor delta	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
lethal factor (plasmid)	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Olfactory receptor 51E2	0	0	1	1
Luciferase	1	0	0	1
pregnane X receptor	1	0	0	1
Cocaine esterase	0	1	0	1
Histone deacetylase 3	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
Histone deacetylase 8	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(13)

Research

Studies (25)

Protein Targets (386)

4p Deletion Syndrome

Synonyms(13)

Research

Studies (25)

Drugs Studied (29)

Protein Targets (386)