46, XY Gonadal Dysgenesis

Defects in the SEX DETERMINATION PROCESS in 46, XY individuals that result in abnormal gonadal development and deficiencies in TESTOSTERONE and subsequently ANTIMULLERIAN HORMONE or other factors required for normal male sex development. This leads to the development of female phenotypes (male to female sex reversal), normal to tall stature, and bilateral streak or dysgenic gonads which are susceptible to GONADAL TISSUE NEOPLASMS. An XY gonadal dysgenesis is associated with structural abnormalities on the Y CHROMOSOME, a mutation in the GENE, SRY, or a mutation in other autosomal genes that are involved in sex determination.

Synonym
46, XY Gonadal Sex Reversal
46,XY Complete Gonadal Dysgenesis
Gonadal Dysgenesis, 46,XY
Sex Reversal, Gonadal, 46, XY
Pure Gonadal Dysgenesis 46,XY
Complete Gonadal Dysgenesis, 46, XY
Pure Gonadal Dysgenesis, 46, XY
Gonadal Dysgenesis, 46, XY
XY Pure Gonadal Dysgenesis
Swyer Syndrome
46, XY Gonadal Dysgenesis

Excerpt	Reference
"Swyer syndrome is characterized by a higher risk of developing genital malignancies."	( Balcerska, A; Iżycka-Świeszewska, E; Kobierska-Gulida, G; Stachowicz-Stencel, T; Synakiewicz, A, 2011)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	23 (20.18)	23.3326
1990's	15 (13.16)	12.5806
2000's	23 (20.18)	18.1394
2010's	44 (38.60)	28.8240
2020's	9 (7.89)	9.53

Drug	Relationship Strength	Studies
adenine	low	1
glycine	low	1
melatonin	low	2
calmidazolium	low	1
ifosfamide	low	1
khellin	low	1
thyroxine	low	1
norethindrone acetate	low	1
estrone	low	1
dehydroepiandrosterone	low	2
alanine	low	2
serine	low	2
ethinyl estradiol	low	1
tyrosine	low	2
leucine	low	1
androstenedione	low	7
methionine	low	1
phenylalanine	low	1
norethindrone	low	1
17-alpha-hydroxyprogesterone	low	4
asparagine	low	1
medroxyprogesterone acetate	low	1
threonine	low	1
mestranol	low	2
tryptophan	low	1
isoleucine	low	1
arginine	low	4
chlormadinone acetate	low	1
nandrolone	low	1
medroxyprogesterone	low	1
dihydrotestosterone	low	10
dehydroepiandrosterone sulfate	low	1
levonorgestrel	low	1
boldenone	low	1
ethinyl estradiol-norgestrel combination	low	1
etoposide	low	3
methyldopa	low	1
6-sulfatoxymelatonin	low	1
testosterone undecanoate	low	1
(s-dinitrophenyl)-6-mercaptopurine riboside triphosphate	low	1
mibolerone	low	1
decitabine	low	1
propylthiouracil	low	1
oligonucleotides	low	1
menotropins	low	1
sodium ethylxanthate	low	1
muramidase	low	1
guanine	low	1

Protein Targets (480)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
acetylcholinesterase	5	0	0	5
pregnane X receptor	3	0	0	3
SMAD family member 2	10	0	0	10
SMAD family member 3	10	0	0	10
TDP1 protein	20	0	0	20
GLI family zinc finger 3	21	0	0	21
Microtubule-associated protein tau	6	0	0	6
AR protein	21	0	0	21
progesterone receptor	17	0	0	17
glucocorticoid receptor [Homo sapiens]	19	0	0	19
retinoic acid nuclear receptor alpha variant 1	18	0	0	18
retinoid X nuclear receptor alpha	14	0	0	14
estrogen-related nuclear receptor alpha	20	0	0	20
farnesoid X nuclear receptor	10	0	0	10
pregnane X nuclear receptor	19	0	0	19
estrogen nuclear receptor alpha	25	0	0	25
G	11	0	0	11
vitamin D (1,25- dihydroxyvitamin D3) receptor	14	0	0	14
arylsulfatase A	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	11	0	0	11
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	14	0	0	14
activating transcription factor 6	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
chromobox protein homolog 1	16	0	0	16
nuclear factor erythroid 2-related factor 2 isoform 1	18	0	0	18
geminin	15	0	0	15
survival motor neuron protein isoform d	4	0	0	4
histone acetyltransferase KAT2A isoform 1	4	0	0	4
lamin isoform A-delta10	14	0	0	14
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Interferon beta	13	0	0	13
HLA class I histocompatibility antigen, B alpha chain	11	0	0	11
Glucocorticoid receptor	0	15	1	17
Sex hormone-binding globulin	0	1	9	10
Glycine receptor subunit alpha-1	0	14	0	14
Corticosteroid-binding globulin	0	6	0	6
Adenosine receptor A3	0	4	0	4
Replicase polyprotein 1ab	0	1	0	1
Androgen receptor	0	25	1	26
Alpha-1B adrenergic receptor	0	4	0	4
Glutamate receptor 2	9	0	0	9
Glycine receptor subunit beta	0	14	0	14
Glycine receptor subunit alpha-2	0	14	0	14
Glycine receptor subunit alpha-3	0	14	0	14
Mitogen-activated protein kinase 3	0	1	0	1
Alpha-1A adrenergic receptor	0	5	0	5
Sodium-dependent dopamine transporter	0	4	0	4
TAR DNA-binding protein 43	6	0	0	6
Inositol hexakisphosphate kinase 1	11	0	0	11
cytochrome P450 2C9, partial	11	0	0	11
ATP-dependent phosphofructokinase	7	0	0	7
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	18	0	0	18
nuclear receptor subfamily 1, group I, member 3	14	0	0	14
cytochrome P450 family 3 subfamily A polypeptide 4	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
heat shock protein beta-1	5	0	0	5
importin subunit beta-1 isoform 1	5	0	0	5
snurportin-1	5	0	0	5
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
Bile salt export pump	0	12	0	12
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	5	0	0	5
Ataxin-2	7	0	0	7
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Carbonic anhydrase 1	0	0	0	5
Carbonic anhydrase 2	0	0	0	5
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	1	8
Proton-coupled amino acid transporter 1	0	5	0	6
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	1
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Acetylcholinesterase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
interleukin 8	6	0	0	6
Smad3	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
estrogen receptor 2 (ER beta)	11	0	0	11
regulator of G-protein signaling 4	4	0	0	4
nonstructural protein 1	3	0	0	3
peroxisome proliferator-activated receptor delta	12	0	0	12
peroxisome proliferator activated receptor gamma	12	0	0	12
Histone H2A.x	9	0	0	9
Caspase-7	2	0	0	2
Bloom syndrome protein isoform 1	6	0	0	6
peripheral myelin protein 22 isoform 1	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
caspase-3	2	0	0	2
thyroid hormone receptor beta isoform 2	17	0	0	17
mitogen-activated protein kinase 1	3	0	0	3
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	9	0	0	9
nuclear receptor ROR-gamma isoform 1	5	0	0	5
peripheral myelin protein 22	7	0	0	7
muscleblind-like protein 1 isoform 1	2	0	0	2
neuropeptide S receptor isoform A	3	0	0	3
Beta-glucuronidase	0	2	0	2
Cholinesterase	0	3	0	3
Aromatase	0	6	0	9
Gastrin/cholecystokinin type B receptor	0	0	0	1
Testosterone 17-beta-dehydrogenase 3	0	2	0	2
Alpha-synuclein	3	2	0	5
Nuclear receptor ROR-gamma	5	0	0	5
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	7	0	0	7
phosphopantetheinyl transferase	7	0	0	7
NFKB1 protein, partial	2	0	0	2
GLS protein	4	0	0	4
thyroid stimulating hormone receptor	4	0	0	4
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	3	0	0	3
flap endonuclease 1	3	0	0	3
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	3	0	0	3
Cytochrome P450 3A4	0	3	0	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Neutral amino acid transporter A	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	4
Amino acid transporter	0	2	0	2
ATAD5 protein, partial	7	0	0	7
Fumarate hydratase	2	0	0	2
USP1 protein, partial	5	0	0	5
PPM1D protein	2	0	0	2
EWS/FLI fusion protein	6	0	0	6
polyprotein	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
hexokinase-4 isoform 1	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
glucokinase regulatory protein	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, Ferritin light chain	2	0	0	2
Chain A, Cruzipain	2	0	0	2
thioredoxin glutathione reductase	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
thyroid stimulating hormone receptor	9	0	0	9
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	9	0	0	9
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
vitamin D3 receptor isoform VDRA	4	0	0	4
thyroid hormone receptor beta isoform a	5	0	0	5
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
transcriptional regulator ERG isoform 3	4	0	0	4
Cellular tumor antigen p53	9	0	0	9
Cytochrome P450 2C19	0	4	0	4
Spike glycoprotein	7	0	0	7
Chain A, Beta-lactamase	6	0	0	6
67.9K protein	3	0	0	3
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-binding cassette sub-family C member 3	0	8	0	8
Multidrug resistance-associated protein 4	0	9	0	10
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	9	0	10
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
cytochrome P450 2D6	4	0	0	4
aryl hydrocarbon receptor	5	0	0	5
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
G-protein coupled bile acid receptor 1	0	0	3	3
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Steryl-sulfatase	0	1	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	2
ATP-binding cassette sub-family C member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	2
Chain A, Sex Hormone-Binding Globulin	0	0	1	1
glp-1 receptor, partial	3	0	0	3
thyrotropin-releasing hormone receptor	1	0	0	1
cytochrome P450 3A4 isoform 1	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	7	0	0	7
Plasma kallikrein	0	1	0	4
Progesterone receptor	0	1	0	1
Progesterone receptor	0	5	5	10
Glucocorticoid receptor	0	1	0	1
Mineralocorticoid receptor	0	2	0	2
Sex hormone-binding globulin	0	1	0	1
Androgen receptor	0	4	4	10
Gamma-aminobutyric acid receptor subunit beta-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit delta	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	7	0	0	7
Androgen receptor	0	1	2	3
Gamma-aminobutyric acid receptor subunit alpha-5	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	7	0	0	7
Mineralocorticoid receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-4	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	7	0	0	7
Angiotensin-converting enzyme	0	0	1	1
Cannabinoid receptor 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-2	7	0	0	7
Muscarinic acetylcholine receptor	0	1	0	1
GABA theta subunit	7	0	0	7
Neuropeptide FF receptor 2	0	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	7	0	0	7
ALK tyrosine kinase receptor	0	1	0	1
endonuclease IV	2	0	0	2
GALC protein	4	0	0	4
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Rap guanine nucleotide exchange factor 3	4	0	0	4
Estrogen receptor	0	9	3	13
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Sodium-dependent serotonin transporter	0	8	0	8
Mu-type opioid receptor	0	1	1	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Mu-type opioid receptor	0	0	1	1
Inositol monophosphatase 1	1	0	0	1
Cytochrome P450 1B1	0	3	0	3
Estrogen receptor beta	0	3	3	7
Ghrelin O-acyltransferase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Luciferase	3	0	0	3
caspase 7, apoptosis-related cysteine protease	3	0	0	3
caspase-3	3	0	0	3
IDH1	2	0	0	2
lysosomal alpha-glucosidase preproprotein	2	0	0	2
Vpr	1	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Cytochrome P450 2B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Cytochrome P450 2B6	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	4
Sodium-dependent noradrenaline transporter	0	4	0	4
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Adenosine receptor A2a	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Sulfotransferase 1A1	0	2	1	4
Aldehyde oxidase	0	1	0	1
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Prothrombin	0	0	0	1
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	3
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
Cytochrome P450 2C9	0	2	0	2
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	2	0	2
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	7
Glutamate receptor ionotropic, NMDA 2B	0	2	1	7
Glutamate receptor ionotropic, NMDA 2C	0	2	1	7
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Glutamate receptor ionotropic, NMDA 2D	0	2	1	7
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	1	7
Glutamate receptor ionotropic, NMDA 3A	0	2	1	7
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	7	0	8
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
cytochrome P450 2D6 isoform 1	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
Cytochrome P450 1A1	0	3	0	3
Cytochrome P450 1A2	0	3	0	3
Cytochrome P450 2D6	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	3	0	3
Phospholipase A-2-activating protein	0	3	0	3
DNA polymerase beta	2	0	0	2
PINK1	2	0	0	2
Parkin	2	0	0	2
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	1	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
ClpP	1	0	0	1
M-phase phosphoprotein 8	3	0	0	3
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	3	0	3
Cytochrome P450 2C11	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Histamine H3 receptor	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Cannabinoid receptor 1	0	2	0	2
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
hypothetical protein, conserved	1	0	0	1
pyruvate kinase	1	0	0	1
estrogen receptor beta isoform 1	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase kappa isoform 1	3	0	0	3
Bile salt export pump	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
phosphoglycerate kinase	1	0	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
glucocerebrosidase	1	0	0	1
Solute carrier family 22 member 1	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
Estrogen receptor	0	0	1	1
Estrogen receptor beta	0	0	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Carbonic anhydrase 12	0	0	0	3
Carbonic anhydrase 3	0	0	0	3
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Carbonic anhydrase 4	0	0	0	3
Carbonic anhydrase 6	0	0	0	3
Adenosine receptor A1	0	0	0	2
Adenosine receptor A2a	0	0	0	2
Carbonic anhydrase 5A, mitochondrial	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 7	0	0	0	3
Carbonic anhydrase	0	0	0	3
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	3
Carbonic anhydrase 9	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 13	0	0	0	1
Monocarboxylate transporter 10	0	0	0	3
Carbonic anhydrase 15	0	0	0	3
Carbonic anhydrase 13	0	0	0	2
Carbonic anhydrase 14	0	0	0	3
Carbonic anhydrase 5B, mitochondrial	0	0	0	3
NADH-cytochrome b5 reductase 3	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Cholinesterase	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
serine/threonine-protein kinase PLK1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Dihydrofolate reductase	0	2	0	2
Stromelysin-1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(11)

Research Excerpts

Overview

Research

Studies (114)

Protein Targets (480)

46, XY Gonadal Dysgenesis

Synonyms(11)

Research Excerpts

Overview

Research

Studies (114)

Drugs Studied (63)

Protein Targets (480)