xiamycin profile

xiamycin: from Streptomyces sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	38358410
CHEMBL ID	1270030
MeSH ID	M0555905

Synonym
hydroxy(dimethyl)[?]carboxylic acid
xiamycin
CHEMBL1270030
(3s,4s,4ar,13bs)-3-hydroxy-4,13b-dimethyl-2,3,4,4a,5,6,8,13b-octahydro-1h-naphtho[2,1-b]carbazole-4-carboxylic acid
xiamycin a

Bioassays (31)

Assay ID	Title	Year	Journal	Article
AID527051	Antimicrobial activity against Candida albicans at 50 ug after 24 hrs by paper disk method	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527058	Antimicrobial activity against Enterococcus faecalis 1528 R10 at 50 ug after 24 hrs by paper disk method	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527054	Antimicrobial activity against Mycobacterium vaccae IMET 10670 at 50 ug after 24 hrs by paper disk method	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527066	Antitumor activity against human PAXF 1657L by modified propidium iodide assay	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID1289314	Selectivity index, ratio of CC50 for African green monkey Vero cells to EC50 for PEDV infected in African green monkey Vero cells	2016	Journal of natural products, Jan-22, Volume: 79, Issue:1	Antiviral Indolosesquiterpenoid Xiamycins C-E from a Halophilic Actinomycete.
AID1289316	Cytotoxicity against African green monkey Vero cells after 48 hrs by MTT assay	2016	Journal of natural products, Jan-22, Volume: 79, Issue:1	Antiviral Indolosesquiterpenoid Xiamycins C-E from a Halophilic Actinomycete.
AID527052	Antimicrobial activity against Penicillium notatum JP36 at 50 ug after 24 hrs by paper disk method	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527053	Antimicrobial activity against Bacillus subtilis ATCC 6633 at 50 ug after 24 hrs by paper disk method	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527048	Antimicrobial activity against Pseudomonas aeruginosa SG137/B7 at 50 ug after 24 hrs by paper disk method	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID1289315	Antiviral activity against PEDV infected in African green monkey Vero cells assessed as reduction in virus-induced cytopathic effect after 72 hrs by MTT assay	2016	Journal of natural products, Jan-22, Volume: 79, Issue:1	Antiviral Indolosesquiterpenoid Xiamycins C-E from a Halophilic Actinomycete.
AID527072	Antiproliferative activity against human K562 cells	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527060	Antitumor activity against human GXF251L by modified propidium iodide assay	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527073	Antiproliferative activity against human HeLa cells	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527067	Antitumor activity against human 22Rv1 by modified propidium iodide assay	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527069	Antitumor activity against human RXF 486L by modified propidium iodide assay	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527056	Antimicrobial activity against Staphylococcus aureus SG 511 at 50 ug after 24 hrs by paper disk method	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527068	Antitumor activity against human PXF 1752L by modified propidium iodide assay	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527063	Antitumor activity against human MAXF 401NL by modified propidium iodide assay	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527050	Antimicrobial activity against Sporobolomyces salmonicolor SBUG 549 at 50 ug after 24 hrs by paper disk method	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527064	Antitumor activity against human MEXF 462NL by modified propidium iodide assay	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527065	Antitumor activity against human OVXF 899L by modified propidium iodide assay	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527059	Antitumor activity against human HT-29 by modified propidium iodide assay	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527047	Inhibition of HIV1 NL4-3 replication in CD4-CCR5 expressing human TZM-bl cells assessed as decrease in p24 antigen production	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527071	Antiproliferative activity against mouse L929 cells	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527062	Antitumor activity against human LXFL 529L by modified propidium iodide assay	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527070	Antitumor activity against human UXF 1138L by modified propidium iodide assay	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527055	Antimicrobial activity against Pseudomonas aeruginosa K799/61 at 50 ug after 24 hrs by paper disk method	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527049	Antimicrobial activity against Escherichia coli SG458 at 50 ug after 24 hrs by paper disk method	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID526858	Inhibition of HIV1 NL4-3 replication in CD4-CXCR4 expressing human TZM-bl cells assessed as decrease in p24 antigen production	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527061	Antitumor activity against human LXFA 629L by modified propidium iodide assay	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
AID527057	Antimicrobial activity against Staphylococcus aureus 134/94 R9 at 50 ug after 24 hrs by paper disk method	2010	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22	Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	12 (100.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
indole [no description available]	2.53	2	indole; polycyclic heteroarene	Escherichia coli metabolite
sulfur dioxide Sulfur Dioxide: A highly toxic, colorless, nonflammable gas. It is used as a pharmaceutical aid and antioxidant. It is also an environmental air pollutant.	2.11	1	sulfur oxide	Escherichia coli metabolite; food bleaching agent; refrigerant
azauridine Azauridine: A triazine nucleoside used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.	2.13	1	N-glycosyl-1,2,4-triazine	antimetabolite; antineoplastic agent; drug metabolite
carvone carvone: an oxidized derivative of limonene; RN given refers to cpd without isomeric designation; L-carvone has spearmint flavor, D-carvone has dill/caraway flavor. carvone : A p-menthane monoterpenoid that consists of cyclohex-2-enone having methyl and isopropenyl substituents at positions 2 and 5, respectively.	2.21	1	botanical anti-fungal agent; carvones	allergen
sesquiterpenes [no description available]	8.98	12

xiamycin

Description

Cross-References

Synonyms (5)

Bioassays (31)

Research

Studies (12)

Study Types

xiamycin

Description

Cross-References

Synonyms (5)

Bioassays (31)

Research

Studies (12)

Study Types

Related Drugs (5)

Related Conditions (0)