Compounds > xanthinosin
Page last updated: 2024-11-13

xanthinosin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

xanthinosin: a potential anticancer agent from Xanthium strumarium [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
XanthiumgenusA plant genus of the family ASTERACEAE. The name prickly burweed is sometimes used but causes confusion with AMSINCKIA.[MeSH]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]
Xanthium strumariumspecies[no description available]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]
Xanthium strumariumspecies[no description available]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]
Xanthium strumariumspecies[no description available]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]

Cross-References

ID SourceID
PubMed CID44453629
CHEMBL ID257513
MeSH IDM0519437

Synonyms (3)

Synonym
CHEMBL257513
xanthinosin
(3ar,7s,8as)-7-methyl-3-methylidene-6-(3-oxobutyl)-4,7,8,8a-tetrahydro-3ah-cyclohepta[b]furan-2-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (38)

Assay IDTitleYearJournalArticle
AID1234794Increase in cleaved caspase-8 protein expression in human AGS cells at 8 uM incubated for 24 hrs in presence of 100 ng/ml TRAIL by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234825Increase in CHOP protein expression in human AGS cells incubated for 24 hrs by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234814Increase in cleaved caspase-8 protein expression in human AGS cells at 8 uM incubated for 24 hrs by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234818Increase in caspase-3 protein expression in human AGS cells at 8 uM incubated for 24 hrs by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID321378Inhibition of COX2 expression in LPS-stimulated mouse BV2 cells after 20 hrs by Western blot analysis2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium.
AID1234807Inhibition of TRAIL-resistance in human MCF7 cells assessed as inhibition of cell viability at 4 to 12 uM incubated for 24 hrs in presence of 100 ng/ml TRAIL by FMCA method relative to TRAIL alone2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1235015Antiviral activity against Coxsackievirus B3 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Bioactive Sesquiterpenes and Lignans from the Fruits of Xanthium sibiricum.
AID1234809Increase in DR4 protein expression in human AGS cells incubated for 24 hrs by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234812Increase in cleaved caspase-9 protein expression in human AGS cells at 4 to 12 uM s by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234806Inhibition of TRAIL-resistance in human DU145 cells assessed as inhibition of cell viability at 4 to 12 uM incubated for 24 hrs in presence of 100 ng/ml TRAIL by FMCA method relative to TRAIL alone2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234819Increase in caspase-3 protein expression in human AGS cells at 8 uM incubated for 24 hrs in presence of 100 ng/ml TRAIL by Western blotting method relative to TRAIL alone2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234824Increase in p53 protein expression in human AGS cells incubated for 24 hrs by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234793Increase in cleaved caspase-8 protein expression in human AGS cells at 8 uM incubated for 24 hrs in presence of 100 ng/ml TRAIL by Western blotting method relative to TRAIL alone2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID321377Inhibition of iNOS expression in LPS-stimulated mouse BV2 cells at 20 uM after 20 hrs by Western blot analysis2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium.
AID1235013Antiinflammatory activity in ICR mouse assessed as inhibition of croton oil-induced ear edema at 50 mg/ml administered 1 hr prior to croton oil challenge measured after 4 hrs relative to control2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Bioactive Sesquiterpenes and Lignans from the Fruits of Xanthium sibiricum.
AID1234797Inhibition of TRAIL-resistance in human AGS cells assessed as inhibition of cell viability at 8 uM incubated for 24 hrs in presence of 100 ng/ml TRAIL by FMCA method relative to TRAIL alone2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234815Increase in cleaved caspase-9 protein expression in human AGS cells at 8 uM incubated for 24 hrs in presence of 100 ng/ml TRAIL by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234816Increase in cleaved caspase-9 protein expression in human AGS cells at 8 uM incubated for 24 hrs by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234811Increase in cleaved caspase-8 protein expression in human AGS cells incubated for 24 hrs by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234804Inhibition of TRAIL-resistance in human HeLa cells assessed as inhibition of cell viability at 4 to 12 uM incubated for 24 hrs in presence of 100 ng/ml TRAIL by FMCA method relative to TRAIL alone2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1235012Antiinflammatory activity in C57BL6/J mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Bioactive Sesquiterpenes and Lignans from the Fruits of Xanthium sibiricum.
AID1234795Increase in caspase-3 protein expression in human AGS cells at 8 uM incubated for 24 hrs in presence of 100 ng/ml TRAIL by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234820Decrease in Bcl2 protein expression in human AGS cells incubated for 24 hrs by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234822Increase in DR4 protein expression in human AGS cells at 8 uM incubated for 3 to 12 hrs by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234813Increase in caspase-3 protein expression in human AGS cells incubated for 24 hrs by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234823Increase in DR5 protein expression in human AGS cells at 8 uM incubated for 3 to 12 hrs by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234796Inhibition of TRAIL-resistance in human AGS cells assessed as inhibition of cell viability at 4 uM incubated for 24 hrs in presence of 100 ng/ml TRAIL by FMCA method relative to TRAIL alone2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234817Increase in cleaved caspase-9 protein expression in human AGS cells at 8 uM incubated for 24 hrs in presence of 100 ng/ml TRAIL by Western blotting method relative to TRAIL alone2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234805Inhibition of TRAIL-resistance in human DLD1 cells assessed as inhibition of cell viability at 4 to 12 uM incubated for 24 hrs in presence of 100 ng/ml TRAIL by FMCA method relative to TRAIL alone2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1234798Inhibition of TRAIL-resistance in human AGS cells assessed as inhibition of cell viability at 12 uM incubated for 24 hrs in presence of 100 ng/ml TRAIL by FMCA method relative to TRAIL alone2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID321379Inhibition of iNOS mRNA expression in LPS-stimulated mouse BV2 cells at 20 uM after 4 hrs by RT-PCR2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium.
AID321380Inhibition of COX2 mRNA expression in LPS-stimulated mouse BV2 cells at 20 uM after 4 hrs by RT-PCR2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium.
AID1234808Inhibition of TRAIL-resistance in HEK293 cells assessed as inhibition of cell viability at 4 to 8 uM incubated for 24 hrs in presence of 100 ng/ml TRAIL by FMCA method relative to TRAIL alone2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID321376Inhibition of NO production in LPS-activated mouse BV2 cells by ELISA2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium.
AID321381Inhibition of IkappaB alpha degradation in LPS-induced mouse BV2 cells at 20 uM after 30 mins by Western blot analysis2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium.
AID1234810Increase in DR5 protein expression in human AGS cells incubated for 24 hrs by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
AID1235019Antiviral activity against Influenza A virus (A/FM/1/47(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Bioactive Sesquiterpenes and Lignans from the Fruits of Xanthium sibiricum.
AID1234821Increase in Bax protein expression in human AGS cells at incubated for 24 hrs by Western blotting method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's4 (57.14)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pleconaril
WIN 63843: structure given in first source		2.1110
ribavirin
Rebetron: Rebetron is tradename		2.11101-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
oseltamivir
Oseltamivir: An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.. oseltamivir : A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.		2.1110acetamides;
amino acid ester;
cyclohexenecarboxylate ester;
primary amino compound		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
environmental contaminant;
prodrug;
xenobiotic
ethyl protocatechuate
ethyl protocatechuate: structure. ethyl 3,4-dihydroxybenzoate : An ethyl ester resulting from the formal condensation of the carboxy group of 3,4-dihydroxybenzoic acid with ethanol. It is the anti-oxidative component of peanut seed testa.		2.1110catechols;
ethyl ester		antibacterial agent;
antioxidant;
apoptosis inducer;
EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor;
plant metabolite
sesquiterpenes
[no description available]		3.1750
xanthatin
xanthatin: a phytogenic antineoplastic agent; RN given refers to (3aR-(3aalpha,7beta,8abeta))-isomer; structure		7.9940sesquiterpene lactone
phaseic acid
phaseic acid: a plant hormone derived from abscisic acid; structure in first source		2.1110alpha,beta-unsaturated monocarboxylic acid;
apo carotenoid sesquiterpenoid		metabolite
ethyl caffeate
(E)-ethyl 3-(3,4-dihydroxyphenyl)prop-2-enoate: structure in first source. ethyl trans-caffeate : An ethyl ester resulting from the formal condensation of the carboxy group of trans-caffeic acid with ethanol.		2.1110alkyl caffeate ester;
ethyl ester;
hydroxycinnamic acid		anti-inflammatory agent;
antineoplastic agent;
metabolite
ConditionIndicatedRelationship StrengthStudiesTrials