Compounds > vufb 16066
Page last updated: 2024-09-26

vufb 16066

Description

flobufen: antirheumatic drug [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID159476
SCHEMBL ID187209
MeSH IDM0158377

Synonyms (26)

Synonym
flobufen
vufb-16066
4-(2',4'-difluorobiphenylyl)-4-oxo-2-methylbutanoic acid
vufb16066
2',4'-difluoro-alpha-methyl-gamma-oxo-(1,1'-biphenyl)-4-butanoic acid
4-(2',4'-difluorbiphenyl-4-yl)-2-methyl-4-oxobutansaeure [german]
3-(4-(2,4-difluorophenyl)benzoyl)-2-methylpropionic acid
vufb 16066
gamma-oxo-(2',4'-difluoro-(1,1')-biphenyl-4-yl)-2-methylbutanoic acid
(1,1'-biphenyl)-4-butanoic acid, 2',4'-difluoro-alpha-methyl-gamma-oxo-
brn 4522244
L001349
112344-52-2
4-[4-(2,4-difluorophenyl)phenyl]-2-methyl-4-oxobutanoic acid
4-(2',4'-difluorbiphenyl-4-yl)-2-methyl-4-oxobutansaeure
0lnc8ezt75 ,
unii-0lnc8ezt75
104941-35-7
SCHEMBL187209
flobufen, (+/-)-
(1,1'-biphenyl)-4-butanoic acid, 2',4'-difluoro-.alpha.-methyl-.gamma.-oxo-
DTXSID70874896
Q27236946
4-(2',4'-difluoro-[1,1'-biphenyl]-4-yl)-2-methyl-4-oxobutanoic acid
BS-51531
F73749

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (10.53)18.7374
1990's7 (36.84)18.2507
2000's10 (52.63)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
theophylline[no description available]medium10dimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent
aminocaproic acid[no description available]medium10amino acid zwitterion;
epsilon-amino acid;
omega-amino fatty acid		antifibrinolytic drug;
hematologic agent;
metabolite
clotrimazole[no description available]medium10conazole antifungal drug;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes		antiinfective agent;
environmental contaminant;
xenobiotic
griseofulvin[no description available]medium101-benzofurans;
antibiotic antifungal drug;
benzofuran antifungal drug;
organochlorine compound;
oxaspiro compound		antibacterial agent;
Penicillium metabolite
carbamates[no description available]medium10amino-acid anion
transkarbam 12[no description available]medium10
fenbufen[no description available]medium104-oxo monocarboxylic acid;
biphenyls		non-steroidal anti-inflammatory drug
dinoprostone[no description available]medium10prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
diclofenac[no description available]medium10amino acid;
aromatic amine;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound		antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
leukotriene b4[no description available]medium10dihydroxy monocarboxylic acid;
hydroxy polyunsaturated fatty acid;
leukotriene;
long-chain fatty acid		human metabolite;
mouse metabolite;
plant metabolite;
vasoconstrictor agent
acetic acid[no description available]medium10monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
arachidonic acid[no description available]medium10icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
lisuride[no description available]medium10monocarboxylic acid amideantidyskinesia agent;
antiparkinson drug;
dopamine agonist;
serotonergic agonist
dironyl[no description available]medium10organic molecular entity
betadex[no description available]medium10cyclodextrin
ergoline[no description available]medium10diamine;
ergoline alkaloid;
indole alkaloid fundamental parent;
indole alkaloid;
organic heterotetracyclic compound
nad[no description available]medium10organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
nadp[no description available]medium10
tolfenamic acid[no description available]medium10aminobenzoic acid;
organochlorine compound;
secondary amino compound		EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
ibuprofen[no description available]medium10monocarboxylic acidantipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic
ketoprofen[no description available]medium10benzophenones;
oxo monocarboxylic acid		antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-steroidal anti-inflammatory drug;
xenobiotic
fenoprofen[no description available]medium10monocarboxylic acidantipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
3-chloro-4-benzoyloxyphenylacetic acid[no description available]medium10
ConditionIndicatedRelationship StrengthStudiesTrials
Abdominal Pain0low10
Adjuvant Arthritis0low10
Anasarca0low10
Arthritis, Adjuvant0low10
Arthritis, Adjuvant-Induced0low10
Arthritis, Collagen-Induced0low10
Arthritis, Experimental0low10
Colicky Pain0low10
Collagen Arthritis0low10
Dropsy0low10
Edema0low10
Gastric Ulcer0low10
Hydrops0low10
Pleurisy0low10
Pleuritis0low10
Stomach Ulcer0low10

Research Highlights

Pharmacokinetics (3)

ArticleYear
Stereoselective pharmacokinetics and metabolism of flobufen in guinea pigs.
Chirality, Volume: 15, Issue: 8		2003
Stereoselective pharmacokinetics of flobufen in rats.
Chirality, Volume: 11, Issue: 10		1999
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]