vertilmicin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 101268397 |
| MeSH ID | M0469026 |
| Synonym |
|---|
| vertilmicin |
| 59711-97-6 |
| (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4-amino-3-[[(2s,3r)-3-amino-6-(1-aminoethyl)-3,4-dihydro-2h-pyran-2-yl]oxy]-6-(ethylamino)-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol |
| gtpl11018 |
Vertilmicin is a new semisynthetic aminoglycoside. It has a structure similar to that of netilmic in except for a methyl group at the C-6' position.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Vertilmicin is a new semisynthetic aminoglycoside with a structure similar to that of netilmicin except for a methyl group at the C-6' position. " | ( In vitro antibacterial activity of vertilmicin and its susceptibility to modifications by the recombinant AAC6'-APH2'' enzyme. Chen, HZ; Hong, B; Jiang, JD; Li, CR; Li, Y; Li, ZR; Lou, RH; Sun, CH; Wang, YM; Yang, XY; You, XF; Yuan, M; Zhang, WX; Zhao, LX, 2008) | 2.07 |
Vertilmicin displayed a concentration-dependent killing effect against the three bacterial strains. Its short half-life may possibly have a dramatic impact on antimicrobial activities.
| Excerpt | Reference | Relevance |
|---|---|---|
| " The pharmacokinetic behavior of vertilmicin was dose-dependent when increasing doses of vertilmicin were administered intravenously to rats." | ( Pharmacokinetics of vertilmicin, a novel aminoglycoside antibiotic, in rats and dogs. Liu, CX; Su, MY; Wan, RZ; Zhou, MJ, 2010) | 0.97 |
| " Vertilmicin displayed a concentration-dependent killing effect against the three bacterial strains, and its short half-life may possibly have a dramatic impact on antimicrobial activities." | ( Evaluation of in vitro synergy between vertilmicin and ceftazidime against Pseudomonas aeruginosa using a semi-mechanistic pharmacokinetic/pharmacodynamic model. Derendorf, H; Liu, C; Mulder, MB; Singh, RP; Sy, SK; Xia, H; Zhuang, L, 2015) | 1.6 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " After intravenous dosing to rats vertilmicin was distributed to most organs and tissues, and kidney tissue exhibited the highest exposure, while the tissue with the lowest exposure was the brain." | ( Pharmacokinetics of vertilmicin, a novel aminoglycoside antibiotic, in rats and dogs. Liu, CX; Su, MY; Wan, RZ; Zhou, MJ, 2010) | 0.96 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.95) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||