Compounds > varitriol
Page last updated: 2024-12-09

varitriol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

varitriol: from marine-derived strain of the fungus Emericella variecolor; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID636888
CHEMBL ID445220
SCHEMBL ID6507300
MeSH IDM0426404

Synonyms (14)

Synonym
inchi=1/c15h20o5/c1-9-14(17)15(18)13(20-9)7-6-10-4-3-5-12(19-2)11(10)8-16/h3-7,9,13-18h,8h2,1-2h3/b7-6+/t9-,13+,14-,15+/m0/s
varitriol
2-[2-(2-hydroxymethyl-3-methoxy-phenyl)-vinyl]-5-methyl-tetrahydro-furan-3,4-diol
(3'r*,4'r*,5's*,6's*)-2-methoxy-6-(3',6'-epoxy-4',5'-dihydroxyheptenyl)benzyl alcohol
d-allo-hept-6-enitol, 2,5-anhydro-1,6,7-trideoxy-7-[2-(hydroxymethyl)-3-methoxyphenyl]-, (6e)-
(1e)-3,6-anhydro-1,2,7-trideoxy-1-[2-(hydroxymethyl)-3-methoxyphenyl]-allo-hept-1-enitol
CHEMBL445220
(2r,3s,4r,5s)-2-[(e)-2-[2-(hydroxymethyl)-3-methoxyphenyl]ethenyl]-5-methyloxolane-3,4-diol
(+)-varitriol
419568-67-5
SCHEMBL6507300
DTXSID60348394
nsc754774
nsc-754774
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (66)

Assay IDTitleYearJournalArticle
AID338577Growth inhibition of human EKVX cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338627Growth inhibition of human BT549 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338619Growth inhibition of human PC3 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338615Growth inhibition of human RXF393 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338574Growth inhibition of human RPMI8266 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338595Growth inhibition of human SNB75 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338591Growth inhibition of human SW620 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338616Growth inhibition of human SN12C cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338580Growth inhibition of human NCI-H226 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338604Growth inhibition of human UACC62 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338617Growth inhibition of human TK10 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338572Growth inhibition of human K562 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338579Growth inhibition of human HOP92 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338603Growth inhibition of human UACC257 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338623Growth inhibition of human MDA-MB-231 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338586Growth inhibition of human HCC2998 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338596Growth inhibition of human U251 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338584Growth inhibition of human NCI-H522 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338611Growth inhibition of human 786-0 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338576Growth inhibition of human A549 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338575Growth inhibition of human SR cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338585Growth inhibition of human COLO205 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338633Antimicrobial activity against Escherichia coli at 100 ug/ml2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338625Growth inhibition of human MDA-MB-435 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338624Growth inhibition of human Hs 578T cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338597Growth inhibition of human LOXIMVI cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338607Growth inhibition of human OVCAR4 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338601Growth inhibition of human SK-MEL-28 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338599Growth inhibition of human MALME-3M cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338581Growth inhibition of human NCI-H23 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338590Growth inhibition of human KM12 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338622Growth inhibition of human NCI/ADR-RES cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338583Growth inhibition of human NCI-H460 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338598Growth inhibition of human M14 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338614Growth inhibition of human Caki1 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338571Growth inhibition of human HL-60(TB) cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338628Growth inhibition of human T47D cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338634Antimicrobial activity against Proteus sp. at 100 ug/ml2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338605Growth inhibition of human IGROV1 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338610Growth inhibition of human SKOV3 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338602Growth inhibition of human SK-MEL-5 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338612Growth inhibition of human A498 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338593Growth inhibition of human SF295 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338621Growth inhibition of human MCF7 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338588Growth inhibition of human HCT15 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338620Growth inhibition of human DU145 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338589Growth inhibition of human HT-29 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338635Antimicrobial activity against Candida albicans at 100 ug/ml2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338626Growth inhibition of human MDA-N cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338573Growth inhibition of human MOLT4 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338613Growth inhibition of human ACHN cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338608Growth inhibition of human OVCAR5 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338606Growth inhibition of human OVCAR-3 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338592Growth inhibition of human SF268 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338587Growth inhibition of human HCT116 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338631Antimicrobial activity against Staphylococcus aureus at 100 ug/ml2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338600Growth inhibition of human SK-MEL-2 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338609Growth inhibition of human OVCAR8 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338582Growth inhibition of human NCI-H322M cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338630Antimicrobial activity against Bacillus subtilis at 100 ug/ml2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338578Growth inhibition of human HOP62 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338618Growth inhibition of human UO31 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338570Growth inhibition of human CCRF-CEM cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338594Growth inhibition of human SNB19 cells2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338632Antimicrobial activity against Salmonella Typhimurium at 100 ug/ml2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
AID338629Antimicrobial activity against Enterococcus faecalis at 100 ug/ml2002Journal of natural products, Mar, Volume: 65, Issue:3
Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (41.67)29.6817
2010's7 (58.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.57

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.57 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.57)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (8.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
kojic acid
[no description available]		2.02104-pyranones;
enol;
primary alcohol		Aspergillus metabolite;
EC 1.10.3.1 (catechol oxidase) inhibitor;
EC 1.10.3.2 (laccase) inhibitor;
EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 1.4.3.3 (D-amino-acid oxidase) inhibitor;
NF-kappaB inhibitor;
skin lightening agent
mannitol
[no description available]		7.0510mannitolallergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent
xanthone
xanthone : The parent compound of the xanthone class consisting of xanthene bearing a single oxo substituent at position 9.		2.0110xanthonesinsecticide
xanthenes
Xanthenes: Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring.		2.0110xanthene
cyclopentane
Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.		2.4220cycloalkane;
cyclopentanes;
volatile organic compound		non-polar solvent
fluorides
[no description available]		7.0610halide anion;
monoatomic fluorine
alkenes
[no description available]		2.7530
aflatoxin b1
Aflatoxin B1: A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.. aflatoxin B1 : An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.		2.0210aflatoxin;
aromatic ether;
aromatic ketone		carcinogenic agent;
human metabolite
ergosterol
[no description available]		2.01103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols		fungal metabolite;
Saccharomyces cerevisiae metabolite
sterigmatocystin
[no description available]		2.0210sterigmatocystinsmetabolite
terrein
terrein: from culture solution of fungus, Pestilotiopsis microspora;structure in first source		2.4220polyol
asteltoxin
asteltoxin: polyenic alpha-pyrone mycotoxin closely related to aurovertins isolated from Aspergillus stellatus; structure given in first source		2.0210furofuran
emerin
emerin: a serine-rich protein; responsible for Emery-Dreifuss muscular dystrophy (EDMD)		2.0210
shamixanthone
shamixanthone : A pyranoxanthene that is 2,3-dihydropyrano[3,2-a]xanthen-12(1H)-one bearing hydroxy substituents at positions 1 and 11 as well as a prop-1-en-2-yl group at position 2, a methyl substituent at position 5 and a 3,3-dimethylallyl group at position 8. A secondary metabolite produced by Aspergillus nidulans.		2.0110cyclic ketone;
phenols;
pyranoxanthene		metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.0110
Cancer of Colon
[description not available]		02.0110
Cancer of Kidney
[description not available]		02.0110
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.0110
Cancer of Lung
[description not available]		02.0110
Cancer of Prostate
[description not available]		02.0110
Central Nervous System Neoplasm
[description not available]		02.0110
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0110
Colonic Neoplasms
Tumors or cancer of the COLON.		02.0110
Kidney Neoplasms
Tumors or cancers of the KIDNEY.		02.0110
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0110
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.0110
Central Nervous System Neoplasms
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.		02.0110