tropapride profile

Tropapride is a dopamine D2 receptor antagonist with high selectivity for D2 receptors over D1 receptors. It has been studied for its potential use in the treatment of Parkinson's disease, Tourette's syndrome, and other neurological disorders. The synthesis of tropapride involves a multi-step process that starts with the preparation of a key intermediate, followed by a series of reactions to introduce the desired functional groups. Tropapride exhibits antipsychotic effects by blocking dopamine receptors in the brain, which is thought to reduce the symptoms of psychosis. It has also been shown to have anti-emetic effects and may be beneficial in the treatment of nausea and vomiting associated with chemotherapy. Tropapride is being studied for its potential therapeutic applications in various neurological disorders due to its high affinity for D2 receptors and its unique pharmacological profile. Research on tropapride is ongoing to further evaluate its efficacy, safety, and potential benefits for patients with these conditions.'

tropapride: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	71148
CHEMBL ID	3989712
MeSH ID	M0118021

Synonym
tropapride
76352-13-1
n-(8-benzyl-8-azabicyclo[3.2.1]octan-3-yl)-2,3-dimethoxybenzamide
benzamide, 2,3-dimethoxy-n-((3-exo)-8-(phenylmethyl)-8-azabicyclo(3.2.1)oct-3-yl)-
benzamide, 2,3-dimethoxy-n-(8-(phenylmethyl)-8-azabicyclo(3.2.1)oct-3-yl)-, exo-
unii-5zfb9y7bh0
n-((1beta,5beta)-8-benzyl-8-azabicyclo(3.2.1)octan-3beta-yl)-2,3-dimethoxybenzamid
tropapridum
tropaprida [spanish]
n-(8-benzyl-1alphah,5alphah-nortropan-3beta-yl)-o-veratramide
2,3-dimethoxy-n-((3-exo)-8-(phenylmethyl)-8-azabicyclo(3.2.1)oct-3-yl)benzamide
tropaprida
tropapride [inn]
5zfb9y7bh0 ,
md 790501
tropapridum [latin]
n-(8-benzyl-1.alpha.h,5.alpha.h-nortropan-3.beta.-yl)-o-veratramide
CHEMBL3989712
n-[(1s,5r)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]-2,3-dimethoxybenzamide
Q27263094
AKOS040754271

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (60.00)	18.7374
1990's	2 (40.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
haloperidol Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.	2	1	aromatic ketone; hydroxypiperidine; monochlorobenzenes; organofluorine compound; tertiary alcohol	antidyskinesia agent; antiemetic; dopaminergic antagonist; first generation antipsychotic; serotonergic antagonist
metoclopramide Metoclopramide: A dopamine D2 antagonist that is used as an antiemetic.. metoclopramide : A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.	6.97	1	benzamides; monochlorobenzenes; substituted aniline; tertiary amino compound	antiemetic; dopaminergic antagonist; environmental contaminant; gastrointestinal drug; xenobiotic
risperidone Risperidone: A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.. risperidone : A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.	2	1	1,2-benzoxazoles; heteroarylpiperidine; organofluorine compound; pyridopyrimidine	alpha-adrenergic antagonist; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; H1-receptor antagonist; psychotropic drug; second generation antipsychotic; serotonergic antagonist
spiperone Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.. spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.	1.96	1	aromatic ketone; azaspiro compound; organofluorine compound; piperidines; tertiary amino compound	alpha-adrenergic antagonist; antipsychotic agent; dopaminergic antagonist; psychotropic drug; serotonergic antagonist
sulpiride Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed). sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.	1.96	1	benzamides; N-alkylpyrrolidine; sulfonamide	antidepressant; antiemetic; antipsychotic agent; dopaminergic antagonist
apomorphine Apomorphine: A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.	2.37	2	aporphine alkaloid	alpha-adrenergic drug; antidyskinesia agent; antiparkinson drug; dopamine agonist; emetic; serotonergic drug
zetidoline zetidoline: structure given in first source	6.97	1
ro 22-1319 Ro 22-1319: RN refers to (trans(+-)-isomer); structure in first source	1.97	1

Condition	Relationship Strength	Studies
Anochlesia [description not available]	1.96	1
Dyskinesia, Medication-Induced [description not available]	1.96	1
Dyskinesia, Drug-Induced Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)	1.96	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2	1
Dementia Praecox [description not available]	2	1
Schizophrenia A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.	2	1

tropapride

Description

Cross-References

Synonyms (21)

Research Excerpts

Research

Studies (5)

Market Indicators

Research Demand Index: 12.44

Study Types