Compounds > tris(4-chlorophenyl)methane
Page last updated: 2024-12-07

tris(4-chlorophenyl)methane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Tris(4-chlorophenyl)methane, also known as tri-p-chlorophenylmethane, is a colorless to pale yellow solid organic compound with the formula (ClC6H4)3CH. It is a triarylmethane derivative and is used as a starting material in the synthesis of other organic compounds, including pharmaceuticals and pesticides. It has been studied for its potential anticancer activity. The synthesis of tris(4-chlorophenyl)methane typically involves the Friedel-Crafts alkylation of benzene with 4-chlorobenzoyl chloride, followed by reduction of the resulting ketone. The compound has been investigated for its potential environmental impact, as it may persist in the environment and be bioaccumulated in aquatic organisms. It has been used as a model compound in studies of the environmental fate of other triarylmethane compounds.'

tris(4-chlorophenyl)methane: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID92256
SCHEMBL ID4088048
MeSH IDM0391383

Synonyms (13)

Synonym
1-[bis(4-chlorophenyl)methyl]-4-chloro-benzene
tris(4-chlorophenyl)methane
27575-78-6
1-[bis(4-chlorophenyl)methyl]-4-chlorobenzene
methane, 4,4',4''-trichlorotriphenyl-
tris(p-chlorophenyl)methane
benzene, 1,1',1''-methylidynetris(4-chloro-
SCHEMBL4088048
WAGIESWOTQOLJS-UHFFFAOYSA-N
triphenylmethane, 4,4',4''-trichloro
DTXSID70181976
benzene, 1,1',1''-methylidynetris[4-chloro-
A876893
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (83.33)29.6817
2010's0 (0.00)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.41 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methane
Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).		7.610alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound		bacterial metabolite;
fossil fuel;
greenhouse gas
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		7.610alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
dichlorodiphenyl dichloroethylene
Dichlorodiphenyl Dichloroethylene: An organochlorine pesticide, it is the ethylene metabolite of DDT.		2.0310chlorophenylethylene;
monochlorobenzenes		human xenobiotic metabolite;
persistent organic pollutant
ddt
1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane: structure in first source		2.610benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant
4,4'-dichlorodiphenyl sulfone
[no description available]		2.0310
tris(4-chlorophenyl)methanol
[no description available]		2.9640
1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene
1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene: structure given in first source		2.0310
ConditionIndicatedRelationship StrengthStudiesTrials